• 한국식품영양과학회지
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• 제45권6호
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• pp.903-910
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• 2016

엉겅퀴와 타임의 복합추출물인 MS-10이 여성호르몬 수용체를 가역적으로 활성화해 여성갱년기에 감소하는 에스트로겐이 효율적으로 사용될 수 있도록 작용한다는 것이 확인되었다. 12주간의 인체적용시험에서 MS-10은 안면홍조 및 야한증, 감각마비, 수면장애, 신경과민, 우울, 현기증, 피로, 관절 및 근육통, 두통, 가슴 두근거림(심계항진), 그리고 질건조 등의 여성갱년기 증상이 개선되었음이 확인되었다. 이러한 MS-10의 여성갱년기 증상 개선은 MS-10에 의한 insulin-like growth factor-1의 개선에 기인한 것으로 판단된다. MS-10은 여성갱년기 증상을 개선하는 천연소재 건강 기능식품으로 사용될 수 있다.

• 한국융합학회논문지
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• 제13권4호
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• pp.573-582
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• 2022

부작용을 줄인 사물탕을 개발하고자 오미자를 사용한 변형 사물탕을 난소를 절제한 랫드에 경구투여하고 여성갱년기 기능성 효능의 평가지표 변화를 측정하였다. 체중 증가, 자궁과 질의 상대 장기중량, 혈중 지질관련 지표, 혈중 estradiol 의 변화에서 대조군과 비교하여 변형 사물탕이 통계적으로 유의한 개선효과는 나타나지 않았다. 그러나 자궁 조직내 단백질 변화에서 estrogen receptor alpha 와 beta 의 발현이 증가하는 경향성이 관찰되었고 estrogen receptor 신호전달에 관여하는 것으로 알려진 ERK와 AKT에서 활성화에 기여하는 인산화 ERK의 발현량이 유의한 증가를 나타내었고 인산화 AKT의 발현량은 유의하진 않지만 증가하는 경향성을 나타내었다. 난소절제로 유도한 여성갱년기 모델에서 시험물질 변형 사물탕을 비교적 적은 용량 투여했음에도 이러한 결과를 나타내는 것은 시험물질인 변형 사물탕에 estrogen receptor를 활성화시키는 능력이 있는 것으로 판단된다. 추후 위장장애가 적으면서 사물탕의 효능을 나타내고자 할 때 유용한 천연물 배합으로 이용이 가능할 것으로 본다.

• 생명과학회지
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• 제33권3호
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• pp.252-259
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• 2023

노화에 따른 난소 기능 저하와 성호르몬 생성 감소는 호르몬 결핍을 유발하여 여성의 갱년기를 유발한다. 여성 갱년기 증상 개선을 목적으로 에스트로겐 유사 물질이 함유된 천연물을 연구하였다. 본 연구는 난소 적출술을 받은 쥐를 대상으로 Gastrodia elata Blume 추출물(TVB-1000)의 효능을 평가하였다. 난소 적출 수술을 한뒤 7일의 회복 기간 후 TVB-1000 처리군에게 16, 40, 100 mg/kg을 12주 동안 경구 투여하였다. OVX 양성 대조군에는 17β-estradiol을 10 ㎍/kg의 용량으로 쥐의 등 부위에 피하 주사하였다. 그 결과 TVB-1000 처리군에서 심혈관질환 지표인 TG와 LDL-C가 모든 농도에서 유의하게 감소했다. LDL-C/HDLC 비는 TVB-1000 투여군 중 Medium, High군에서 유의하게 감소하였다. 또한 TVB-1000 고농도 처리군에서 복부지방 무게가 통계적으로 유의하게 감소하였다. ER- α의 발현량은 저농도 및 중농도 투여군에서 통계적 유의성을 보이며 증가하였으나 ER-β는 유의한 변화를 보이지 않았다. 실험을 통해 TVB-1000은 에스트로겐 유사 효과로 인해 갱년기 증상 중 하나인 심혈관계 질환을 예방하는 기능성 식품 소재로써 유용할 수 있음을 보여준다.

• 대한한의학방제학회지
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• 제20권2호
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• pp.199-211
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Gamisoyo-san on severe menopausal disorder patients. Methods : We recruited 2 severe menopausal disorder patients who have been suffering from hot flush and heat sensation. The patients had been administrated Gamisoyo-san. The patients of severe menopausal disorder had been estimated with Kupperman's index(KI), Menopause rating scale(MRS), Beck's depression Inventory(BDI), Visual analogue scale(VAS) and Heart rate variability (HRV). Kupperman's index, Menopause rating scale and Beck's depression inventory for every seven days. We measured VAS everyday. Heart rate variability was estimated twice, before and after treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Gamisoyo-san is significantly effective on severe menopausal disorder patients with hot flush and heat sensation.

• 동의신경정신과학회지
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• 제23권4호
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• pp.199-214
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Daeyeongjeongami-bang on menopausal disorder patients. Methods : We recruited 3 menopausal disorder patients who have been suffering from hot flush, fatigue and depression. In addition, the patients had been administrated Daeyeongjeongami-bang. The patients of menopausal disorder had been estimated with Kupperman's index, Menopause rating scale, Beck's depression Inventory, Self rating depression scale, Visual analogue scale and Heart rate variability. We measured Kupperman's index, Menopause rating scale, Beck's depression inventory and Self rating depression scale for every seven days. Heart rate variability was estimated twice, before and after the treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Daeyeongjeongami-bang is significantly effective on menopausal disorder patients with hot flush, fatigue and depression.

• 동의신경정신과학회지
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• 제20권2호
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• pp.177-186
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• 2009

Objectives : We investigated if korean traditional treatment and psychotherapy is effective in patients with depression and menopausal symptoms. Methods : We treated two patients with typical korean traditional medical treatment( Acupuncture, Giungoroen therapy(至言高論療法), Moxibustion ) and progressive muscle relaxation. Results : After treatment, the chief complaint and accompanying symptoms were subsided and improved. BDI score and Kupperman's index were decreased. Conclusions : We may conclude that korean traditional treatment and psychotherapy is effective in patients with depression and menopausal symptoms.

• 대한한방부인과학회지
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• 제30권4호
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• pp.135-148
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• 2017

Objectives: This study was aimed to develop a Korean medicine clinical practice guidelines (CPG) of Climacteric and Postmenopausal Syndrome Methods: We conducted a questionnaire survey targeting Korean medicine doctors belonging to the Association of Korean Obstetrics and gynecology by e-mail and analyzed the answers. On October 18, 2016, we sent questionnaires to 583 people, and on October 31, 2016, we sent questionnaires to 581 people again. A survey ended on November 15, 2016. A total of 56 responded. Results: 1. 91.07% of respondents knew the concepts and contents of CPG, and all respondents agreed about the necessity of CPG. 2. Most common symptom of climacteric and postmenopausal syndrome that 65.75% of the respondents answered was the hot flush 3. To diagnosis a climacteric and postmenopausal syndrome, 69.64% of the respondents used pattern identification diagnosis mainly. 4. 36.84% of the respondents answered that herbal medicine and acupuncture are the most effective treatments for climacteric and postmenopausal syndrome. The most commonly used herb medicine was Kamisoyo-san. Conclusions: We figured out Korean Medicine doctors' recognition of Korean medicine clinical practice guideline, clinical diagnosis, treatment on climacteric and postmenopausal syndrome to make the contents of the CPG reflecting the clinical situation. Further research will be needed in the future.

• 대한한방부인과학회지
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• 제30권4호
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• pp.175-202
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• 2017

Objectives: This study was conducted towards developing a screening tool for syndrome differentiation in the diagnosis of menopause in menopausal and perimenopausal women. Methods: We conducted a literature review of studies on menopausal diagnosis based on syndrome differentiation, and examined well-founded differentiated syndromes and their respective clinical symptoms. Based on the findings, we created a questionnaire through consultations with Oriental medicine experts in physiology, pathology, and diagnostics. Finally, the research team conducted an expert Delphi study on differentiated syndromes and the associated clinical symptoms. Results: Seven differentiated syndromes were selected, including Liver Depression (肝鬱), Kidney Yin Deficiency (腎陰虛), Kidney Yang Deficiency (腎陽虛), Liver and Kidney Yin Deficiency (肝腎陰虛), Kidney Yin and Yang Deficiency (腎陰陽兩虛), Heart-Kidney Noninteraction (心腎不交), and Dual Deficiency of Heart and Spleen (心脾兩虛); 4 disease locations, including liver (肝), heart (心), spleen (脾), and kidney (腎); and 3 disease natures, including Yin Deficiency (陰虛), Qi Stagnation (氣滯), and Blood Deficiency (血虛). In addition, we added 3 supplemental disease natures, including Yang Deficiency (陽虛), Qi Deficiency (氣虛), and Heat (火熱), in consideration of syndrome differentiation categories that may possibly be added in a follow-up clinical questionnaire. Conclusions: This resulted in a total of 7 differentiated syndromes, 4 disease locations, and 6 disease natures. We translated the clinical symptoms of these 17 categories into Korean Hangeul. After consulting with 5 Oriental medicine experts and a psychology expert, we produced a questionnaire for use in diagnosing menopause based on syndrome differentiation. The calculation of scores for the syndrome differentiation screening tool will be confirmed through clinical research based on the results of a review of existing literature.

• 대한한방부인과학회지
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• 제30권3호
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• pp.65-78
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• 2017

Objectives: This study was aimed to develop a guideline for the application of diagnostic devices for menopausal syndrome. Methods: We conducted a literature review and a questionnaire survey on diagnostic devices including Digital Infrared Thermal Imaging (DITI), pulse diagnosis device, Heart Rate Variability (HRV), body composition analyzer, Yangdorak. Results: We retrieved some clinical values for usage of devices from the articles. Especially, DITI was useful to identify the pattern of body temperature distribution. The respondents answered that they diagnosed menopausal syndrome by using body composition analyzer (62.3%), DITI (60%), HRV (60%), pulse diagnosis device (45.7%), Yangdorak (34.3%). The respondents answered that they don't use diagnostic devices when they diagnosed menopausal syndrome because of absence of device, cost, difficulty of interpretation, substitution of another diagnostic method. After experts survey, it was recommended to use DITI, HRV, body composition analyzer. There was no consensus on the use of pulse diagnosis device, Yangdorak in diagnosing menopausal syndrome. Conclusions: We developed a guideline for the application of diagnostic devices for menopausal syndrome.

• 대한한방부인과학회지
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• 제36권4호
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• pp.1-20
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• 2023

Objectives: The object of this study was to observe the complex anti-climacterium potentials of Yuklinzu aqueous extracts (YLZ), using bilateral ovariectomy (OVX) female ddY mice similar to women postmenopausal symptoms, as including cardiovascular diseases, obesity, hyperlipidemia, osteoporosis and hepatic steatosis. Methods: In order to evaluate anti-climacterium effects of YLZ, six groups of mice were used; sham control, OVX control, 17β-estradiol, YLZ 500, 250 and 125 mg/kg treated groups. Since 28 days after bilateral OVX surgery, YLZ were administered orally for 84 days, once a day. And then we evaluated anti-climacterium effects divided into five categories; estrogenic effects, anti-obesity, hypolipidemic effects, hepatoprotective effects and anti-osteoporotic effects. The results of YLZ were compared with 17β-estradiol 0.03 ㎍/head/day subcutaneous treated OVX mice. Results: As a result of OVX, obvious changes related to the estrogen-deficient menopausal symptoms - obesity, hyperlipidemia, hepatic steatosis and osteoporosis were displayed in mice. However, these menopausal symptoms induced by OVX were significantly inhibited by 84 days of consecutive treatment of 17β-estradiol, YLZ 500, 250 and 125 mg/kg, respectively. Especially, YLZ showed obvious dose-dependent inhibitory activities on the OVX-induced climacterium changes in mice, and YLZ 500 mg/kg showed comparable inhibitory effects against menopausal symptoms in comparison with those of 17β-estradiol 0.03 ㎍/head/day subcutaneous treatment. Conclusions: The results suggest that oral administration of YLZ 500, 250 and 125 mg/kg has obvious dose-dependent favorable anti-climacterium effects in OVX mice. Especially, YLZ 500 mg/kg showed comparable inhibitory effects against menopausal symptoms in comparison with those of 17β-estradiol 0.03 ㎍/head/day subcutaneous treatment.