• 생물정신의학
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• 제9권2호
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• pp.112-119
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• 2002

Object:This study was to investigate the difference of speech perception ability in schizophrenic patients, and depression patients in order to explore trait-dependent speech perception ability of each disorder. Methods:The speech perception ability was assessed with masked speech tracking test(MST) in schizophrenic patients(N=31), depression patients(N=25), and normal controls(N=21). The continuous performance test(CPT) and sentence repetition test(SRT) were also used for assessment of attention and working memory. Results:The schizophrenic patients showed significant impaired MST performance, compared with depressive patients and normal controls. The performances of CPT and SRT were also more impaired in schizophrenic patients. The difference of MST performances between two patient group was cancelled out after consideration of differences in CPT & SRT performances. Conclusions:These results imply that schizophrenic patients have the impaired speech perception ability compared with depressive patients and normal controls. But speech perception ability was significantly influenced with CPT and SRT. For evaluation of pure speech perception ability, the more elaborate controlled study that excluded factors such as attention, working memory and intelligence is needed.

• 생물정신의학
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• 제5권2호
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• pp.210-214
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• 1998

An association study with Korean schizophrenic patients(N=84) and normal controls(N=87) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Bgl I COMT gene polymorphism in schizophrenics and normal controls, there was no significant difference between two groups. Our results do not support an association between the Bgl I polymorphism of COMT gene and schizophrenia.

• 생물정신의학
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• 제13권4호
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• pp.267-272
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• 2006

Objectives : Schizophrenia is a clinically heterogenous disease with a strong genetic component. Many studies have suggested that brain-derived neurotrophic factor(BDNF) is involved in the pathophysiology of schizophrenia. This study was performed to determine whether there is an association between BDNF Val66Met polymorphism and schizophrenia. Methods : To identify any genetic predisposition to schizophrenia, we investigated the BDNF Val66Met polymorphism in 106 patients with schizophrenia and 147 normal controls with PCR-RFLP method. Statistical analyses were used to test the association between and BDNF Val66Met genotype and Schizophrenia. Results : No association was found between BDNF Val66Met polymorphism and schizophrenia. No significant differences were found comparing the BDNF genotype distributions according to the age of onset, the number of admission and familial loading in schizophrenia. Conclusion : This result indicates that BDNF Val66Met polymorphism is not associated with schizophrenia. However, further studies with a large number of subjects are needed to confirm whether the BDNF gene is related to schizophrenia.

• 생물정신의학
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• 제13권1호
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• pp.26-31
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• 2006

Object : To evaluate how the therapeutic factors affect post-discharge course of patients with schizophrenia, we analyzed relationship between each therapeutic factor and outcome of inpatients with schizophrenia in Hanyang University Hospital. Methods : This study is a retrospective report. Subjects were schizophrenic inpatients who were discharged from Hanyang University Hospital from January 1, 2003 through December 31, 2004. We obtained demographic and clinical data from review of inpatient and outpatient charts. Results : We analyzed the records of 104 patients with schizophrenia(44 males and 60 females). Patients who had longer first admission days have fewer number of readmission. There were no significant correlation between psychiatric rehabilitation and course of schizophrenia. Courses, such as duration of outpatient department follow-up and number and duration of rehospitalization, did not differ according to the existence of extrapyramidal symptoms or types of antipsychotics prescribed. Conclusion : Among the therapeutic factors, longer duration of the first admission only affected better post-discharge course of patients with schizophrenia.

• 생물정신의학
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• 제3권1호
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• pp.75-82
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• 1996

Object : The aim of this study was to evaluate the changes of positive stmtoms. negative symptoms, and depressive symptoms after fluoxetine trial in haloperidol-stabilized schizophrenic in-patients. Method : Fluoxetine(20mg/day) was added for 6weeks to stable doses of haloperidol given to 32 schizophrenic in-patients. The subjects was divided into positive and negative schizophrenics by PANSS. The authors checked PANSS. HRSD at baseline, the 2nd week. the 4th week, the 6th week of treatment. Result were as follows : 1) In all subjects, positive and depressive symptoms were significantly improved. 2) As time went on, positive and negative symptoms were not significantly improved in positive and negative schizophrenics. 3) As time went on, depressive symptoms were not significantly improved in positive and negative schizophrenics. Conclusion : We suggested that fluoxetine may be useful in the treatment of positive symptoms in schizophrenia and, It may be due to the effect on the serotonin system and the interaction between serotonin and dopamine system.

• 생물정신의학
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• 제21권4호
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• pp.161-167
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• 2014

Objectives This study aims to investigate possible associations between proneness toward smartphone addiction and certain psychopathological variables to evaluate the psychopathological meaning of smartphone addiction. Methods Questionnaires were assigned to 755 adults between September and November 2012. We used the Korean Smartphone Addiction Proneness Scale (SAPS), the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Obsessive-Compulsive Inventory-Revised (OCI-R), and the Barratt Impulsivity Scale-11 (BIS-11). Subjects were classified into two groups according to the scores of the SAPS ; the addiction proneness group and the normal-user group. Results The addiction proneness group had significantly higher scores than the normal-user group in the BDI, BAI, OCI-R, and BIS-11. The scores of the SAPS were positively correlated with the scores of the BDI, BAI, OCI-R, and BIS-11. Using logistic regression analysis, smartphone addiction proneness showed a significant association with BIS-11. Conclusions The results of this study suggest that smartphone addiction proneness may be associated with depression, anxiety, obsessive-compulsive symptoms, and impulsivity. Furthermore, impulsivity could be a vulnerability marker for smartphone addiction proneness.

• 생물정신의학
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• 제5권1호
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• pp.122-128
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• 1998

본 연구는 만성 정신분열병 여성환자에서 항정신병약물에 대한 estrogen병합투여 효과를 정신병리 측면에서 조사한 것이다. Estrogen 투약군과 대조군으로 나누어 8주에 걸쳐 시행하였고, 그 결과를 PANSS, CGI를 통하여 비교하였다. 8주간의 연구기간 동안 PANSS, CGI모두에서 투약군이 대조군보다 유의한 호전을 보였다. 투약군에서 연구 8주동안의 PANSS 각 소항목군의 변화율은 양성증상 30.52%, 음성증상 15.06%, 일반정신병리증상 13.60%로 양성증상이 다른 군에 비하여 큰 호전을 보였다. 이상의 연구결과는 만성정신분열병의 치료에 있어 기존의 항정신병 약물과 estrogen의 병합투여가 치료적 효과적가 있다는 것을 제시하였다. 또한 estrogen의 항정신병적 효과의 기전은 명확치 않지만, estrogen이 뇌에서 도파민과 세로토닌체계에 영향을 주어 정신분열병의 호전에 기여했을 것으로 추측된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.5-14
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• 2005

이전까지는 많은 정신장애가 유전으로 대표되는 생물학적 소인과 환경적 소인에 의한 것이라는 논의는 많았지만 실제 유전적 소인이 구체적으로 어떻게 장애의 발병과 임상 경과에 관여하는 지에 대한 명확한 증거를 갖기 어려웠다. 그러나 최근 들어 분자 생물학, 분자 유전학, 신경과학 등의 학문의 발달로 인해 유전 인자가 정상 또는 비정상 발달에 어떻게 기여 하는가에 대한 객관적 증거들이 많아지면서 좀더 이런 영향에 대한 조망이 용이해진 상황이다. 향후 이 분야들의 발달은 더욱 다양한 정신 장애에서 유전 인자의 역할을 밝혀 줄 것이며 정신과 임상 영역에서 유전적 검사를 통해 정신 장애를 진단하게 되는 것도 가능하게 해 줄 것이다.

• 생물정신의학
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• 제14권1호
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• pp.14-20
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• 2007

Objectives : The diagnosis of depression is based on a highly variable set of symptoms. Therefore, depression should not be viewed as a single disease, but a heterogenous syndrome comprised of different pathophysiologies. There are several subtypes of depression which were already incorporated in DSM-IV. This article provides a systematic review of pharmacological treatments of two recognized subtypes of depression-dysthymic disorder and atypical depression. Methods : Systematic search of relevant literatures on dysthymic disorder and atypical depression was performed by proposed search strategy of the Clinical Research Center for Depression of Korean Health 21 R&D Project. All identified literatures were carefully reviewed and classified according to SIGN grading system and summarized in a narrative manner. Results : For the treatment of dysthymic disorder and atypical depression, selective serotonin reuptake inhibitors( SSRIs) and moclobemide have more evidence than the other antidepressants. SSRIs and moclobemide showed superior tolerability than tricyclic antidepressants. Conclusions : The authors proposed treatment recommendations for dysthymic disorder and atypical depression by the methods of evidence-based medicine(EBM). However, guideline developing methods of EBM also have several inevitable limitations. Therefore, in the absence of clear and significant differences in efficacy, the choice of medication must be individualized for a particular patient based on psychiatrist's own clinical decision.

• 정신신체의학
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• 제4권2호
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• pp.262-268
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• 1996

신체화를 이해하는데 신체화를 형성하게 된 행동이면의 정신적인 갈등배경을 이해하는 것이 중요하다. 그러나 신체화의 생물학적 과정을 파악하고 증상의 유지요인과 악화요소를 알아보아 변화되어 가는 형성과정을 이해하는 점이 더욱 중요하다. 그리고 문화-사회적 특성에 따라 신체증상호소의 방법이나 내용이 다르다는 점을 염두에 두어야 한다. 신체화를 이해하는 데에는 심리적, 생물학적, 사회, 인종, 역사적인 요소가 모두 함께 영향을 미치므로 통합적인 관점에서 파악해 나가지 않으면 안된다.