• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.365-374
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• 2019

Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.

• Clinics in Shoulder and Elbow
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• v.10 no.1
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• pp.23-26
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• 2007

관절와 병변은 급성 외상으로 인한 골절뿐 아니라 불안정성으로 인한 골 침윤으로 정의할 수 있으며, 이는 통상의 방사선학적 검사를 통하여 진단을 하지 못하는 경우도 있다. 전방 탈구와 동반된 전방 관절와 골절의 빈도는 5.4%에서 32%까지 보고되었다. Hovelius 등이 226명의 탈구환자를 대상으로한 연구에서 8%의 관절와 골절이 있었다고 보고하였고, 노령의 환자에서 약간의 빈도가 증가한다고 하였다. 또한 Rowe는 전방 관절와 골절이 있는 27명의 환자에서 기계적 안정성의 결함으로 62%의 재발성 탈구가 있었다고 보고하였다. 보다 최근의 방카르트 술기에 대한 보고에서 수술적 처치를 한 환자중 44%가 관절와 골절을 동반하였다고 보고하였다. Rowe 와 Zarins는 다발성 전방탈구 환자에서 관절와 병변이 잘 치료되었는지 여부에 따라 다른 결과를 낸다고 보고하였다. 전자에 따르면, 관절와 병변을 진단하는 것은 중요하며 환자의 최종적 예후는 이를 어떻게 치료했는지 여부에 따라 결정된다고 하였다. 관절와 상완관절의 불안정성에서 동반된 관절와 병변의 진단은 보존적 치료시나 수술적 치료 시 모두 중요한 인자라고 하겠다.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2009.03a
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• pp.27-29
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• 2009

견관절 전방 불안정성에서 관절와 및 상완골 결손이 동반된 경우 적절한 진단과 치료는 치료 결과에 직접적인 영향을 주므로 중요하다. 견관절 불안정성은 정적 및 동적 안정화 구조물의 손상으로 기인하며, 상완골 두감입 골절(Hill-Sachs 병변), 관절와 골절이나 전하방 관절와 가장자리의 소실 등 정상적인 관절의 해부학 구조물을 훼손시키는 골성 이상 소견이 동반되면 경우에 따라 견관절 불안정성에 영향을 끼칠 수 있다. 본 강좌에서는 견관절 전방 불안정성에서 동반된 관절와 및 상완골의 골 결손에 대하여 논하고자 한다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1987.05a
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• pp.7.1-7
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• 1987

청력장애가 있고 반복성 뇌막염을 앓는 환자에서는 일단 외임파누공을 의심하고 이에 대한 이비인후과 의사의 철저한 진찰 및 검사를 통해 진단 및 치료에 임해야 하겠다. 저자들은 최근에 경험한 재발성 뇌막염 환아에서 외임파누공을 진단하고 치료한 2예를 보고하고자 한다. 선천적으로 청력장애가 있고 수술전 1년동안 5∼6회의 뇌막염을 앓은 환아를 이학적검사, 청력검사 및 전산화 단층촬영을 이용하여 외임파누공을 진단하고 근막을 포함한 연조직으로 누공을 봉쇄하는 수술적 요법을 사용하여 완치시켰기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Dental Rehabilitation and Applied Science
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• v.23 no.1
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• pp.1-10
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• 2007

악관절 잡음과 동통,과두 흡수를 동반한 퇴행성 측두하악장애는 교합 불안정과 개구장애 를 동반하기도 한다. 진단을 위해 CT나 MRI를 이용해 과두 형태 및 디스크 위치를 파악하 는 것이 유용한 접근법이다. 퇴행성 측두하악관절 환자는 CT나 MRI를 이용하여 진단하고, 과두-원판 재위치와 근 기능 개선을 위해 장기간 교합 안정장치 사용이 필요하므로 교정치료 기간에 변형된 교합 안정장치의 병용이 필요하다. 이에 본 연구에서 교합 안정장치를 병용하여 교합 재구성 증례를 CT나 MRI로 고찰해 보고자 한다.

• Proceedings of the KSLP Conference
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• 1998.11a
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• pp.187-187
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• 1998

위식도 역류 질환의 전형적인 증상에 반하여 인후두에서 나타나는 애성, 만성 기침, 헛기침, 인후두 이물감등의 비전형적인 증상에 대해 최근 관심이 높아지고 있다. 특히 애성이 주된 증상으로 나타나는 경우 일부에서 후두 후방에 점막의 비후 소견이나 육아종을 보이기도 하지만 많은 경우 후두내 기질적 병변을 찾기 어려울 때가 많으므로 의식도 역류 질환과 연관된 애성으로 진단하기 위해서는 자세한 병력 파악 및 이학적 검진, 그리고 위식도 역류 진단을 위한 검사 둥이 요구된다. 저자들은 인후두 이물감을 주소로 내원하여 위식도 역류 검사상 위식도 역류 질환으로 판명되었던 환자 중 애성이 동반된 환자 20례에 대하여 치료전 음성 검사를 시행하였으며 일반적인 치료 후 8주째 추적 검사를 시행하여 그 결과를 문헌 고찰과 함께 보고하고자 한다. (중략)

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.169-177
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• 1998

Purpose : Renal duplication is a common occurrence, and the range of ureteral and renal anomalies draining the two poles of the duplex kidney leads to a variety of clinical presentations. Method : A series of 61 children with duplicated systems was studied retrospectively who were admitted during last 12years. Results : Of the children $60.6\%$ were accompanied with urologic anomalies that required surgical treatment, and most children initially were presented with urinary tract infection. $42.6\%$ of children were either diagnosed incidentally during evaluation of other non-urologic disease or during follow-up evaluation of abnormal antenatal renal sonogram. Conclusion : From our point view, children with history of abnormal antenatal renal sonogram, or with symptoms such as urinary tract infection, hematuria, abdominal pain should be evaluated radiologially fully to confirm further abnormality and accompanied complications. And routine follow-up using abdominal ultrasonogram, VCUG, and urine culture should be used to prevent and detect early treatable complications.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.10 no.1
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• pp.64-75
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• 1999

Objective：The purpose of this study was to investigate the prevalence and characteristics of comorbid disorders and associated symptoms in pervasive developmental disorder(PDD) and to examine the correlation between associated symptoms and developmental characteristics in PDD children. Method：The sample consisted of 209 cases of PDD and 143 cases of developmental language disorder(DLD)(control group) who were treated at the Seoul National Mental Hospital from Jan. 1996 to Mar. 1999. The diagnostic work based on DSM-IV criteria was performed by one or two child psychiatrists, while the clinical feature was evaluated by doctors’s notes, occupational/speech therapy reports, and results of social maturity scale(SMS), childhood autism rating scale(CARS), and psycho-educational profile(PEP). Two groups were compared on a wide range of measures including comorbid disorders, associated symptoms, treatment drugs, and PEP. The relation between associated symptom & PEP was investigated in total(106 cases) and in each dignostic group. Sixty-four cases of PDD were divided into three groups by CARS and then compared on associated symptoms. Result：The prevalence of comorbid disorder was 19.6% in PDD, 41.2% in DLD. The rate of manifestation of 13 associated symptoms was 31.47% in PDD, 22.13% in DLD on the average. Associated symptoms significantly high in PDD were preoccupation, obsession, self-mutilation, stereotypy, sleep problems, and odd response. In total patient group, associated symptoms that significantly influenced PEP were preoccupation, self-stimulation, stereotypy, inappropriate affect, sleep problems, and odd response. But, in each diagnostic group, no associated symptom influenced PEP. Associated symptoms significantly different between the 3 groups of CARS were stereotypy, anxiety, and sleep problems. Conclusion：These preliminary results suggest that developmental characteristics may influence associated symptoms in PDD children and a realistic approach considering minute diagnosis by associated symptoms and comorbid disorders is required.

• Childhood Kidney Diseases
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• v.16 no.1
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• pp.51-53
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• 2012

Henoch-Sch$\ddot{o}$nlein purpura (HSP) is the most common vasculitis in children and is characterized by cutaneous purpura, arthritis, abdominal pain, and nephritis. Bullous skin lesions are rare in children. We report a case involving a 9-year-old female with HSP who displayed rapidly evolving hemorrhagic bullae from the primary purpuric lesions during systemic corticosteroid therapy. The bullae disappeared within 7 days of systemic corticosteroid therapy. Some scar lesions of the skin developed on acute phase recovered completely after 6 months. Bullae should not be considered as a poor prognostic factor of HSP and its renal outcome. Skin biopsy in HSP children with bullae is not necessary if clinical diagnostic criteria of HSP are met. However, further evaluation of more pediatric HSP with bullae is needed to get the clearer conclusions. We report a 9-year-old female with HSP who showed the rapidly evolving hemorrhagic bullae from primary purpuric lesions during systemic corticosteroid therapy.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.11 no.1
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• pp.100-109
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• 2000

Objective：This was conduced to evaluate the effect of early intervention to promote the development of children with developmental disorders. Methods：49 children(31 in PDD group and 18 in DLD group) participated in a one year day treatment program conduced from 1996 to 1999. They were performed PEP, CARS, and SMS. They were grouped by diagnosis, comorbidity, chronological age and CARS score at the beginning of the program and the treatment effect was compared. Results：The children who participated in the day treatment program showed significant increase in their PEP, SMS score, and decrease trend in their CARS score. When children were grouped by diagnosis, comorbidity, chronological age, and severity in CARS score we did not find out significant difference between groups. Conclusion：Our data suggest that the day treatment program which emphasis on development is effective in treating children with developmental disorders.