Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Plants with Liver Protective Activities (V) -Liver protective activities of Atractylodes japonica (alba) and Gentiana scabra-

강간제(强肝劑)로 사용(使用)된 생약(生藥)의 조사연구(調査硏究) (V) -백출(白朮) 및 용담(龍膽)의 강간효과(强肝效果)에 관(關)한 연구(硏究)-

  • YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Yu, Jae-Chun (Natural Products Research Institute, Seoul National University) ;
  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University)
  • Published : 1981.03.30
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Abstract

Methanol extracts of the roots of Atractylodes japonica (alba) (Compositae) and Gentiana scabra (Gentianaceae) were further fractionated with n-butanol, chloroform, n-hexane and water. Then each fraction was p.o. administered to an animal model of hepatitis caused by $CCl_4$ intoxication. Measurements of sleeping time of mice induced by hexobarbital administration indicated that n-butanol and chloroform fractions of Atractylodes japonica (alba), and chloroform and n-hexane fractions of Gentiana scabra showed significant liver protective activities. Measurements of the activities of serum transaminase, S-GOT and S-GPT appeared to support these results.

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