• Journal of Life Science
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• v.30 no.11
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• pp.1012-1020
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• 2020

Remicade is a therapeutic biosimilar natural antibody in which the mouse variable domain has been linked to the human constant domain. It is a chimeric monoclonal antibody specific to tumor necrosis factor-alpha (TNF-α) and has been developed for the treatment of rheumatoid arthritis. To investigate the biological activity of the Remicade antibody, we carried out a bioinformatics study using a protein data bank to characterize the TNF-α antigen binding mechanism of the Remicade natural antibody. Because the production of the Remicade antibody is often limited by genetic instability of the natural antibody-producing cell, we generated a Remicade single-chain variable domain fragment antibody (Remicade) in which a heavy chain variable domain (VH) is joined with a light chain variable domain (VL) by a polypeptide linker. Furthermore, Remicade was fused to a leucine zipper (RemicadeScZip) for higher production and higher antigen-binding activity than Remicade. The Remicade and Remicade ScZip were expressed in Escherichia coli and purified by a Ni⁺-NTA-agarose column. As expected, the purified proteins had migrated as 28.80 kDa and 33.96 kDa in sodium dodecyl sulfate-polyacrylamide electrophoresis. The TNF-α antigen binding activity of Remicade was not observed by ELISA and western blot. In contrast, RemicadeScZip showed antigen-binding activity. Additional bio-layer interferometry analysis confirmed the antigen-binding activity of RemicadeScZip, suggesting that the leucine zipper stabilized the folding of RemicadeScZip in a denatured condition and improved the TNF-α antigenbinding activity.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.47 no.2
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• pp.21-28
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• 2010

This paper reports an experimental result on optimizing dissimilarity-based classification(DBC) by simultaneously using a dynamic time warping(DTW) and a multiple fusion strategy(MFS). DBC is a way of defining classifiers among classes; they are not based on the feature measurements of individual samples, but rather on a suitable dissimilarity measure among the samples. In DTW, the dissimilarity is measured in two steps: first, we adjust the object samples by finding the best warping path with a correlation coefficient-based DTW technique. We then compute the dissimilarity distance between the adjusted objects with conventional measures. In MFS, fusion strategies are repeatedly used in generating dissimilarity matrices as well as in designing classifiers: we first combine the dissimilarity matrices obtained with the DTW technique to a new matrix. After training some base classifiers in the new matrix, we again combine the results of the base classifiers. Our experimental results for well-known benchmark databases demonstrate that the proposed mechanism achieves further improved results in terms of classification accuracy compared with the previous approaches. From this consideration, the method could also be applied to other high-dimensional tasks, such as multimedia information retrieval.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.4
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• pp.33-42
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• 2013

This paper describes a multiple vehicle tracking algorithm using an integrated probabilistic data association filter (IPDAF) in urban environments. The algorithm consists of two parts; a pre-processing stage and an IPDA tracker. In the pre-processing stage, measurements are generated by a feature extraction method that manipulates raw data into predefined geometric features of vehicles as lines and boxes. After that, the measurements are divided into two different objects, dynamic and static objects, by using information of ego-vehicle motion. The IPDA tracker estimates not only states of tracks but also existence probability recursively. The existence probability greatly assists reliable initiation and termination of track in cluttered environment. The algorithm was validated by using experimental data which is collected in urban environment by using single laser scanner.

• The Korean Journal of Applied Statistics
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• v.11 no.1
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• pp.65-81
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• 1998

Simultaneous equation models, increasingly used in many detailed analyses, tend to get larger and more sophisticated to describe the structure of the study area to be close to the actual situations. In setting up such a system of equations, statistical results and simulation performance of the model as a whole may be meaningless and unrepresentative of the real world due to a structural instability that is built into the model when the equations are combined and solved simultaneously. Even though the use and subsequent analysis of an unstable system are likely to mislead us, most of the studies that take the simultaneous equation approaches neglect such a serious problem. Thus it is necessary to illustrate how to check the stability problem and apply to the actual model, then investigate how such as analysis is able to provide useful information about the structural characteristics of the model from the dynamic viewpoint.

• Proceedings of the Korean Society of Computer Information Conference
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• 2024.01a
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• pp.191-192
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• 2024

고령 인구의 지속적인 증가로 인해 고령자의 안전과 관련된 문제는 주요한 관심사 중 하나로 부상하고 있다. 특히, 고령자들 사이에서 자주 발생하는 낙상 사고는 심각한 건강 문제를 일으킬 수 있으며, 이를 예방하고 대응하는 것은 고령 인구의 삶의 질을 향상하는 데 중요한 역할을 한다. 본 연구는 8대의 카메라로 촬영된 영상과 센서 데이터를 통합한 낙상 감지 기법을 제안한다. 제안한 기법은 MediaPipe를 활용하여 Skeleton Keypoint를 추출하는 이미지 인식 기법과 센서 데이터에서 얻은 특징을 활용하는 센서 기반 기술을 결합하여 낙상 사고의 발생 및 방향을 효과적으로 감지할 수 있다. 이러한 결과를 바탕으로 본 연구는 향후 고령자들의 생활 안전성과 의료 시스템의 효율성을 높이는 데 이바지할 수 있을 것으로 기대한다.

• Journal of Sensor Science and Technology
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• v.5 no.1
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• pp.43-50
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• 1996

This paper presents a manufacture of the multiple subjects biotelemetry system using custom CMOS IC fabricated $1.5{\mu}m$ n-well process technology. The implantable circuits of the system except sensor interface circuits including FM transmitter are fabricated on a single chip with the sire of $4{\times}4mm^{2}$. It is possible to assemble the implantable system in a hybrid package as small as $3{\times}3{\times}2.5cm$ by using this chip, It's main function is to enable continuous measurement simultaneously up to 7-channel physiological signals from the selected one among 8 subjects. Another features of this system are to enable continuous measurement of physiological signals, and to accomplish ON/OFF switching of an implanted battery by subject selection signal with command signal from the external circuit. If this system is coupled with another appropriate sensors in medical field, various physiological parameters such as pressure, pH and temperature are to be measured effectively in the near future.

• Journal of Advanced Navigation Technology
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• v.26 no.4
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• pp.226-234
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• 2022

With advances in autonomous vehicles and networked control, there is a growing interest in the consensus control of a multi-agents system to control multi-agents with distributed control beyond the control of a single agent. Since consensus control is a distributed control, it is bound to have delay in a practical system. In addition, it is often difficult to have a very accurate mathematical model for a system. Even though a reinforcement learning (RL) method was developed to deal with these issues, it often experiences slow convergence in the presence of large uncertainties. Thus, we propose a slide RL which combines the sliding mode control with RL to be robust to the uncertainties. The structure of a sliding mode control is introduced to the action in RL while an auxiliary sliding variable is included in the state information. Numerical simulation results show that the slide RL provides comparable performance to the model-based consensus control in the presence of unknown time-varying delay and disturbance while outperforming existing state-of-the-art RL-based consensus algorithms.

• Journal of KIISE:Software and Applications
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• v.26 no.12
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• pp.1482-1496
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• 1999

기존의 스테레오 정합 알고리즘은 크게 명암기반기법과 특징기반기법의 두 가지로 나눌 수 있다. 그리고, 각 기법은 그들 나름대로의 장단점을 갖는다. 본 논문은 이 두 기법을 결합하는 새로운 알고리즘을 제안한다. 본 논문에서는 물체모델링을 목적으로 하기 때문에 배경을 제거하여 정합하는 방법을 사용한다. 이를 위해, 정합요소들과 정합유사함수가 정의되고, 정합유사함수는 두 기법사이의 장단점을 하나의 인수에 의해 조절한다. 그 외에도 거리차 지도의 오류를 제거하는 coarse-to-fine기법, 폐색문제를 해결하는 다중윈도우 기법을 사용하였고, 물체의 표면형태를 알아내기 위해 morphological closing 연산자를 이용하여 물체와 배경을 분리하는 방법을 제안하였다. 이러한 기법들을 기반으로 하여 여러가지 영상에 대해 실험을 수행하였으며, 그 결과들은 본 논문이 제안하는 기법의 효율성을 보여준다. 정합의 결과로 만들어지는 거리차 지도는 3차원 모델링을 통해 가상공간상에서 보여지도록 하였다.Abstract Classical stereo matching algorithms can be classified into two major areas; intensity-based and feature-based stereo matching. Each technique has advantages and disadvantages. This paper proposes a new algorithm which merges two main matching techniques. Since the goal of our stereo algorithm is in object modeling, we use images for which background is removed. Primitives and a similarity function are defined. The matching similarity function selectively controls the advantages and disadvantages of intensity-based and feature-based matching by a parameter.As an additional matching strategy, a coarse-to-fine method is used to remove a errorneous data on the disparity map. To handle occlusions, multiple windowing method is used. For finding the surface shape of an object, we propose a method that separates an object and the background by a morphological closing operator. All processes have been implemented and tested with various image pairs. The matching results showed the effectiveness of our method. From the disparity map computed by the matching process, 3D modeling is possible. 3D modeling is manipulated by VRML(Virtual Reality Manipulation Language). The results are summarized in a virtual reality space.

• Journal of the Korea Society of Computer and Information
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• v.19 no.2
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• pp.21-30
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• 2014

The use of induction motors has been recently increasing in a variety of industrial sites, and they play a significant role. This has motivated that many researchers have studied on developing fault detection and classification systems of induction motors in order to reduce economical damage caused by their faults. To early identify induction motor faults, this paper effectively estimates spectral envelopes of each induction motor fault by utilizing a linear prediction coding (LPC) analysis technique and an expectation maximization (EM) algorithm. Moreover, this paper classifies induction motor faults into their corresponding categories by calculating Mahalanobis distance using the estimated spectral envelopes and finding the minimum distance. Experimental results show that the proposed approach yields higher classification accuracies than the state-of-the-art conventional approach for both noiseless and noisy environments for identifying the induction motor faults.

• Journal of Satellite, Information and Communications
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• v.6 no.1
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• pp.86-96
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• 2011

In this paper we propose a Pre-rake system applied with a frequency domain equalizer in TDD/CDMA multi-code transmission. The Pre-rake system has been well known technique in TDD/CDMA to make a receiver simple. However, it still has residual losses of path diversity and signal to noise ratio (SNR). However, gathering all the residual paths demands an additional hardware such as a rake combiner at the receiver. For the reason Pre/Post-rake system has already been proposed at up/downlink correlated channel conditionunder the assumption of noisier channel. There is a trade-off between the first purpose of Pre-rake that makes hardware simple at the receiver and the performance improvement. From the point the frequency domain equalizer (FDE) can be considered in Pre/Post-rake to supply the receiver with the flexible equalizing methods with rather reduced complexity compared with time domain rake combiner or equalizers. Pre-rake itself increases the number of multipath, which results from the convolution of Pre-rake filter and wireless channel, and FDE must be well matched to Pre/Post-rake, while it considers the relationship of hardware complexity and the performance. In this paper, the Pre-rake/Post-FDE system is introduced at TDD/CDMA multi-code transmission. In addition, the cyclic prefix reduction method in the proposed system is introduced, and the theoretical analysis to the proposed system is given by assuming Gaussian approximation, and finally the numerical simulation results are provided.