• Korean Journal of Environmental Agriculture
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• v.28 no.3
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• pp.310-325
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• 2009

Veterinary drugs have been used to prevent livestock diseases for many years. In spite of having advantages, sometimes indiscriminate application, overdose and abuse may cause risk for human. Therefore, management and risk assessment of veterinary drugs become essential to ensure food safety. So the National Veterinary Research & Quarantine Service (NVRQS) impose on registration for use of veterinary drugs also Korea Food and Drug Administration (KFDA) fixed the maximum residue limits (MRLs) for veterinary drugs in food. Basically, KFDA set MRLs based on the veterinary drugs residual data. Moreover, KFDA estimates the theoretical maximum daily intake (TMDI) with food consumption data and population mean body weight. Recently, 116 veterinary drug MRLs including banned veterinary drugs have been established and other 32 veterinary drugs MRLs will be established within 2009. In 2010, MRLs among antibiotics and synthetic antibacterial agents in livestock fishery products (including milk and eggs) and honey (including royal jelly and propolis) which have not been set in Korea Food Code and Codex Alimentarius Commission (CAC) will be regulated as uniform limit (0.03 mg/kg). In future, veterinary drugs will be controlled strictly to strengthen public health by improving analytical method.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.1-15
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• 2009

Newly published IEC 60601-1-3 ; 2008 2nd Edition has two important meanings. First, Radiation Quality and Dose should make sure for safety of patient and staff in manufacturing diagnostic X-ray equipment. Second, it should be minimized of Leakage Radiation, Residual Radiation, and Stray Radiation. The requirement to make enactment or revision of national standard for diagnostic X-ray Equipment is as follows : 1. It should be adjusted the new standard to the recent IEC Publication under the consideration of the Korea medical circumstances. 2. For focus to the Radiation Safety, IEC 60601-1-3 (General requirements for radiation protection in diagnostic X-ray equipment) could be applied to the new regulation. It should be compact sentence. 3. A sudden Notification change should not be desired. It needs a enough time to make easy the circumstances.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.28 no.1
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• pp.15-30
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• 2002

최근 화장품 사용인구의 증가와 안전성에 대한 관심 증대에 따라 화장품 중 유해성분 함유에 대한 논란이 종종 있어왔다. 화장품에 대한 전문적 지식이 없는 사람들에 의하여 진행된 잘못된 정보로 인하여 화장품 중에 포함된 모든 중금속이 인체에 심각한 영향을 초래한다는 등의 오해를 불러와 관련 업계에 적지 않은 피해를 주기도 하였다. 이에 본 자료에서는 구체적 근거자료와 연구 논문들을 기반으로 유해한 중금속, 안전하여 사용이 공인된 중금속 등을 조사하여 화장품에서의 중금속의 개념을 정립하고자 하였다. 국내에서는 식품의약품안전청 고시 제2000-27호에 화장품에 포함되었을 때 유해한 중금속으로 납, 비소 및 수은을 명시하고 그 규제농도를 규정하고 있다. 규제 중금속은 아니지만 피부에 알러지를 일으키는 중금속으로는 니켈이 있는데 화장품 중 몇몇 제품군에서 소량(수∼수십ppm) 이 검출되기도 한다. 그러나 이는 일상으로 사용하는 각종 귀금속, 시계, 안경테, 클립, 지퍼 등의 금속 용품에 포함된 니켈의 양(수∼수십%)에 비하여 매우 적은 양이며 정상적인 사람에게는 무해하다. 실제 대다수의 니켈 알러지는 화장품이 아닌 귀금속이나 시계 등의 금속류 제품 등에 의하여 유발된다. 또한 많은 종류의 중금속 화합물이 화장품 원료로 사용되고 있다. 전세계적으로 널리 사용되는 것으로 크롬, 망간, 비스머스, 구리, 철, 코발트, 티타늄, 아연 등의 화합물이 있으며 이들은 각종 화장품 공정서 및 원료집 등에 수재되어 사용되고 있다. 이들 중 코발트와 크롬이 피부에 유해하다는 몇몇 보고가 있지만, 이는 이들 원소의 수용성염형태의 특정 화합물인 cobalt chloride와 chromate 및 dichromate의 염에 관한 것으로 화장품에서 사용되는 불용성 산화물인 cobalt aluminum oxide, cobalt titanium oxide, cobalt blue, chromium oxde greens 및 chromium hydroide green 등, 국제적으로 널리 사용되는 안전한 중금속 화합물과는 그 특성 및 독성이 판이하게 다르다. 따라서 화장품에서는 매우 안전한 중금속 화합물만이 사용된다. 업계는 유해 중금속에 관해서는 규제에 입각한 엄격한 품질관리에 힘쓰고 중금속의 화학적 분자구조(수용성염 vs 불용성산화물)를 구별할 수 있는 분석방법 개발에 주력하여야 한다. 그리고 안전한 화장품을 사용하고자 하는 소비자의 욕구를 충족시키고 잘못된 인식과 보도로 인하여 안전한 화장품이 유해한 것으로 오도되는 것을 막아야 할 것이다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.10
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• pp.1343-1356
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• 2008

The evaluation of microbiological quality for school food samples collected from 19 selected middle and high schools located in Seoul was undertaken. Eighty-nine food samples consisting of 38 non-pretreated vegetables, 13 pre-washed and cut vegetables, 9 meats and poultry, 3 fish and shellfish, 7 dried fish, and shellfish and 20 processed foods were collected. Aerobic plate count, total coliforms, and Escherichia coli (E. coli ) were detected using $Petrifilm^{TM}$, and the food-borne pathogens were screened by multiplex PCR with species-specific primer sets. Sequentially, the quantitative and confirmative test of the food-borne pathogens were carried out with the selective media and biochemical kits. The contamination of coliform counts was observed on the pre-washed vegetables ($3.4{\sim}4.3\;log\;CFU/g$) and meats ($2.2{\sim}4.3\;log\;CFU/g$). Also, the cooked foods were heavily contaminated with coliform, ranging from 1.0 to $5.5\;log\;CFU/g$. E. coli counts were found in 16 raw and cooked food samples, exceeding the microbiological standards for the guideline of safety management for school foods. Through PCR detection, B acillus cereus was detected in 32 raw and cooked foods, and quantitatively found in pre-washed carrot, radish, and pan-broiled dried shrimp and filefish ranging from $2.3{\sim}3.6\;log\;CFU/g$, respectively. E. coli O157:H7 was detected on frozen pork sample and was confirmed with API kit. Campylobacter jejuni was found in 3 ready-to-eat type vegetables. Vibrio parahaemolyticus were found in 4 pre-washed vegetables and 2 cooked foods, indicating unsatisfactory quality based upon the microbiological standards of ready-to-eat vegetables and cooked foods by Korea Food and Drug Administration. Salmonella spp. was detected in frozen chicken sample and confirmed by API kit and latex antisera agglutination.

• Korean Journal of Oriental Medicine
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• v.11 no.2
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• pp.155-165
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• 2005

This study was investigated to determine the quality control of Oriental medicine from stores dealing in Oriental medicine around Seoul and Daegu. We tested total 120 samples that widely used 15 species in herbal medicine (Lycii Fructus, Platycodi Radix, Angelicae Gigantis Radix and 12 others) being collected from Oriental medicine clinic, pharmacy, Oriental pharmacy, Oriental medical hospital and Oriental drug store. We have estimated Oriental medicine by K.P. (Korean Pharmacopoeia), K.H.P(Korean Herbal Pharmacopoeia) and announcement of KFDA. The items of examination were identification, purity, loss on drying, ash, acid insoluble ash, extract content, essential oil content, assay, heavy metal limit, and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin). As a result, 20 samples in total 120 samples were not satisfied with the standard and 7 species in total 15 species were not satisfied with the standard. Identification test, extract content test and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin) were satisfied with the standard. The result will be the basic data for the quality control of Oriental medicine.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.4
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• pp.219-225
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• 2007

Bis-ethylhexyloxyphenolmethoxyphenyltrizine (BEMT) is one of the most widely used chemical UVA+UVB double absorbers in sunscreen products. But topical application of BEMT is restricted due to its defects in product. The purpose of this study is to adopt the sunscreen product of solid lipid nano-particles containing BEMT (BEMT-SLN). The particle diameters, the encapsulation efficiencies and the crystallization index (C.I.) are about 330nm, 93.3 % and the 4.3 %. As a result, in vitro penetration and release of BEMT were generally higher in O/W emulsion than the SLN formulation. However in vivo study, it was shown that the rate of release could be decreased by 80 % in the SLN formulation. The sun protection factor (SPF) of the SLN formulation increased by 100 % in the in vitro UV protection test. Therefore, SLN formulation potentiated the UV-blocking power of BEMT. This study suggest that SLN can be used for the encapsulation of BEMT.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.251-270
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• 2003

Cosmetics have had only simple efficacy such as cleansing, beautification, and so on. The latest development tendency for cosmetics turned to make goods that is effective and efficacious for whitening, anti-wrinkle, etc., due to various wants of consumers, development of relative technical, etc. According to this stream, Korea Cosmetics Law has been enacted by the Notification of the Korea Food and Drug Administration in 2000. The establishment of Korea Cosmetics industry and opened regular 'Cosmeceuticals Time'. Since the Korea Cosmetics Law took effect on July 2000, the cosmeceuticals system has settled down according to its lights. This research studied how women consumers were understanding the cosmeceuticals system focused on their life style. This study is considered to offer a basic information about consumer's type and to be a groundwork data for working out a marketing strategy about the subdivision of cosmeceuticals market.

• Journal of Food Hygiene and Safety
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• v.23 no.3
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• pp.206-211
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• 2008

Photostimulated luminescence(PSL)-Thermoluminescence(TL) combined analysis was applied to detect whether composite seasoning products and spices were irradiated or not. Samples were irradiated with $^{60}Co$ at $0{\sim}7$ kGy. A total of 12 different samples(6 of composite seasoning products and 6 of spices) was examined. Depending on the PSL results, TL analysis was performed. In case of both PSL positive(${\geq}5,000$ counts) and intermediate($700{\sim}5000$ counts), TL analysis had to be performed to confirm the result of PSL. Using TL, the shape of the glow curve(Glow 1) made it possible to identify the irradiated samples. In addition, The TL glow ratio(Glow 1/Glow 2) obtained by normalization was less than 0.1 for the non-irradiated samples and ${\geq}0.29$ for irradiated ones, respectively.

• Journal of Life Science
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• v.26 no.2
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• pp.204-211
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• 2016

The objective of this study was to obtain acute (single) oral dose toxicity information on Lactobacillus-fermented Araliae Continentalis Radix aqueous extracts (fACR) in female and male ICR mice, as compared with Araliae Continentalis Radix aqueous extracts (ACR). After administering a single oral dose of fACR, no treatment-related mortalities were observed within 14 days after the end of treatment up to 2,000 mg/kg, the maximum dosage for rodents of both sexes; moreover, no fACR treatment-related changes in the body and organ weights, clinical signs, necropsy, and histopathological findings were detected in this experiment. In addition, no ACR 2,000 mg/kg treatment-related mortalities, clinical signs, body and organ weights, or gross and histopathological findings were observed, as compared with equal genders of vehicle control. The results obtained in this study suggest that fACR is non-toxic in mice and is, therefore, likely to be safe for clinical use. The LD₅₀ and approximate LD in female mice and male mice, respectively, were considered after a single oral dose of fACR over 2,000 mg/kg, the maximum dosage for rodents. In addition, no specific targets or clinical signs were detected in the present study. ACR 2,000 mg/kg-treated mice also did not show any treatment-related mortalities, clinical signs, changes to body and organ weights, or gross and histopathological findings, as compared with equal genders of vehicle control.

• Journal of Food Hygiene and Safety
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• v.21 no.2
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• pp.52-59
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• 2006

This survey was conducted to monitor the current status of pesticide residues in imported agricultural products circulated in Gwangju, 2005. A total of 108 samples was analyzed by multiresidue method. Of these samples, 32 were citrus fruits, 60 were tropical fruits and grapes, and 16 were vagetables. The origin was Philippine for 39 samples, U.S.A. for 36, China for 12, New Zealand for 11, Chile for 6, etc. The overall rate of detections was 30.6% and no samples had violative residues. Of citrus fruits,20 samples (62.5%) had residues and the residues were thiabendazole, imazalil, chlorpyrifos, etc. Of tropical fruits and grapes, 13 samples (12.0%) had residues and the residues were azoxystrobin, chlorpyrifos, carbendazim, captan, etc. 16 of vagetables had no detectable pesticide residues. Thiabendazole (71% in oranges and 56% in grapefruits) and imazalil (50% in oranges) were found in citrus fruits, which were frequently used as post-harvest pesticides. And azoxystrobin which is one of strobilurin fungicides, was often detected in mango, tropical fruit(27%).