• Korean Journal of Food Science and Technology
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• v.36 no.6
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• pp.986-990
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• 2004

The immunomodulatory effect of Codonopsis lanceolata based on the production of cytokines and the activation of macrophage was studied. The mRNA expression of nitric oxide synthase (iNOS) was gradually induced after 24 hr treatment of Codonopsis lanceolata, and NO production was a maximum after 24 hr treatment with 1 mg/mL. RAW 264.7 cell on in vitro treatment with Codonopsis lanceolata induced mRNA of cytokines such as interleukin-1(IL-1)${\beta}$, interleukin-6(IL-6), tumor necrosis $factor(TNF)-{\alpha}\;and\;interferon(IFN)-{\gamma}$; $IL-1{\beta}$ and IL-6 mRNA were gradually induced up to 24 hr, $TNF-{\alpha}\;mRNA$ was regularly induced up to 24 hr, and $IFN-{\gamma}\;mRNA$ level was a maximum within 1 hr. These results suggest that Codonopsis lanceolata exerts as an effective immunomodulator and enhances antitumor activity of macrophages.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05a
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• pp.462-465
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• 2006

This paper is aimed at proposing the sampling method to reduce variance of statistical parameters in uncertainty analysis of concrete structures. The proposed method is a modification of Latin Hypercube sampling method. This uses specially modified tables of random permutations of rank number. Also, the Spearman coefficient is used to make modified tables. Numerical analysis is carried out to predict the uncertainty of axial shortening in prestressed concrete bridge. The numerical results show that the method is efficient for uncertainty analysis of complex structural system such as prestressed concrete bridges.

• Journal of Korea Multimedia Society
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• v.11 no.4
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• pp.434-442
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• 2008

The parallel beam SPECT acquires projection data by using parallel hole collimators in conjunction with photon detectors. Those projection data of the parallel beam SPECT are, however, contaminated by the distance dependent blurring because of the inaccuracy of the point response function of the collimator that is used to define the range of directions where photons can be detected. Thus an efficient aperture correction is required. In this paper we propose a distance dependent backprojection method to overcome the time limitation of iterative aperture correction methods and the performance limitation of Fourier-Distance Relation based method. The proposed method achieves aperture correction and fast image reconstruction by replacing the distance independent backprojection of the direct image reconstruction with the distance dependent one. We conducted several simulations to compare the performance of the proposed method with that of the conventional Fourier-Distance Relation based method. The simulation result shows that the proposed method outperforms the Fourier-Distance Relation based method in spatial resolution and robustness against noise.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.3A
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• pp.221-228
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• 2010

External bonding of carbon fiber reinforced polymer (CFRP) sheets has been widely accepted as a popular method for strengthening of deteriorated RC structures. The long-term behavior of CFRP-strengthened RC structure is often affected by that of the interface between CFRP sheets and concrete. This study aims at applying a viscoelastic model to describe the creep behaviour of the adhesive layer bonding CFRP sheet to concrete, the CFRP-concrete interface. Reviews of available models on concrete creep behavior have been first carried out and then new FE analysis model is proposed. The proposed FE analysis model based on the maxwell model has been verified by previous experimental results. It is shown that the creep effect of interfacial adhesive layer is very important on the long-term behavior of concrete structures strengthened with CFRP.

• Proceedings of the Korean Information Science Society Conference
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• 2006.06d
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• pp.169-171
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• 2006

무선 센서 네트워크에서는 고정된 인프라에 의존하기 어려운 환경을 가지고 있다. 하지만, 위치기반 기술을 접목하여 센서의 절대적 또는 상대적인 위치정보를 이용하면 다양한 응용서비스를 효과적으로 적용 할 수 있다. 이러한 센서 노드의 위치를 측정하는 방법 중에 시간을 기반으로 위치를 측정하는 방법이 가장 정확도가 높게 평가되었다[1]. 그러나 이러한 TOA방법은 노드의 Clock Rate에 의존적이기 때문에 위치오차가 발생하게 된다. 따라서 Node의 Clock Drifi를 줄이기 위해서 주기적인 시간동기화가 필요했다[3,4]. 하지만 본 논문에서는 이러한 거리오차를 제거하기 위한 방법으로 시간 비동기화 방법(ALS)을 소개하고, ALS를 기반으로 시뮬레이션과 실질적인 센서를 가지고 노드 사이의 거리와 위치를 측정하였다. 실험 결과, 기존의 TOA방법과 비교하여 거리 및 위치 정확도, Packet 트래픽에 대해서 성능 향상을 확인한다.

• The Journal of the Acoustical Society of Korea
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• v.17 no.4
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• pp.45-53
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• 1998

본 논문에서는 선스펙트럼 주파수(LSF) 파라미터를 위한 제한된 시간적 분해법을 제안한다. LSF 파라미터는 인접 차수에 대해 의존적이고, 차수간 순차성이 있으나, 기존의 시간적 분해법은 이러한 성질을 보존하지 못한다. 즉, 추정된 사건 벡터가 더 이상 LSF 파 라미터로서 해석되지 못하는 문제가 있다. 이를 해결하기 위하여, 본 논문에서는 사건 함수 간에 새로운 제약을 두어, 추정된 사건 벡터가 LSF 파라미터의 성질을 유지하도록 한다. 결 과적으로 제안된 방법을 이용하여 구해진 사건 벡터는 LSF 파라미터와 동일한 방법을 적용 하여 효과적으로 양자화될 수 있고, 실험 결과 평균 752bps의 전송률로 투명한 양자화를 수 행할 수 있었다.

• Journal of Ginseng Research
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• v.24 no.4
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• pp.202-205
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• 2000

KJHST (Kejihongsarntang) is a modified oriental prescription that consists of five herbs such as Ginseng Radix rubra Koreana, Atractylodis Rhizoma, Zingiberis Rhiaoma, Cinnamomi Ramulus and Glycyrrhizae Radix. For the evaluation of antioxidant and staminal activities of KJHST (Kejihongsarntang), the study was done in comparison of Ginseng Radix rubra (GR). For the antioxidant study, KJHST inhibited hemolysis of erythrocyte and decolored the DPPH(2,2-diphenyl-1-picrylhydrazyl) free radical in a dose depenrlent manner more effectively than GR alone in vitro. KJHST and GR significantly suppressed the time course (1 hr∼6 hr)-level of MDA (malondialdehyde) following AAPH (2,2'-azo-bis-(2-amidino-propane) dihydrochloride) treatment in vivo as compared with control data with no statistical difference. From the evaluation of stamina by swimming test GR and KJHST significantly increased the swimming time in a time and dose dependent manner as compared with control data, while GR was more effective than KJHST in 2 weeks after treatment, though KJHST was more effective than GR at low dose (25 m/kg) 4 weeks after treatment. From the results it can be concluded GR and KJHST had antioxidant and staminal activities.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.2
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• pp.109-120
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• 2007

Auxiliary support systems such as the reinforced protective umbrella method have been applied before tunnel excavation to increase ground stiffness and to prevent the large deformation. However, determination procedure of geotechnical parameters along the construction sequence contains various errors. This study suggests a method to characterize the time-dependent behavior of pre-reinforced zones around the tunnel using elastic waves. Experimental results show that shear strength as well as elastic wave velocities increase with the curing time. Shear strength and strength parameters can be uniquely correlated to elastic wave velocities. Obtained results from the laboratory tests are applied to numerical simulation of tunnel considering its construction sequences. Based on numerical analysis, initial installation part of pre-reinforcement and portal of tunnel are critical for tunnel stability. Result of the time-dependent condition is similar to the results of for $1{\sim}2$ days of the constant time conditions. Finally, suggested simple analysis method combining experimental and numerical procedure which considering time-dependent behavior of pre-reinforced zone on tunnel would provide reliable and reasonable design and analysis for tunnel.

• Journal of Acupuncture Research
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• v.26 no.4
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• pp.49-58
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• 2009

목적 : 파킨슨 병은 기저핵 흑질의 치밀부에서 도파민성 신경세포의 퇴행으로 인하여 발생하는 질병으로 신경 염증이 주요 병인으로 밝혀져 있다. 이 연구는 MPTP 유발 파킨슨 병 동물 모델에서 신수혈($BL_{23}$)에 대한 봉독 약침의 항염증 효과 및 그 기전을 확인하기 위해 시행되었다. 방법 : $C57_{BL}$/6쥐를 무처치군, MPTP+saline군, MPTP+BVA(0.06mg/kg)군, MPTP+BVA(0.6mg/kg)군의 4군으로 나눈 뒤 무처치군을 제외한 모든 그룹에 총 8시간 동안 2시간 간격으로 MPTP-HCl(20mg/kg per dose$\times$4)을 복강내로 주입하였다. MPTP+BVA 군에서 봉독약침은 마지막 MPTP 주입 2시간 후부터 48시간 간격으로 신수혈($BL_{23}$)에 양측으로 각 20${\mu}\ell$씩 주입하였고 MPTP+saline군에서는 봉독약침 대신 Saline을 주입하였다. 마지막 MPTP 주입 후 7일째에 쥐의 뇌를 적출한 후 면역조직화학법을 시행하였다. 결과 : MPTP 유발 파킨슨 병 동물 모델에서 신수혈에 대한 봉독약침은 농도 의존적으로 TH-Immunoreactivity neuron의 감소와 microglial activation을 억제하였다. HSP70-IR neuron은 모든 군에서 나타나지 않았다. 결론 : 봉독약침이 용량의존적으로 microglial activation을 억제하는 효과를 통해 도파민성 신경세포의 파괴를 억제함으로써 항염 효과를 나타냄을 알 수 있었다. 이 결과는 봉독약침이 microglial activation 억제를 통해 임상적으로 파킨슨 병과 같은 신경 퇴행성 질병에 있어 유용한 치료수단이 될 수 있음을 시사한다.

• Journal of Korean Society of Steel Construction
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• v.14 no.3
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• pp.443-452
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• 2002

Construction of highway bridges is almost complete in many countries. Thus, the government and highway agencies are shifting their remaining life span from the viewpoint of system reliability. As such, it is necessary to develop maintenance models based on system reliability concept. In this paper, preventive and essential maintenance models were developed using system reliability and lifetime distribution.