• Nuclear Medicine and Molecular Imaging
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• v.41 no.4
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• pp.326-334
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• 2007

Purpose: The estrogen receptor (ER), which is over-expressed in ER-positive breast tumors, has been imaged by positron emission tomography (PET) using $[^{18}F]$ labeled estrogen ligands, especially $[^{18}F]FES$. However, $[^{18}F]$ has relatively short-lived half-life ($t_{1/2}$ =1.8 h) and the labeling yield of radio-fluorination is usually low compared with $^{64}Cu\;(t_{1/2}=12.7\;h)$. 1,4,7,10-tetraazacyclododecane (cyclen) is used to form stable metal complexes with copper, indium, gallium, and gadolinium. With these in mind, we prepared cyclen-based Cu complexes which mimic estradiol in aspect of two hydroxyl groups. Materials and Methods: 1.7-Protected cyclen, 1.7-bis (benzyloxycarbonyl)-cyclen was synthesized according to the reported procedure. After introducing two 4-benzyloxybenzyl groups at 4,10-positions, the benzyloxycarbonyl and benzyl groups were removed at the same time by hydrogenation on Pd/C to give 1,7-bis(4-hydroxybenzyl)-1,4,7,10-tetraazacyclododecane (1). Results: The prepared ligand 1 was fully characterized by $^1H,\;^{13}C$ NMR, and mass spectrometer. The synthesized ligand was reacted with copper chloride and copper perchlorate to give copper complexes $[Cu(1)]^{2+}2(CIO_4^-)\;and\;[Cu(1)Cl]^+Cl^-$ which were confirmed by high-resolution mass (FAB). Conclusion: We successfully synthesized a cyclen derivative of which two phenol groups are located on trans position of N-atoms. And, two Cu(ll) complexes of +2 and +1 overall charge, were prepared as a potential PET tracers for ER imaging.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.3
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• pp.21-29
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• 2023

In this study, the stress characteristics of temporary fixed steel rods were analyzed in the "temporary fixing system using internal prestressing tension", which is mainly applied to the construction of superstructures by FCM. It was difficult to confirm the changes in initial tensile force in this system because the steel rod was internally connected to the pier and the PSC BOX. Therefore, measurement was performed before and after the completion of each segment using an FBG sensor to measure the change in the micro length of the steel rod. The results of the analysis showed that 75% to 90% of the maximum vertical contraction of the steel rod that occurred until the completion of the cantilever segment occurred in the fixing ~ 1segment, and the maximum loss of initial prestressing force was 39%. Such excessive loss of tension force to 1 segment means that tension is needed to improve the precision of construction during the fixation, and re-tension is needed to secure stability for conduction of cantilever segments after the completion of 1segment. In the 2 ~ last segment, the stress of the steel rod decreased gradually, and in the summer, the decrease in stress tended to partially recover due to the increase in the length of the steel rod corresponding to the increase in the vertical volume of PSC BOX. The dominant factor in the stress change in 2~ last segment in this phenomenon is judged to be the change in the length of the steel rod according to the temperature. Unlike the change in length, the relaxation was 1.2-2.7%, which was mostly offset by the opposite stress corresponding to the temperature stress. Therefore, a plan was proposed to improve the internal stress, such as adjusting the fixation time.

• Korean Journal of Mineralogy and Petrology
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• v.36 no.4
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• pp.313-321
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• 2023

Numerous studies have investigated the adsorptive sequestration of radioactive cesium in the natural environment. Among these studies, adsorption onto minerals and high-temperature treatment stand out as highly effective, as demonstrated by the use of zeolite. In this study, cesium was ion-exchanged with birnessite and subsequently underwent high-temperature treatment up to 1100℃ to investigate both mineral phase transformation and the leaching characteristics of cesium. Birnessite has a layered structure consisting of MnO₆ octahedrons that share edges, demonstrating excellent cation adsorption capacity. The high-temperature treatment of cesium-ion-exchanged birnessite resulted in changes in the mineral phase, progressing from cryptomelane, bixbyite, birnessite to hausmannite as the temperature increased. This differs from the phase transformation observed in the tunneled manganese oxide mineral todorokite ion-exchanged with cesium, which shows phase transformation only to birnessite and hausmannite. The leaching of cesium from cesium-ion-exchanged birnessite was estimated by varying the reaction time using both distilled water and a 1 M NaCl solution. The leaching quantity changed according to the treatment temperature, reaction time, and type of reaction solution. Specifically, the cesium leaching was higher in the sample reacted with 1 M NaCl compared to the sample with distilled water and also increased with longer reaction time. For the samples reacted with distilled water, the cesium leaching initially increased and then decreased, while in the NaCl solution, the leaching decreased, increased again, and finally nearly stopped like the sample in the distilled water for the sample treated at 1100℃. These changes in leaching are closely associated with the mineral phases formed at different temperatures. The phase transformation to cryptomelane and birnessite enhanced cesium leaching, whereas bixbyite and hausmannite hindered leaching. Notably, hausmannite, the most stable phase occurring at the highest temperature, demonstrated the greatest ability to inhibit cesium leaching. This results strongly suggest that high-temperature treatment of cesium-ion-exchanged birnessite effectively immobilizes and sequesters cesium.

• Economic and Environmental Geology
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• v.27 no.2
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• pp.147-160
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• 1994

Copper-bearing hydrothermal vein mineralization of the Samsan area was deposited in two stages (I and II) of quartz-calcite-sulfide veins which fill fissures in Cretaceous volcanic and sedimentary rocks of the Gyeongsang basin. The major ore minerals, chalcopyrite and sphalerite, together with pyrite, galena, hematite, and minor sulfosalts, occur with epidote and chlorite as gangue minerals in stage I quartz veins. Chlorite geothermometry, fluid inclusion and stable isotope data indicate that copper ore was deposited mainly at temperatures between $330^{\circ}C$ and $280^{\circ}C$ from fluids with salinities between 12 and 3 equiv. wt % NaCl. Evidence of fluid boiling indicates a range of pressures from ${\leq}100$ to 200 bars bars. Within ore stage I there was an apparent decrease in ${\delta}^{34}S$ values of $H_{2}S$ with paragenetic time, from 8.0 to 2.3 per mil. This pattern was likely achieved through progressive increases in activity of oxygen accompanying boiling and mixing. In the early part of the first stage, the high temperature, high salinity fluids gave way to progressively cooler and more dilute fluids of the late parts in the first stage and of the second stage. There is a systematic decrease in calculated ${\delta}^{18}O_{water}$ values with decreasing temperature in the Samsan hydrothermal system, from values of -86 per mil for early portion of stage I through -5.9 per mil for late portion of stage I to -6.3 per mil for stage II. The ${\delta}D$ values of fluid inclusion waters also decrease with paragenetic time from -76 per mil to -86 per mil. These trends combined with mineral paragenesis and fluid inclusion data are interpreted to indicate progressive cooler, more oxidizing meteoric water inundation of an early exchanged meteoric hydrothermal system.

• Journal of the Korean GEO-environmental Society
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• v.15 no.12
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• pp.117-128
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• 2014

Generally, when constructing a tunnel close to existing structures, the tunnel must be built at a constant distance from the structures that is more than width of tunnel to minimize the impact of interference between an existing structures and new tunnel. Spacing of these closed tunnels should be designed considering soil state, size of tunnel and reinforcement method. Particularly when the ground is soft, a care should be taken with the tunnel plans because the closer the tunnel is to the existing structures, the greater the deformation becomes. As methods of reviewing the effect of cavities on the stability of a tunnel, field measurement, numerical analysis and scaled model test can be considered. In the methods, the scaled model test can reproduce the engineering characteristics of a rock in a field condition and the shape of structures using the scale factor even not all conditions cannot be considered. In this study, when construction of a tunnel close to existing structures, the method and considering factors of the scaled model test were studied to predict the actual tunnel behavior in planning stage. Furthermore, model test results were compared with the numerical analysis results for verifying the proposed model test procedure. Also, practical results were derived to verify the stability of a tunnel vis-a-vis cavities through the scaled model test, which assumed spacing distances of 0.25 D, 0.50 D, and 1.00 D between the cavities and tunnel as well as the network state distribution. The spacing distances of 1.0 D is evaluated as the critical distance by the results of model test and numerical analysis.

• Korean Journal of Remote Sensing
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• v.32 no.3
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• pp.307-321
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• 2016

Planetary Boundary Layer Height (PBLH) is a major input parameter for weather forecasting and atmosphere diffusion models. In order to estimate the sub-grid scale variability of PBLH, we need to monitor PBLH data with high spatio-temporal resolution. Accordingly, we introduce a LIdar observation VEhicle (LIVE), and analyze PBLH derived from the lidar loaded in LIVE. PBLH estimated from LIVE shows high correlations with those estimated from both WRF model ($R^2=0.68$) and radiosonde ($R^2=0.72$). However, PBLH from lidar tend to be overestimated in comparison with those from both WRF and radiosonde because lidar appears to detect height of Residual Layer (RL) as PBLH which is overall below near the overlap height (< 300 m). PBLH from lidar with 10 min time resolution shows typical diurnal variation since it grows up after sunrise and reaches the maximum after 2 hours of sun culmination. The average growth rate of PBLH during the analysis period (2014/06/26 ~ 30) is 1.79 (-2.9 ~ 5.7) m $min^{-1}$. In addition, the lidar signal measured from moving LIVE shows that there is very low noise in comparison with that from the stationary observation. The PBLH from LIVE is 1065 m, similar to the value (1150 m) derived from the radiosonde launched at Sokcho. This study suggests that LIVE can observe continuous and reliable PBLH with high resolution in both stationary and mobile systems.

• Journal of Korean Society of Environmental Engineers
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• v.29 no.1
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• pp.23-30
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• 2007

The ultimate objective of this study is to develop oxygen-enriched combustion techniques applicable to the system of practical industrial boiler. To this end the combustion characteristics of lab-scale LNG combustor were investigated as a first step using the method of numerical simulation by analyzing the flame characteristics and pollutant emission behaviour as a function of oxygen enrichment level. Several useful conclusions could be drawn based on this study. First of all, the increase of oxygen enrichment level instead of air caused long and thin flame called laminar flame feature. This was in good agreement with experimental results appeared in open literature and explained by the effect of the decrease of turbulent mixing due to the decrease of absolute amount of oxidizer flow rate by the absence of the nitrogen species. Further, as expected, oxygen enrichment increased the flame temperatures to a significant level together with concentrations of $CO_2$ and $H_2O$ species because of the elimination of the heat sink and dilution effects by the presence of $N_2$ inert gas. However, the increased flame temperature with $O_2$ enriched air showed the high possibility of the generation of thermal $NO_x$ if nitrogen species were present. In order to remedy the problem caused by the oxygen-enriched combustion, the appropriate amount of recirculation $CO_2$ gas was desirable to enhance the turbulent mixing and thereby flame stability and further optimum determination of operational conditions were necessary. For example, the adjustment of burner with swirl angle of $30\sim45^{\circ}$ increased the combustion efficiency of LNG fuel and simultaneously dropped the $NO_x$ formation.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.3
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• pp.75-85
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• 2009

This work proposes a 13b 100MS/s 0.13um CMOS ADC for 3G communication systems such as two-carrier W-CDMA applications simultaneously requiring high resolution, low power, and small size at high speed. The proposed ADC employs a four-step pipeline architecture to optimize power consumption and chip area at the target resolution and sampling rate. Area-efficient high-speed high-resolution gate-bootstrapping circuits are implemented at the sampling switches of the input SHA to maintain signal linearity over the Nyquist rate even at a 1.0V supply operation. The cascode compensation technique on a low-impedance path implemented in the two-stage amplifiers of the SHA and MDAC simultaneously achieves the required operation speed and phase margin with more reduced power consumption than the Miller compensation technique. Low-glitch dynamic latches in sub-ranging flash ADCs reduce kickback-noise referred to the differential input stage of the comparator by isolating the input stage from output nodes to improve system accuracy. The proposed low-noise current and voltage references based on triple negative T.C. circuits are employed on chip with optional off-chip reference voltages. The prototype ADC in a 0.13um 1P8M CMOS technology demonstrates the measured DNL and INL within 0.70LSB and 1.79LSB, respectively. The ADC shows a maximum SNDR of 64.5dB and a maximum SFDR of 78.0dB at 100MS/s, respectively. The ABC with an active die area of $1.22mm^2$ consumes 42.0mW at 100MS/s and a 1.2V supply, corresponding to a FOM of 0.31pJ/conv-step.

• Journal of the Korean Geophysical Society
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• v.7 no.3
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• pp.193-206
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• 2004

Geophysical data including chirp (3 7 kHz) subbottom profile and detailed bathymetry were obtained over three seamounts in the Ogasawara Fracture Zone (OFZ) of the western Pacific, as a part of manganese crust survey onboard R/V Onnuri in 2003. The OFZ is a 150-km-wide, 600-km-long rift zone, which separates the East Mariana and Pigafetta Basin. The OFZ is unique in that it includes many seamounts (e.g., Magellan Seamounts andseamounts on the Dutton Ridge). The sub-seafloor acoustic echoes obtained near the OFZ were classified into following types on the basis of their characteristics: types I-1(pelagic sediment with parallel or subparallel reflectors), I-2 (pelagic sediment with no internal reflectors), and III-1 (reef build-up complex) on summit; types II-1 and III-2 (basement outcrop) on flank rift zone and upper slope, respectively; type III-3 (slump) on the lower slope and embayment between the flank rift zones; types II-2 (debrite) on the base of slope and basin floor; and types II-3 (turbidite or pelagic sediment) and II-4 (turbidite) on the basin floor. The mass-wasting that produced the complex of type II-2 debrite and III-3 slump on the lower slope and basin may have been caused by (1) strong tensional stress in the OFZ which may cause the numerous fissures or basement faults and (2) complex of the faults on the summit and steep upper slope. The variations in the echo type of pelagic sediment in the summit of seamounts may be related with the changes in the depositional and/or erosional environments. Type I-2 pelagic sediment, which is characterized by a thin and intermittent coverage, was probably deposited at a sheltered area when the current was strong, whereas type I-1 pelagic deposit occurred during a stage of progressive sedimentation.

• Science of Emotion and Sensibility
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• v.13 no.4
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• pp.703-710
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• 2010

In this study, a tactile stimulator was developed to resolve some problems from the previous version of the system such as system configuration, inappropriate stimulation control and additional problems. The developed tactile stimulator consists of control unit, drive unit and vibrator unit. The control unit was controlled by E-Prime software to generate appropriate vibration pulses. The drive unit supplies enough energy to the vibrator to generate effective stimulation pulses. The vibrator unit consists of small coin type vibrator and velcro, and was made to be attached at the hand easily. The developed tactile stimulator was designed by small-size, light-weight, low-power, simple-fabrication, max 35 channels and little delay time from instruction signal of E-Prime software to vibrator. The duration and magnitude of stimulation was controlled by 10 grades and the problems concerning stimulation control were compensated by wideband frequency ranges. Additionally, the electrical safety was ensured by low voltage operation. Vibrator was made to be attached on finger as well as on any part of the subject. Since this tactile stimulator is developed based on E-Prime software which is widely used in cognitive science, it is believed that this stimulator be suitable for the wide application of cognitive science study.