• 생물치료정신의학
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• 제24권3호
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• pp.163-172
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• 2018

Objectives : The aim of this study was to examine associations between quality of life in patients with schizophrenia and their family relationships. Methods : A total of 68 patients with schizophrenia participated in the study. Socio-demographic and clinical data were collected, as well as results from the Subjective Well-being under Neuroleptic Treatment Scale-Short Form(SWN-K), Family Emotional Involvement and Criticism Scale(FEICS), a visual analogue scale for evaluating the degree of perceived criticism(VAS), the Family Adaptability and Cohesion Evaluation Scale(FACES), Beck Cognitive Insight Scale(BCIS), and Rosenberg Self Esteem Scale(R-SES). Psychiatrists administered the Positive and Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia(CDSS), and collected a history of previous suicide attempts. Results : The SWN-K total scores showed significant negative correlations with scores on the FEICS perceived criticism, CDSS, and VAS measures and significant positive correlations with scores on the R-SES, FACES, and BCIS. Multiple regression analysis revealed that FEICS perceived criticism, FACES, and BCIS scores were significantly associated with SWN-K scores. The FACES total score was significantly lower in patients with a history of previous suicide attempt. Conclusion : The quality of life of patients with schizophrenia was negatively associated with greater perceived familial criticism and positively associated with better family cohesion and higher patient insight. In patients with a history of suicide attempts, family adaptability and cohesion were significantly low.

• 생물치료정신의학
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• 제24권3호
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• pp.194-201
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• 2018

Objectives : Some studies have reported that chronotypes, among several factors, could contribute to problematic drinking. However, there is little evidence confirming this relationship between chronotype and problematic drinking based on gender differences in mood disorder. This study is to investigate the difference of the relationship between chronotype and problematic drinking according to gender differences in mood disorder. Methods : Two hundred fifteen patients with mood disorder were recruited. Problematic drinking and chronotypes were assessed by the Alcohol Use Disorder Identification Test in Korea(AUDIT) and the Korean translation of composite scale of morningness(KtCS). We analyzed the correlation between KtCS and AUDIT using Pearson's correlation, and compared AUDIT scores according to chronotypes classified by KtCS between male and female patients using analysis of variance(ANOVA). Results : There was no significant difference in AUDIT scores between the male and female patients(t=0.91, p=0.183). In female patients, eveningness had significantly higher AUDIT scores than other chronotypes(F=0.199, p=0.033). Meanwhile, in male patients, there was no significant difference in AUDIT score among chronotypes(F=0.008, p=0.933). Conclusion : This study suggests that eveningness might be associated with problematic drinking in female patients who suffer from mood disorder. It also suggests that chronotherapeutical treatment might be able to help improve the course in female patients with mood disorder. In the future, a large-scale prospective study is needed to confirm these results.

• 생물정신의학
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• 제25권4호
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• pp.110-117
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• 2018

Objectives This study aimed to investigate the relationship between depressive and anxiety symptoms and tardive dyskinesia (TD) and reveal the association of cognitive function and TD in patients with schizophrenia. Methods We recruited 30 schizophrenia patients with TD and 31 without TD from a national mental hospital in South Korea. To assess depressive and anxiety symptoms, the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI) were conducted. Using the five-factor structure of the BDI-II and BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety were assessed. Computerized neurocognitive function test (CNT) was performed to assess levels of cognitive functions. We compared the clinical characteristics, levels of cognitive functions, and depressive and anxiety symptoms between schizophrenia patients with TD and without TD. Chi-square test, Fisher's exact test, independent t-test and Mann Whitney U test were conducted to compare two groups. Pearson correlation analysis was conducted to evaluate relationships among the abnormal involuntary movement scale (AIMS), BDI-II, BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety. Results The subjects with TD had significantly lower score on the cognitive depression than those without TD (t = -2.087, p = 0.041). There were significant correlations between the AIMS score and the BDI-II score (r = -0.386, p = 0.035) and between the AIMS score and cognitive depression score (r = - 0.385, p = 0.035). Conclusions Our findings suggest the inverse relationship between severities in TD and depression and support the assumption that there is an inverse relationship between the pathophysiology of TD and depression.

• 생물정신의학
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• 제29권2호
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• pp.40-45
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• 2022

Objectives This study aims to assess the status quo of depression among Korean physicians and identify stressors and psychiatric assets related to it. Methods The questionnaire was designed to assess depression, stressors, burnout and psychiatric assets. 343 physicians were included in the analyses. Results Physician depression in Korea was found to be related to several daily life stressors and occupational stressors. It was also related to higher burnout and lower psychological assets. Physicians who reported workplace problems, familial problems, and mannerism were at higher risk of depression while who reported passion (in psychiatric assets) were at lower risk of depression. Conclusions This study identified factors affecting physician depression in Korea. Further research would benefit physicians and their patients by identifying and testing various, including personal and organizational, intervention methods.

• 생물정신의학
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• 제6권1호
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• pp.30-33
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• 1999

While depression is certainly a prevalent disorder, it is often severe and debilitating and does not always have the good prognosis we have been led to expect. Social approaches to affective disorders have not been subjected to the same level of scrutiny as the interventions used in the management of schizophrenia. Psychosocial Rehabilitation is now at a critical stage. Psychoeducation, social skill training, cognitive remediation, family education, vocational rehabilitation and case management programs are essential for the rehabilitation of chronic depression.

• 생물치료정신의학
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• 제24권3호
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• pp.184-193
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• 2018

Objectives : This study investigated the effects of social support and chronic medical conditions on depressive symptoms in elderly people living alone in a rural community. Methods : Sociodemographic information on 173 subjects aged 65 years or older who lived alone in a rural community and were recipients of National Basic Livelihood Security was collected and analyzed. All participants completed the Korean Form of the Geriatric Depression Scale and the Lubben Social Network Scale. Additionally, the current prevalence of chronic medical conditions that interfere with the activities of daily living was examined. Multiple logistic regression analysis was conducted to analyze the associations of social support and chronic medical conditions with depressive symptoms. Results : Social support(odds ratio: OR, 0.96; 95% confidence interval: 95% CI, 0.92-0.99) and chronic medical conditions(OR, 1.59; 95% CI, 1.23-2.05) were significantly associated with depressive symptoms in all subjects. When analyzed by gender, social support served as a protective factor against depressive symptoms in elderly men only(OR, 0.91; 95% CI, 0.83-0.99), and chronic medical conditions increased the risk of depressive symptoms in elderly women only(OR, 1.74; 95% CI, 1.26-2.40). Furthermore, osteoarthritis and lumbar pain were risk factors for depressive symptoms in all subjects(OR, 2.24; 95% CI, 1.10-4.56 and OR, 2.10; 95% CI, 1.08-4.12) and in elderly women(OR, 4.07; 95% CI, 1.68-9.84 and OR, 3.34; 95% CI, 1.47-7.57), respectively. Conclusion : This study indicates that improving the social support and managing the chronic medical conditions of elderly people living alone are important for the prevention of depression in this population. Additionally, the present results suggest that it is necessary to establish different depression-prevention strategies for elderly men and women living alone.

• 생물정신의학
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• 제27권2호
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• pp.84-93
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• 2020

Objectives The purpose of the present study was to examine the relationship between the chronotype and the burnout, so we investigated the mediating effects of the mediators such as perceived stress, stress response, and depression. Methods Employees working at Incheon Customs conducted a mental health self-examination through the internet. Among them, 174 people who agreed to the mental health survey participated in the study. Participants completed questionnaires including Composite Scale of Morningness (CSM), Center for Epidemiological Studies-Depression Scale (CES-D), Perceived Stress Scale (PSS), Stress Response Inventory (SRI), Maslach Burnout Inventory-General Survey (MBI-GS). Results Our results showed a higher degree of CES-D, SRI, exhaustion, and cynicism in evening and intermediate type compared to morning type, and a higher degree of professional efficacy in morning type compared to intermediate type. CSM was shown to have a direct effect on exhaustion and indirect effect through CES-D and SRI. CSM also had a direct effect on professional efficacy and had an indirect effect through the CES-D. However, CSM was found to have only indirect effects through the SRI for Cynicism. Conclusions In this study, individuals with evening type tend to experience a high degree of burnout (exhaustion, cynicism and professional efficacy) through the mediation effect of depression and stress response. Further study is necessary to reveal the effect of management of the depression and stress response in the employee with evening type.

• 생물정신의학
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• 제1권1호
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• pp.60-66
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• 1994

Advances in molecular biology have renewed hope for the discovery of disease relevant gene. The basic strategy is gene mapping and likely to have on important role in psychiatric research and practice. Recent linkage studies of chromosomal loci to psychiatric diseases shed light on the potential for new genetics in psychiatric science. This article reviews molecular application to psychiatrymethodological issues in genetic linkage, study of gene expression by analysis of mRNA, and current linkage studies in psychiatric diseases.

• 정신신체의학
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• 제20권1호
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• pp.14-17
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• 2012

1960년대부터 지금까지 정신신체의학의 교육에 대한 관심이 있었지만 의학 교육에서 정신신체의학이 차지하는 비중은 적은 편이었다. 현재에도 대학마다 배정된 시간과 비율이 다르고 일정한 틀과 일치된 목표도 없이 교육이 실시되고 있다. 임상적으로도 자문-조정 정신의학에 대한 인식과 교육은 여전히 비체계적이고 미흡하였다. 앞으로 의과대학의 교육에서, 전공의 교육, 전임의 제도, 세부 전공 제도로 이어지는 지속적이고 체계적인 교육의 틀이 확립되어야 할 것이다. 자문-조정 의학의 활성화, 종사자 훈련에 이르는 임상 교육 체계도 정립되어야 한다. 다른 나라의 정신신체의학의 교육 지향점을 참고하여 생물-정신-사회적 모델에 기초한전인적 질병 개념과 치료 주관을 가진 의사를 양성하고 이를 정신신체의학 교육의 목표로 정립하는 것이 필요하다. 또 목표를 담을 수 있는 교육 내용을 통일되게 규정하고 그 교육 과정이 지속적이고 효율적으로 이루어질 수 있게 체계화해야 한다.

• 생물치료정신의학
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• 제24권3호
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• pp.156-162
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• 2018

Objectives : This study aimed to investigate the relationship between the level of ego-resilience and depression, anxiety, conduct problems and self-esteem in a large sample of Korean adolescents. Methods : A total 4508(2036 males and 2472 females) middle and high school students in Gwang-ju metropolitan city were included in this study. Subjects were asked to complete a self-reported questionnaire, including Ego-Resilience(ER) scale, Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Self-Esteem Scale(SES), 15 items in Korean-Youth Self Report(K-YSR) to measure conduct problems and demographic variables. Subjects were classified into three high, intermediate and low ER group according to total ER scale scores. Results : Total ER scores was positively correlated with total SES scores and negatively correlated with total BDI, BAI, and conduct problem scores. Using analysis ANOVA(analysis and variance) and post hoc test, significant mean differences in BDI, BAI, SES and conduct problem scores were observed among the three groups. High ER group showed that SES scores were significantly higher and BDI, BAI and conduct problem scores were significantly lower than that observed in middle and lower ER group. Using multiple regression analysis, the results showed that depression, low self-esteem were significant factors affecting ego-resilience in adolescents. Conclusion : Our findings indicate that depression, anxiety, behavioral problem such as conduct problems and low self-esteem are associated with low ego-resilience.