• Journal of Korean Medicine for Obesity Research
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• v.21 no.2
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• pp.95-104
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• 2021

Objectives: The purpose of this study is to analyze the adverse events and safety of Mahuang used as anti-obesity treatment in Korean medicine. Methods: PubMed, EMBASE, Cochrane, KoreaMed, Oriental Medicine Advanced Searching Integrated System (OASIS) and SCIENCE-ON were used as searching for randomized controlled trials investigating the safety of Mahuang for treating obesity from January, 2000 to July, 2021. Results: Total 6 studies were included for analyzing. In most studies, heart rate was higher in experimental group than in placebo group with statistically significant difference. Both systolic and diastolic blood pressure had no significant differences between both groups, but systolic blood pressure got lower in experimental group. Most adverse events reported in experimental group were dry mouth, constipation, diarrhea, palpitation and insomnia, but serious adverse events were not reported. Conclusions: This study provides the evidence about the safety of Mahuang for treating obesity. However, increase of heart rate and minor adverse events could be occurred. Further study is needed to confirm the safety of Mahuang.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.3
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• pp.27-41
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• 2023

Objectives : The purpose of this study is to analyze the trends of Korean medicine treatment on postherpetic neuralgia. Methods : Domestic databases(OASIS, KISS, RISS, KISTI, NDSL, KMbase) were used to search case studies related to Korean medical treatment of postherpetic neuralgia. Total 9 studies were selected. Results : A total 15 prescriptions were used 22 times in 14 cases. Among them, Sipjeondaebo-tang(十全大補湯) was the most frequently prescribed. Total 91 herbs were used and they were classified as tonifying and replenishing medicine(補益藥), exterior-releasing medicine(解表藥) and blood-activating and stasis-dispelling medicine(活血祛瘀藥) in the order of mostly used. In 8 studies, in addition to herbal medicine treatment, other Korean medicine treatments such as acupuncture, pharmacopuncture, moxibusiton, cupping therapy and external agents were performed at the same time. Most frequently used acupoints were 足竅陰(GB44) and 商陽(LI1). Conclusions : This is the first study to analyze the trends of Korean medicine treatment for postherpetic neuralgia. Although there are some limitations, this study is thought to be helpful in the domestic treatment of postherpetic neuralgia in the future.

• The Journal of Internal Korean Medicine
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• v.45 no.4
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• pp.744-759
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• 2024

Objectives: This study reviewed randomized controlled trials (RCTs) investigating the effects of Neiguan (PC6) stimulation on blood pressure and suggests a better research process. Methods: We searched for RCTs for effects of Neiguan (PC6) stimulations on blood pressure published until July 2024 using six databases (PubMed, Oriental Medicine Advanced Searching Integrated System (OASIS), Korea Citation Index (KCI), Research Information Service System (RISS), Korean Studies Information Service System (KISS), and Science ON). In total, eight RCTs that met all the inclusion criteria were selected. Results: All the selected studies showed significant effects of Neiguan (PC6) stimulation on blood pressure. In most studies, Neiguan (PC6) stimulation was effective in stabilizing blood pressure and improving various indicators related to blood pressure. Conclusion: Neiguan (PC6) stimulation is an effective treatment for stabilizing blood pressure. However, the selected RCTs were short-term studies and had small number of subjects; so, long-term and large-scale studies are needed.

• Journal of The Korean Association For Science Education
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• v.42 no.6
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• pp.579-595
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• 2022

This study is a qualitative case study of secondary science teachers who are doing educational activities in YouTube. In particular, this study attempts to interpret this case based on Foucault's concept of 'Heterotopia', which means a space that allows for private freedom or deviance by reflecting various utopias without the norms and constraints from every day or real space. Five secondary science teachers who voluntarily opened a personal channel on the YouTube platform and actively uploaded their own videos related to science education participated in the study. In order to understand the experiences of five secondary science teachers, data were individually collected through semi-structured in-depth interviews, and the collected data were analyzed using qualitative case study method. For valid interpretation of the study, we also referred to the video contents, teacher training materials, and teaching and learning materials produced by the participants. As a result of the study, seven themes were revealed: 'Desire for one's own unique educational activities,' 'Youtube as an extended classroom space,' 'Expanded network of relationships beyond the classroom barrier,' 'Satisfaction of desire for recognition and experience of identity as a YouTuber,' 'Tension between the educational space and the YouTube,' 'Space to be reborn as a craftsman,' and 'Finding one's own direction as a Teacher-YouTuber.' Given those findings, we found that the identity and desire of secondary science teachers, which were limited in the existing secondary schools and classrooms, was expanded in a new space called YouTube. In addition, we suggested that YouTube could be a space where science teachers can realize their own ideals and feel the joy. And simple regulating teacher's behavior in Youtube space only based on norms and standards shared in traditional educational space would rather hinder their healthy construction of identity and growth.

• Communications of Mathematical Education
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• v.37 no.3
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• pp.369-392
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• 2023

Equity in mathematics education focuses on the relationship between social inequality caused by factors including culture and race. Equity in mathematics education has recently been recognized as one of the important issues of mathematics education and may provide grounds for setting the new direction of mathematics education for the future society. However, research on mathematics education equity in South Korea is still insufficient. The purpose of the paper is to provide implications for mathematics education research by reviewing the the literature regarding mathematics education equity. Focusing on 195 previous studies, I analyzed the significance of discussions on mathematics education equity in mathematics education, the concept of mathematics education equity, and research questions. In addition, I divided the previous studies into five categories based on their research questions: mathematics teachers, mathematics curriculum, mathematics classrooms, mathematics assessment, and socio-cultural environments surrounding mathematics classrooms. The analysis of the study are expected to provide implications in terms of new research questions and methods to domestic mathematics education researchers.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.94-101
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• 2016

Objectives : Anemia is a common problem in the management of elderly patients. Recent studies reported that anemia was associated with cognitive impairment and Alzheimer's disease. This study was aimed to analyze the differences of hemoglobin levels in Korean patients with Alzheimer's disease(AD) dementia, mild cognitive impairment(MCI), and healthy controls. Furthermore, the study also examined if any association between hemoglobin levels and cognitive functions existed. Methods : A total of 116 Korean elderly adults were participated in this study(mean age 74.67 years ; 60.3% female). The Korean version of the Mini-Mental State Examination(MMSE-K), Clinical Dementia Rating(CDR) and Global Deterioration Scale(GDS) were applied to all subjects. Hematological and related blood chemistry values were investigated. Results : We found that patients with AD dementia had significantly lower hemoglobin and hematocrit levels than MCI subjects and healthy control group. The hemoglobin levels showed a positive correlation with MMSE-K and negative correlation with CDR, GDS. Conclusions : Among Korean elderly, low hemoglobin level is associated with a cognitive impairment. This study indicates that AD is associated with anemia, and low hemoglobin levels may contribute to potentially useful clinical markers of AD. The risk factor for dementia needs to be confirmed by prospective longitudinal studies in a larger group of patients.

• Communications of Mathematical Education
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• v.14
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• pp.27-41
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• 2001

인지적으로 안내된 교수(CGI)는 학생들의 수학적 사고(특히, 비형식적 지식)의 발달; 그러한 발달에 영향을 미치는 교수; 교수 실제에 영향을 미치는 교사의 지식과 신념들; 교사의 지식, 신념들, 실제들이 학생들의 수학적 사고에 대한 이해에 의해 영향을 받는다는 점에 초점을 둔 통합된 연구 프로그램이다. 본 논문에서는 아동의 비형식적인 지식을 중시하는 최근의 연구들을 고찰하고, CGI를 위한 수업을 어떻게 조직하며, 그러한 교수법이 수업을 어떻게 진행할 것인지에 대한 구체적이고 명확한 지침을 제공하지 않으므로 CGI를 적용하는 교실들의 유사점을 살펴본다. 그리고, 마지막으로 최근의 연구들을 고찰함으로써 CGI의 효과를 알아본다.

• The Science & Technology
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• v.31 no.1 s.344
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• pp.82-83
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• 1998

87년 서울대에서 박사학위를 받은 후 그 이듬해 미국 NIH에서 방사성동위원소 표지 단일클론항체의 영상이용에 관한 연구를 하고 귀국한 서울대의대 정준기교수는 우리나라 핵의학의 정착과 발전을 위해 땀을 흘리고 있다. 서울대 암연구센터 제2연구부장을 맡고 있는 정교수는 자체 개발한 항체를 이용한 새로운 골수영상진단법으로 암의 전이 등을 진단분석하는 연구로 큰 성과를 거두고 있다. 정교수는 내년부터 의대 3학년과정에 개설된 핵의학과목을 강의하게 되어 그 준비에 바쁘다.

• Journal of Life Science
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• v.29 no.3
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• pp.369-375
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• 2019

Microtubules form through the polymerization of ${\alpha}-$ and ${\beta}-tubulin$, and tubulin transport plays an important role in defining the rate of microtubule growth inside cellular appendages, such as the cilia and flagella. Heterotrimeric kinesin 2 is a molecular motor member of the kinesin superfamily (KIF) that moves along the microtubules to transport multiple cargoes. It consists of two motor subunits (KIF3A and KIF3B) and a kinesin-associated protein 3 (KAP3), forming a heterotrimeric complex. Heterotrimeric kinesin 2 interacts with many different binding proteins through the cargo-binding domains of the KIF3s, but these binding proteins have not yet been specified. To identify these proteins for KIF3A, we performed yeast two-hybrid (Y2H) screening and found a specific interaction with ${\beta}2-tubulin$ (Tubb2), a microtubule component. Tubb2 was found to bind to the cargo-binding domain of KIF3A but did not interact with KIF3B, KIF5B, or kinesin light chain 1 in the Y2H assay. The carboxyl-terminal region of Tubb2 is essential for interaction with KIF3A. Other Tubb isoforms, including Tubb1, Tubb3, Tubb4, and Tubb5, also interacted with KIF3A in the Y2H screening. However, ${\alpha}1-tubulin$ (Tuba1) did not interact with KIF3A. In addition, an antibody to KIF3A specifically co-immunoprecipitated the KIF3B and KAP3 associated with Tubb2 from mouse brain extracts. In combination, these results suggest that a heterotrimeric kinesin 2 motor protein is capable of binding to tubulin and may transport it in cells.

• Laboratory Medicine Online
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• v.2 no.1
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• pp.10-14
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• 2012

Background: Measurement of HbA_1c levels is widely used to diagnose diabetes mellitus and to evaluate and monitor plasma-glucose concentrations over 6-8 weeks. In this study, we evaluated the diagnostic performance of the newly developed latex immunoturbidimetric method by using Autolab HbA_1c. Methods: We analyzed and compared the diagnostic performance of Autolab HbA_1c with that of Toshiba 200FR between April 2009 and July 2009. According to guidelines (EP5-A2, EP6-P, EP9-A2) of the clinical and laboratory standards institute (CLSI), we compared linearity, precision and correlation of Autolab HbA_1c with those of G7 (Tosoh Corp., Kyoto, Japan) by using high-performance liquid chromatography (HPLC) method. Results: Data obtained using Autolab HbA_1c showed good linearity in mixtures of samples with low (3.1%) and high (15.1%) levels of HbA_1c (r²=0.9997). In the analysis of within-run precision of the samples with HbA_1c levels of 5.1% and 12.1%, the SDs were 0.04 and 0.06 and covariances of these samples were 0.8% and 0.5%, respectively. In the Deming regression model, the regression equation was as follows: Autolab HbA_1c=1.0859×Tosoh HPLC-0.6957. Conclusions: In this study, Autolab HbA_1c method showed better performance characteristics than Tosoh G7 did. In reference review, there was no interference of variant hemoglobin. The data acquisition time of Autolab HbA_1c was lower than that of Tosoh G7. The advantages of Autolab HbA_1c are that it can be used as an autoanlyzer in routine chemical analysis, it does not require pre-analytical treatment, and the samples are automatically treated with distilled water for hemolysis.