• Journal of Applied Biological Chemistry
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• v.61 no.3
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• pp.283-290
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• 2018

In this study, we verified the 1-1-diphenyl-2-picryl-hydrazyl radical scavenge, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenge, elastase, tyrosinase inhibitory effect by using the solvent fractions of Maekmoondong-tang hot water extract. As a result, the ethyl acetate fraction (MW-EA) showed the highest inhibitory activity. In cell-based assays, MW-EA treatment confirmed a 34% ($100{\mu}g/mL$) efficacy in reactive oxygen species inhibitory activity, and at the same concentration, MMPs showed more than 50% inhibition and tyrosinase inhibited 25% ($50{\mu}g/mL$). Therefore Maekmoondong-tang is considered high development potential as a material to improve the skin.

• Journal of the korean veterinary medical association
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• v.50 no.11
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• pp.646-648
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• 2014

• The Journal of Internal Korean Medicine
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• v.14 no.2
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• pp.112-116
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• 1993

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2007.05a
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• pp.577-579
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• 2007

탕액으로 제조된 생약제제 4개 제품의 중금속의 농도는 허용치보다 낮게 검출이 되었으며, 맥문동탕의 경우 As의 농도는 0.048ppm, Cd의 농도는 0.0001ppm, Pb의 농도는 0.002ppm, Hg의 농도는 0.003ppm으로 측정되었으며, 갈근탕의 경우 As의 농도는 0.05ppm, Cd의 농도는 0.0002ppm, Pb의 농도는 0.003ppm, Hg의 농도는 0.003ppm으로 측정되었고, 쌍화탕의 경우 As의 농도는 0.063ppm, Cd의 농도는 0.001ppm, Pb의 농도는 0.004ppm, Hg의 농도는 0.002ppm으로 측정되었으며 20전 대보탕의 경우 As의 농도는 0.049ppm, Cd의 농도는 0.001ppm, Pb의 농도는 0.0185ppm, Hg의 농도는 0.003ppm으로 측정되었다.

• Herbal Formula Science
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• v.21 no.2
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• pp.165-172
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• 2013

Objectives : This experiment was performed in order to study the effect of Maekmundong-tang on dyspnea patients. Methods : This study involved 14 dyspnea patients from March 1, 2012 to May 31, 2012. Lung capacity of the patients is evaluated with Peak flow meter. Results : Maekmundong-tang administration was revealed effect on dyspnea patients' lung capacity. Conclusions : It was found that Maekmundong-tang administration was effective on dyspnea patients' lung capacity. The mean degree of improvement was 21.79(L/min). It was shown that the more mild dyspnea level was, the more effective and short-term administration more effective.

• The Journal of Internal Korean Medicine
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• v.15 no.2
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• pp.240-248
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• 1994

These studies were carried out to investigate the effects of Macmundongtang extract on the inhibitory contractile action of acetylcholine in control rat. The results of these studies were as follows: 1. Contractile force of acetylcholine from tracheal smooth muscle in control rat was significantly inhibited by Macmundongtang. 2. Inhibition contractile action of acetylcholine pretreated ACH $ED_{50}$ in control rat was significantly changed. 3. Dose-response of acetylcholine pretreated Macmundongtang in control rat was not significant. 4. Inhibitory contractile action of acetylcholine pretreated propranolol in control rat was not significantly changed by Macmundongtang. 5. Inhibitory contractile action of acetylcholine pretreated methylene blue in control rat was significantly changed. 6. Contractile force of acetylcholine pretreated indomethacin from trachea smooth muscle in control rat was not significantly inhibited by Macmundongtang.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.946-951
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• 2003

The purpose of this research was to investigate the effect of Maekmoondong-tang(MMDT) on the activity of immune cell. The addition of MMDT(10 ㎍/㎖) enhanced the proliferation of cultured-splenocytes and thymocytes. And administration of MMDT(250, 500 ㎎/㎏) accelerated subpopulation of splenic T lymphocytes in BALB/c mice. In contrast, the treatment of the high concentration (500 ㎎/㎏)of MMDT were decreased thymic T lymphocytes. Administration of MMDT(250, 500 ㎎/㎏) eminently enhanced the production of IFN-γ. And MMDT did not affect the cell viability of Jurkat leukemia cells. These results suggest that MMDT have a immunoregulatory effect via enhanced cell mediated immunity

• Journal of Haehwa Medicine
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• v.19 no.2
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• pp.165-171
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• 2011

Objectives: This study analyzed the contents of the research papers of Maekmundong-tang (MMDT). This study was conducted to help development of new clinical application and clinical studies for treating COPD with Oriental medicine. Materials and Methods: We inspected 26 theses and scrutinized their classification, objective diseases, study design, participants, methodological quality of clinical trial. Results: The following results were obtained in this study. 1. The studies of MMDT started in 1989 and have continuously increased, but it decreased recently. 2. The studies were mainly focused on experimental models rather than clinical studies. The topics of studies were mainly relaxation of airway contraction and anti-asthmatic effect. 3. MMDT was showed to have effects on chronic cough and asthma in these papers. Conclusion: MMDT is being used in respiratory disease. However, mechanism study should be conducted at experimental study and more clinical studies on the efficacy of MMDT for chronic respiratory disease are needed.

• The Journal of Korean Medicine
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• v.15 no.2 s.28
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• pp.173-183
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• 1994

The results about effects of Maecmoondongtang on the pulmonary function of $SO_2$ exposed rats were summerized as follows: 1. Maecmoondongtang reavealed significant effect on decrease of the lung weight in pulmomary edema of rats. 2. Maecmoondongtang reavealed very significant effect on decrease of the TBA value of lung. 3. It was recognized Maecmoondongtang had signiftcant effect on decrease of glycoprotein contents in trachea. 4. It was recognized maecmoondongtang had significant effect on decrease of mucos area in tracheal epithelium. 5. Maecmoondongtang had effects on recovery of the cillia cells of tracheal epithelium and inhibition of mucous secretion. According to the above result. it was recognized Gamimaecdongtang had significant effect on decrease of lung weight in pulmonary edema. the TBA value. glycoprotein contents in trachea. and mucous area in tracheal epithelium. and recovery of the cillia cells of tracheal epithelium. and inhibition of mucous secretion. So I think we can take advantage of this medicine very usefully for treatment of pulmonary edema. pheumonia. acute and chronic bronchitis etc.

• Journal of Life Science
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• v.7 no.1
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• pp.39-48
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• 1997

Cigarette is the risk factor of Lung cancer, chronic obstructive pulmonary disease and ischemic heart disease. So I have studied the effect of Macmoondongtang in rat exposed to cigarette smoke. Thirty-six healthy rat subjects were divided into 6 groups-the control group(sample I), the groups of administration of Platycodi Radix(sampleII), Adenophorae Radix(sampleIII), Liriopsis Tuber(sampleIV), Maximowicziae Fructus(sample V) and Macmoondongtang(sample VI), and expose to cigarette per day for 12 days. 1. On level of leckocyte are significant all the group of sampleII, sampleIII, sample IV, sample V, sample VI on 6th day and singificant the groups of sampleIV, sample V on 12th day. 2. On level of hemoglobin are singificant the groups of sample IV, sample V, sample VI, on 6th day, and significant sample II, sample III, sample IV, sample V, sample VI on 12th day. 3. On platelet level are significant all the group of sampleII, sample III, sample IV, sample V, sample VI on 12th day. 4. On SOD activity are significant all the groups of sample IV, sample VI, on 6th day, and significant sampleII, sample III, sample VI on 12th day. According to the results, Macmoondogtang is effective to risk of cigarette smoke.