• Journal of Nutrition and Health
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• v.34 no.4
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• pp.426-432
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• 2001

Vitamin B(sub)12(cobalamin) is an essential nutrient in human and it is particularly important during pregnancy. Nevertheless very few studies have reported, concerning vitamin B(sub)12 in relation with reproduction. This study was conducted to evaluate the vitamin B(sub)12 nutrition status of Korean pregnant women and to investigate the relationship between serum vitamin B(sub)12 levels of maternal-umbilical cord blood and pregnancy outcomes. Dietary vitamin B(sub)12 intakes of the pregnants were estimated by semiquantitative frequency questionnaire. Serum vitamin B(sub)12 levels in both maternal blood and umbilical cord blood of 30 pregnant women at delivery were measured by radioimmunoassay. Mean vitamin B(sub)12 intake was 3.3$\pm$1.4$\mu\textrm{g}$/d which was 125.8% of the Korean RDA(2.6$\mu\textrm{g}$) for vitamin B(sub)12 level of umbilical cord blood was 607.8$\pm$282.9pg/ml, more than two fold of maternal vitamin B(sub)12 level 268.6$\pm$97.8pg/ml. This finding indicates that fetal uptake of vitamin B(sub)12 in the fetus may be due to an active transport mchanism across the placenta. Umbilical cord blood vitamin B(sub)12 levels were highly correlated with maternal levels($r^2$=0.548, p<0.001), showing that fetal vitamin B(sub)12 level is affected by maternal status. However there was no significant correlation between the serum vitamin B(sub)12 levels in maternal-umbilical cord blood and the pregnancy outcomes except for the birth weight. Maternal-umbilical serum vitamin B(sub)12 levels were the highest in the group of birth weight 3.0-3.5kg, and the lowest in the group of birthweight below 3.0kg. (Korean J Nutrition 34(4) : 426~432, 2001)

• Journal of Nutrition and Health
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• v.34 no.8
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• pp.936-945
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• 2001

This study was conducted to investigate the menu patterns consumed frequently in 5 Korean rural areas for all seasons, using 24-hour recall method with 1,185 subjects. The purpose of this study was to suggest the menu pattern in rural areas for the basis data of the nutrition education program and nutrition intervention project. The result were following : most frequently used menu patterns by the number of side dish were rice + soup + kimchi + 1 side dish> rice + soup + kimchi + 2 side dish> rice + soup + kimchi > rice + stew + kimchi + 1 side dish in the order. Most frequently used menu patterns by the kind of side dish were rice + soup + kimchi > rice + stew + kimch > rice + kimchi> noodle + kimchi in the order. In menu patterns showed higher frequency, Nutrient Adequacy Ratio(NAR) of all nutrients except Ca and Vit A was over 0.7. The Mean Adequacy Ratio (MAR) of rice + soup(or stew) + kimchi + 2(or 3) side dish was 0.76∼0.82. The number of dishes consumed in winter was the highest. The menu had traditional menu pattern based on cooked rice, Korean soup and kimchi in Korean rural areas. With these results, we can conclude that nutrient balances from the menu pattern can be improved, if the composition of main dish and side dish are adequate . For the nutrition program in the community menu patterns should be examined carefully. The result from this study can be used as basic data for nutrition education programs in Korean rural areas.

• Clinical and Experimental Pediatrics
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• v.45 no.3
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• pp.325-330
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• 2002

Purpose : We intended to find out how the red cell transfusion would change the white cell count in preterm neonates under treatment in the intensive care unit. We also speculated whether the magnitude of such a change could indicate a potential neonatal infection. Methods : Total white blood cell count, total neutrophil count, and band count were compared and analyzed retrospectively on 33 preterm neonates who received red cell transfusions in our hospital's intensive care unit over a period of two years and a month. Results : We found a mean change of $1.33{\times}10^3/mm^3$ and $0.55{\times}10^3/mm^3$ in total white blood cell count and total neutrophil count in the first eight hours following the red cell transfusion. No significant change was observed in band count between pre and post-red cell transfusion. Conclusion : A mild increase in the white blood cell count caused by an increase in neutrophil count was observed temporarily following the red cell transfusion. But the white blood cell count returned to the pre-transfusion level in about 24 hours, indicating that such a low level of increase cannot be interpreted as an infection of a preterm neonate.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2011.10a
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• pp.13-13
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• 2011

보이차의 주요산지는 중국 운남성이며 특히 란창강 유역이 그 중심지이다. 천연 사포닌과 미네랄류를 풍부하게 포함하고, 지방의 용해, 다이어트 효과, 소화 촉진, 정장 작용, 숙취 해소, 위가 더부룩할 증상 개선, 혈당치 상승 억제, 혈액 순환 촉진에 효과가 있는 것으로 알려져 있다．또한, 면역력 강화 효과와 노화예방, 암 예방효과도 있는 것으로 알려져 있다. 보이차의 기능성 물질은 일반적으로 메탄올 또는 에탄올 용매에 의하여 추출한다. 용매에 의하여 추출하기 전에 메카노케미스트리 분쇄기술을 적용하여 전처리하면 재료의 표면적을 증가시키고 부분적으로 화학적 성분을 변화시켜 기능성 물질의 추출효율을 증가시킬 수 있다. 본 연구에서는 메카노케미스트리 분쇄기술을 적용하여 보이차를 전처리한 다음 메탄올과 에탄올 용매에 의하여 기능성 물질을 추출하여 메카노케미스트리 전처리가 항산화 물질의 추출효율에 미친 효과를 분석하였다. 보이차는 메탄올과 에탄올 추출 전에 유성밀에 의하여 분쇄되었으며 분쇄 후의 형상을 SEM 현미경으로 분석하였다. 아질산성질소 소거능은 pH 1.2에서 메탄올 용매추출을 했을 때 전처리하지 않는 경우 63.0-83.0%로부터 메카노케미스트리 분쇄기술을 적용한 전처리를 한 경우에 74.0-92.0%로 증가하였다. 전자공여능은 DPPH(1,1-diphenyl-2-pycrylhydrazyl)를 이용한 방법으로 측정하였으며, 메탄올 용매추출의 경우에 13.12-49.29%로부터 메카노케미스트리 전처리 후에 15.12-64.29%로 증가하였다. DPPH radical 50% 소거능을 나타내는 $IC_{50}$은 전처리하지 않는 경우 164 ug/mL로부터 전처리한 경우에 151ug/mL로 감소하였다.

• Journal of Acupuncture Research
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• v.20 no.4
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• pp.11-23
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• 2003

Objective: In this study, the analgesic effect of gold injection aqua-acupuncture on CFA induced arthritis in rats was inverstigated. Furthermore, to determine the antinociceptive mechanism of gold injection aqua-acupuncture, naloxone and yohimbine were administrated intraperitoneally 15min prior to the gold injection aqua-acupuncture. Methods: The experimental groups were divided into 6 groups. Control group, NSI, AMI, AMI+SL : AMI+Nx, AMI+Yb. Thereafter we measured the chages of TFL between control and experimental groups. Results: 1. The tail flick latency induced by CFA was significantly increased on AMI as compared with the NSI group. 2. Effect of sodium aurothiomalate aqua-acupuncture in TFL on CFA was decreased after application of naloxone. The anti-nociceptive effect of AMI was completely antagonized by naloxone(an opioid receptor antagonist). 3. Effect of sodium aurothiomalate aqua-acupuncture in TFL on CFA was decreased after application of yohimbine. The anti-nociceptive effect of AMI was completely antagonized by yohimbine(${\alpha}2$-adrenoceptor antagonist). Conclusions: According to the results, gold injection aqua-acupuncture has significant analgesic effects on adjuvant induced arthritis in rats and the effect of anti-nociception was mediated by opiodergic system and ${\alpha}2$-adrenergic system.

• Journal of Acupuncture Research
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• v.33 no.1
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• pp.79-93
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• 2016

Objectives : The purpose of this study is to explore research trends in gold implantation therapy performed on the animal and human body, through a review of clinical studies focused on gold thread, gold needle and gold bead. Methods : Medical databases, including Pubmed, CENTRAL, MEDLINE, EMBASE, RISS4u, KISTI, OASIS and KTKP, were searched for relevant articles published from their launch to December 31, 2015 using the key word 'gold' with '$thread^*$', '$needle^*$', '$acupuncture^*$', '$wire^*$', '$bead^*$', '$embed^*$', '$implant^*$', or '$insert^*$'. The results were classified into in vivo studies, clinical trials and clinical reports. Analysis of the results was conducted in several research areas, from the identity of studies such as nationality and published year, to the gold preparations-features and implanted locations and to the outcomes that reflect the clinically favorable or adverse effect of gold implantation therapy. Results : A total of 30 studies including 11 in vivo studies, 4 clinical trials and 15 case reports, were found in the search. We observed certain research trends according to the research time, nationality and target indication of the studies. The studies primarily revealed a chronic local inflammatory response which could be a useful mechanism for pain-relief in musculoskeletal diseases and facial rejuvenation. Researches concerning long-term reactions or adverse effects were rare. Conclusion : The results show that the efforts to discover the level of clinical efficacy of gold implantation therapy were steady and worldwide. However, further researches on the longterm effect, and more importantly, the safety of gold implantation therapy are required.

• Research in Community and Public Health Nursing
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• v.27 no.1
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• pp.72-80
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• 2016

Purpose: The purpose of this study was to identify the effect of subjective xerostomia and salivary pH in salivary glands stimulated by laughter therapy in frail elderly women. Methods: The research used a one-group pretest-posttest design. Data were collected from July 2, 2015 to September 30, 2015. A sample of 41 frail female elderly patients was recruited at A Nursing Home in K City, Korea. We measured xerostomia and salivary pH using a questionnaire and BCP test paper (pH 5.6~7.2). Laughter therapy was given once a week for four weeks (3 items). Data were analyzed through descriptive statistics, independent t-test, ANOVA, paired t-test and Cronbach's using the SPSS 18.0 program. Results: There were significant differences in salivary pH according to oral health (t=-2.06, p<.05). There were significant differences in xerostomia (t=4.41, p<.001) and salivary pH (t=-7.94, p<.001) after salivary glands stimulated by laughter therapy. Conclusion: Salivary glands stimulated by laughter therapy improved xerostomia and salivary pH of the frail elderly. Therefore, salivary glands stimulated by laughter therapy may be useful in promoting and maintaining oral health among the frail elderly in the rapidly increasing population of old people.

• Korean Journal of Occupational Health Nursing
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• v.2
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• pp.52-59
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• 1992

본 연구는 예방적 건강행위에 대한 필요성 인식 정도와 실천정도를 파악하고 이를 요인분석하여 산업장의 예방적 건강행위를 이끌기 위한 프로그램의 기틀을 세우기 위해 시도되었다. 연구도구는 참고문헌과 선행연구 등을 참조하여 본 연구자가 만든 설문지를 사전 조사후 수정, 보완하여 사용하였다. 연구대상은 경기도 소재의 2개 기계제조업체에 근무하는 근로자들이였으며 1989년 5월 5일부터 10일까지 자료를 수집하였다. 수집된 자료 중 탈락 및 기재가 불충분한 질문지를 제외한 284명의 응답자를 분석에 사용하였다. 자료분석은 SPSS를 이용하여 전산처리하였으며, 연구결과는 다음과 같다. 1) 예방적 건강행위의 필요성 인식정도의 평균은 122.1점으로 매우 높은 점수분포를 나타냈으며, 실천정도의 평균은 87.6점으로 필요성 인식정도 보다는 낮은 실천정도를 나타냈었다. 2) 예방적 건강행위에 대한 필요성 인식정도와 실천 정도간의 상관관계를 분석한 결과 29개 예방적 건강행위 중 20개의 항목에서 통계적으로 유의한 상관관계를 보였다. 이것을 예방적 건강행위에 대한 필요성 인식정도가 높을수록 실천정도가 높은 것을 의미하는 것으로 인식정도가 행위에 영향을 미침을 반영하고 있다. 3) 요인분석결과 29개의 예방적 건강행위 항목들은 7가지의 요인으로 범주화되었으며 각 범주들은 요인부하량이 높은 것들을 참고로 하여 보건의료자원활동을 통한 예방적 건강행위, 개인위생에 대한 예방적 건강행위, 작업과 관련된 건강행위, 식습관을 통한 예방적 건강행위, 휴식을 통한 예방적 건강행위, 기호습관(금연, 금주)을 통한 예방적 건강행위, 활동을 통한 예방적 건강행위등으로 명명할 수 있었다. 결론적으로 생산직에 종사하고 있는 근로자들은 예방적 건강행위에 대한 필요성을 깊이 인식하고 있으나, 실천정도는 그에 미치지 못하고 있었다. 그러나 예방적 건강행위의 필요성 인식정도와 실천정도간의 상관관계에서 29개 항목중 20개 항목에서 유의한 상관관계를 보여 인식정도가 높을 수록 실천정도가 높은 것으로 나타났다. 이는 근로자의 건강에 대한 인식 및 태도가 가장 직접적으로 영향을 미칠 수 있는 산업간호사의 역할 중 보건교육에 대한 업무가 보다 중요한 비중으로 수행되어져야 함을 시사하는 결과라고 볼수 있다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.1
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• pp.32-38
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• 2009

In this study, we investigated the anti-obesity activity of the herbal extract mixture (HEM). The inhibitory effect of HEM on triglyceride accumulation of 3T3-L1 preadipocyte was examined by Oil-Red O staining. HEM inhibited the triglyceride accumulation of 3T3-L1 preadipocyte cell and reduced glycerol-3-phosphate dehydrogenase (GPDH) activity. We further investigated the effect of HEM in prevention of obesity in male ICR mouse for 5 weeks. Experimental groups were divided into high fat diet group (HFD), HFD supplemented with 100 mg/kg HEM group (HEM1) and HFD supplemented with 200 mg/kg HEM group (HEM2). Body weight and food efficiency ration of HEM1 and HEM2 was decreased by 52% and 50% and by 45% and 50%, respectively. The amount of adipocyte in body weight was decreased. Blood triglyceride and total cholesterol of HEM1 was significantly decreased. These results indicate that HEM may be useful in preventing obesity.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.4
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• pp.317-323
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• 2009

Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging with wrinkle formation. This study was performed to investigate anti-wrinkle effects of Lindera obtusiloba extract (LO) on UVB-induced wrinkle formation. We first measured cell proliferation and type I pN collagen synthesis activities in normal human dermal fibroblasts. Cell proliferation and type I pN collagen synthesis were increased by 33.8 % and 91.8 %, respectively, compared with no treatment control. SKH-1 hairless mice were topically applied 5 % LO solution for 10 weeks with UVB irradiation three times a week. After 10 weeks, a visual assessment and replica assay were performed on each mouse. According to visual assessment of close-up photos and skin replica, application of 5 % LO solution inhibited UV-induced wrinkle formation in mouse skin as compared to the vehicle-applied control mice. These results indicated that LO could protect skin wrinkle formation caused by chronic photo-irradiation in hairless mice.