• Journal of the Korean Society of Clothing and Textiles
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• v.25 no.9
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• pp.1655-1660
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• 2001

여성의 생리주기가 행동성 체온조절에 미치는 영향을 관찰하고자, 본 연구에서는 6명의 건강한 여자대 학생을 대상으로 하여 22.5$^{\circ}C$와 55%RH의 환경에서 피험자 스스로가 의복을 선택하는 쾌적의복선택 실험과 피험자 스스로가 온도를 선택하는 쾌적 온도선택 실험을 각각 수행하였다. 평균피부온은 생리주기에 관계없이 쾌적온도선택 실험보다 쾌적의복선택 실험에서 높게 유지되었고, 생리주기에 따른 쾌적착의량과 쾌적온도의 차이는 보이지 않았다. 그러나, 6명의 피험자 중 4명의 피험자가 선택하여 착용한 착의량은 황체기보다 여포기에 더 많았고 (p<0.05), 5명의 피험자가 선택한 쾌적온도 역시 황체기보다 여포기에 평균 1.4$^{\circ}C$ 더 높은 것으로 나타났다 (p<0.01). 이러한 결과는, 피부의 온도를 조절함으로써 여포기보다 황체기에 심부체온을 높게 유지하기 위한 행동성 체온조절반응을 나타낸 것으로 보이나, 보다 명확한 결론을 내리기 위해서는 다양한 환경조건에서 다수의 피험자를 대상으로 하는 후속연구가 지속적으로 수행되어 야 할 것이다.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.115-120
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• 2008

Purpose : This post-marketing surveillance (PMS) study was conducted in Korea to assess the safety and reactogenicity of hepatitis A vaccine (GlaxoSmithKlineBiologicals'$Havrix^{TM}$) administered to the Korean population. Methods : A total of 1,188 healthy subjects with 1,122 subjects <6 years of age were enrolled to receive one dose of the hepatitis A vaccine from April 2005 to January 2006. Diary cards were provided to the subjects or subjects' parents for reporting solicited and unsolicited symptoms during the 4-day and 31-day post-vaccination follow-up period. Results : The number of subjects who returned diary cards was 568, whereas, 620 subjects did not return diary cards. Among the subjects who returned diary cards, 9.9% and 14.3% reported local and general solicited/unsolicited symptoms. Among the subjects who did not return diary cards, 1.6% and 8.4% reported local and general solicited/unsolicited symptoms. At least one unsolicited symptom was reported by 13.2% of the subjects. Conclusion : Results indicate that the vaccine was well-tolerated and had an acceptable safety profile. The use of diary cards in such a survey provided a prompt and reliable option for recording symptoms.

• Journal of Korean Society of Forest Science
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• v.97 no.6
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• pp.634-640
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• 2008

The purpose of this study is to clarify the physiological effects of Shinrin-yoku (taking in the atmosphere of the forest of forest bathing). The subjects were twelve male university students ($21.6{\pm}2.1$ years old). On the first day, six subjects were sent to a forest area, and the others to a city area. On the second day, the subjects were sent to the opposite areas for a cross check. The subjects were seated on chairs and viewing the landscapes of their given areas for 15 minutes. HRV (Heart Rate Variability) and diastolic blood pressure were used as physiological indices. Diastolic blood pressure and LF/(LF+HF) components of HRV in the forest area were significantly lower than in the city area. And HF power components of HRV in the forest settings were significantly enhanced than in city settings. In conclusion, the results of the physiological measurements show that Shinrin-yoku was able to effectively relax people in both mind and body.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.2
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• pp.113-119
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• 2015

The measurement of hydration level in the surface layer of the skin, stratum corneum (SC), gives important information on the biophysical properties and function of the skin barrier such as softness, flexibility, and healthiness of the skin. But it is difficult to measure a consistent hydration level from a sample to another sample due to individual variations and environmental changes. The aim of this study was to evaluate objective hydration after using various products in the SC. The SC Hydration was measured by capacitance (Corneometer$^{(R)}$, C+K, Germany) on the ventral site of forearm from 40 healthy volunteers. The skin surface was chronologically measured immediately after application of the test products and 3 and 6 hours later. We analyzed the averages of five measurements of each site and used the hydration increase rate for correction on untreated site variation. We found that most polyols including glycerol and butylenes glycol influenced directly the hydration increase rate in the SC previously. In this study, glycerol was used to prepare the standard products from 0 to 20 percents and applied to the same volunteers. The individual standard curve showed linear relation to glycerol concentrations. Based on the the standard curve, hydration of SC was converted into hydration increase rate to glycerol concentrations. The converted glycerol concentrations of products were repetitive and reproducible. In addition, the individual standard curve was used to relate the skin type of each individual. These results suggest that the hydration of the SC standardized regardless of external variation and individual skin condition can explain detailed skin state variation. Further studies will be conducted with other ingredients such as surfactants, lipids and aqueous materials, and with other methods for noninvasive measurement.

• Science of Emotion and Sensibility
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• v.2 no.2
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• pp.75-82
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• 1999

지금까지 인간 감성의 측정은 대부분 제한된 실험실에서 실시되었다. 보다 자연스러운 동적인 환경에서 인간의 감성을 자율신경계의 반응을 통해 추출하고자 본 연구를 수행하였다. 쾌 또는 불쾌한 도로의 시각 환경이 긍정 및 부정 시각으로 제시되었고, 아스팔트, 시멘트, 비포장 도로 등의 도로 굴곡 변화가 또 다른 쾌/불쾌 관련 감성 자극으로 제시되었다. 건강한 5명의 피험자는 실험을 위해 차량 내부에서 도로의 시각 환경을 관찰하게 하였고, 세 가지 굴곡이 다른 도로를 주행하면서 굴곡 변화에 따른 감성을 느끼게 하였다. 심박 변화율, 피부 저항, 피부온도 등의 생리 신호를 측정하였고 주관적 평가와 비교 분석하였다. 피험자가 긍정 시각 장면에 비해 부정 시각 장면을 보았을 때 또한 도로 굴곡의 변화가 클수록 평균 R-R 간격과 피부온도의 감소율은 컸고 피부 전도도는 증가하였다. 본 연구로부터 동적 환경에서 긍정 감성 자극에 비해 부정 감성 자극이 주어 졌을 때 교감 신경계의 활성화가 보다 증가함을 관찰할 수 있었다.

• Proceedings of the Korean Society of Community Living Science Conference
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• 2003.11a
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• pp.152-152
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• 2003

본 연구의 목적은 고추 수확과 같은 여름철 농작업 시 농민의 온열 스트레스 경감을 위한 피복 장비 개발 연구의 일환으로 두 종류의 기능성 모자를 개발하고 그 성능을 비교 검토하는 것이다. 피험자로는 건강한 남자 대학생 열 두 명이 참가하였다. 인공기후실 실험 조건은 네 가지로 모자를 쓰지 않은 경우 (Control), 챙이 넓은 시판 농작업모를 착용한 경우 (Hat A), 반사 소재의 냉각 모자를 착용한 경우 (Hat B), 반사소재이면서 통기 구조를 갖는 냉각 모자를 착용한 경우 (Hat C)이다. 인공 기후실 내 환경 조건은 기온 33$\pm$0.5$^{\circ}C$, 습도 65$\pm$5%RH, 복사 온도 39$\pm$1$^{\circ}C$로 WBGT 33$^{\circ}C$를 유지하였고, 피험자들은 120분(50분 작업, 10분 휴식, 50분 작업, 10분 휴식) 동안 모델화된 고추 수확 작업을 수행하였다.

• Journal of Korean Society of Forest Science
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• v.97 no.4
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• pp.423-430
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• 2008

Negative ion is considered as one of the forest health attributes. The overall purpose of this study was to investigate the influence of air negative ions on physiological effects. Data were collected from 12 volunteers (university students) who were randomly assigned into treatment and control groups. Subjects in treatment group were exposed to air with negative (2,001,000 ion/cc). Using pretest-posttest control group design, blood cortisol, norepinephrine, epinephrine, and cognitive function were measured. Data analysis indicated that negative ions influenced on positive effects of stress responses.

• Journal of the Korea Knowledge Information Technology Society
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• v.13 no.3
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• pp.351-357
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• 2018

This study is on the elderly people's use and experience of a wearable device. By using wearable device, the elderly can monitor their health data at real time. As a result, their motivation for health care, exercise, and so on can improve and enhance. Across the globe, population aging becomes one of the most important problems in each nation. The social and economic burden from aging is one of most serious challenges to sustainability of the world and its economy, including South Korea. Information Communication Technology including wearable device can help the elderly health care improve. In 2016, the number of wearable devices is more than 19 million. Many of them are the devices related to health data monitoring. In the experiment, the authors measure real time health data from the subjects' wearable devices. In the first experiment day, subjects' average waist size was 36.29 inches. In the final experiment day, 31st day later from start of the experiment, the average waist size was 35.51 inches. At the beginning of the experiment, standard deviation was 1.93. At the final day of the experiment, it was 2.24. In regression analysis, when experiment day extends, average waist size seems to decrease. The trend is significant (t=2.719, p<0.05). That result may mean the subjects' motivation for health care improve. Wearable device can increase the elderly people's motivation for health care and exercise. As a result, their health can improve.

• Korean journal of health promotion
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• v.18 no.4
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• pp.147-158
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• 2018

Background: This study was designed to investigate the effects of usual negative emotional experiences on biological aging progression of human. Methods: A total of 237 subjects who visited the Health Promotion Center at Chungnam National University Hospital from May 2013 through September 2013 was enrolled. Each subject had been drawn up a structured questionnaire about usual experiences of depression, anxiety, anger, and anger expression. The degree of biological aging progression of each subject was computed by a specific formula which consisted of chronological age and biological age reflecting obesity and aging of main organs. Results: Trait anger and low education level showed the significant correlations with biological aging (r=0.160, P=0.014, and r=-0.189, P=0.024, respectively). Trait anger and low education level solely displayed the significant $R^2s$ for biological aging in consequence of multivariate analyses; $R^2=0.044$, P=0.020, and $R^2=0.022$, P=0.038, respectively. Conclusions: This study suggests that the significant relationship between usual anger experience (i.e., trait anger) and biological aging would be present. In addition, lower education level may be related with biological aging.

• The Korean Journal of Applied Statistics
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• v.35 no.2
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• pp.251-263
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• 2022

Phase I clinical trial is called 'Dose finding study'. It is first step of experimenting on humans with new drugs developed through animal experiments or vitro experiments. The important area of interest in designing Phase I clinical trial is determining the dose that acceptable level to the patients and provides the greatest efficacy. In this paper, we explain about methods to determine the maximum tolerated dose using various stopping rules. The SM3, NM, Rim, J3, BSM methods are compared through simulation. And we consider how the methods might be reformed. As a result of the simulation, BSM estimated the MTD closest to the target toxicity probability. J3 method required the least number of subjects. These results are due to the feature of the stopping rules of both methods. The BSM adds 2 or 1 subject at the same dose level when there is a toxic reaction. In addition, the J3 method has a smaller number of subjects than the other methods. If the methods are improved by combining these features, MTD can be estimated more efficiently. If the total number of subjects can be reduced while using the stopping rule of the BSM, accurate estimation is possible for a small number of subjects.