The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Review of Randomized Controlled Clinical Trials on the Effects of PC6 Stimulation on Blood Pressure - Focusing on Domestic Studies and PubMed

내관혈(PC6) 자극이 혈압에 미치는 영향에 관한 무작위 대조 임상시험 연구 검토 - 국내 연구 및 PubMed를 중심으로

  • Chae-eun Kim (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Haany University Korean medicine hospital) ;
  • Kyung-min Baek (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Haany University Korean medicine hospital)
  • 김채은 (대구한의대 한방병원 심계내과학교실) ;
  • 백경민 (대구한의대 한방병원 심계내과학교실)
  • Received : 2024.08.31
  • Accepted : 2024.10.08
  • Published : 2024.09.30
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Abstract

Objectives: This study reviewed randomized controlled trials (RCTs) investigating the effects of Neiguan (PC6) stimulation on blood pressure and suggests a better research process. Methods: We searched for RCTs for effects of Neiguan (PC6) stimulations on blood pressure published until July 2024 using six databases (PubMed, Oriental Medicine Advanced Searching Integrated System (OASIS), Korea Citation Index (KCI), Research Information Service System (RISS), Korean Studies Information Service System (KISS), and Science ON). In total, eight RCTs that met all the inclusion criteria were selected. Results: All the selected studies showed significant effects of Neiguan (PC6) stimulation on blood pressure. In most studies, Neiguan (PC6) stimulation was effective in stabilizing blood pressure and improving various indicators related to blood pressure. Conclusion: Neiguan (PC6) stimulation is an effective treatment for stabilizing blood pressure. However, the selected RCTs were short-term studies and had small number of subjects; so, long-term and large-scale studies are needed.

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References

  1. Meridians & Acupoints Compilation Committee. Principles of Meridians & Acupoints; A Guidebook for College students. 7st rev. Daejeon: Jongryeonamu; 2015, p. 183-92, 299, 319, 325, 351.
  2. Xiao C, Qin M, Xia H, Xing Q, Wang D, Qian W. Effects of PC6 acupressure on acute and delayed nausea and vomiting induced by chemotherapy in patients with malignant neoplasm: a meta-analysis. Support Care Cancer 2023;31(9):510.
  3. Zhang Y, Zhang C, Yan M, Wang N, Liu J, Wu A. The effectiveness of PC6 acupuncture in the prevention of postoperative nausea and vomiting in children: A systematic review and meta-analysis. Paediatr Anaesth 2020;30(5):552-63.
  4. Bicer S, unsal A, Tasci S, Demir G, Ceyhan YS. The effect of acupressure on blood pressure level and pulse rate in individuals with essential hypertension: A randomized controlled trial. Holist Nurs Pract 2021;35(1):40-8.
  5. Bicer S, Tasci S. The effect of body acupressure on blood pressure and fatigue levels in individuals suffering from hypotension during hemodialysis: A randomized controlled trial. Altern Ther Health Med 2022;28(2):6-16.
  6. Liu X, Gao Z, Jiang Y, Tuo X, He S, Xu F, et al. Comparison of low-frequency or high-frequency electrical acupoint stimulation on hypotension after spinal anesthesia in parturients: A prospective randomized controlled clinical trial. J Integr Complement Med 2024;30(8):770-5.
  7. Chen Y, Gong Y, Huai X, Gu X, Su D, Yu W, et al. Effects of transcutaneous electrical acupuncture point stimulation on peripheral capillary oxygen saturation in elderly patients undergoing colonoscopy with sedation: a prospective randomized controlled trial. Acupunct Med 2021;39(4):292-8.
  8. Ding Y, Su SY, Lin YL, Wei YT, Cai YC, Shi JD, et al. Effect of electroacupuncture at Neiguan(PC6) on pulmonary function during one-lung ventilation in patients with lobectomy. Zhongguo Zhen Jiu 2021;41(6):598-602.
  9. Shin HH, Choi W, Yoo J, Kwon KM, Kim MS, Kim SJ, et al. Effect of Magnetic Acupuncture Attachment on PC6 (Neiguan) on Autonomic Nervous System. Korean J Fam Pract 2018;8(4):499-503.
  10. Li C, Wang Y, Li B, Su S. Effects of acupuncture at neiguan in neural activity of related brain regions: A resting-state fMRI study in anxiety. Neuropsychiatric Disease and Treatment 2022;18:1375-84.
  11. Department of Internal Medicine, National University of Oriental Medicine. Asakura Internal medicine 11th ed. II. Seoul: Woori medical books; 2020, p. 342-79.
  12. The Korean Society of Hypertension. 2022 Guideline for Hypertension. Seoul: 대한고혈압학회 진료지침제정위원회; 2022, p. 11-8.
  13. Butt DA, Harvey PJ. Benefits and risks of antihypertensive medications in the elderly (Review). J Intern Med 2015;278(6):599-626.
  14. Olowofela AO, Isah AO. A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria. Ann Afr Med 2017 Jul-Sep;16(3):114-9.
  15. Kang JY, Kang KW, Jeong MJ, Kim HJ, Jang IS. A Survey of Hypertension Treatment in Korean Medicine. The Journal of Internal Korean Medicine 2016;37(6):1022-9.
  16. Bang SK, Chang SC, Kin HY. A short review concerning the effects of TENS or electro-acupuncture treatment at Nei guan (PC-6) on blood pressure. The Journal of East-West Medicine 2014 June;39(20):1-9.
  17. Bang SK, Ryu Y, Chang S, Im CK, Bae JH, Gwak YS, et al. Attenuation of hypertension by C-fiber stimulation of the human median nerve and the concept-based novel device. Sci Rep 2018 Oct 8;8(1):14967.
  18. Kim SY, Won JH, Lee I. A Review of Recent Acupuncture Treatment for Hypertension - PubMed and Domestic Studies. The Journal of Internal Korean Medicine 2020;41(1):29-43.
  19. Jung SY, Hwang YC, Cho SY, Lee HG, Kwon SW, Jung WS, et al. Effect of Acupuncture on Patients with Hypertension : A Review of Clinical Studies in the Republic of Korea. The Journal of the Society of Stroke on Korean Medicine 2022;23(1):25-40.
  20. Li P, Wang H, Gao J. Clinical observation on 31 cases of low pulse pressure syndrome treated with acupuncture at neiguan (PC 6). Journal of traditional Chinese medicine 2003;44(4):262-3.
  21. Chang S, Chao W, Chiang M, et al. Effects of acupuncture at neiguan (PC 6) of the pericardial meridian on blood pressure and heart rate variability. Chin J Physiol 2008;51(3):167-77.
  22. Ng MCS, Jones AYM, Cheng LC. The role of acu-TENS in hemodynamic recovery after open-heart surgery. Evidence-based Complementary and Alternative Medicine : eCAM 2011;2011:301974.
  23. Sun J, Li X, Yang C, et al. Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans. Acupunct Med 2015;33(5):381-7.
  24. Pritha L, Valliammal S, Goothy SK, Vijayaraghavan R. Effectiveness of acupressure on bio-physiological parameters in mediosternotomy patients. International journal of research in pharmaceutical sciences IJRPS 2019;10(3):2082-9.
  25. The Korean Geriatrics Society. Textbook of geriatric medicine. 4th rev. Seoul: Panmuneducation; 2023, p. 223-37.
  26. Chang YC, Chen CM, Lay IS, Lee YC, Tu CH. The Dosage Effect of Laser Acupuncture at PC6 (Neiguan) on Heart Rate Variability: A Pilot Study. Life (Basel) 2022;12(12):1951.
  27. Jones AY, Kwan YL, Leung NT, Yu RP, Wu CM, Warburton DE. Electrical stimulation of acupuncture points and blood pressure responses to postural changes: a pilot study. Am J Crit Care. 2011;20(3):e67-e74.
  28. Ma F, Zhang Y, Chen H, Sun L, Wang M. Impacts on oxidative stress in the patients with cardiac valve replacement treated with electroacupuncture at Neiguan (PC 6). Zhongguo Zhen Jiu 2015 Jul;35(7):707-10.
  29. Chang S, Kwon OS, Bang SK, Kim DH, Baek MW, Ryu Y, et al. Peripheral Sensory Nerve Tissue but Not Connective Tissue Is Involved in the Action of Acupuncture. Front Neurosci 2019 Feb 20;13:110.
  30. Shin JH, Fan Y, Kim DH, Jang HB, Chang S, Ryu Y, et al. Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats. J Physiol Sci 2020 Feb 6;70(1):14.
  31. Kim YH, Jung SD, Lee SK, Kim HJ, Byun CW, Lee JI, et al. R&D Trends in Bioelectronic Medicines. Electronics and Telecommunications Trends 2020;35(3):98-110.