• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.4
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• pp.312-318
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• 2015

The aim of this study was to investigate the possibility of the supernumerary teeth for the stem cell source in dentistry. The Real Time Quantitative Reverse Transcription Polymerase Chain Reaction (Real Time qRT-PCR) method was used to evaluate the differentiation toward the odontoblast of the supernumerary dental pulp stem cells (sDPSCs). Supernumerary dental pulp stem cells were obtained from 3 children (2 males and 1 female, age 7 to 9) diagnosed that the eruption of permanent teeth was disturbed by supernumerary teeth. The common genes for odontoblasts are alkaline phosphatase (ALP), osteocalcin (OC), osteonectin (ON), dentin matrix acidic phosphoprotein 1 (DMP-1), dentin sialophosphoprotein (DSPP). The sDPSCs were treated for 0 days, 8 days and 14 days with additives and then Real Time qRT-PCR was performed in intervals of 0 days, 8 days and 14 days. The alizarin-red solution staining was performed to visualize the stained color for the degree of calcification at 7 days, 14 days, 21 days and 28 days after treating additives to the sDPSCs. From the result of the Real Time qRT-PCR, the manifestation exhibit maximum value at 8 days after additive treatment and shifted to a decrease trend at 14 days. Alizarin-red solution staining exhibit light results at 7 days after staining and generalized dark result at 14 days. Consequently, in studies with sDPSCs, appropriate treatment time of additives for Real Time qRT-PCR is 8 days. Also, a suitable period of Alizarin-red solution staining is 14 days.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.39 no.6
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• pp.49-58
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• 2002

Based on electrophysiological retina mechanism, a retina model is proposed, which has similar response characteristics compared with the real primate retina. Photoreceptors, horizontal cells, and bipolar cells are modeled based on the previously studied retina models. And amacrine cells known to have relation to movements detection, and bipolar cell terminals are newly modeled using 3 NDP mechanism. The proposed model verified by analyzing the spatial response characteristics to stationary and moving stimuli, and characteristics for different speeds. Through this retina model, human vision system could be applied to computer vision systems for movement detection, and it could be the basic research for the implantable artificial retina.

• Applied Microscopy
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• v.42 no.1
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• pp.17-26
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• 2012

Histologic and microstructural changes during the postembryonic development of the wolf spider Arctosa kwangreungensis were studied using light and scanning electron microscopy to examine the relationship between a morphological differentiation and behavioral properties. The postembryo with abdominal yolk sac was stayed inactive in the egg case because its muscular and visual systems were not fully developed to a functional level. The first instar spiderlings, developed from the postembryo by a first molting process, started to exhibit its pigmentation on their body cuticles. In particular, undifferentiated cell clusters of central nervous system (CNS) were densely distributed within the cephalothorax, and highly differentiated abdominal ganglion was observed. They had a characteristic visual system looks more like its adult counterpart, and had segmented appendages looks more like the tiny spiders containing well oriented muscular system. After 3rd instar, spiderlings grew more rapidly with accordance to their consistent growth and periodical molting processes. Thus, the relative area of CNS with respect to cephalothorax was gradually decreased, instead a pair of venom glands, musculature, and connectives occupied the residual area. It has been revealed that the early development of spider can be controled by the feeding condition of larval period, since histologic and microstructural differentiations in both appendages and optic system were completed at the second instar. In particular, behavioral properties of the wandering spiders that depend on vision and their running ability were deeply related to physiological differentiation of the microstructural development.

• Proceedings of the Korean Information Science Society Conference
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• 2004.10b
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• pp.289-291
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• 2004

본 논문에서는 생물체의 세포 내에 존재하는 방대한 객체들 사이의 복잡한 관계들로 표현되는 상호작용 네트워크를 효율적으로 구축할 수 있는 시스템을 제안한다. 이 시스템은 바이오 도메인 지식을 사용하여 상호작용 네트워크를 관리 및 활용하기 쉽도록 구축하고, 단백질과 같은 단순 바이오 객체뿐만 아니라 여러 개의 바이오 객체들로 구성된 복합 객체도 관리 할 수 있다. 여기서, 사용자가 바이오 객체들과 이들간의 복잡한 상호작용 관계를 직관적으로 정의 할 수 있는 인터페이스를 제공한다. 또한, 정의된 객체 및 상호작용 관계 정보를 이용하여 바이오 네트워크를 개념적으로 단순하게 표현할 수 있으며, 시각적으로도 네트워크를 자동으로 최적화하여 사용자가 복잡한 네트워크를 쉽게 분석 할 수 있도록 지원한다.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.34C no.10
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• pp.43-50
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• 1997

In this paper, we present a method that can recognize face images by use of a sparse population code that is a learning model about a receptive fields of the simple cells in the primary visual cortex. Twenty front-view facial images form twenty persons were used for the training process, and 200 varied facial images, 20 per person, were used for test. The correct recognition rate was 100% for only the front-view test facial images, which include the images either with spectacles or of various expressions, while it was 90% in average for the total input images that include rotated faces. We analyzed the effect of nonlinear functon that determine the sparseness, and compared recognition rate using the sparese population code with that using eigenvectors (eigenfaces), which is compact code that makes contrast with the sparse population code.

• Proceedings of the Korea Information Processing Society Conference
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• 2016.04a
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• pp.826-829
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• 2016

뇌파는 뇌신경 세포의 활동으로 발생하는 전기적 변화를 두피 표면에서 측정하여 기록한 것이다. 뇌활동의 변화는 공간적 시각적으로 파악할 수 있는 지표이며, 바이오 센싱을 통해 측정된 데이터를 활용한 미디어 컨텐츠 적용이 최근 시도되고 있다. 본 연구는 미디어 컨텐츠 평가를 위한 감성 지표로 뇌파 데이터를 인간의 오감으로 느낄 수 있는 표현으로 변환하는 프로세스를 구현하는 함으로써 현재 행해지고 있는 많은 미디어 아트에 대해 뇌파를 활용한 실시간 객관적 감성지표를 완성하는데 목적이 있다. 이에 대한 사전 연구로 본 논문에서는 측정된 뇌파 데이터를 인터렉티브 컨테츠적인 요소인 사운드로 청각화 하는 과정을 구현하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06c
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• pp.113-115
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• 2012

전사체(transcriptome) 분석이란 주어진 조건 하에서 현재 세포 내에 발현된 모든 트랜스크립트의 종류와 양을 밝히는 것을 의미하며, 분석 결과는 질병 관련성/유전적 요인 규명 등의 연구에 직접 활용한다. 우리는 선행 연구에서 RNA-Seq 데이터를 이용하여 선택 스플라이싱 과정에 의하여 생성되는 모든 트랜스크립트의 유형을 분류/추출하는 새로운 방법론을 제안한 바 있다. 그 후속 연구로서 본 연구에서는 시간/공간 효율적인 알고리즘 구현을 위한 최적화 방법론을 제안하고, 실용화를 위한 전사체 분석 도구 개발에 대하여 논한다. 개발된 전사체 분석 도구에서는 기존의 분석 도구와 달리 RNA-Seq 데이터의 단계적 분석 결과를 시각적 뷰어를 통하여 검색 가능하며, 이들 기능은 복잡한 전사체 분석 결과의 이해와 타당성 검증에 활용한다.

• Journal of Sensor Science and Technology
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• v.11 no.2
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• pp.84-92
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• 2002

A $32{\times}32$ pixels foveated (linear-polar) structure retina chip with the function of local-light adaptation for edge detection has been designed and fabricated using CMOS technology. Human retina can detect a wide range of light intensity. In this study, we use the biologically-inspired visual signal processing mechanism that consists of photoreceptors, horizontal cells, and bipolar cells in order to implement the function of edge detection in the retina chip. For a local-light adaptive function, the size of receptive field is changed locally according to the input light intensity. The spatial distribution of sensing pixels in the foveated retina chip has the advantages of selective reduction of image data and good resolution in central part to carry out the elaborate image processing with still enough resolution in the outer parts. The designed chip has been fabricated using standard $0.6\;{\mu}m$ double-poly triple-metal CMOS technology and optimized using HSPICE simulator.

• Journal of Korean Ophthalmic Optics Society
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• v.3 no.1
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• pp.9-13
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• 1998

Visual system of Korean Salamander(Hynobius leechi) was morphologically studied. Fertilized eggs in egg sacs were collected and were developed in sterile saline solution. Various sized larvae of 5-30mm in length were fixed. Specimens were paraffin sectioned and were observed under light microscope. In 5mm length larva, lens rudiment induced by optic cup was combined with sensory ectoderm. The shape of lens was changed as spherical in 12mm length larva, but the retinal layer did not differentiated into three layers. The differentiation of retinal layer was clear in 14-16mm length larva. The central region of lens fibers was degenerated. Iris and ciliary body were formed from the marginal zone of optic cup in 20mm length larva. Choroid was thicker in elder eye of 30mm length larva and cartilage developed at outer region of optic cup. The outer segment of photoreceptor cell layer grew longitudinally. Optic nerve was connected to the ventral part of brain through cartilage.

• Journal of the Korea Computer Graphics Society
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• v.28 no.2
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• pp.11-19
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• 2022

Recently, various researches on medical image generation have been suggested, and it becomes crucial to accurately evaluate the quality and diversity of the generated medical images. For this purpose, the expert's visual turing test, feature distribution visualization, and quantitative evaluation through IS and FID are evaluated. However, there are few methods for quantitatively evaluating medical images in terms of fidelity and diversity. In this paper, images are generated by learning a chest CT dataset of non-small cell lung cancer patients through DCGAN and PGGAN generative models, and the performance of the two generative models are evaluated in terms of fidelity and diversity. The performance is quantitatively evaluated through IS and FID, which are one-dimensional score-based evaluation methods, and Precision and Recall, Improved Precision and Recall, which are two-dimensional score-based evaluation methods, and the characteristics and limitations of each evaluation method are also analyzed in medical imaging.