• Proceedings of the EASDL Conference
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• 2003.04a
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• pp.81-82
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• 2003

국민소득 증대에 따른 사회경제 수준의 향상과 의학발달에 의해 평균 수명이 연장되었다. 이로 인한 인구의 노령화로 노인관련 질환 즉, 류마티스성 관절염, 심장질환 등과 같은 만성 퇴행성질환과 암 등 영양섭취의 불균형과 관련된 질병이 급증되었다. 최근 ROS(reactive oxygen species), PGs(prostaglandins), 및 NO(nitric oxide)가 각종 염증성 질환, 순환계 질환 및 암화 과정에 밀접한 연관이 있기 때문에 이들을 조절할 수 있는 식품류가 각종 질환의 예방을 목적으로 각광을 받고 있다.(중략)

• 대한예방의학회:학술대회논문집
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• 2000.10a
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• pp.272-273
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• 2000

• Journal of Animal Science and Technology
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• v.46 no.2
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• pp.183-192
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• 2004

Two experiments were conducted to examine the effects of the acute phase response on the performance and superoxide dismutase(SOD) activities in liver and erythrocyte of broiler chicks fed dietary krill meals A and B in experiment 1 and krill meal A in experiment 2. The experimental diets are basal diet based on yellow corn and soybean meal and diets substituted 2.0% of krill meal A or B with soybean meal of the basal diet, respectively. Day-old birds fed on the experimental diets and the acute phase response(immunological stress) was activated in the birds on 8-day of age by alternate day injection i.p. with 3 doses the Salmonella typhymurium lipopolysaccharide(LPS) in saline. The values during the acute phase response were compared with those controls injected with saline. The performance; daily gain, feed intake, and feed efficiency were different between dietary krill meal A and B in birds during the acute phase response and in the control. The acute phase response increased relative liver and spleen weights. Recovery of birds from the immunological stress was different between krill meals. Dietary krill meals increased activities of MnSOD and Cu/ZnSOD in erythrocyte cytosols during the actute phase response. Dietary krill meals did not affect the PHA-p response. The results indicated that the dietary krill meals may accentuate oxidative stress during the acute phase response.

• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.490-498
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• 2010

Isotianil is a fungicide which has prevention effects against rice blast disease. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and to determine its acceptable daily intake. Isotianil was almost excreted by urine and feces. It has low acute oral toxicity while has no skin toxicity and ocular irritation. Its skin sensitization was evaluated as slight. Genotoxicity of parent compound and metabolite was negligible. Chronic toxicity tests on rats and dogs showed changes of hematology, clinical biochemistry and liver weight. It had no reproductive and teratogenic effects. The estimation of Acceptable Daily Intake(ADI) is based on the lowest no-observed adverse effect level (NOAEL). The lowest NOAEL of 2.83 mg/kg bw/day was found in the twelve-months rats study. The NOAEL was based on increased liver weight and treatment-related effect on clinica chemistry finding at the nest higher dose level of 2.83 mg/kg bw/day. Therefore, it is considered appropriated to apply an uncertainty factor of 100 to the NOAEL 2.83 mg/kg bw/day from the rat study, resulting in an ADI of 0.028 mg/kg bw/day.

• Journal of Food Hygiene and Safety
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• v.8 no.2
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• pp.105-117
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• 1993

The objective of this investigation was to characterize the subacute toxic potency of orally administered poly(sodium acrylic acid-acrylic acid), super absorbent polymer. Four groups of rats were maintained on diets containing 0, 1.25, 2.5 or 5% of poly(sodium acrylic acid-acrylic acid). The mean dosages of poly(sodium acrylic acid-acrylic acid) were estimated to be 1025 mg/kg/day, 2009 mg/kg/day and 4728 mg/kg/day in the male groups. The estimated average dosages of poly(sodium acrylic acid-acrylic acid) in the female groups were 1011 mg/kg/day, 2088 mg /kg/day and 4576 mg/kg/day, respectively. Few test compound-related toxic effects were observed in body weight gain, clinical signs, hematological parameters and serum biochemical values. Urinalyses, gross necropsy and histopathology revealed no evidence of specific toxicity. Food and water consumption tended to increase in the animals fed the diet of 2.5% and 5%. Our data indicate that no-observed effect level of poly(sodium acrylic acid-acrylic acid) was estimated to be 1.25% in the diet (mean dosage: 1025 mg/kg/day in male rats, 1011 mg/kg/day in female rats).

• Journal of Radiation Protection and Research
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• v.28 no.4
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• pp.321-325
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• 2003

The effects of AMAD, absorption type, and intake pattern were compared and analysed for the internal dose evaluation of workers who chronically inhale uranium. The committed effective doses$(E_{50})$ based on AMAD, absorption type, and intake pattern were evaluated using 3 monthly lung predicted monitoring data due to a chronic intake of uranium for 5 years. The relative error ranges of $E_{50}$ evaluated with each AMAD$(0.1{\sim}10{\mu}m)\;to\;E_{50}$ evaluated with $5{\mu}m$ AMAD were $-37.0{\sim}49.8%$, and the relative error ranges of En evaluated with Type M to $E_{50}$ evaluated with Type S were $15.9{\sim}56.6%$, and the relative error ranges of $E_{50}$ evaluated with an acute intake to $E_{50}$ evaluated with a chronic intake were $0.55{\sim}4.52%$. Thus AMAD and the absorption type affected the results of $E_{50}$, but the intake pattern didn't really affect the results of $E_{50}$.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.1
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• pp.44-51
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• 2008

Purpose: We performed this study to evaluate reliability on interpretation of three phase bone scintigraphy (TPBS) in patients with post-traumatic complex regional pain syndrome (PT-CRPS). Methods: Based on International Association for the Study of Pain guideline in 1994, 34 patients with PT-CRPS were selected for this study. Two nuclear medicine physicians evaluated identical TPBS according to the uptake pattern, extent and intensity of the lesion, and their agreements (kappa values) were analysed. The final diagnosis based on arbitrary criteria of each physician were compared with those obtained by the criteria for PT-CRPS established in this study, which are hyperactivity on all phases (criteria 1), hyperactivity of whole joints on delayed phase (criteria 2), and hyperactivity of either whole or FDGal joints on delayed phase (criteria 3). Results: Intra-observer agreements were good for uptake pattern, intensity, and extent on TPBS. Inter-observer agreements were also good, except extent on blood pool phase (0.55). The inter-observer agreements on final diagnosis improved when criteria 1-3 were applied (0.77-0.88), compared to when physician's own criteria were used (0.63). Those also improved from 0.29 to 0.47-0.82 for acute stage, and from 0.37 to 1.0 for chronic stage. The sensitivities of chronic stage were relatively lower to those of acute stage. Conclusions: Inter-observer's variations in diagnosis of the patients with PT-CRPS using TPBS were observed. These results were attributed to different criteria set by observers. In order to improve agreement on interpretation of TPBS, common positive criteria should be established, especially considering uptake pattern and clinical stages.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.3
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• pp.321-326
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• 2016

The objective of this study was to obtain data on safety-in-use of yeast hydrolysate with a molecular weight of 10~30 kDa as a dietary supplement by assessing its subacute oral toxicity in ovariectomized rats. Yeast hydrolysate did not produce mortality or significant changes in general behavior or gross appearance of internal organs of rats. There were no significant differences in organ weights between control and yeast hydrolysate groups. Hematological analysis and blood chemistry revealed no toxic effects of yeast hydrolysate. Neither gross abnormalities nor histopathological changes were observed. These results show that yeast hydrolysate possesses very low toxicity as indicated in a postmenopausal animal model.

• Journal of Nutrition and Health
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• v.43 no.1
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• pp.26-33
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• 2010

This study was performed to investigate the changes of oral diet intake during the admission period and identify the factors related with nutritional status in discharging of leukemia patients. This is a retrospective cross sectional study on 46 leukemia patients receiving chemotherapy at the Catholic University of Korea Seoul St. Mary's Hospital from July to September 2009. The patients' charts were surveyed on the general characteristics and factors relating chemotherapy. The calorie count method was used to investigate diet intake during admission period. Multivariate logistic regression analysis was used to identify possible confounding factors. A p < 0.05 was considered statistically significant. The mean age was $42.8\;{\pm}\;14.6$ years and the average length of stay was $30.4\;{\pm}\;7.0$ days. The incidence of malnourished patients was 60.9% in discharging. There was a significant difference in chemotherapy sessions and chemotherapy period between well-nourished and malnourished patients. The average energy intake was 1,525.9 kcal in well-nourished patients and 1,143 kcal in malnourished patients, which was significant different. From repeated measures ANOVA test, the changes of oral intake during admission period were significant by groups. In addition, there were significant differences in oral intake according to each period between well-nourished and malnourished patients. In multivariate logistic regression analysis, both the ratio of total oral energy intake to recommended energy intake and chemotherapy sessions were significantly associated with nutritional status in discharging. The results of this study could be used to establish a protocol of nutritional management for leukemia patients receiving chemotherapy.

• Journal of Food Hygiene and Safety
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• v.27 no.2
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• pp.188-193
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• 2012

This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was "0" in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score "0" of primary irritation index.