• Journal of Yeungnam Medical Science
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• v.25 no.1
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• pp.64-71
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• 2008

Evaluation of a fever of unknown origin (FUO) is complex. Recently, PET scanning has been approved for screening in FUO evaluation. We treated three cases of FUO associated with increased FDG uptake in the bone marrow of the femur and tibia on the fusion PET/CT; all three had the same pattern of uptake. Bone marrow biopsies revealed mature lymphocyte and histiocyte infiltration and myxoid changes in one case, and cortical bone involvement in another case. The cases were all young females who had fever with neutropenia and relative lymphocytosis that lasted for several weeks and then remitted spontaneously. Even though the results of the studies were not diagnostic, the unique uptake pattern on PET/CT and the histology might be related to the cause of the illness and should be studied further to assess the association with classic FUO.

• Pediatric Infection and Vaccine
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• v.8 no.2
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• pp.253-259
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• 2001

Kikuchi's disease(histiocytic necrotizing lymphadenitis) is characterized by lymphadenopathy in young patients below 30 years old, and persistent fever, lymphopenia and splenomegaly are concomitantly developed in many cases. So, it has been confused with lymphoma, SLE, and tuberculosis, and has easily led to inappropriate diagnostic procedures and administration of drugs. Many reports have indicated that Kikuchi's disease should be added to the list of causes of FUO in the setting of lymphadenopathy, and recommended early lymph node biopsy to distinguish from lymphoma, SLE, and tuberculosis to avoid unnecessary treatments. We experienced a case of subacute necrotizing lymphadenitis in a 14-year-old boy who presented with persistent high fever, productive coughing and cervical lymphadenopathy for about 1 month. Initially, diagnostic workup was done to look for the causes of FUO in vain. Finally, we confirmed diagnosis by histopathological findings of lymph node biopsy and detected latent gene of EBV in the biopsied specimen using in situ hybridization.

• Clinical and Experimental Pediatrics
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• v.49 no.12
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• pp.1282-1286
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• 2006

Purpose : The causes of prolonged fever have changed during the years and are influenced by age, geographic location and availability of diagnostic facilities/techniques. The aim of the present study was to determine the causes of prolonged fever, to know the proportion and outcomes of undiagnosed children. Methods : We reviewed patients with fever persisting for more than 2 weeks in duration, with documented temperatures of $38^{\circ}C$ on several occasions, or uncertain diagnosis after intensive study of 1 week duration in other hospitals who were admitted to Pusan National University Hospital during the period from July 1999 to June 2004. Results : Fifty-four (59.0 percent) were boys and thirty-seven (41 percent) were girls. Forty-six cases were less than 6 years and 45 cases were more than 6 years; the mean age was $6.48{\pm}6.56years$. In 62 cases (68.1 percent), the fever had persisted for 2 to 3 weeks before admission and in 26 cases (28.6 percent), had lasted longer than a month. Final diagnosis had been reached in 66 of 91 children (72.5 percent). The most common cause was infection (38/91), followed by collagen vascular disease (12/91), immune deficiency (3/91), neoplasia (2/91), and miscellaneous disease. Tuberculosis was the most common infectious cause. The causes of fever were not revealed in 25 cases. Outcome on discharge were as follows; 77 cases (84.6 percent) were improved, 10 cases (11.0 percent) discharged without improvement and 4 cases (4.4 percent) expired. Conclusion : The most common cause of prolonged fever in Korean children remains infection, but the incidence of infection was decreased as compared with previous studies. Tuberculosis is the most common among infectious causes. As Kikuchi disease (subacute necrotizing lymphadenitis) represented a significant cause of prolonged fever, it should be considered if a patient has neutropenia with lymphadenopathy. Undiagnosed patients with prolonged fever (27.5 percent) have increased over previous studies.

• The Journal of Pediatrics of Korean Medicine
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• v.14 no.1
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• pp.189-196
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• 2000

Recently, By the climatic change and increased resistance to antibiotics, diseases with atypical fever are increasing. FUO(Fever unknown origin) is defined' as fever persisting for $1{\sim}3weeks$ which origins are not found. through the reports of two clinical cases presenting FUO, I pretend to show the orient-medical and west-medical approachs to FUO.

• Biomedical Science Letters
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• v.3 no.2
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• pp.95-105
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• 1997

Currently, the laboratory diagnosis for lyme disease have been performed with the detection of antibodies against Borrelia burgdorferi. However there might be some difficulties in the interpretation of obtained results due to the usage of foreign isolates as an antigen in the test. Therefore the optimization of serological tests with Korean isolates of B. burgdorferi as an antigen would be needed to establish the standardized diagnostic method for the detection of antibodies against B. burgdorferi infection. In this study, the optimization of ELISA was investigated with experimentally challenged rabbit sera and sonicated B. burgdorferi antigens of Korean isolates. Of 217 human patient's sera with unknown fever, the mean seropositivities in ELISA, done under the optimized conditions obtained in this study, were found to be about 8％ against B. burgdorferi sensu late, showing the highest seropositivity of 14.3％ against B. afzelii. In immunoblotting assay with ELISA-positive human sera, the major reactive bands were 41kDa (flagellin) which might be the indication of early infection, and 27kDa, 31kDa (OspA), 34kDa (OspB) which are the characteristics of late infection. Obtained results in this study might strongly indicate the possibility of B. burgdorferi infections in Korea.

• Fire Science and Engineering
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• v.16 no.2
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• pp.75-80
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• 2002

In this paper, some experiments of a heat release rate and toxicity for underground utility 22.9kv cable in fire was conducted and analysed applying plume equation and smoke chamber test separately, A 22.9 ㎸ power cable is selected for testing heat release in ISO 9705 geometry and toxicity production is measured with NES 713 (British-Naval Engineering Standard)test. In test results, Cable heat release reached about 60 ㎾ above 1.2 m from heptane pan and CO generated lethal concentration under 30 min. exposure condition.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.3 no.2
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• pp.212-216
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• 2000

Subacute necrotizing lymphadenitis was first reported by Kikuchi and Fujimoto in 1972. Young females no more than 30 years of age are mainly affected. It usually manifests as fever and cervical lymphadenopathy. We experienced one case of subacute necrotizing lymphadenitis with hepatic complication in an 11-year-old boy. Symptoms presented were URI signs, diarrhea, headache, and weight loss along with fever and cervical lymphadenopathy. Elevated serum AST/ALT levels were also noted up to 682/1560 (IU/L) and were normalized within one month. We performed aspiration biopsy of the liver twice (at admission and 5 months thereafter). The hepatic histopathologic findings were nonspecific.

• The Journal of Internal Korean Medicine
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• v.40 no.2
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• pp.181-191
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• 2019

Objective: This study evaluates the effect of Korean medicine in a patient who suffered from unspecified arthritis with fever of unknown origin. Methods: A patient was treated with herbal medicine for 12 weeks. The clinical improvements were evaluated by body temperature, blood test (CBC-diffcount, CRP, ESR, etc.) and Visual Analogue Scale (VAS). Results: Improvements in body temperature, blood tests and clinical symptoms were observed after Korean medicine treatments. Conclusions: Korean medicine treatment may be an effective treatment for unspecified arthritis with fever of unknown origin.

• Journal of the Korea Institute of Military Science and Technology
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• v.5 no.3
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• pp.45-55
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• 2002

중거리 유도무기 체계가 탄도탄과 같이 기동이 심한 표적과 교전할 때에는 지상 레이더는 표적 및 유도탄 위치정보를 보다 빈번하게 전송하여야 하지만, 자신의 임무를 수행해야 하므로 유도탄 및 교전 표적에 대한 정보를 필요이상으로 자주 전송할 수 없다. 이러한 상황에서 탐색기가 자체적으로 표적의 거리, 속도, 방향을 측정함으로서 지상레이더에 추가 부담을 지우지 않고 우수한 추적 정밀도로 교전성능을 향상할 시킬 수 있는 고반복 펄스열을 사용하는 PRF 변조방식을 제안한다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.6
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• pp.683-688
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• 2014

Fever of Unknown Origin(FUO) is defined as a temperature higher than 38.3'C that persists without diagnosis for at least 3 weeks despite appropriate investigation. The purpose of this study was to analyze the effectiveness of oriental medical treatment on the patient with FUO. We treated a female patient with FUO by oriental medical treatment with appropriate herbal medicine and balanced acupuncture. We prescribed Galgunhaegi-tang (Gegenjieji-tang) for 5 days and Handayeolso-tang(Handuoreshao-tang) for 9 days. At the same period, we also applied acupuncture and checked body temperature. In order to measure a pain of the patient, we used Visual Analogue Scale(VAS). It was found that Galgunhaegi-tang had little effect at this time, but the administration of Handayeolso-tang brought the positive effect on the patient. The body temperature of the patient was lowered and VAS score was reduced apparently after treatment. Handayeolso-tang might be used for relieving symptoms of FUO.