• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.10
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• pp.1446-1451
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• 2010

Silk sericin protein was hydrolyzed by seven proteolytic enzymes to examine the effectiveness of the hydrolysates to bind iron. The amino acid nitrogen contents of hydrolysates by Flavourzyme were higher than the others enzymes, and its iron binding capacity showed dose-dependent increase. The bioavailability of iron binding peptide from sericin hydolysates was investigated in iron-deficient rats. Three-week-old male rats were fed iron-deficient diet for three weeks. Rats were divided into four groups (DD: no treated group on iron deficient diet, DD+HI: heme-iron treated group, DD+OI: sericin-Fe, and DD+II: inorganic iron ($FeSO_4$) treated group, and then iron supplemented by injection for one week. After oral administration for one week, the iron contents of serum and liver were significantly higher in DD+OI ($4.2\;{\mu}g/mL$ and $80.1\;{\mu}g/mL$) and DD+HI ($3.2\;{\mu}g/mL$ and $70.6\;{\mu}g/mL$) than DD ($2.0\;{\mu}g/mL$ and $47.9\;{\mu}g/mL$). Hemoglobin content of treated groups was significantly higher than DD, but the significant difference among groups was not shown. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels did not show any significant difference among all groups. Binding iron to peptide from sericin hydolysates seems to improve its bioavailability and to hasten the cure of iron deficiency in experimental rat.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.319-324
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• 1998

본 연구의 목적은 개에서 사염화탄소에 의하여 실험적으로 유발된 급성 간장질환에 대 한 침술의 치료효과를 알아보는데 있다. 잡종의 성견 24두를 실험에 사용하였다. 사염화탄소 를 동량의 광유에 회석하고, 24두의 개에 kg당 2 ml을 피하로 주사하였으며, 그리고 6두는 laserpuncture로 치료하였고, 6두는 침으로 치료하였으며, 6두는 전침으로 치료하였고, 6두는 대조군으로서 처치를 안 하였다. 치료는 매일 1회씩 4일동안 실시하였다. 적용된 경혈은 간유 와 영태이었다. 침술의 치료효과는 임상증상, 혈액화학치 및 심전도에 의하여 측정되었다. 치 료후에, laserpuncture군이 다른 군들에 비하여 임상중상, 혈액화학치 및 심전도에 있어서 비 교적 빠른 회복을 나타내었다. 전침 및 침군은 대조군에 비하여 약간 빠른 회복을 나타내었다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.44-52
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• 2020

This study was conducted to investigate the effect on Brain Quotient from inhalation of blended oils. The subjects of the study were 64 people aged 20 to 59 years, with 32 in the experimental group and 32 in the control group. Blended oil with six aromas (Lavender, Bergamot, Mandarin, Lemon, Cedarwood, Roman Chamomile) was given to the experimental group, and Jojoba oil was given to the control group, for 30 minutes. Before and after the experiment, BQ tests (SRQ, BRQ, ATQ, ACQ, EQ, ASQ, CQ, and BQ) from the experimental group and the control group were compared and analyzed using a brain-training machine (NeuroHarmony S). There was a significant difference between the experimental group and the control group in three out of the eight tests analyzed ATQ (p<.05), ACQ (p<.05), BQ (p<.05). In other words, aromatherapy improves concentration and memory by increasing attention, and helps to maintain mental activity, thinking ability, and behavioral balance. BQ also represents a comprehensive brain function, and aromatherapy is a good way to maintain human mental and physical health.

• Journal of Veterinary Clinics
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• v.25 no.4
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• pp.245-248
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• 2008

Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP were equally divided into the control and an herbal medicine-treated groups (5 dogs, Oyaksungisan-treated group), respectively. No treatment was given to the control group. In the Oyaksungisan-treated group, Oyaksungisan was administered orally, twice per day for 2 weeks (50 mg/kg) after inducing FNP. Significant differences in the clinical scores were detected between the Oyaksungisan-treated and control groups on day 14 (p < 0.05). The serum creatine kinase (CK) activities in the Oyaksungisan-treated group showed a tendency to decrease but there was no significant difference compared with those of the control group. In conclusion, Oyaksungisan was effective for the induced canine FNP.

• Biomedical Science Letters
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• v.6 no.3
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• pp.223-228
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• 2000

The purpose of this study was to find out the effect of He-Ne, IR laser therapy for 4 and 10 minutes on healing of septic arthritis. Sprague-Bawley rats (212.1$\pm$10 g) were randomly assigned to one control and three arthritis groups. Septic arthritis groups were divided into arthritis control, 4 or 10 minute laser therapy groups. Arthritis was experimentally induced by intraperitoneally administration of staphylococcus aureus in citrate buffer(pH 4.3). These result were obtained as follows: AST, LDH, ALP, CK activities and IgG concentration in 10 minute laser group were signifantly increased compare with those in the arthritis group. AST, LDH and CK activities in 4 minute laser group were significantly decreased compare with those in the arthritis group. We think that laser therapy in 4 minute may effective on the healing of septic arthritis. And we will have to study of the effect of laser therapy on healing mechanism, appropriate time of septic arthritis.

• Journal of Nutrition and Health
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• v.24 no.2
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• pp.97-103
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• 1991

The increase in alcohol consumption level has been noticed in Korea recently. Alcohol appreciably inhibits cell mediated immunity and this may contribute to the high prevalence of serious infection such as pulmonary tuberculosis among alcoholic subjects. The present study was undertaken to examine the effect of ethanol on the cyclooxygenase metabolites of human monocyte in vitro. Monocytes were activated with 800 units of gamma interferon(IFN-${\gamma}$) for 3 days following apply of Ficool-hypaque density gradient and gelatin coated flasks for separation of monocytes. Ethanol with addition of 100mM, 300mM and 600 mM for 30 minutes to 106 monocytes with/without previous IFN-${\gamma}$ treatment caused a dose dependent decrease in the production of thromboxane B2, 6-keto-PGE1$\alpha$ and PGE2 by radioimmunoassay at 6 hours after ethanol treatment. Quite different from the findings after 6 hours there was dose dependent increase in three prostaglandins without IFN-${\gamma}$ treatment after 24 hours of incubation. With previous treatment of IFN-${\gamma}$ reduced productions of three prostaglandins at 24 hours than control is spite of ethanol stimjulation. These findings show that IFN-${\gamma}$ can inhibit alcohol induced derangement of arachidonic acid metabolism of monocytes.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.12-24
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• 2017

The purpose of this study was to evaluate the effects of personality virtue education program using visual media for college students. This program was run in parallel with "Educational Psychology" lecture from August 30th through December 4th, 2015. The subjects of study were 348 freshmen of nursing department in J college. The methodology of this study was nonequivalent pretest-posttest control group experimental design. The researcher carried out pretest for experimental group and control group both before program execution by KEDI Personality Inventory and repeated the test afterwards to measure the effects of the program. The data analysis was implemented by SPSS 22.0. The ANCOVA was used to verify the hypothesis. The result showed that all personality virtues(self-respect, integrity, consideration communication, responsibility, etiquette, self-control, honesty courage, wisdom, justice, citizenship) scores were improved significantly after the program. In conclusion, virtue-centered personality education can make students realize and internalize the value of virtues and have motivation and will to act, when they empathized with visual media on the various situation and learned repeatedly in integrated curriculum.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.125-134
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• 2005

목적 : 이 연구의 목적은 플라시보 자락요법을 계발하기 위함이다. 방법 : 이 연구에서 우리는 자락요법을 잘 알고 있는 특정 피시험군에 진자락요법과 위자락요법을 시행하고, 피시험자에게 본인이 받은 치료가 무엇이었는지 설문조사하였다. 위자락요법은 피부를 뚫어 혈관을 자파시키지 않고 피부 겉에서 느낌만 나도록 자극을 주고 흡입하는 것이다. 결과 : 총 53명의 피시험자가 모든 시험과정에 적절하게 참가하였으므로 모든 데이터를 신뢰할 수 있었다. 결과는 두 그룹간에 유의한 차이를 발견할 수 없었다. 위자락요법을 받은 피시험자중 44.4%는 그들이 받은 치료가 진자락요법이라고 생각했고, 55.6%는 위자락요법이라고 생각했다. 진자락요법을 받은 피시험자중 53.8%는 그들이 받은 치료가 진자락요법이라고 생각했고, 46.2%는 위자락요법이라고 생각했다. 결론 : 각 군간의 민감도와 특이도 간에 유의한 차이가 나타나지 않으므로, 자락요법에 있어 플라시보가 성공했다고 볼 수 있다. 이 연구는 자락요법을 적응증으로 하는 다양한 질환의 임상연구에 있어서 대조군 처치시 좋은 모델을 제시하였다.

• Tuberculosis and Respiratory Diseases
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• v.54 no.1
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• pp.91-103
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• 2003

Background : Histamine is widely distributed in the lung. It increases capillary permeability and the P-selectin expression on vascular endothelial cell surfaces. We studied the role of endogenous histamine on the pathogenesis of endotoxin-induced acute lung injury (ALI) in rats. Methods: We instilled either normal saline (control group) or lipopolysaccharide (3 mg/Kg, LPS group) to tracheas of Sprague-Dawley rats. H1-receptor blocker (mepyramine, 10 mg/Kg, H1RB group), H2-receptor blocker (ranitidine, 10 mg/Kg, H2RB group), and H3-receptor blocker (thioperamide, 2 mg/Kg, H3RB group) were administered through vein or peritoneum along with intratracheal LPS administration. Statistical significance was accepted at p<0.05. Results : LPS increases the histamine level in BAL fluid significantly at 2 h after the treatment compared with control group. LPS significantly increases protein concentration, PMN cell count in bronchoalveolar lavage (BAL) fluid, and myeloperoxidase (MPO) activity in the lung tissue at 6 h compared to control group. PMN cell count in BAL fluid and MPO activity in lung tissue were significantly lower in H2RB-group compared to LPS-group. However, protein concentration in BAL fluid showed no significant differences between the LPS alone and LPS with histamine receptor blockade. Conclusions : Endogenous histamine might be involved in the recruitment of PMNs in LPS-induced ALI via H2 receptor. However, its role in ALI would not be significant in this model.

• Tuberculosis and Respiratory Diseases
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• v.60 no.1
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• pp.83-91
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• 2006

Background : For unknown reasons, the serum ferritin concentrations are higher in patients with acute lung injury. A pretreatment with aspirin reduces the acute lung injury in rats subjected severe hemorrhage, and increases the rate of ferritin synthesis in vitro. This study investigated the effect of aspirin on the serum ferritin changes in rats subjected to severe hemorrhage. Methods : Hemorrhagic shock was induced by withdrawing blood (20 ml/kg of B.W.) through the femoral artery for 5 min. The rats were pretreated with aspirin (10 mg/kg, i.v.) 30 min before hemorrhage. Results : The protein content and leukocyte count in the bronchoalveolar lavage fluid, lung tissue myeloperoxidase activities were significantly higher after hemorrhage. The aspirin pretreatment prevented these changes. The serum and lavage fluid ferritin concentrations were elevated higher after hemorrhage. These were also attenuated by the aspirin pretreatment. Conclusion : The changes in the serum and lung lavage ferritin level might be closely related to the severity of hemorrhage-induced acute lung injury. Therefore, the serum and lavage ferritin concentrations can be a useful biomarker for patients with precipitating conditions.