• The Journal of the Convergence on Culture Technology
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• v.4 no.4
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• pp.349-354
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• 2018

Human beings have made remarkable advances in medical technology as well as technological advances. However, as was the case in the past, incurable diseases still exist: temporo-mandibular joint (TMJ). The diagnosis of the Korean medical staff, currently called a "medical advance," is adhering to the outdated patient's comments, diagnosis using a doctor's auditory diagnosis and a ruler, and diagnosis of X-ray imaging. Therefore, it is important to have accurate patient symptoms, to have a doctor's own diagnosis and experience, to increase the number of diagnoses due to the severity of the symptoms, and to cover the costs of medical care. To solve this problem, the core conductive signal generated from the bridge was quantified through %MVC. Quantified EMG will be assessed and compared with Cortex to establish a jaw joint condition evaluation criterion.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.33 no.1
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• pp.26-30
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• 2022

Background and Objectives Cough suppression therapy (CST) is a physiotherapy that can be used for patients with chronic refractory cough (CRC). We aimed to investigate the efficacy of CST for CRC. Materials and Method A prospective randomized controlled trial was conducted in 27 patients with CRC. Participants were randomized to receive either standard mucolytic medications for CRC combined with supplemental CST (CST group) or standard medications alone (control group). CST consists of laryngeal hygiene management, humidification, cough suppression technique, breathing method, and counseling. We assessed the symptoms change at baseline and week 4 with the Leicester Cough Questionnaire (LCQ). Secondary efficacy outcomes included the degree of cough Visual Analog Scale (VAS) score (0 to 100 scale). Results From 2019 to 2021, 14 CST group patients and 13 control group patients were included. The improvement was significantly greater in the CST group than in the control group for cough VAS score (36.67 to 13.33 vs. 74.29 to 16.43, p<0.001). Patients in the CST group had a significant improvement in total (70.14 to 107.71, p=0.005), physical (31.42 to 43.86, p=0.015), psychological (23.57 to 40.14, p=0.003), and social (15.14 to 23.71, p=0.005) LCQ scores. However, there was not a significant pre- to post-treatment LCQ score improvement in control group. Conclusion CST might be an effective supplemental intervention for CRC.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.158-158
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• 1993

노화현상에 따른 여러 가지 병태생리조건의 형성과 난치성 성인병질환의 발병 및 진행과정에 활성산소류들과 이들에 의해 유도되어지는 free radical이 관여하고 있다는 증거가 여러연구진에 의해서 보고되어지고 있다. 산소를 이용하여 생명현상을 이어가는 생물체들은 필연적으로 활성산소들을 생성하는 생화학적 산화반응기구를 효율적으로 활용하면서 항상성을 유지시키고 있다. 그러므로 활성산소의 생성과 분해과정의 평형유지는 생물학적으로 대단히 중요한 의미를 갖고 있다. 임상적으로 alcohol은 질병의 악화 내지는 질환의 발병조건을 조성하는 병태생리기구에 기여할 것으로 생각되어 대부분의 환자에게 금주시키고 있으나 그 작용기전에 대해서는 충분히 설명되지 못하고 있다. 본 연구에서는 alcohol을 급ㆍ만성으로 실험동물에 투여하고 생체에서 활성산소 생성에 중요한 역할을 하는 xanthine oxidase와 aldehyde oxidase의 활성변화를 관찰하면서 전자의 형전환속도와 과산화지질 생성속도와의 상관성을 중점 비교 관찰하므로서 alcohol성 간손상 실험 model을 계획하였다. 간 및 신장조직에서 alcohol에 유래되는 활성산소의 생성계에 관여하는 효소 활성의 변화와 조직의 과산화지질 생성반응 속도는 alcohol의 투여방법, 기간, 시간(diurnal variation), 나이 및 암수에 따라 다르게 나타남을 관찰할 수 있었다.

• The Science & Technology
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• no.3 s.418
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• pp.51-53
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• 2004

• Clinical Pain
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• v.20 no.1
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• pp.30-34
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• 2021

Multifidus cervicis plane block has been effectively used to provide analgesia during and after cervical spine surgery, but not for any other purpose. Here, we report three cases of chronic axial neck pain unresponsive to medical treatment. We performed multifidus cervicis plane block bilaterally, which lowered numerical rating scale (NRS) score within 2 weeks. Thus, multifidus cervicis plane block is one of the novel options that may be used for chronic axial neck pain.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.1
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• pp.28-35
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• 2008

Purpose: The aim of this study is to report the efficacy of infliximab, a monoclonal antibody directed against tumor necrosis factor alpha which is used for both treatment of refractory pediatric Crohn disease (CD) and induction of remission. Methods: Among pediatric patients who were diagnosed with CD at Samsung Medical Center between March 2001 and August 2007, a total of 16 patients were given infliximab to treat conventional therapyresistant refractory CD and severe active CD for induction of remission. Patients needing maintenance therapy were treated with an infliximab infusion every 8 weeks, and fistulizing CD patients occasionally received the infusion upon the condition that a fistula developed. The efficacy of treatment was assessed by comparing the Pediatric Crohn Disease Activity Index (PCDAI), Hct, ESR, CRP, and serum albumin levels using paired t-test. Results: The male/female ratio was 13:3, and the median age was 13 years (range, 21 months~15 years). The patients included 7 cases of therapy-resistant refractory CD, 7 cases of severe active CD, and 2 cases of fistulizing CD. Mean PCDAI before infliximab therapy was 34.19${\pm}$14.96, and mean follow-up PCDAI within 2 to 4 weeks after the last infusion was significantly lower, at 6.88${\pm}$10.31 (p=0.000). Hematological markers such as ESR (p=0.000), serum albumin (p=0.016), and CRP (p=0.009) also improved significantly after infusion. Remission was achieved in 2 of 4 patients refractory to conventional therapy. Among 3 steroid-dependent patients, 2 were able to discontinue steroid therapy, and dose reduction was possible in 1 patient. Remission after top-down therapy without prior use of other immunomodulators was achieved in 6 weeks in all 7 of the patients who had severe CD. Nine of ten refractory fistulizing CD patients also showed improvement after infliximab therapy. Conclusion: Infliximab was effective in pediatric refractory CD for induction of remission and maintenance therapy, as well as in severe CD for top-down induction therapy. Furthermore, infliximab has contributed to steroid cessation and dose reduction. Long-term follow-up evaluation is needed to determine safety and efficacy of infliximab in the future.

• Journal of Korean Foot and Ankle Society
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• v.25 no.4
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• pp.190-194
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• 2021

A bursa is an obstructive sac filled with synovial fluid and usually occurs in any area of the body exposed to friction. The bursa of the ankle is not a normal anatomical structure and is caused by repetitive trauma, constant friction, or inflammatory disease of the ankle. Bursitis can occur in any bursa in the human body; however it rarely progresses to septic arthritis. We report a rare case of septic ankle arthritis following intractable lateral malleolar bursitis successfully treated with negative-pressure wound therapy.

• Health and Mission
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• s.1
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• pp.17-20
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• 2004

다수결 원칙으로 결정될 사안이 아닌 '생명의 존엄성'이 '생명윤리 및 안전에 관한 법률'의 제정으로 흔들리고 있다. 인간배아복제는 난치병 환자들을 치료하기 위한 획기적인 방법으로 포장되고 있으나 결국은 한 인간을 수단으로 이용하는 생명파괴 행위일 뿐이다.

• Clinical and Experimental Pediatrics
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• v.52 no.9
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• pp.1029-1034
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• 2009

Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that affects children. There are few reports that describe the Epstein-Barr virus (EBV) as the possible infectious agent of KD. Here, we describe a case of KD in a 15-year-old boy complicated with giant coronary artery aneurysms, pericardial effusion, and splenic infarction. The clinical course of KD was refractory to intravenous gamma globulin and aspirin. Our patient also showed typical findings of concomitant EBV-associated infectious mononucleosis, such as hepatosplenomegaly and generalized lymphadenopathy, with EBV-positive atypical lymphoid hyperplasia. He improved dramatically after receiving intravenous methylprednisolone followed by oral prednisolone. Ultimately, the coronary artery aneurysms remained as the only sequelae. We report a rare case of adolescent KD with EBV-associated infectious mononucleosis and splenic infarction.

• Clinical Pain
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• v.20 no.2
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• pp.127-130
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• 2021

Ultrasound (US)-guided hydrodissection (HD) is a widely applied therapeutic method to release the entrapped peripheral nerve. However, this therapy has only been studied for the nerve entrapments such as carpal tunnel syndrome, and there are no reports of its effect on direct nerve injuries with incomplete axonal damage. Here, we report a case of direct traumatic injury of a median nerve with incomplete axonal injury in a 28-year-old man. He presented hypoesthesia and weakness along with the median nerve territory of the left hand after a laceration wound of the wrist. The patient underwent a surgical procedure, but did not experience prominent improvement for the next six months. Symptoms improved after we performed the US-guided HD with dextrose. We propose this procedure as one of the new treatment methods for direct axonal injury of nerves including the median nerve.