• Journal of Chest Surgery
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• 제29권12호
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• pp.1360-1365
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• 1996

From September 1992 to May 1996, 38 patients ranging in age from 23 to 78, were operated for aortic dissection at Asan medical center There were 21 men and 17 women. The underlying aortic pathology were acute aortic dissection in 23, chronic aortic dissection in 15. Eight patients had Martian syndrome. In 34 cases of DeBakey type I, II patients, femoral artery and vein and/or right atrial auricle were used as cannulation site. With deep hypothermic c rculatory arrest (esophageal temperature 12 $\pm$ 2.5$^{\circ}C$) and retrograde cerebral perfusion of cold oxygenated blood through SVC, we replaced the ascending aorta and the part of arch if necessary. The mean duration of the total circulatory arrest time was 25 $\pm$ 1.7 mintstuts. In 4 cases of DeBakey type III patients, we replaced descending thoracic aorta or thoracoabdomlnal aorta without shunt or bypass under normothermia with an average 30: 1.5 minutesaortic cross clamp time. One death(2.6%) occurred on the twenty-second postoperative day owing to asphyxia related to ulcer bleeding. Postoperative complications were myocardial infarction with transient left peroneal palsy in 1 case, transient lower extremity weakness in 1 case and prolonged ventilatory support in 1 case. Two patients required reoperation due to retrograde extended dissection and aortic insufuciency. There was no late death with an average 25 months follow-up period.

• Journal of Chest Surgery
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• 제43권1호
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• pp.11-19
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• 2010

Background: The commercially used vascular xenografts have some problems such as calcification, fibrosis and tissue degeneration that are associated with inflammatory and immunologic reactions. We compared two methods of xenograft preservation (fresh cryopreservation versus acellularized cryopreservation) of goat aorta. Material and Method: Aortic valved xenografts were harvested from adult pigs, and these were preserved using fresh cryopreservation (FC group, n=4) or acellularized crypreservation (AC group, n=4). These xenografts were implanted into adult goats. There were 2 short-term survivors (less than 100 days) and 2 long-term survivors in each group. These xenografts were explanted and they underwent microscopic examination. Result: The goats survived 31, 40, 107 and 411 days in the FC group and the other goats survived 5, 40, 363 and 636 days in the AC group. All the short-term survivors in each group expired because of rupture at the proximal anastomosis site. Marked neutrophil infiltration was observed in the FC group FC and lymphocytes were observed in the AC group. There were no differences in the occurrence of calcification, fibrosis and thrombosis among the groups. Conclusion: Some goats survived more than 100 days after the xenograft implantation irrespective of the methods of preservation. Because severe tissue degeneration developed in both groups, we think these methods are not appropriate for xenograft preservation of aorta. It was worth a preliminary trial for improving the preservation method or to modify the processing of xenografts.

• Korean Journal of Heritage: History & Science
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• 제44권3호
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• pp.150-163
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• 2011

In Ryeojidoseo(輿地圖書) Jinging(進貢) Bangmul(方物) item, The Goods name, date, How to make, quantity, etc. are recorded. However, the difference between the towns by the way it is written. at Goods in Jinging(進貢) Bangmul(方物) item, contained medicines, fish and shellfish, provisions, fruit, salted seaweed, weaponry, Leather, buchaeryu are included. And these goods are the town were offering some of the tribute(貢物) and the donation to the palace(進上物) in the mid 18th century. And this is closely related to daedongbeop(大同法). If this analysis approach to the provinces, This analysis makes clear. for example, in Gyeonggido(京畿道) only 12 species recorded and in Chungcheongdo(忠淸道) no a monthly-Jinsang(朔膳進上), in Chollado(全羅道) Sammyeongilbangmul(三名日方物) is not recorded but Bamboo and liabilities are recorded, no bangmul-Jinsang(方物進上) in Gangwondo(江原道), etc. This shows the nature of the Jinging(進貢) Bangmul(方物) item.

• Journal of Chest Surgery
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• 제38권4호
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• pp.291-300
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• 2005

One-stage repair of aortic arch anomalies and intracardiac defects through median sternotomy has been recently adopted by many institutions since it is known to be safer than the staged repair. The early and midterm results of the one-stage repair of aortic arch anomalies and intracardiac defects were retrospectively evaluated. Material and Method: 45 patients who underwent one-stage repair of aortic arch anomalies and intracardiac defects performed by one surgeon from January 1996 to July 2003 were included in this retrospective study. The median age of repair was 16 days (range, 3 days$\~$23.7 months) and the mean weight was $3.62\;\pm\;1.30 kg$. Thirty one $(68.9\%)$ had coarctation and 14 $(31.1\%)$ had interrupted aortic arch. Associated intracardiac anomalies were VSD in 31 patients (VSD group), TGA or Taussig-Bing anomaly in 10 (TGA group), and others in 4 (ASD in 1, aortopulmonary window 1, truncus arteriosus 1, aortic and mitral stenoses 1, miscellaneous group). The arch obstruction was repaired with end-to-side anastomosis in 23 patients and end-to-end anastomosis in 22. Result: Overall postoperative hospital mortality was $22.2\%\;(10/45);\;16.1\%$ (5/31) in VSD group, $40\%$ (4/10) in TGA group, and$25\%$ (1/4) in miscellaneous group. There was no mortality in VSD group since 1998, and the mortality in TGA group has remarkably reduced since technical modification for coronary transfer was adopted $(75\%\;vs\;16.7\%)$. There was no postoperative seizure or other neurological complications. Postoperative aortic restenosis occurred in 5 patients $(5/35,\;14.3\%)$. Two patients underwent balloon aortoplasty with successful results. There was no reoperation. There was one late death caused by pneumonia 5 months after the operation. Two-year actuarial survival rate including operative death was $72.9\%$. Conclusion: The operative mortality of one-stage repair has been reduced with time and aortic restenosis rate was also acceptable. We concluded that this procedure is a reproducible procedure for aortic arch anomalies associated with intracardiac defects.

• Journal of Chest Surgery
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• 제42권5호
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• pp.576-587
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• 2009

Background: The up-regulation of the nitric oxide (NO)-cGMP pathway might be involved in the change of vascular reactivity in rats 3 days after they suffer acute myocardial infarction. However, the underlying mechanism for this has not been clarified. Material and Method: Acute myocardial infarction (AMI) was induced by occluding the left anterior descending coronary artery (LAD) for 30 min (Group AMI), whereas the sham-operated control rats were treated similarly without LAD occlusion (Group SHAM), The concentration-response relationships for phenylephrine (PE), KCl, acetylcholine (Ach) and sodium nitroprusside (SNP) were determined in the endothelium intact E(+) and endothelium denuded E(-) thoracic aortic rings from the rats 3 days after AMI or a SHAM operation. The concentration-response relationships of PE in the E(+) rings from the AMI rats were compared with those relationships in the rings pretreated with nitric oxide synthase (NOS) inhibitor $N{\omega}$-nitro-L-arginine methyl ester (L-NAME) or the cyclooxygenase inhibitor indomethacin. The plasma nitrite/nitrate concentrations were checked via a Griess reaction. The cyclic GMP content in the thoracic aortic rings was measured by radioimmunoassay and the endothelial nitric oxide synthase (eNOS) mRNA expression was assessed by real time PCR. Result: The mean infarct size (%) in the rats with AMI was $21.3{\pm}0.62%$. The heart rate and the systolic and diastolic blood pressure were not significantly changed in the AMI rats. The sensitivity of the contractile response to PE and KCl was significantly decreased in both the E(+) and E(-) aortic rings of the AMI group (p<0.05). L-NAME completely reversed these contractile responses whereas indomethacin did not (p<0.05). Moreover, the sensitivity of the relaxation response to Ach was also significantly decreased in the AMI group (p<0.05). The plasma nitrite and nitrate content (p<0.05), the basal cGMP content (p<0.05) and the eNOS mRNA expression (p=0.056) in the AMI rats were increased as compared with the SHAM group. Conclusion: Our findings indicate that the increased eNOS activity and the up-regulation of the NO-cGMP pathway can be attributed to the decreased contractile or relaxation response in the rat thoracic aorta 3 days after AMI.

• Journal of Chest Surgery
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• 제43권4호
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• pp.458-461
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• 2010

A 53-year-old woman had right aortic arch, Kommerell’s diverticulum and aberrant left subclavian artery (LSA) without any compressive symptoms. Hybrid operation was performed. This consisted of LSA bypass using a 6 mm ringed Gore-Tex graft between the left common carotid artery and aberrant LSA via a left supraclavicular incision, and stent graft insertion into the aortic arch via the right femoral artery. Postoperative computed tomography as well as intraoperative angiography demonstrated successful occlusion of Kommerell’s diverticulum and bypass of the aberrant LSA. There were no complications related to the operation or the intervention.

• Journal of the Korea Computer Graphics Society
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• 제1권2호
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• pp.226-233
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• 1995

본 논문에서는 심장과 심장 상부의 대동맥 및 폐동맥에 대한 형태-기반 보간법을 이용한 3차원 가시화 방법을 제안하였다. CT, MR과 같은 의학 영상들은 x나 y축 방향보다 z축 방향으로 더 낮은 해상도를 갖기 때문에 3차원적 가시화를 위해서는 먼저 각 단층 영상들간의 보간이 수행되어야 한다. 그러나, 지금까지 대부분의 3차원 의학영상 가시화에서는 선형보간법이나 또는 그와 유사한 보간법들을 주로 사용했는데, 이런 보간법들은 분기나 휘어지는 구조를 갖는 기관에는 좋은 결과를 생성하지 못했었다. 따라서, 본 논문에서는 분기와 휘어짐이 있는 심장부위 구조를 3차원적으로 가시화하기 위하여 형태-기반 보간법을 이용하였다. 형태-기반 보간법을 이용한 가시화는 다른 보간법을 사용한 경우와 달리 분명하고 자연스러운 구조 표현을 할 수 있었고, 각 단층 영상간의 보간수를 증가시킴에 따라 더 좋은 결과를 생성하는 것으로 나타났다.

• Journal of the korean veterinary medical association
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• 제36권6호
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• pp.502-516
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• 2000

질병은 여러 가지 인자가 복합되어서 발생하는 것으로 특히 사료에 기인한 질병은 단순한 약품 처방만으로는 치료효과를 기대하기가 어렵다. 그러므로 발생한 질병이 영양의 불균형으로 인하여 발생하는 것인가를 알아보기 위하여 이와 관련된 현장에서 사용할 수 있는 간단하고 판독 용이한 간이진단법을 우선 소개하고 영양성 불균형에 기인된 몇 가지 질병들의 원인, 임상증상 및 치료에 관하여 살펴보고자 한다. 또한 급여사료내의 적합한 에너지함량과 조단백함량을 측정하여 영양불균형에 기인한 질병을 예방하는 방안에 대하여 설명 드리고자 한다.

• Journal of the KSME
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• 제22권1호
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• pp.53-61
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• 1982

최근년의 철도차량의 동향을 살펴보면, 고속경량화와 더불어 차체강도 및 진동특성 등이 중요 시됨에 따라 안전운행을 위하여 제작된 차량의 실제강도가 설계치의 허용범위내에 있어야 하 므로, 우리나라에서도 차량안전성차량을 위하여 전기제한 스트레인 게이지를 이용한 능력해석을 개발하여 성능평가에 도입할 수 있게 되었다. 본 연구에서는 선진외국과 같은 방식의 스트레인 게이지 법을 사용하여 전동객차의 차체 및 대동수 측정에는 가속도계와 스트레인 게이지를 transducer 로 사용하여 진동특성을 기록 및 분석하고, 안정성을 평가하였다.

• Polymer(Korea)
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• 제37권2호
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• pp.127-134
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• 2013

The vascular endothelial cells are the inner layers of blood vessels. It regulates the function of blood vessels and proliferation of vascular smooth muscle cells. Poly(lactide-co-glycolic acid) (PLGA) is a biodegradable synthetic polymer with a well-controlled degradation rate and an acceptable mechanical strength. It can be easily fabricated into many shapes. Silk consists of 18 amino acids. It found important for attaching cells cultured in vitro, and maintaining cell functions. In this study, we fabricated silk/PLGA biomaterial hybrid films of 0, 10, 20, 40 and 80 wt% silk. We performed MTT, SEM, ELISA, and immunocytochemistry analyses. We confirmed the adhesion and the proliferation of HAECs on silk/PLGA according to the content of silk, and 40 wt% silk/PLGA hybrid films have superior adhesion and proliferation properties. These results demonstrate that silk/PLGA hybrid films provide suitable surfaces for HAECs, and there is the effect of silk on cell growth and proliferation.