• 생물정신의학
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• 제29권1호
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• pp.32-32
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• 2022

• 생물정신의학
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• 제27권2호
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• pp.37-41
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• 2020

Modified electroconvulsive therapy (ECT) which started in 1950s is a safe and efficacious treatment for several mental disorders including mood disorders and psychotic disorders. However, its usage in present days is still limited by misconceptions and stigmata of ECT. This paper overviews the background from which the stigmata of ECT stemmed and the current status of stigmata surrounding ECT among the public and medical professionals. In addition, a few potential strategies for reducing stigmata of ECT are provided in this review.

• 생물정신의학
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• 제4권2호
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• pp.194-197
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• 1997

Neural network models, also known as connectionist models or PDP models, simulate some functions of the brain and may promise to give insight in understanding the cognitive brain functions. The models composed of neuron-like elements that are linked into circuits can learn and adapt to its environment in a trial and error fashion. In this article, the history and principles of the neural network modeling are briefly reviewed, and its applications to psychiatry are discussed.

• 생물정신의학
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• 제8권1호
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• pp.53-61
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• 2001

현재 국내 신경정신의학계가 당면하고 있는 학문과 진료 영역의 문제점들과 그 원인들을 살펴보고 정신과 의사들의 학문적인 성숙과 진료 영역의 확대를 위한 해결 방안을 모색해 보았다. 진료 영역이 축소된 이유로 의료계 내부에서는 최근에 이루어진 신경과학의 눈부신 발전, 신경정신과에서 신경과와 정신과로의 분리, 의료 제도의 변화, 정신과 의사들의 안이한 대처, 정신의학 교육의 왜곡 등을 생각할 수 있다. 의료계 외부의 조건들로는 정신의학과 정신과에 대한 사회적 편견, 의료에 대한 외부의 규제를 들 수 있다. 정신의학의 영역을 확대하기 위해서는 의과대학생 교육, 전공의 수련 과정, 전문의 연수 교육, 정신의학 교과서의 편찬 등을 통한 정신의학 교육의 개편 강화, 신경정신의학의 정체성 재확립, 그리고 신경과학과 신경학 교육의 강화 등을 적극적으로 추진해야 할 것이다. 아울러 정신과 의사들의 활동 분야를 확대하고 행동과학을 임상 진료 과목으로 개발하며 정신의학과 유관한 제 3 의 전문 진료 과목을 창출하고 정신과 의사의 기본적인 술기에 일차 진료 의사의 역할을 추가하는 방안들도 고려해 볼 필요가 있다.

• 생물정신의학
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• 제28권1호
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• pp.1-6
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• 2021

Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.

• 정신신체의학
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• 제20권1호
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• pp.9-13
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• 2012

정신신체의학은 심리적, 행동적, 의학적 요인들이 인간의 신체에 미치는 영향을 알아보기 위해 생물정신사회적 관점에서 통합적으로 접근하는 의학 분야이다. 초기의 정신신체의학은 신체 질환의 원인을 심리적인 요인으로 이해하고 접근하고자 하였으며 이후 다양한 관련 분야의 발전을 통해 보다 확대된 관점에서 신체 질환을 바라보기 시작하였다. 이러한 결과 내외과 질환 환자들의 정신과적인 문제를 다루는 자문조정이 임상적으로 주목을 받게 되었다. 여러 내과적 질환들의 원인, 경과, 치료에 스트레스 혹은 정신과적 요인이 영향을 미친다는 사실이 확인되었고 더 나아가 질환뿐 아니라 삶의 질이나 인격 특성 등 인간의 행동적인 측면 역시 연구 대상으로 확대되게 된다. 최근 내외과 질환이 보다 세분화되고 그 원인에 대한 생물학적 연구들이 진행되며 다양한 검사 및 평가 도구가 개발되는 등 연구 여건이 변화됨에 따라 정신신체의학 연구도 더욱 다양화되고 세분화되고 있다. 이에 저자는 한국 정신신체의학 연구의 발전을 모색하기 위해 국내 정신신체의학 연구의 과거와 현주소를 확인하고 미래를 전망하고자 한다.

• 생물정신의학
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• 제26권2호
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• pp.33-38
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• 2019

Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.

• 생물정신의학
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• 제30권1호
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• pp.17-23
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• 2023

Objectives This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio). Methods The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated. Results Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased. Conclusions Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.

• 생물정신의학
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• 제27권2호
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• pp.42-57
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• 2020

Electroconvulsive therapy (ECT) is indicated for various mental disorders (e.g., major depressive disorder, schizophrenia, and bipolar disorder) and the behavioral and psychological symptoms of dementia in elderly patients. Furthermore, ECT is a useful first-line treatment in emergency and crisis situations such as suicide risk, violent behavior, catatonia, and food refusal, which are more frequent in elderly patients. ECT is also effective in the treatment of the motor symptoms of neurological disorders, such as Parkinson's disease and Huntington's disease. Due to the high risk of various physical diseases, the comorbid physical conditions of elderly patients should be individually controlled to optimize ECT treatment. Compared to young adults, in elderly patients the seizure threshold is higher, the seizure duration is shorter, and the anesthetic dose is lower. On the contrary, the response rate in the elderly is both faster and higher. Considering potential cognitive decline and the prevention of further deterioration of cognitive function in elderly patients, in the absence of significant comorbidities, twice weekly sessions and right unilateral electrode placement with a lower seizure threshold and less cognitive effect are preferred to bilateral electrode placement, which has a high risk of adverse cognitive effects. After an acute course of ECT, continuation and maintenance of ECT, combined with prescription of therapeutic drugs, may prevent possible relapse or recurrence of mental disorders. In conclusion, ECT can be used to treat mental disorders in elderly adults, with safety and effectiveness comparable to that in young adults.

• 생물정신의학
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• 제2권1호
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• pp.44-48
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• 1995