• Title/Summary/Keyword: 간접적 손상

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Effects of Pueraria flos and radix Water-extracts on levels of Several Serum Biomarkers in Ethanol-treated Rats (갈화와 갈근 열수추출물들이 에탄올 투여 흰쥐의 혈청성분에 미치는 영향)

  • 조수열;장주연;김명주
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.30 no.1
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    • pp.92-96
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    • 2001
  • The present study was investigated effect of each water extract from Pueraria flos (PF) and Pueraria radix (PR) on serum several biomarkers in ethanol-treated rats. Male Sprague-Dawley rats were randomly divided into six groups: Normal (None-treated group); Ethanol (only ethanol-treated group); EPF I (ethanol-treated, supplemented group); EPR (ethanol-treated, PF II-supplemented group); EPR I (ethanol-treated, PR I-supplemented group) ; EPR (ethanoltreated, PR II-supplemented grou). Five groups of male Sprague-Dawley rats were orally administered 25% ethanol (5 g/kg body weight/day) and sacrified 5 weeks post treatment. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and ${\gamma}-glutamyl$ transpeptidase activities were significiantly lowered by feeding of PF or PR than those of only ethanol-treated group. Whereas serum glucoseand liver glycogen contents were significantly decreased (p<0.05) by ethanol administration and increased decreased (p<0.05) by PF or PR supplement. This results indicate that Pueraria flos and radix water extract supplement improves alcoholic disorder.

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A Study on the Indirect Copy of Dancheong Patterns Using Three-dimensional Scanning (3차원 스캐닝을 활용한 단청문양의 간접전사 연구)

  • An, Ji Eun;Choi, Chan Ho;Kim, Sung June;Yoon, Man Young
    • Journal of Conservation Science
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    • v.34 no.6
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    • pp.471-479
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    • 2018
  • Seonunsa Temple is a site of Dancheong cultural significance in Daewoongjeon. Three-dimensional (3D) scanning can be used to create a simulation in 1:1 ratio without touching the Dancheong patterns directly. The traditional method of recreating Dancheong was paining with tracing paper using a fix pin. However, manual direct copy processes can cause and damage to the objects. This study shows the results of a simulation of a tranditional Dancheong patterns as an alternative; the simulation was able to reduce dimensional errors and prevent damage by using 3D scanning. As a result, objective and precise proportions of the simulation were acquired. The 3D scanning method may be applied for work such as the replication and restoration of the drawing, 3D fabrication of the original data, and printing of the additional drawing. In addition, with the production of 3D materials, a virtual museum is possible.

Fragility Curve of PSC Box Girder Bridge using Isolator (면진 받침을 사용한 PSC Box Girder 교량의 손상도 곡선)

  • Lee, Jongheon;Kim, Woonhak;Seo, Sangmok
    • Journal of the Society of Disaster Information
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    • v.8 no.1
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    • pp.36-46
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    • 2012
  • After the east Japan earthquake last March 2011, social interests are intensified in the area of increasing the earthquake resistant ability and the necessity of design method that can minimize the damage from earthquake. If bridges are damaged or collapsed, the social and economic effects are so severe that the evaluation of earthquake resistant ability becomes very important. The reviewing methods for earthquake resistant ability are many, but majority of these methods are deterministic. Thus, for the safety assessment of structures for earthquake, the method for evaluating fragility according to the stage of damage is necessary. In this paper, the fragility curves for PSC Box Girder bridge using LRB and RFPB are constructed for PGA, PGV, SA, SV, SI and the two isolators are compared.

A Becoming-Nonhuman Animal in the Neurological State of Exception: Black Swan and Birdman (신경학적 예외상태에서 비인간적 동물-되기: <블랙스완>과 <버드맨>)

  • Park, Jecheol
    • Cross-Cultural Studies
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    • v.50
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    • pp.1-29
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    • 2018
  • In the contemporary American cinematic landscape, there is a distinctive tendency to depict the disturbing ways in which characters with brain damages perceive, remember, and think about the world. Despite its attempts to examine the socio-political implications of these characters' subjectivities, the previous scholarship on this trend of film was limited in being either too pessimistically deterministic or too euphorically optimistic. Critically reading neuroscientific discourses on the brain-damaged subject from the perspective of Giorgio Agamben's critique of biopolitics, this paper explores how the contemporary American cinema of the impaired brain attempts to mediate the neurologically inexplicable affects of those subjects who are in the neurological state of exception and to express their experiences of a becoming-nonhuman. By closely reading Darren Aronofsky's Black Swan and Alejandro $Gonz{\acute{a}}lez$ $I{\tilde{n}}{\acute{a}}rritu^{\prime}s$ Birdman in this regard, I show how the two films, by employing different sets of cinematic free indirect techniques, express the neurologically impaired subject's affective experience of a becoming-nonhuman animal in different ways, and thereby to a more or less extent act as 'profaned' neuro-biopolitical apparatuses.

Significant Proteinuria Caused by Posterior Nutcracker Phenomenon (호두까기 증후군으로 인해 발생한 다량의 단백뇨)

  • Lee, Jun-Ho;Kim, Geun-Jung
    • Childhood Kidney Diseases
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    • v.14 no.1
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    • pp.84-88
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    • 2010
  • Posterior nutcracker phenomenon (PNP) was found to be the cause of significant proteinuria in a 10-year-old female. PNP was documented by Doppler ultrasonography and abdominal 3D CT as a cause of her proteinuria. Despite treatment with ACE inhibitor for several months, her persistent and progressive proteinuria lead us to perform a left renal biopsy, which revealed no significant finding except for focal effacement of foot processes. We speculate that nutcracker phenomenon can induce not only orthostatic proteinuria but also significant proteinuria by focal effacement of foot processes.

Seismic Risk Assessment of Bridges Using Fragility Analysis (지진취약도분석을 통한 교량의 지진위험도 평가)

  • Yi, Jin-Hak;Youn, Jin-Yeong;Yun, Chung-Bang
    • Journal of the Earthquake Engineering Society of Korea
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    • v.8 no.6 s.40
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    • pp.31-43
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    • 2004
  • Seismic risk assessment of bridge is presented using fragility curves which represent the probability of damage of a structure virsus the peak ground acceleration. In theseismic fragility analysis, the structural damage is defined using the rotational ductility at the base of the bridge pier, which is obtained through nonlinear dynamic analysis for various input earthquakes. For the assessment of seismic risk of bridge, peak ground accelerations are obatined for various return periods from the seismic hazard map of Korea, which enables to calculate the probability density function of peak ground acceleration. Combining the probability density function of peak ground acceleration and the seismic fragility analysis, seismic risk assessment is performed. In this study, seismic fragility analysis is developed as a function of not the surface motion which the bridge actually suffers, but the rock outcrop motion which the aseismic design code is defined on, so that further analysis for the seismic hazard assessment may become available. Besides, the effects of the friction pot bearings and the friction pendulum bearings on the seismic fragility and risk analysis are examined. Lastly, three regions in Korea are considered and compared in the seismic risk assessment.

Evaluation of Membrane Damage Sensitivity by Defect Types for Improving Reliability of Membrane Integrity Monitoring (막 완결성 모니터링 신뢰성 향상을 위한 손상 유형별 막 손상 감도 평가)

  • Lee, Yong-Soo;Kang, Ha-Young;Kim, Hyung-Soo;Kim, Jong-Oh
    • Membrane Journal
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    • v.27 no.3
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    • pp.248-254
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    • 2017
  • In order to secure the reliability of pathogenic microorganisms such as Cryptosporidium and Giaridia, which are chlorophilic protozoans, membrane filtration systems have been widely used in water purification process. hese integrity tests are classified into direct and indirect methods. Based on the bubble point theory, the pressure-based test in the direct method is presented in the USEPA Guidance Manual with sensitivity to detect a minimum size of pathogenic microorganisms of $3{\mu}m$ or more. Indirect methods are widely used in that they are capable of continuous operation in on-line state, but there is a very low sensitivity of damage detection compared to the direct method, and there is a limit that can not specify the damage area, so it is necessary to improve this sensitivity. In this study, we compared the LRVDIT and UCL values according to the type of membrane defect, number of fiber breaks, and initial set pressure value through the Integrity Test by Pressure Decay Test (PDT).

IT Risk Assessment: Case Study on Domestic Construction company (IT 리스크 평가 연구사례: 국내 건설사 적용 사례)

  • Lee, youngjai;Lee, Sungjung;Lee, Seongil
    • Journal of Korean Society of societal Security
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    • v.2 no.1
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    • pp.47-55
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    • 2009
  • Organizations and customers lose if business activities are discontinued by an incident of information systems under the current business environment because they pursue real time enterprise and on demand enterprise. The loss includes the intangible decline in brand image, customer separation, and the tangible loss such as decrease in business profits. Thus, it is necessary to have preparedness in advance and mitigation for minimization of a loss due to the business discontinuity and IT risks. This paper described a IT risk assessment case about domestic construction company.

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Oxidative damage biomarker levels according to Mn-SOD and GST gene polymorphisms in preschool children (Mn-SOD와 GST 유전자 다형성에 따른 유아의 산화손상지표의 분포)

  • Shin, You-kyung;Choi, Ji-Won;Oh, Se-Young;Chung, Jayong
    • Journal of Nutrition and Health
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    • v.48 no.6
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    • pp.468-475
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    • 2015
  • Purpose: Genetic polymorphisms in antioxidant defense and detoxification genes may modulate the levels of oxidative stress biomarkers. Methods: A total of 301 healthy preschool-aged children in the Seoul and Kyung-gi areas were recruited. DNA was extracted from blood for genotyping of manganese superoxide dismutase (Mn-SOD) Val16Ala, glutathione S-transferase (GST) P1 Ile105Val, GSTT1 present/null, and GSTM1 present/null polymorphisms by PCR-restriction fragment length polymorphism or multiplex PCR analyses. In addition to a questionnaire survey, the levels of urinary 8-hydroxyl-2-deoxiguanosine (8-OHdG) and plasma malondialdehyde (MDA) were measured by ELISA. Results: Significantly higher urinary 8-OHdG concentrations were observed in GSTP1 Ile/Val + Val/Val genotype (p = 0.030), and tended to be higher in Mn-SOD Val/Val genotype (p = 0.065). On the other hand, exposure to environmental tobacco smoking (ETS) and interaction between ETS and gene polymorphisms did not significantly influence either urinary 8-OHdG concentrations or serum MDA. Conclusion: Based on our findings, GSTP1 Ile/Val gene polymorphisms might modulate the levels of oxidative stress biomarkers in healthy preschool children.

Calculation of Crack Width of the Top Flange of PSC Box Girder Bridge Considering Restraint Drying Shrinkage (구속 건조수축을 고려한 PSC BOX 거더교 상부플랜지 균열폭 산정)

  • Young-Ho Ku;Sang-Mook Han
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.3
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    • pp.30-37
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    • 2023
  • The PSCB girder bridge is a closed cross-section in which the top and bottom flanges and the web are integrated, and the structural characteristics are generally different from the bridges in which the girder and the floor plate are separated, so a maintenance plan that reflects the characteristics of the PSCB girder bridge is required. As a result of analyzing damage types by collecting detailed safety diagnosis reports of highway PSCB girder bridges, most of the deterioration and damage occurring during use is concentrated on the top flange. In particular, cracks in the bridge direction on the underside of the top flange occurred in about 70 % of the PSCB girder bridges to be analyzed, and these cracks were judged to be caused by indirect loads such as heat of hydration and drying shrinkage rather than structural cracks caused by external loads. In order to improve durability and reduce maintenance costs of PSCB girder bridges in use, it is necessary to control restraint drying shrinkage cracks from the design stage. Therefore, in this paper, the cracks caused by drying shrinkage under restraint, which is the main cause of cracks under the flanges of the top part of the PSCB girder bridge, were directly calculated using the Gilbert Model, and the influencing factors such as the amount of reinforcing bars, diameter and spacing of reinforcing bars were analyzed. As a result of the analysis, it was found that the crack width caused by restraint drying shrinkage exceeded the allowable crack width of 0.2 mm for reinforcing bars with a reinforcing bar ratio of 0.01 or less based on the H16 reinforcing bar and a reinforcing bar with a diameter greater than H19 based on the reinforcing bar ratio of 0.01. Finally, based on the results of the crack width review, a method for controlling the crack width of the top flange of the PSCB girder bridge was proposed.