• Korean Journal of Social Welfare
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• v.51
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• pp.93-118
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• 2002

The objective of this study was to determine the effect of a psycho-educational group intervention in reducing psychologic distress and enhancing coping in Korean breast cancer patients. The patient selection criteria were age younger than 70 years, having any postoperative adjuvant therapy, and surgery undergone within the previous 12 months as of the start of the study and there were 70 patients eligible for this criteria. They were randomized into three groups; experimental group(24 patients), wait-list control group(24 patients) and wait-list group(36 patients). We conducted a 8-week, structured, psychosocial group intervention, which used psycho-educational strategies combining education and psychological support. Subjects were assessed for psychological distress and coping by administering the Beck Depression Inventory(BDI) and the Ways of Coping Checklist-Revised(WCCL-R) at the baseline and after 8 weeks. Forty eight patients were participated and thirty five patients completed the study. The experimental group had significantly lower scores than the controls for depression on the BDI(p=.012) after 8-week intervention. However, coping did not show a significant difference on WCCL-R after the intervention. Despite of some limitations, the results of this study suggest that a short term psychosocial group intervention produces a significant improvement in the quality of life of patients with primary breast carcinoma in Korea in terms of managing depression.

• Radiation Oncology Journal
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• v.22 no.4
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• pp.307-315
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• 2004

Purpose: The purpose of this work was to study the differences of cyclooxygenase (COX-2) expression between Korean and Caucasian patients with early-onset breast carcinoma by immunohistochemistry. The test were analyzed to find a correlation between COX-2 and other biomarkers including HER-2/neu amplification, because we previously reported that a significant difference had been found in the expression of HER-2/neu between the two races. Furthermore, we investigated prognostic significance of COX-2 in korean patients. Materials and Methods: Sixty Korean women who were diagnosed breast carcinoma at 45 years old or younger and 60 Caucasian women with breast carcinoma were selected for this study. The median age of both groups was 37 years and tumor sizes were distributed evenly between the two group. Paraffin embedded blocks of primary tumor were processed for immunohistochemical staining of COX-2. The COX-2 expression was evaluated according to the percentage of positive cells and the intensity of staining. And the results were compared with the data of the previous studies to find correlation between COX-2 and other parameters and survival data. Results: Proportion of the COX-2 expression in total patients was $27.6\%$. The percentage of tumors that stained positive for COX-2 in korean and Caucasian women with early-onset breast carcinoma were $37.9\%$ and $20.8\%$, respectively. The difference was statistically not significant(p=0.090). Expression of COX-2 was not associated with several clinicopathologic parameters including HER-2/neu overexpression, but negative estrogen receptor status was correlated with significance (p=0.046). The 5 year disease free survival rate for patients with COX-2 expression was $67.9\%$, compared to $81.9\%$ of the COX-2 negative patients and the result was statistically not significant. Conclusions : A significant difference was not found in the expression of COX-2 between the two groups of patients with early-onset breast carcinoma. And correlation between COX-2 and other parameters was not observed except estrogen receptor negativity. Large scaled further research including radiotherapy factors will be needed to identify COX-2 as a prognostic role in patients with early-onset breast carcinoma.

• Journal of Digital Convergence
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• v.12 no.5
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• pp.305-310
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• 2014

This study was attempted to identify the factors influencing on cervical cancer screening acceptance using Pap smear in women over 20 years old. The subjects of this study were 192 screening acceptance group who visited health examination center. Data were collected by interview and self-administered questionnaire from April 22 through May 24, 2013. The results of this study as follows. Firstly, the response rate(45.8%) of non-screening acceptance group who is not a religion was significantly higher than the response rate(32.3%) of screening acceptance group($X^2=4.82$, p<.05). Secondly, the response rate(61.5%) of non-screening acceptance group who performed breast-feeding was significantly higher than the response rate(46.9%) of screening acceptance group($X^2=0.61$, p<.05). Thirdly, screening acceptance group who performed other screening was significantly higher 4.62 times than non-screening acceptance group(95% Cl=1.15-9.84, P=0.006). Based on the results of this study, it necessary to provide more cervical cancer screening information which can change the negative attitude among the public toward cancer screening acceptance using Pap smear.

• Journal of the Korea Society of Computer and Information
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• v.25 no.6
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• pp.155-164
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• 2020

In this paper, we proposed the dimensional system and pattern of middle-aged women's rashguard swimwear for breast cancer patients. First, a survey of 37 breast cancer patients was conducted to determine the preferred swimsuit design for breast cancer patients. According to a survey of breast cancer patients, a rashguard swimwear with a low-exposure chest was designed. It has a pocket shape in which the cap is easy to insert and the cap is fixed. Second, we developed a dimensional system for swimsuits for breast cancer patients. Using direct measurement data from Size Korea for 1,625 women aged 30 to 69, 17-sizes for breast cancer patient's swimsuits were set through cross-analysis of major dimensions, with a coverage rate of 74.3%. It also extracted a standard size of bust circ. 90cm, hip circ. 95cm, and trunk circ. 150cm. Third, we developed a pattern for the central size of the swimsuit for breast cancer patients. For this purpose, we first produced the first central size pattern, and then completed the pattern after modifying it through the second and third wearing experiments. Experimental suits were produced at each pattern-making stage to evaluate wearing fit and motion suitability. Finally, the reduction rate of each dimension item for optimal pattern production was obtained, and the lashguard swimwear pattern for breast cancer patients was developed.

• Women's Health Nursing
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• v.18 no.1
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• pp.1-16
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• 2012

Purpose: The purpose of this study was to describe the experiences of the process of the change in cognitive function for women treated with chemotherapy for breast cancer. Methods: There were ten participants in total in this study. Data were gathered utilizing in-depth interviews over 3 times from September 2010 to January 2011. Data were analyzed by employing Strauss and Corbin's (1998) grounded theory methodology. Results: Findings indicate that causal conditions of these results were 'side effects of chemotherapy' and 'menopausal state', including contextual conditions as, 'mental fatigue' and 'anxiety about recurrence'. The core category was identified as 'confronting with unexpected chaos'. Intervening conditions were 'support from other people', 'lack of information on cognitive impairment'. Interaction strategies were 'changing the habit of life', 'making efforts for living life' and 'seeking for medical information'. Consequences of the process were 'physical restriction', 'difficulty in social life', 'disturbed working ability' and 'psychological distress'. Conclusion: The results of this study show that nurses should recognize there is a notable difference between individual patient's contextual conditions and interactive strategies. Furthermore educational information and individualized intervention should be provided to improve cognitive function for women with breast cancer.

• Korean Journal of Adult Nursing
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• v.19 no.5
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• pp.138-149
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• 2007

Purpose: This study was to identify the level of quality of life in patients with woman cancer across treatment phases. Methods: The research method was a cross-sectional descriptive study. Data was collected by questionnaires from 226 female, who were in- and out-patients. They were diagnosed with breast and uterine cancer from three university hospitals and two general hospitals. The instruments used for this study included, "the Quality Of Life Scale(QOL)". The collected data were analyzed using Frequency, Percentage, ANOVA, Two-Way ANOVA. Results: Quality of life of women cancer patients was significantly different according to three treatment phases. Quality of life of women cancer patients was not significantly different according to areas of disease in the three treatment phases. Quality of life of women cancer patients was significantly different according to level of fatigue in the three treatment phases. Quality of life of women cancer patients was significantly different according to level of perceived health status in the three treatment phases(F=60.14, p=0.000). Quality of life of women cancer patients was significantly different according to education level(F=3.70, p=0.027) & occupation(F=5.67, p=0.018) in three treatment phases. Conclusion: Strategies for intervention are needed to improve the quality of life in women cancer patients across the treatment phases. The significant several characteristics of affecting on quality of life across treatment phases should be considered in sociopsychological nursing intervention.

• KSBB Journal
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• v.17 no.4
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• pp.409-415
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• 2002

A certain group of phytochemicals such as isoflavone have been proven to act as a phytoestrogen. After thorough the study of different bibliographic herbs excluding soybeans, dates, pomegranates, and other publicized plants, three different edible herbs by Korean Food Regulation were extracted for the animal study on the effect of estrogen replacement. The herbal extract(FGF271) has been orally administered into 51 weeks old partial ovariectomized rats for 5 weeks with the different dosages of 100 and 1,000 mg/kg, respectively. It was observed that 1) serum estrogen level was increased in both 100 and 1,000 mg/kg group, 2) the distension of uterus was made dose dependently and significantly different in 1,000 mg/kg group (p.0.05) from control in the gross findings, 3) the weight of uterus was increased in 1,000 mg/kg group, and 4) the action on reproductive tissues was clear in the microscopic findings in terms of hyperplasia of endometrial epithelial cell, cystic change of submucosa, dilatation of uterus (significantly increased in 1,000 kg/mg), and follicular cystic changes in ovary. As a result, FGF271 seemed to act as a phytoestrogen by inducing the change in ovary and uterus and by increasing the serum estrogen concentration.

• Research in Community and Public Health Nursing
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• v.11 no.2
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• pp.606-612
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• 2000

본 연구의 목적은 유방자가검진(BSE)의 지식정도, 훈련도, 숙련도 및 빈도와의 관계를 파악하고, BSE 빈도를 가장 잘 예측하는 변수를 결정하기 위함이다. 연구대상자는 미국에 이민 온 40세-60세 사이의 중년 여성 58명으로 와싱톤주의 시애틀과 타코마 지역에 거주하고 있었다. 연구도구는 미국암협회의 BSE 안내책자를 기초로 하여 개발하였다. 자료는 자가보고형 질문지를 이용하여 한국교회 4곳으로부터 연구의 취지를 설명하고 연구대상자들의 연구동의를 얻은 후 우편으로 질문지를 회수하였다. 자료수집 기간은 2000년 3월 6일부터 2000년 5월13일이었으며. 질문지 회수율은 77%이었다. 수집된 자료는 SPSS를 이용하여 Frequency, Percentage, Pearson correlation, Regression analysis로 분석하였다. 연구 결과는 주요 변수사이의 관련성에서 그 이전연구 결과와 대개 일치하였다. 대상자의 BSE 빈도는 년간 10회-12회 실행이 21.08%이였고, 전혀 실행하지 않는 정도가 4.80%를 차지했다. BSE 빈도와 관련변수와의 상관관계에서 나이는 BSE 빈도와 역상관 관계(r=-.289, p=.038)를 나타냈고, BSE 훈련에 대한 지도(r=0521, p=.000). BSE 지식에 대한 기술(r=.573, p=.000) 및 BSE 숙련도(R=.694 P=.000)는 BSE 빈도와 정상관 관계를 보였다. 회귀분석 결과는 BSE 빈도의 가장 유의한 예측변수로서 BSE 지식에 대한 기술(beta=.5813. p=.003)로 지지되었다. 이 연구의 의의는 지역사회간호사가 이민 온 한국 중년여성들의 BSE실행에 대한 이해를 높임으로 유방암의 조기발견에 대한 예방적 행위를 증진시키는 데 유용한 기초 자료로 제공될 것이다.

• Journal of Genetic Medicine
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• v.6 no.2
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• pp.179-182
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• 2009

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer. Among BRCA1- and BRCA2- mutation carriers, the average cumulative risks for ovarian cancer by age 70 years were 39% and 11%, respectively. There are other hereditary cancer syndromes such as Hereditary nonpolyposis colorectal cancer also confer a higher risk for developing ovarian cancer, but over 90% of all hereditary ovarian cancers are thought to be associated with BRCA1 or BRCA2 mutations. This report concerns a Korean woman diagnosed with ovarian cancer present with a family history of ovarian and various other cancers, in whom a germline BRCA1 mutation was identified and the same mutation was found in one of two daughters of her's. Since there could be more hereditary ovarian cancer patients in Korean than clinicians thought, both primary and secondary prevention of ovarian cancer based on family history and genetic information is important to reduce cancer incidence and mortality.

• Tuberculosis and Respiratory Diseases
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• v.62 no.3
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• pp.203-210
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• 2007

Background: The incidence of adenocarcinoma of the lung has been increasing worldwide, and it has been generally been accepted to be relatively unrelated to smoking with a female preponderance. The aim of this study was to examine the gender-related pathological and survival differences in patients with an adenocarcinoma of the lung. Material and Method: A retrospective review of the clinical information of patients diagnosed with an adenocarcinoma of the lung at Kosin Medical Center from January 1999 to September 2005 was performed. The patient's demographics (age, gender), smoking history, stage, serum tumor marker, pathology classification, EGFR mutation, K-ras mutation, treatment methods, and survival time were analyzed. Result: Of the 438 patients, 179 (40.9%) were female. The median age at the diagnosis was 58 years for females and 59 years for males. However, 25.8% of women and only 17.7% of men were under 50 years of age (p=0.02). The distribution of the disease stage was similar in both men and women. The bronchioloalveolar carcinoma component was diagnosed more often in women (11.2%) than in men (5.0%). The overall survival rate was higher in women than in men (p=0.01), and women had a superior therapeutic response to a combined treatment of surgery and chemotherapy. Conclusion: This study showed significant genders differences in terms of the smoking history, bronchioloalveolar carcinoma component, overall survival, and survival after combined treatment of surgery and chemotherapy. Therefore, gender differences should be considered when diagnosing and treating adenocarcinomas of the lung.