• Proceedings of the KIEE Conference
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• 2006.10a
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• pp.160-161
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• 2006

본 연구는 살균선 및 오존선을 방사하는 저압 자외선램프를 이용하여 한약재 살균 및 장기간의 보관에 따른 변질 원인을 제거하고, 고품질 유지를 위한 것이다. 본 연구에서는 이미 발표한 오존 및 전기적 특성을 연구한 '오존램프를 이용한 약재 보관 특성(1)'에 이어서, 주로 약재 보관 특성의 관점에서 연구를 하였다. 대구 약전골목에서 현재 가장 많이 사용되고 유통되고 있는 작약, 백출, 왕기, 감초, 당귀를 실험에 이용 하였으며, 오존램프 보관 유무에 따른 약재의 외관상의 변화, 일반성분의 변화, 생리활성 물질의 변화 등 특성 평가를 연구하였다.

• 한국약용작물학회:학술대회논문집
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• 2008.05a
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• pp.273-274
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• 2008

• Proceedings of the Korean Society of Crop Science Conference
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• 2001.05a
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• pp.208-209
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• 2001

• Journal of Radiation Protection and Research
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• v.26 no.1
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• pp.13-18
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• 2001

We performed this study to determine the effect of Baizhu (Atractylodes japonica), Chuanxiong (Cnidium officinale), Shanyao (Discorea japonica) and Shengma (Cimicifuga heracleifolia), as Oriental rhizomata herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}$-radiation. Shengma was effective in intestinal crypt survival(p<0.05). The frequency of radiation induced apoptosis was also reduced by pretreatment with Chuanxiong and Shengma(p<0.05). Although the mechanisms of this effort remain to be elucidated, these results indicated that Shengma might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Korean Journal of Medicinal Crop Science
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• v.8 no.4
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• pp.319-326
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• 2000

This experiment was carried out to determine the effects of $GA_3$ treatment (concentration: period) to rhizomes before planting on their growth, morphology and yield. $GA_3$ treatment increased the number of shoots, leaves or latent buds, plant height, and leaf length per plant compared with non-treatment. The best treatment concentrations were 50 ppm in stem per plant, 100 ppm in latent bud and rhizome fresh weight per plant and 250 ppm in shoot fresh weight per plant. The number of leaves and roots per plant, plant height and fresh weights of shoot and root were the greatest in one day imbibition of $GA_3$. Numbers of stems and latent buds per plant and rhizome fresh weight, however, were the highest in two day imbibition. In addition, the most rhizomes per land unit were produced in one day imbibition treatment of 100 ppm $GA_3$.

• Journal of Korean Medicine for Obesity Research
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• v.13 no.1
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• pp.24-32
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• 2013

Objectives: The aim of this study is to investigate anti-imflammatory and protective effect for intestinal epithelial cells with Atractylodes macrocephae (AM), a traditional Korean Herbal medicine and fermented Atractylodes macrocephae (FAM) with Lactobacillus plantarum. Methods: HCT-116 and Raw 264.7 cells were used in this study. Using NO assay, we measured lipopolysaccharide (LPS)-induced anti-inflammatory effect. We measured permeability of intestinal epithelial cells with transepithelial electrical resistance and horseradish peroxide flux assay. Water soluble tetrazolium salt assay was used to see cell proliferation. All the results were presented in mean and standard deviation. We used Student's t-test for analyzing significance of results. Results: In Raw 264.7 cells NO production decreased 22.4% with pre-treatment of AM and FAM, especially with FAM in high concentration. In HCT-116 cells LPS-induced intestinal permeability had a protective effect with both AM and FAM, which was also tend to be proportional to the concentration. Cell viability increased up to 135.52% after treatment of high concentration of FAM in HCT-116, while there was no significant change in Raw 264.7 cells with herb treatments. Conclusions: These results show evidence that AM, especially fermented ones, significantly reduced intestinal membrane permeability. They also had a protective effect as well as an anti-inflammation effect for HCT-116 and Raw 264.7 cells. This suggest that FAM may be a therapeutic agent for Leaky gut syndrome by reducing intestinal permeability.

• Korean Journal of Pharmacognosy
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• v.12 no.1
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• pp.23-25
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• 1981

Methanol extracts of the roots of Atractylodes japonica (alba) (Compositae) and Gentiana scabra (Gentianaceae) were further fractionated with n-butanol, chloroform, n-hexane and water. Then each fraction was p.o. administered to an animal model of hepatitis caused by $CCl_4$ intoxication. Measurements of sleeping time of mice induced by hexobarbital administration indicated that n-butanol and chloroform fractions of Atractylodes japonica (alba), and chloroform and n-hexane fractions of Gentiana scabra showed significant liver protective activities. Measurements of the activities of serum transaminase, S-GOT and S-GPT appeared to support these results.

• Korean Journal of Pharmacognosy
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• v.36 no.1 s.140
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• pp.60-63
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• 2005

One sesquiterpenoid was isolated from the methanol extract of Atractylodes rhizomes which has been used as traditional medicine for diuresis and the compound was established as selina-4(14),7(11)-dien-8-one by the spectroscopic methods. The compound$(IC_{50}<10\;ppm)$ has inhibitory effects on melanogenesis in B16 mouse melanoma.

• YAKHAK HOEJI
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• v.20 no.1
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• pp.97-106
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• 1976

The actions of Atractylodes rhizoma alba on renal function of dog were investigated with water and methanol extract of it, utilizing clearance technique. Water extract elicited diuresis while methanol extract induced antidiuresis in the dog when they were given intravenously. The diuresis induced by the intravenous water extract seemed to be closely related to the decrement of reabsorption of electrolytes in renal tubules. On the contrary, the antidiuresis by intravenous methanol extract appeared to be related to the increment of renal reabsorption of sodium. Water and methanol extract, when infused into a renal artery, exhibited identical resposes to the intravenous actions confined only to the infused kidney, inferring that renal actions of water and methanol extract are not mediated by any endognous humoral extract are not mediated by any endogenous humoral agents. From these observations it is concluded that diuretic action of water extract and antidiuretic action of methanol extract were brought about by direct action in the renal tubules.

• 한국약용작물학회:학술대회논문집
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• 2008.05a
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• pp.276-277
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• 2008