• Title/Summary/Keyword: 고환암

Search Result 35, Processing Time 0.027 seconds

Intracardiac Metastasis of Testicular Embryonal Carcinoma That Presented with a Right Ventricular Mass (우심실 종괴로 나타난 고환 태생암의 심장 전이)

  • Shim, Man-Shik;Kim, Wook-Sung;Sung, Ki-Ick;Lee, Young-Tak;Park, Pyo-Won;Lim, Ho-Yeong
    • Journal of Chest Surgery
    • /
    • v.43 no.1
    • /
    • pp.81-85
    • /
    • 2010
  • Metastases to the heart are rarely diagnosed before the patient dies. A 26-year-old man was admitted with multiple metastasis of a testicular embryonal carcinoma and he was found to have intracardiac metastasis. Echocardiography showed that he had a mass rising from the interventricular septum and it was floating through the right ventricular outflow tract. The histology of the mass we removed from the right ventricle was consistent with testicular embryonal carcinoma. The patient made a smooth recovery after surgical intervention and chemotherapy. We believe this is the first reported case of testicular embryonal carcinoma that metastasized to the heart and that was successfully removed via surgery in Korea.

반응성을 이용한 항암성 2-alkoxy-1-arylsufonylimidazoline 유도체의 설계 및 합성

  • 정상헌;송재신
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1992.05a
    • /
    • pp.16-16
    • /
    • 1992
  • 1940년대에 처음으로 암의 화학요법이 시도된 이래 많은 항암제들이 도입되어 사용되고 있다. 현재 항암제를 사용하여 비교적 치료율이 높은 암은 leukemia나 lymphoma와 같은 혈액암에 국한되어 있다. 고형암에 대하여는 고환암과 같은 극히 일부가 항암제에 의해 비교적 잘 치료되나 대부분은 여전히 치료가 되지 않고 있는 상태에 있다. 고형암의 발생빈도는 전체 암의 90%를 차지하고 있는 상태로 사망율이 매우 높아, 현대의 40대 이상 사망원인의 1위를 나타내고 있어 그 치료제의 개발이 매우 시급히 요구되고 있다. 이에 따라 고형암의 치료를 목적으로 많은 화합물들이 검토되어 왔다. 이중 최근 매우 큰 가능성을 보여주고 있는 diarysulfonylurea 유도체가 발견되어 임상시험에 도입됨으로서 이 화합물들에 대한 관심이 고조되고 있다. 이와 관련하여 고형암의 치료제를 개발할 목적으로 diarysulfonylurea의 특성과 강력한 항암효과를 발현하는 alkylating agent의 특성을 갖을 것으로 예상되는 새로운 2-alkoxy-1-arylsufonylimidazoline 유도체를 설계하고, 이들 유도체의 합성법을 개발하였다. 이들 유도체들은 일차적으로 생체내에서 DNA 또는 효소등에 alkylation을 일으킨후 diarysulfonylurea로 변하여 작용함으로서 보다 큰 항암효과를 발현할 것으로 기대된다.

  • PDF

Radiologic Manifestations of Pulmonary Nuclear Protein in Testis Midline Carcinoma: A Case Report (폐에 발생한 고환 핵단백질 정중선 암의 영상의학적 소견: 증례 보고)

  • Jung A Kim;Mi-jin Kang;Jung Yeon Kim;Ji-Young Kim;Soung Hee Kim;Myeong Ja Jeong;Ji Hae Lee
    • Journal of the Korean Society of Radiology
    • /
    • v.84 no.2
    • /
    • pp.498-503
    • /
    • 2023
  • Nuclear portein in testis (NUT) midline carcinoma is a very rare and low-differentiating malignant epithelial tumor that differentiates very aggressively and has poor prognosis. NUT midline carcinoma occurring in the lungs in particular can be confused with other cancers because few cases have been reported in Korea to date and can show various histological forms. Reports of radiology findings are very rare worldwide. Here we report the imaging findings of pulmonary NUT midline carcinoma in a 25-year-old female along with pathological findings.

Pulmonary Metastasectomy from Testicular Germ Cell Tumor - A case report- (고환에서 발생한 종자세포암의 폐전이 절제 - 1예 보고 -)

  • Cho, Jun-Woo;Park, Ki-Sung
    • Journal of Chest Surgery
    • /
    • v.43 no.6
    • /
    • pp.833-837
    • /
    • 2010
  • This is a report of successful management for pulmonary metastasis following chemotherapy in patient with testicular germ cell tumor. Postchemotherapy PET-CT was not uptake FDG in metastatic lesion. Pulmonary metastasectomy was performed, which is important to manage a residual postchemotherapy lung mass in testicular germ cell tumor for histological correlation with primary testicular lesion to select the patients who require subsequent chemotherapy. Our patient was well 6 months after operation, not carried out chemotherapy because of no viable tumor.

Imaging of Scrotal Tumors (음낭 종양의 영상 소견)

  • Seungsoo Lee;Young Taik Oh;Dae Chul Jung
    • Journal of the Korean Society of Radiology
    • /
    • v.82 no.5
    • /
    • pp.1053-1065
    • /
    • 2021
  • Ultrasonography is effective for imaging superficial organs, such as the scrotum. Using a highfrequency transducer, ultrasonography can identify the location and characteristics of scrotal lesions with high accuracy. The primary role of ultrasound (US) in the evaluation of a scrotal mass is to determine if it is intratesticular or extratesticular. Additional clinical information and other imaging options may be needed to diagnose benign tumors and pseudo-tumors. MRI is an effective problem-solving tool in cases with nondiagnostic US findings. CT is helpful for staging testicular cancer and localizing undescended testis. This review covers the imaging features of testicular and extratesticular tumors.

Clinical Application of $^{18}F-FDG$ PET in Testicular Cancer (고환암에서 $^{18}F-FDG$ PET의 임상 이용)

  • Yoon, Joon-Kee
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.42 no.sup1
    • /
    • pp.121-125
    • /
    • 2008
  • $^{18}F-FDG$ PET has a higher diagnostic accuracy than a in initial staging of testicular cancer. In seminoma, it can discriminate residual tumor from necrosis/fibrosis or mature teratoma. $^{18}F-FDG$ PET is also useful for the response evaluation of chemotherapy. However, there's no clinical evidence for the use of $^{18}F-FDG$ PET in the diagnosis and differential diagnosis of testicular cancer.

Histopathological Studies on Tumors of the Testis in the Taegu Area (대구지역 고환 종양에 관한 병리 조직학적 연구)

  • Hong, Suk-Jae;Lee, Tae-Sook;Choi, Won-Hee
    • Journal of Yeungnam Medical Science
    • /
    • v.4 no.2
    • /
    • pp.149-154
    • /
    • 1987
  • For evaluation on the histopathologic studies and age distribution of the testicular tumors in the Taegu area, the inguinal orchiectomized materials were collected at the Department of Pathology, College of Medicine, Yeungnam University, and the analyzed results were as follows : 1. In total of 11 cases of orchiectomized materials, germ cell tumors are 10 cases (90.9%). In germ cell tumors according to the histologic types, seminoma was 5 cases (45.5%), and embryonal carcinoma, 3 (27.2%). 2. The highest age incidence of the group is 20th and 30th, and the next, 50th and 10th.

  • PDF

Effects of Small-Group Education for Testicular Self-Examination on Knowledge, Self-efficacy, and Performance Intention in Male College Students (고환자가검진에 대한 소그룹 교육이 남자 대학생의 지식, 자기효능감 및 수행의도에 미치는 효과)

  • Park, So-Mi;Chung, Chae-Weon;Park, Mi-Jeong
    • The Journal of Korean Academic Society of Nursing Education
    • /
    • v.16 no.2
    • /
    • pp.292-300
    • /
    • 2010
  • Purpose: This study examined the effects of Testicular Self-Examination (TSE) small-group education on knowledge, self-efficacy, and performance intention in male college students. Method: A non-equivalent pre-post test of quasi-experimental design was used. Out of 74 male college students selected by convenient sampling, 37 students were assigned to the experimental group and were given TSE small-group education. A 60-minute program consisted of lecture, demonstration, practice, discussion, and Q&A. Result: With an initial homogeneity between the two group, scores of knowledge about testicular cancer (p<.001), self-efficacy for TSE (p<.001), and performance intention of TSE (p<.01) of the experimental group were significantly higher than those of the control group after the intervention. Conclusion: Small group education for TSE was effective in improving knowledge about testicular cancer, self-efficacy for TSE, and intention to perform TSE. Thus, this education program is considered to be useful for testicular cancer prevention and reproductive health promotion in male college students.