• Herbal Formula Science
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• v.30 no.4
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• pp.319-338
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• 2022

Objectives : The purpose of this study is to investigate the research trend of Korean traditional medicine for edema under Korean healthcare facilities. Methods : We collected data from search engines for research including domestic online database using the keywords edema, Hydrocele, emphysema and Pneumocranium Results : Total of 41 articles were about Lower body edema, General edema, edema of the eyelid, Lymphedema, Hydrocele, Bone marrow edema, hand edema, Brain edema, emphysema, Pneumocranium The treatment methods used were acupuncture and pharmacopuncture treatment, moxibustion treatment, herbal medicine treatment, cupping treatment, massage treatment, radio frequency treatment, and Chuna treatment. Twenty-nine studies used only oriental medicine treatment, and 12 studies combined oriental medicine and western medicine. the most commonly used measurement was Measurement of the perimeter of the area. Conclusions : This study shows the research trend of edema. Through the collected data, the treatment methods and for specific information of treatments were organized. This study can be used in clinical environments and will contribute for further study in edema.

• Journal of Korean Traditional Oncology
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• v.27 no.1
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• pp.57-66
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• 2022

Objective: To report the improvements with Korean medicine-based integrative cancer therapies on adverse effects of adjuvant chemotherapy in non-small cell lung cancer patients. Method: There were two patients complained cough, rhinorrhea, numbness, general weakness, nausea and dyspepsia after chemotherapy. They got treated centered on Korean medicine including herbal medicine, acupuncture, electro-acupuncture, pharmacopuncture, moxibustion, hand and foot bath. They were also treated Western immunotherapies like Thymosin at regular intervals. The symptoms were measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care(EORTC QLQ C-15 PAL) and their subjective assessments. Results: Their chief complaints were relieved and their quality of life scores was improved even though they have been receiving chemotherapy continuously. Conclusion: These cases revealed a possibility that Korean medicine-based integrative cancer therapies could improve some symptoms after chemotherapy in non-small cell lung cancer.

• The Journal of Internal Korean Medicine
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• v.45 no.5
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• pp.937-950
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• 2024

Objective: This study investigated Korean medicine in treating a case of cognition impairment after stroke with diabetes. Methods: A patient was treated with acupuncture, electroacupuncture, moxibustion, and herbal medicine (Yukmijihwang-tang (Liuweidihuang-wan)) for 69 days. Rehabilitation and speech therapy were also provided. Results: The degree of improvement in symptoms was evaluated using the Korea mini-mental state examination (K-MMSE), the Korean version of the modified Barthel index (K-MBI), the functional independence measure (FIM), the manual muscle test (MMT), HbA1c, average fasting blood sugar, glycated hemoglobin level (HbA1c), and changes in insulin usage. After 66 days of treatment, the MMSE-K increased from 8 to 18, the K-MBI score increased from 13 to 69, and the FIM score increased from 30 to 62. The MMT score increased from left upper extremity Gr.2+P and left lower extremity Gr.2P to left upper extremity Gr.3+F and left lower extremity Gr.3+F. HbA1c changed from 7.1% to 6.5%. Conclusion: This case report suggests that Korean medicine therapy can be effective in improving cognition following traumatic intracerebral hemorrhage and diabetes.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.81-88
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• 2009

The purpose of this study is to report the effectiveness of oriental medical treatment including Hubaksenggangbanhagamchoinsam-tang(厚朴生薑半夏甘草人蔘湯) and moxibustion (and acupuncture) on abdominal distension. Two patients complainted of abdominal distension, vomiting, dyschezia and so on. According to the pattern identification (辯證論治), the distension of both patients were diagnosed as deficiency distension(虛脹). So we decided to treat the patients by means of tonification the deficiency(補虛) including Hubaksengganggamchoinsam-tang and moxibustion. And the symptoms improved after treatment. So we report these cases.

• Herbal Formula Science
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• v.32 no.3
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• pp.345-364
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• 2024

Objectives : Gyeongokgo is a representative herbal formula for longevity in Korean medicine and has been applied to prevent and treat various diseases. Gyeongokgo is recognized as a representative tonic for the Joseon royal family. However, there is yet no legitimate research on how the royal family used Gyeongokgo. The present study aims to analyze Gyeongokgo during the reign of King Sukjong and Gyeongjong with historical records. Methods : Historical records were searched through databases such as the veritable records of the Joseon Dynasty and the daily records of royal secretariat of Joseon Dynasty. Results : During the reign of King Myeongjong, the administration of Gyeongokgo started and expanded to the entire royal family, including the king, queen, and queen mother, by King Sukjong. In the early stage, Gyeongokgo was taken to treat coughing or breathing difficulties. Gradually it was recognized as agood tonic for replenishing energy and blood. Conclusions : The tendency to prefer tonic in the late Joseon Dynasty started during the reign of King Sukjong, and Gyeongokgo began to be used as a seasonal tonic in the fall and winter even though no symptoms appear.

• The Journal of the Society of Stroke on Korean Medicine
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• v.21 no.1
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• pp.39-46
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• 2020

■ Objectives The purpose of this case report is to show the effect of Traditional Korean Medicine(TKM) on a patient with Cluster Headache. ■ Methods A patient diagnosed as Cluster Headache was treated with herbal medication(Sihogyejitang plus Oryungsan), acupuncture, electro-acupuncture. Then we evaluated the improvement with NRS(Numeral Rating Scale) of headache, number of headache attack and O2 inhalation. ■ Results We could observe decrease NRS of headache and number of headache and O2 inhalation after 10 days of the TKM treatment and there was no reattack after treatment for 43days follow up period. ■ Conclusion This case showed the effect of TKM treatment on Cluster headache.

• The Journal of Internal Korean Medicine
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• v.42 no.6
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• pp.1223-1236
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• 2021

Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms. Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting. Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen I. Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.

• Herbal Formula Science
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• v.29 no.4
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• pp.297-310
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• 2021

Objectives : In traditional herbal medicine, as clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of Traditional Chinese Medicine Prescriptions. In chapter of Clear Heat (CH; 淸熱劑) of textbook, the 38 formulas were presented. For enhancing understanding of herbal formula, a large majority of books explained each individual formula with description or figure about interactions between constituent herbs. But there is no study on the interrelationship of each CH herbal formulas. This study investigated the interrelationship of CH herbal formulas. Methods : The CH herbal formula were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of CH herbal formulas, we analyzed the formulas and established the 16 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition on the interrelationship of CH herbal formulas.

• Herbal Formula Science
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• v.29 no.2
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• pp.105-118
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• 2021

Objectives : The process of disease treatment in traditional medicine is defined as differentiating patterns and determining treatment. As an important part of this process, the herbal formulas are specific combinations or configurations of medicinal herbs that serve as tools for treatment. As clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of traditional chinese medicine prescriptions. In chapter of Release the exterior syndrome (RES; 解表劑) of textbook, the 42 formulas were presented. For the understanding on the formula, most of books explained with description or figure about the formulas. But there is no study on the interrelationship of each herbal formulas. This study investigated the interrelationship of RES herbal formulas. Methods : The RES herbal formulas were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of RES herbal formulas, we analyzed the formulas and established the 19 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition the interrelationship of RES.

• Herbal Formula Science
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• v.32 no.2
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• pp.129-139
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• 2024

Objective : This study aims to investigate core herbs and formulas in Internal Medicine on the Liver system (IML) to enhance the efficiency of teaching IML, Herbalogy, and Formula Science, as well as to increase the integration of these courses. Methods : The study employed the frequency concept, commonly utilized in previous studies, alongside network analysis. Results : This study identified frequently used herbs, herbs with high centrality, frequently combined herbs, and core formulas. The herb with the highest frequency was 'Angelicae Gigantis Radix', while the herb with the highest centrality was 'Citri Unshius Pericarpium', and the most frequent herb combination was 'Zingiberis Rhizoma - Citri Unshius Pericarpium'. The network analysis results revealed a total of 5 herbal combination communities. Conclusion : In this study, we identified core herbs using traditional frequency analysis methods. Additionally, to complement traditional analysis methods, we discovered core herbal combinations, and fundamental herbal prescriptions through network analysis. The results of this study can be utilized as foundational data to enhance the efficiency of education in Internal Medicine on the Liver system (IML), Herbology, and Formula Science courses, as well as to improve coherence and consistency between foundational and clinical subjects.