• The Korean Journal of Nuclear Medicine
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• v.26 no.2
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• pp.371-379
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• 1992

악성종양의 진단 및 치료에 있어서 특정 종양에 대한 항체를 이용하는 연구가 활발히 진행되고 있다. 단세포군항체를 이용한 방사면역신티그라피로 암의 조기 진단 및 영상화가 가능하고 나아가 방사면역치료는 암의 선택적 치료에 도움이 될 수 있다. 위암은 우리나라에서 가장 흔한 악성종양으로 방사면역신티그라피와 방사면역치료법이 새로운 방법으로 모색되고 있다. 이러한 진단 및 치료법의 성공여부를 결정하는 중요한 인자의 하나가 종양조직내에서 종양관련 항원의 농도와 분포이다. 따라서 본 연구에서는 단세포군 항체를 이용한 방사면역학적 방법의 임상 이용을 위한 기초 연구의 일환으로 in vitro quantitative autoradiography를 이용하여 종양 관련항원인 TAG-72와 CEA의 위암조직내 농도 및 분포를 측정하였다. 33예의 위암조직에서 얻은 동결절편을 $1.3\sim83.3$ nmol/liter의 $^{125}I$ 표지 항 TAG-72 단세포군 항체 B-72.3과 항 CEA 단세포군 항체 CEA-79로 반응시킨 후 이 표본들의 자가방사법 디지탈 영상을 H & E 염색과 immunoperoxidase염색 표본과 비교하였으며, 특정 단세포군 항체의 결합에 대한 컴퓨터 분석으로 조직내 항원의 농도와 분포를 측정하였다. TAG-72는 25예(75.7%)의 조직에서 검출되었으며 그 농도는 $8.4\sim525.3$ pmol/gram이었고, CEA는 32예 (96.9%)에서 검출되었으며 그 농도는 $8.8\sim592.9$ pmol/gram 이었다. CEA의 위암 조직내 발현농도는 중앙치가 101.7 pmol/gram 으로 TAG-72의 중앙치인 27.9 pmol/gram 보다 높았다. TAG-72의 조직내 분포는 41.4%에서 병변 부위의 암세포 분포와 일치하였고, CEA의 분포는 병변 부위의 80.5%에서 암세포와 일치하는 소견을 나타내었다. TAG-72의 농도는 점액성 선종(mucinous adenocarcinoma)과 점액함유 선종(mucin containing adenocarcinoma)에서 다른 선종보다 더 높았다. CEA의 농도는 위암의 병리학적 종류에 따른 유의한 차이가 없었다. 이상의 결과로 위암조직에서 TAG-72와 CEA항원이 다양하게 발현됨을 알 수 있었고 CEA는 TAG-72 보다 더 빈번하게 균일한 분포로 발현하는 것으로 나타났다.

• Korean Journal of Ecology and Environment
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• v.33 no.3 s.91
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• pp.213-221
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• 2000

Seasonal oxygen content and deficit rates were evaluated from 17 sites of Taechung Reservoir during 1993${\sim}$1994. In 1993, river inflows peaked during the monsoon in July${\sim}$August and disrupted thermal stratification and anoxic layers in the headwaters, thereby confining the anoxia to the mid-lake and downlake reach. The volume of anoxic water with < 4 mg/l DO comprised only < 10% of the total lake volume in this period. In contrast, during monsoon 1994, 85% of total lake volume was subject to hypoxic conditions with oxygen concentrations < 30% saturation, resulting in massive fishkills (Hypomesus olidus). Relative areal oxygen deficit (RAOD) was -0.024mg O$_{2}$cm$^{-2}$d$^{-1}$ during monsoon 1993, whereas it rapidly decreased at the rate of 0.080mg O$_{2}$cm$^{-2}$d$^{-1}$ during monsoon 1994. Anoxic factor (AF) showed a same interannual pattern as the RAOD and was greater >50 d in 1994 (76.5 d) than 1993 (21.3 d). Thus, the reservoir showed a river-characteristics (6${\sim}$11 mg/l DO) in 1993 while lacustrine conditions (<4mg/l DO) dominated in 1994. Regression analysis showed that the variation of summer DO was mostly determined (R$^{2}$=0.99, p<0.0001) by inflow. These findings suggest that the primary factor regulating the oxygen content in this system during summer is an intensity of the monsoon rain.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.24 no.2
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• pp.227-234
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• 2006

Ministry of construction & transportation is operating for the soil and rock information system and is considered to accurate application of soil conversion factor that is essentially necessary for accurate calculation of earth volume. Since the balance of cutting earth in public work, the plan of spoil bank or borrow pit are directly related to construction costs, accurate calculation of earth volume and efficient scheme of haul are important. As such, this study has provided methods that can acquire information that is more rapid, applicable to job sites, and trustworthy by comparing resultant values of photogrammetry, laser scanning, or inside job site experimentations, and calculated soil conversion factor by applying photogrammetry and laser scanning methods for hard rock that has difficulty in calculating soil conversion factor. The study can provide alternatives that can resolve the problems of unbalanced earth volume that may arise in applying to plans the earth conversion factor that relies on planning books and experience without considering the characteristics of job site earth, and can establish its relevancy by calculating soil conversion factor for hard rock that has relative difficulties in doing inside or job site testing.

• Tunnel and Underground Space
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• v.30 no.4
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• pp.306-319
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• 2020

Characterizations of Excavation Damage Zone (EDZ), which is hydro-mechanical degrading the host rock, are the important issues on the geological repository for the spent nuclear fuel. In the DECOVALEX 2019 project, Task G aimed to model the fractured rock numerically, describe the hydro-mechanical behavior of EDZ, and predict the change of the hydraulic factor during the lifetime of the geological repository. Task G prepared two-dimensional fractured rock model to compare the characteristics of each simulation tools in Work Package 1, validated the extended three-dimensional model using the TAS04 in-situ interference tests from Äspö Hard Rock Laboratory in Work Package 2, and applied the thermal and glacial loads to monitor the long-term hydro-mechanical response on the fractured rock in Work Package 3. Each modelling team adopted both Finite Element Method (FEM) and Discrete Element Method (DEM) to simulate the hydro-mechanical behavior of the fracture rock, and added the various approaches to describe the EDZ and fracture geometry which are appropriate to each simulation method. Therefore, this research can introduce a variety of numerical approaches and considerations to model the geological repository for the spent nuclear fuel in the crystalline fractured rock.

• Parasites, Hosts and Diseases
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• v.26 no.4
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• pp.255-262
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• 1988

An epidemiological study on brugian filariasis was carried out in endemic areas including Cheju Island in Korea, with a brief review of literatures. The results showed that the incidence among residents has remarkably decreased in Cheju Island, which was the main endemic area. Reviewing available informations on the prevalence of filariasis reported in recent years and also judging from the present socio·economic conditions which enable people to practice personal protection against mosquitos, it can be said with confidence that alariasis has almost disappeared from Cheju Island and inland areas. The disease is considered to remain at a low level of endemicity in Hugsan Islands. Certainly mass diethylcarbamasine (DEC) treatment carried out in Cheju Island in the 1960s and 1970s and remarkable economic growth followed by improved living standard and altered life-style of inhabitants could all have combined effects on the disappearance of this mosquito-borne disease in this island. If the present trends go on, the possibility of resurgence of filariasis in Cheju Island is hardly postulated.

• Korean Journal of Weed Science
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• v.15 no.4
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• pp.278-288
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• 1995

Weed species occurred in dry- and water-seeded rice were 14 (2 grasses, 8 broadleaves, and 4 sedges) and 12 species (1 grasses, 7 broadleaves, and 4 sedges), respectively. Dominant weed species in dry-seeded rice were Lindernia procumbens, Cyperus difformis, Cardamine flexuosa, and Cyperus serotinus in discending order. The species in water-seeded rice were Cyperus difformis, Scirpus juncoides, and Lindernia procumbens. The number of weed species emerged in direct-seeded rice was determined at about 45 days after seeding, and dry weights of weeds were increased up to 75~90 days after seeding. Timing for great increase of plant height varied depending upon weed species. Regardless of weed number emerged, the most dominant weeds until late stage of growth were Cyperus difformis, Bidens frondosa, Digitaria ciliaris and Echinochloa crus-galli in dry- seeded rice, and Cyperus difformis, Echinochloa eras-galli and Scirpus juncoides in water-seeded rice.

• Land and Housing Review
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• v.5 no.4
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• pp.315-323
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• 2014

In this study, thermal transmittance which is a parameter to measure the thermal performance was evaluated for an internal insulation versus an external insulation. Then the ISO regulation was applied to evaluate it, and the superiority of an external insulation was verified by the thermal transmittance values. The three zones of apartment housing were selected to evaluate the performance. (1) The junction of an outer wall and a protruded slab : If there is no a thermal bridge protection system, then the values are about same in the two insulation systems, so the protection system should certainly be installed. If it is installed, then the value for the external insulation is 2 times lower than internal system. (2) The junction of a side wall and a flat slab: The value is 0.509W/mK for the internal insulation and about zero for the external insulation. (3) The junction of an outer wall and a division wall: The value is 0.451W/mK for the internal insulation and also about zero for the external insulation. A domestic regulation that could evaluate a thermal transmittance has to be established by applying the ISO regulation for the evaluation of external insulation systems in apartment housing in the future. Additionally, the government must decide which length should be used for the national standard.

• Journal of Korea Spatial Information System Society
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• v.8 no.1 s.16
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• pp.1-16
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• 2006

Recently, human based computing environment for supporting users to concentrate only user task without sensing other changes from users is being progressively researched and developed. But middleware deletes steream data processed for reducing process load of massive information from RFID sensor in this computing. So, this kind of middleware have problems when user demands probability or statistics needed for data warehousing or data mining and when user demands very important stream data repeatedly but already discarded in the middleware every former time. In this paper, we designs Sensor Middleware Architecture on Multi Level Spatial DBMS with Snapshot and manage repeatedly required stream datas to solve reusing problems of historical stream data in current middleware. This system uses disk databse that manages historical stream datas filtered in middleware for requiring services using historical stream information as data mining or data warehousing from user, and uses memory database that mamages highly reuseable data as a snapshot when stream data storaged in disk database has high reuse frequency from user. For the more, this system processes memory database management policy in a cycle to maintain high reusement and rapid service for users. Our paper system solves problems of repeated requirement of stream datas, or a policy decision service using historical stream data of current middleware. Also offers variant and rapid data services maintaining high data reusement of main memory snapshot datas.

• Korean Journal of Microbiology
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• v.42 no.4
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• pp.271-276
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• 2006

Previously we demonstrated that virus-inducible stress protein (VISP) is induced in fish cells by the infection of a fish rhabdovirus. In this paper, we investigated the subcellular localization of the VISP and determined the region of VISP responsible for the subcellular localization. The CHSE-214 cells were stained with monoclonal antibody raised against VISP and observed with confocal microscope to detect the endogenous VISP. The results showed that the VISP localizes to the perinuclear region as spots. A plasmid expressing VISP fused to enhanced green fluorescent protein (EGFP) was constructed. The transient expression of full-length VISP fused to EGFP in CHSE-214 cells confirmed the spot formation of the VISP at perinuclear region. To determine the region responsible for the perinuclear localization of the VISP, we constructed a series of deletion mutants and, by using these deletion mutants, we found that C-terminal region of the VISP (aa 612-710) is essential for the perinuclear distribution of VISP and that this region contained nuclear receptor binding motif (691-TLTSLLL-697). Our results suggest that VISP localizes to the perinuclear region and C-terminal regions are important for this localization. Further studies on the role of the perinuclear localization of VISP in IHNV growth mali reveal the novel mechanism of IHNV pathogenecity.

• Korean Journal of Materials Research
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• v.6 no.7
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• pp.723-732
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• 1996

Cu films were deposited by chemical wapor deposition on the as-received substrates (TiN/Si) and three kinds of Cu-seeded substrates (Cu/TiN/Si) which had seeding layer in the thick ness of 5 ${\AA}$ and 130 ${\AA}$ coated by ICB(Ionized Cluster Beam) method. The effect of Cu seeding layers on the growth rate, crystallinity, grain size uniformity and film adhesion strength of final CVD-Cu films was investigated by scanning eletron microscopy(SEM), X-ray diffractometry and scratch test. The growth rate was found to incresase somewhat in the case of ICB-seeding. The XRD patterns of the Cu films on the as-received substrate and ICB Cu-seeded substrates exhibited the diffraction peaks corresponding to FCC phase, but the peak intensity ratio($I_{111}/I_{200}$) of Cu films deposited on the ICB Cu-seeded substrates increased compared with that of Cu films on the as-received substrate. The resistivity of final Cu film on 40 ${\AA}$ seeded substrate was observed as the lowest value, 2.42 $\mu\Omega\cdot$cm compared with other Cu films. In adhesion test, as the seeding thickness increased from zero to 130 ${\AA}$, the adhesion strength increased from 21N to 27N.