• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1991.06a
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• pp.44-49
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• 1991

엔진유및 각종 윤활유의 이용범위의 광대 및 재료의 등장으로 사용조건이 더욱 과산화됨에 따라 한 종류의 첨가제를 단독으로 첨가사용하기 보다는 몇 종류 이상의 첨가제가 첨가되는 경우가 대부분이다. 첨가제의 기능상 여러종류의 첨가는 첨가제 자신이 갖고 있는 특성을 충분히 발휘하기 위한 것이지만, 일반적으로 첨가제간의 상호방해작용으로 단독첨가 사용시 각각의 특성을 충분히 발달하기보다는 기등이하의 결과를 가져오는 경우가 많다. 최근, 유용성 몰르브덴계 화합물이 마찰, 마모 및 \ulcorner화방지제로써 잘 알려져 있으며 몰리부덴계 첨가제중 Molybdenium dialkyl dithiocarbamate (MoDTC)는 다기능성 첨가제로서 우수성이 부고되었다. 그러나 특히 타 첨가제와 공존시 MoDTC의 마찰특성의 변화에 대해서는 거의 보고된 바가 없다. 본 연구는 MoDTC와 타 첨가제 간의 마찰특성의 상호작용에 관한 검토로서, 유황계 화합물($S_8$), 인계 화합물(인산에스테르;TBP), 치오인산계 화합물(ZnDTP)과 같은 윤활유에 많이 첨가되고 있는 극압제를 사용해 이들 화합물이 공존시 MoDTC 마찰감소 작용에 미치는 영향을 검토하고 또한 분위기의 영향에 관해서도 검토하였다.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Journal of Life Science
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• v.26 no.8
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• pp.904-910
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• 2016

Complex traits are determined by the combined effects of many loci and are affected by gene networks or biological pathways. Systems biology approaches have an important role in the identification of candidate genes related to complex diseases or traits at the system level. The gene network analysis has been performed by diverse types of methods such as gene co-expression, gene regulatory relationships, protein-protein interaction (PPI) and genetic networks. Moreover, the network-based methods were described for predicting gene functions such as graph theoretic method, neighborhood counting based methods and weighted function. However, there are a limited number of researches in livestock. The present study systemically analyzed genes associated with 102 types of economic traits based on the Animal Trait Ontology (ATO) and identified their relationships based on the gene co-expression network and PPI network in cattle. Then, we constructed the two types of gene network databases and network visualization system (http://www.nabc.go.kr/cg). We used a gene co-expression network analysis from the bovine expression value of bovine genes to generate gene co-expression network. PPI network was constructed from Human protein reference database based on the orthologous relationship between human and cattle. Finally, candidate genes and their network relationships were identified in each trait. They were typologically centered with large degree and betweenness centrality (BC) value in the gene network. The ontle program was applied to generate the database and to visualize the gene network results. This information would serve as valuable resources for exploiting genomic functions that influence economically and agriculturally important traits in cattle.

• Journal of Engineering Education Research
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• v.6 no.2
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• pp.30-37
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• 2003

This paper presents web-based contents for studying electrical machines using Java Bean and Flash. The component-based software development techniques have been used to develop Java Bean and Flash components which are simple and convenient for learners. The components have been used to make 61 contents for the electrical machines. The contents have highly interactive capability, which gives much interest to learners. The learners can easily understand the electro-mechanical concept by changing the parameters interactively. The class load of the lecture can be reduced because the basic explanation of the subject is replaced by the web contents. The better quality of the class is expected by dealing with the higher concept in the classroom lecture because the basic concepts are explained through the contents.

• Journal of Korea Planning Association
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• v.54 no.7
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• pp.5-23
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• 2019

The central government has implemented policies to strengthen the competitiveness of small and medium sized cities for balanced development at the national scale. However, since it is often difficult to enhance the competitiveness through partial projects of each jurisdiction, many local governments collaborate at the regional scale. This suggests that a regional approach is important for the management of small and medium sized cities. On the one hand, the concept of network city suggests that various functional networks can affect the growth of small and medium sized cities. Given this background, the purposes of this study are to delineate regional boundaries at national scale and identify their relations of growth by using functional network and Moran's I index. The study uses the Markov-chain model and cluster analysis to delineate the regions, and Moran's I is employed to identify the relations of growth. The results show that interactions between jurisdictions through networks could be crucial factors for growth of small and medium sized cities, while the networks based on passenger travel and freight movement have different implications. The results suggest that policy makers should not only consider local level investments, but also take the characteristics of networks between cities into account for achieving balanced development and developing regeneration policies.

• Applied Chemistry for Engineering
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• v.34 no.1
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• pp.1-8
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• 2023

Polyethylenimine (PEI) is a cationic polymer that can bind to negatively charged biomaterials such as nucleic acids through strong electrostatic interactions. Based on these properties, PEI has been used as an efficient drug delivery system for a long time. However, the strong cationic nature of PEI has the problem of causing cytotoxicity by non-specific interaction with anionic biological materials in the cells. In order to overcome these problems, many researchers have developed various types of biocompatible PEI-based materials. In this review, we would like to introduce the recent developments of functional PEI and their applications in biomedical research.

• Annual Conference of KIPS
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• 2004.11a
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• pp.237-240
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• 2004

본 논문에서는 URL 동기화 기능을 갖는 멀티미디어 공동 작업 환경에서 오류 상호 인지 및 제어에 대하여 기술한다. 웹 기반 공동 작업 환경에 참여하는 모든 사용자들은 사용자의 명령, 또는 오류가 발생된 응용들을 제어 가능하며 상호 작용 가능하다. 상호 인지란 상호 작업 이해, 참여자 관계 설정 등 결합이라는 구현 기술을 말한다. 파일 공유, 윈도우 복사, 윈도우 오버레이, 또는 윈도우 공유 등 인지의 구현 방법이 있는데 웹 기반 멀티미디어 공동 작업 환경에서 오류 발생시 오류도 하나의 응용으로 취급하여 처리한다. 즉, 윈도우 오버레이 기능에 세션 제어, 발언권 제어 등을 추가한 윈도우 공유 방법을 제안한다.

• Proceedings of the KIEE Conference
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• 2007.10a
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• pp.87-88
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• 2007

URC(Uniform Resource Identifier) 로봇은 기존의 로봇 자체에서 처리하던 기능을 네트워크를 통하여 외부로 분산시켜 외부의 센싱기능과 프로세싱 기능을 활용하여 효율적으로 구동하기 위한 것이다. 즉 많은 파워가 요구되는 센싱 기능이나 프로세싱 기능을 외부에 있는 서버를 활용하여 서비스를 제공함으로써 간단한 로봇으로도 고도의 서비를 제공이 가능토록하여 가격 경쟁력을 갖도록 하기 위함이다. 본 논문에서는 URC 로봇을 원격에서 모니터링 및 제어가 가능하도록 웹 서비스 기술을 임베디드 시스템 환경에 맞게 최적화하였다. 서비스는 인터넷 기반의 SOAP 프로토콜을 통하여 교환되는 XML 기반 메시지를 통하여 다른 응용 에이전트들과 직접적인 상호작용을 지원함으로서 이기종간 호환 및 표준 플랫폼을 지원할 수 있다. 본 논문에서는 URC 시범서비스 참가 로봇인 네토로(한울로보틱스)에 본 연구결과를 적용하여 기능 및 안정성을 검증하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2004.04b
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• pp.328-330
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• 2004

유전자 발현은 다양한 전사 인자들의 상호 작용에 의해서 조절되어진다 이러한 전사 인자들에 존재하는 모티프는 직접적으로 조절 작용을 위한 기능을 수행한다. 또한 대부분의 경우에서 여러 모티프가 함께 유전자 발현 기작을 위하여 조절 작용을 한다. 따라서 이러한 모티프들이 어떤 조합으로 함께 전사 과정에 관여하는지 여부를 밝히는 작업은 중요한 일이다. 본 논문에서 진화 연산을 응용하여, 다양한 조건 하에 전사 과정에 중요하게 작용하는 모티프들의 조합을 알아보았고, 그 결과를 기본적인 k-Means 알고리즘 등과 비교하여 제안한 방법이 유전자들의 상관관계에 있어서 보다 우수한 결과를 보임을 알 수 있었다.

• The Korean Journal of Food And Nutrition
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• v.29 no.6
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• pp.835-848
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• 2016

The purpose of this study was to find efficient and customized tools for delivering the benefit of health functional foods (HFFs). Delivery tools which could influence the impact of advertising were images, explanations of ingredients, diagrams of health benefit, patents, and comments from authority. Six advertisements were developed using these tools: "A": relevant image + explanation of ingredients + scientific diagram of efficacy; "B": relevant image + explanation of ingredients; "C": relevant image; "D": irrelevant image; "E": irrelevant image + explanation of ingredient + patent; "F": irrelevant image + explanation of ingredient + comments from authority. To analyze the consumer perceptions on HFFs and advertisement effects, 300 respondents were requested to answer a questionnaire comprising of the following questions: 5 questions of attitudes (necessity of HFFs, trust in HFFs, gathering information, watching advertisements and trust in advertisement claims) and 6 questions on the 6 developed advertisements (attention, understanding, sufficiency of information, sympathy, trust, and purchase). Scoring was done as per the 5 Likert scale. There was a higher proportion of females and the elderly, as compared to males and youngsters. The overall consumer attitudes were positive. Explanation of ingredients, scientific diagram of health benefit, patents and expert comments were helpful factors in increasing the advertisement evaluation by consumer, but the images were not. Advertisement evaluation of consumer did not differ with gender and age. However, differences were observed between some of the consumer attitudes (necessity of HFFs, trust in HFFs, gathering information and trust in advertisements claim) and advertisement evaluations (attention, understanding, sympathy and purchase). Our results indicate that for consumers utilizing the HFFs, advertisements with concrete tools such as diagrams, patent, and expert comments are more helpful. However, for consumers who do not have interest in HFFs, the scientific information was irrelevant. We believe that to maximize the effect of health information in advertisements, consumers should be segmented, and customized tools for each segment needs to be developed.