• 보건세계
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• v.53 no.5 s.597
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• pp.35-39
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• 2006

다제내성 결핵은 치료 성공률이 낮은데 그 원인으로 사용할 수 있는 효과적인 항결핵 약제의 숫자가 제한되어 있고, 약제 부작용이 많고, 장기간의 치료기간으로 인해 환자의 순응도(compliance)가 낮기 때문이다. 치료에 실패한 다제내성 결핵환자는 본인의 고통뿐만 아니라 지속적으로 결핵균을 배출하는 만성배균자가 되어 수 많은 사람들에게 다제내성 결핵균을 퍼뜨리는 전염원이 된다.

• Journal of Digital Convergence
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• v.18 no.3
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• pp.227-234
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• 2020

This study was carried out to provide basic data for the development of an educational program by assessing the its effects on the MDROs infection management performances of nurses at general hospitals. Data was obtained through a structured questionnaire survey conducted on 202 nurses. The average of knowledge score was 17.68 and their perceived susceptibility, perceived severity, perceived benefits, and performances had correlation. There was difference in their performances in accordance with their general characteristics including marriage, clinical experiences, positions, and affiliated department. Factors that affected MDROs infection management performance included perceived benefits and affiliated department with an explanation power of 35%. Therefore, it is necessary to emphasize the benefits by including advantages and effects of performing the MDROs infection control at the time of the development. In addition, nurses are required to have MDROs infection control education.

• Journal of Industrial Convergence
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• v.20 no.11
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• pp.205-211
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• 2022

This study is a descriptive research study to identify the knowledge and compliance of multidrug-resistant organisms of nursing students with clinical practice. Data were collected from 212 nursing students in two nursing schools in D city from 1 November 2020 to 10 March 2021. The collected data were statistically analyzed using the SPSS/WIN 25.0 program. Correlations were found between knowledge and compliance of multidrug-resistant organisms (r=.40, p<.001). Therefore, to enhance the compliance of multidrug-resistant organisms of nursing students, it is necessary to prepare detailed theoretical and practical guidelines for multidrug-resistant organisms in the curriculum and clinical practice and to increase knowledge through multidrug-resistant organisms infection control education.

• Journal of Chest Surgery
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• v.34 no.1
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• pp.72-79
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• 2001

배경: 일반적으로 다제내성 폐결핵의 경우 화학요법만으로는 치료성적이 만족스럽지 못하였다. 이에 수술적 치료와 항결핵 화학요법의 병합사용이 높은 균음전율과 장기 생존율을 보여주고 있으므로 이러한 치료전략이 다제내성 폐결핵환자의 일반적인 치료방법으로 정립되리라는 전망을 갖게 하고 있다. 대상 및 방법: 1995년 1월부터 1999년 12월까지 국립마산결핵병원에서 폐결핵에 대한 수술을 시행받은 130례 중 다제내성 폐결핵으로 폐절제수술을 받은 49례를 대상으로 의무기록 및 검사기록 등을 근거로 후향적 조사를 실시하였다. 결과: 대상환자들의 평균연령은 35세였고, 내성약제의 수는 평균 4.5였다. 43례(87.8%)의 환자에서 공동성 병소를 보였으며 31례(63.3%)의 환자에서 술전 객담내 균양성 소견을 보였다. 수술술식은 12례에서 전폐적출술을, 28례에서 폐엽절제술을, 7례에서는 폐엽절제술과 구역절제술 혹은 설상절제술 등을, 그리고 설상절제술과 공동성형술을 각각 1례에서 시행하였다. 술후 지속적인 내과적 약물치료를 병합하여 장기적인 균음전율은 93.5%였고 술후 사망환자는 없었다. 술후 합병증으로는 1주일 이상 지속되는 공기유출 6례와 술후 출혈, 창상분열이 각각 1례씩 있었다. 결론: 다제내성 폐결핵환자에서 폐절제 수술에 대해서는 적절한 적응증, 수술후 처방, 그리고 술후 치료기간 등에 대한 이견이 있지만 적극적으로 고려되어야 하며 술후 내과적 치료와 병행함으로 좋은 치료효과를 얻을 수 있었다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.463-470
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• 2020

This study was conducted to aid in the development of an infection control educational program for nurses, by assessing the knowledge and educational demand of nurses for MDRO infection control. Totally, 115 nurses participated in the study. Data were collected from November 15-30, 2019, using structured questionnaires. Descriptive statistics, t-test, and ANOVA were applied for analyzing the data. Experience of caring for MDRO patients was reported by 86.1% nurses, whereas 67.8% nurses had received training on MDROs. The average score for knowledge on MDROs was 25.51 out of 27 points, with minimal correct answers given for the query on level of disinfection for medical equipment used by patients, criteria for the preemptive precaution, patient management in the cohort, and timing for removing personal protective equipment. The educational demand was highest for assignment to the precaution, criteria for screening examination, and management of outbreak. Also, educational needs differed with respect to the general educational characteristics and position of the individual. We propose the need to differentiate the educational status according to the career when developing the MDROs program, and the necessity to execute education of MDROs for new nurses and career nurses.

• Korean Journal of Microbiology
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• v.54 no.1
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• pp.53-59
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• 2018

The objective of this study was to investigate the plasmid profiling of multi-drug resistant (MDR) Vibrio in influent (inflow) and effluent (discharged) water samples of fish farms in Jeju, South Korea. MDR isolates identified through disc diffusion susceptibility tests, were subjected to plasmid profiling. One hundred fifty Vibrio isolates were obtained from each influent and effluent water sample. All MDR isolates were subjected to plasmid profiling. Greater number of bacteria were enumerated from effluents (61%) comparing to influents (39%). High incidence of neomycin, sulfamethoxazole, amoxicillin and oxytetracycline resistance was observed among the isolates, which was higher in effluent samples. In contrast, Vibrio isolates were more susceptible to florfenicol, chloramphenicol, ciprofloxacin, and nalidixic acid. Among 99 (influent 39 and effluent 60) MDR isolates, a total of 58 (influent 38 and effluent 20) were found to bear plasmids ranging from 1.7 kb to >10 kb and showed 19 different antibiograms according to the size of plasmids. MDR isolates showed six and four distinct plasmid profiles in influent and effluent, respectively. Effluent samples contained more plasmid-carrying MDR Vibrio isolates with more diverse plasmid profiles and antibiograms, suggesting that fish farm tanks may serve as a reservoir of antibiotic resistance genes. The presence of plasmid-carrying MDR Vibrio isolates in fish farm effluent water may contribute to the dissemination of antibiotic resistance genes to the environments, which ultimately poses threat to human health.

• Journal of Digital Convergence
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• v.19 no.4
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• pp.159-166
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• 2021

This study was an attempt to develop a multidrug resistant organisms infection control simulation program for nurses at small and medium sized hospitals and to evaluate the effectiveness of said simulation program. This is a single-group, pre-post experimental design study conducted on 33 nurses working at small and medium sized hospitals. Data obtained were analyzed using the IBM SPSS 21.0 program, along with the use of descriptive statistics and paired t-test. Regarding the results of the study, multdrug resistant organisms infecion control knowledge(t=-10.764, p<.001)and performance levels(t=-4.215, p<.001) of the nurses displayed statistically significant increases following application of the simulation program. There is a need for the development of more diversified simulation programs in the future since the improvement in the infection control knowledge and performance levels of nurses is important to block the spread of multidrug resistant organisms and prevent infection outbreak thereof with medical institutions.

• Tuberculosis and Respiratory Diseases
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• v.59 no.6
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• pp.600-605
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• 2005

Background : Primary multidrug-resistant tuberculosis is defined as Mycobacterium tuberculosis isolates that are resistant to at least isoniazid and rifampin in never-been-treated tuberculosis patients, and this malady is caused by the transmission of a resistant strain from one patient, who is infected with a resistant Mycobacterium tuberculosis strain, to another patient. The prevalence of primary multidrug-resistant tuberculosis could be a good indicator of the performance of tuberculosis control programs in recent years. We conducted a case-control study to identify the risk factors for primary multidrug-resistant tuberculosis. Methods : From January 1, 2001 to, June 30, 2003, by conducting prospective laboratory-based surveillance, we identified 29 hospitalized patients with P-MDRTB and these patients constituted a case group in this study. The controls were represented by all the patients with culture-confirmed drug susceptible tuberculosis who were admitted to National Masan Hospital during the same study period. The odds ratios for the patients with primary multidrug-resistant tuberculosis, as compared with those of the patients with drug susceptible tuberculosis, were calculated for each categorical variable with 95% confidence intervals. Results : Multivariate logistic regression showed that the presence of diabetes mellitus (odds ratio 2.68; 95% confidence interval, 1.05-6.86) was independently associated with having primary multidrug-resistant tuberculosis. Conclusion : This study has shown that diabetes mellitus might be one of the risk factors for primary multidrug-resistant tuberculosis.

• 보건세계
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• v.61 no.4
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• pp.36-37
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• 2013

우리는 흔히 절반 정도 채운 컵의 물을 보고 긍정의 여부를 판단하곤 한다. 물이 반만 남았다고 걱정하는 이도 있지만, 반이나 남았다고 생각는 사고의 차이. 여기에 덧붙여 반이나 남은 잔에 나머지 반을 채워가기 위해 현재 누구보다 열심히 노력하는 이가 있다. 다제내성결핵과 싸워 이기는, 힘든 시간을 거쳐 지금은 요양보호사로서 제2의 인생을 꾸려가고 있는 윤석봉 씨다. 그를 만나 용기와 희망에 대한 이야기를 들어보았다.

• Tuberculosis and Respiratory Diseases
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• v.50 no.6
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• pp.686-692
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• 2001

Background : Outbreaks of multidrug-resistant tuberculosis(MDR-TB) are caused by the low rate of treatment response due to limitation in number of available drugs and high rates of adverse drug side-effects. This study analysed the risk factors for MDR-TB patients, who did not respond to treatment, with an aim to improve the rate of treatment response. Methods : Retrospective study of 111 MDR-TB patients at National Mokpo Tuberculosis Hospital from Jan. 1996 to Dec. 1998 was made. The patients were separated into two groups ; group I comprised of patients who were treated successfully and group II comprised of those were not treated successfully. In order to analyze the risk factors for treatment failure, differences between the two groups were compared and the confidence limit regarding the results were tested using an independent t-test. chi-square test and a Fisher's exact test. Results : The treatment failure rate of MDR-TB patients was 32% (36 patients), and treatment success rate 68%(75 patients). This study found no significant difference between two groups in terms of age, sex, family history, extent of the disease on the chest X-ray, the number of sensitive drugs in the treatment regimen, and the number of sensitive bactericidal drugs in the treatment regimen (p>0.05). However, a past history of pulmonary tuberculosis, cavitary lesions on the chest X-ray, the number of treatments, the number of resistant drugs and the number of drugs used showed a significant difference(p<0.05). Conclusion : The rate of treatment failure in MDR-TB was increased by a past history of pulmonary tuberculosis, cavitary lesions on the chest X-ray, the number of treatments, the number of resistant drugs and the number of drugs used. For improving the treatment response of MDR-TB, every effort should be made to reduce the drug resistance caused by failure of the first treatment.