• Korean Journal of Optics and Photonics
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• v.26 no.1
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• pp.1-8
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• 2015

The most common cause of a heart attack is known as coronary artery disease, which narrows the arteries and reduces the blood flow to the heart. To treat coronary artery stenosis, percutaneous coronary intervention (PCI) (a nonsurgical procedure to install a stent, which holds the artery wall open) is performed. Intracoronary optical coherence tomography (OCT) is a catheter-based, invasive optical imaging system. To determine whether PCI is appropriate, and to perform stent evaluation in a catheterization laboratory, OCT examinations are carried out. This review details the fundamental principles and technological status of intracoronary OCT imaging, and discusses the ongoing clinical applications to determine the benefits of OCT-guided PCI.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.330-335
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• 2017

This study applied SONAR(Sound Navigation And Ranging) to the inspection and evaluation of underwater structures. Anactual river bridge was chosen for inspection and evaluation. SONAR and an optical camera were operated together to analyze the underwater image of the bridge. SONAR images were obtained by various methods to remove the environmental variables from the field experiment, and it was confirmed that the reliability of detecting damaged areas on piers was decreased when using SONAR alone. The SONAR equipment and the optical camera can be used simultaneously to overcome the limitations of SONAR in inspecting underwater structures.These results can be used as basic data for the development of similar technologies for underwater structure inspection.

• Korean Journal of Optics and Photonics
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• v.35 no.4
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• pp.135-142
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• 2024

Biomedical imaging technologies refer to imaging techniques used in biological research and medical technology that are essential for exploring biological processes, structures, and conditions. They also play a crucial role in the early diagnosis of diseases and the development of treatments. Optical imaging technologies, in particular, are the most widely used and actively researched in biological studies. The major obstacles to technological advancement are the limitations in resolution and light penetration depth. Recently, many technologies have been studied to overcome these limitations using metamaterials. These are materials that can freely manipulate the properties of light through the regular arrangement of nanostructures and have established themselves as innovative tools in the imaging field. This article aims to provide a detailed introduction to the working principles and key applications of these technologies.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.04a
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• pp.506-507
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• 2017

최근 의료영상진단기기 개발 동향은 ICT 기술과 접목하는 융합진단 영상기기 개발연구로 활발하게 진행되고 있다. 특히, 수술중 CT의 개발은 임상적 미수요 충족을 위한 최첨단 기술개발로 위급한 환자를 의료영상 촬영을 위한 지정장소로 이동해야하는 문제점을 해결하여 현장 어느 곳에서 촬영할 수 있고, 환자의 다양한 의료영상을 융합하여 환자의 병변에 대한 명확한 위치와 형태 그리고 상태를 파악할 수 있도록 하며 수술을 위한 네비게이션 기능을 포함한다. 본 논문에서는 수술중 CT에 대한 설계한 사항에 대해 기술하고자 한다. 제안한 시스템의 개발은 다양한 임상현장에서 신속하게 진단과 수술을 지원할 수 있을 것으로 기대하고 있다.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.125-133
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• 2019

A microscope is the fundamental research and diagnostic apparatus for clinical investigation of signaling transduction, morphological changes and physiological tracking of cells and intact tissues from patients in the biomedical laboratory science. Proper use, care and maintenance of microscope with comprehensive understanding in mechanism are fully requested for reliable image data and accurate interpretation for diagnosis in the clinical laboratory. The standard operating procedure (SOP) for light microscopes includes performance procedure, brief information of all mechanical parts of microscopes with systematic troubleshooting mechanism depending on the laboratory capacity. Maintenance program encompasses cleaning objective, ocular lenses and inner optics; replacement and calibration of light source; XY sample stage management; point spread function (PSF) measurement for confocal laser scanning microscope (CLSM); quality control (QC) program in fluorescent microscopy; and systematic troubleshooting. Laser safety is one of the concern for medical technologists engaged in CLSM laboratory. Laser safety guideline based on the laser classification and risk level, and advisory lab wear for CLSM users are also expatiated in this overview. Since acquired image data presents a wide range of information at the moment of acquisition, well-maintained microscopes with proper microscopic maintenance program are impulsive for its interpretation and diagnosis in the clinical laboratory.

• Childhood Kidney Diseases
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• v.17 no.2
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• pp.49-56
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• 2013

Purpose: IgA nephropathy (IgAN) is one of the major causes of end-stage renal disease. Mass school urine screening (SUS) has been performed to enable early detection of chronic renal diseases, including IgAN. We wanted to evaluate the patients with IgAN, including those diagnosed through SUS. Methods: Between 1998 and 2010, 64 children were diagnosed with IgAN based on renal biopsy results obtained at the Pediatric Nephrology Department, ${\bigcirc\bigcirc}$ University Hospital. We divided these patients into the SUS group (37 cases), diagnosed through SUS, and the symptomatic (Sx) group (27 cases), diagnosed clinically. The medical records of both groups were analyzed retrospectively. Results: The mean age of the SUS and Sx groups was $10.8{\pm}2.7$ and $9.5{\pm}3.4$ years (P >0.05), respectively. Both groups had a higher proportion of male patients. The time from the notification of an abnormal urinary finding to a hospital visit or renal biopsy was shorter in the Sx group than in the SUS group. Regarding clinical manifestations, there were fewer cases with gross hematuria (P <0.001) and edema (P =0.008) in the SUS group, but there were no differences in terms of the therapeutic regimen and treatment duration. Regarding laboratory parameters, the Sx group had a higher white blood cell count (P =0.007) and lower hemoglobin (P =0.007) and albumin (P =0.000) levels. There were no differences in the renal biopsy findings in both groups, based on the history of gross hematuria or the severity of proteinuria. However, in all 64 patients with IgAN, the light microscopy findings (Hass classification) were related to a history of gross hematuria or the severity of proteinuria. Conclusion: There were no significant clinical and histological differences between the groups, as both had early stage IgAN. Although SUS facilitates the early detection of IgAN, long-term, large-scale prospective controlled studies are needed to assess the benefits of early diagnosis and treatment in chronic renal disease progression.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.549-549
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• 2013

고전압 펄스 플라즈마를 액체 속에서 발생시켜 수소 스펙트럼의 광학적 특성을 연구하였다. 고전압 펄스 발생 장치인 막스 제네레이터는 용량이 $0.5{\mu}F$인 축전기 5개로 이루어져 있다. 각각의 축전기는 전원 장치를 이용하여 저항을 통해 병렬로 충전되며, 방전 시에는 불꽃 방전 스위치에 의해 동시에 직렬로 연결되어 고전압을 발생시킨다. 따라서, 출력 전압과 전류는 40kV, 3 kA이며 총 에너지는 약 125 J이다. 직육면체 모양의 폴리카보네이트 용기 내부의 양쪽면에는 탐침 모양의 전극이 구성되어 있으며 전극 사이에서 고전압을 가진 플라즈마가 형성된다. 실험에서 액체로는 증류수를 사용하였다. 액체 방전 시 발생하는 수소 스펙트럼을 관측하기 위해 초점거리 30 cm의 monochromator를 이용하였고, 수소 알파선의 656.3 nm와 수소 베타선의 434.1 nm를 관측하였다. 전자 밀도의 측정법으로는 Stark broadening법을 이용하여 측정하였으며, 전자 온도는 Stark profile의 상대적인 전자 밀도의 비를 이용하여 계산하였다. 전자밀도는 실험조건에서 약 $3{\times}10^{15}cm^{-3}$, 전자온도는 약 2.5 eV가 측정되었다.

• Korean Journal of Optics and Photonics
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• v.3 no.1
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• pp.67-72
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• 1992

Since the inception of the idea to develop an X-ray laser in 1960's, a rapid progress to demonstrate soft X-ray lasers in the wavelength region below 300$\AA$ has been made during the last ten years. Among many prospective proposals, the recombination scheme and the collisional exitation scheme have been most successful in achieving a significant gain. An appreciable single-pass amplification was achieved at 182 $\AA$ from CVI ions using the recombination scheme and at 206 and 290$\AA$ from the Se XXV ions using the collisional excitation scheme. The current research on X-ray lasers emphasizes the enhancement of amplification upto saturation and the extension of operating wavelength to shorter wavelengths, especially to the water window region between 23 and 44 $\AA$. X-ray lasers are expected to open many application fields, such as X-ray laser microscopy, X-ray holography, X-ray lithography, and more, in the near future.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.05a
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• pp.627-629
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• 2023

생체 신호를 분석하여 사용자의 건강과 정신 상태를 예측하고, 관련 질병에 관해 예방하는 연구가 늘어나고 있다. 생체 신호 중 심박은 사람의 육체, 정신적인 상태를 반영하는 대표적인 신호이지만 기존의 접촉 패드를 통한 ECG나 광학 센서를 통한 PPG로 심박을 예측할 때는 구속적인 환경이 필요하여 일상적인 상황 속에 적용하기 어려웠다. 이러한 단점을 해결하고자 본 논문은 UBFC-RPPG 데이터셋의 동영상 프레임을 RGB 채널마다 다른 가중치를 적용하는 전처리를 하여 학습 데이터의 크기를 줄이면서 정확도를 높이고, 3D-CNN을 활용한 딥러닝으로 순간적인 영상에서도 PPG 신호를 예측할 수 있도록 1초 전처리 영상을 학습한 후, 신호를 예측하는 것을 목표로 한다. 이렇게 비접촉식으로 취득된 신호는 더 다양한 환경에서의 감정분류, 우울증 진단, 질병 감지 등 다양한 분야에 활용될 수 있다.

• Progress in Medical Physics
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• v.10 no.1
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• pp.9-15
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• 1999

The oxygen saturation of blood can be measured by the difference absorption in optical spectra of Hb and Hb0$_2$, as the well known previous study. In this study we developed the non-invasive oxygen measurement device for diagnosis of peripheral vascular disease in lower extremity using infrared and red LED which produce a peak spectral emission at a wavelength of 660 nm, and 940 nm. To evaluate the clinical application of the oxygen measurement device, we performed lower extremity study to measure the oxygen changes in response to physiological changes within biological tissue. The results showed that oxygen saturation of blood in biological tissue can be monitored from the separation arrangement light source and detector.