• Title/Summary/Keyword: ‘One-pot’ synthesis

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A Regiospecific One-Pot, Three Component Synthesis of 4-Aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones as New Potential Monoamine Oxidase Inhibitors

  • Khalafy, Jabbar;Rimaz, Mehdi;Panahi, Leila;Rabiei, Hossein
    • Bulletin of the Korean Chemical Society
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    • v.32 no.7
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    • pp.2428-2432
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    • 2011
  • A series of new 4-aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones have been synthesized via three component reaction of 1,3-dimethylbarbituric acid with arylglyoxals in the presence of hydrazinium dihydrochloride in ethanol. All of these derivatives may act as potential monoamine oxidase inhibitors.

Magnesium Bistrifluoromethanesulfonimide Catalyzed Three-component Synthesis of Protected Homoallylic Amines

  • Wang, Hongshe;Zeng, June
    • Bulletin of the Korean Chemical Society
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    • v.32 no.7
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    • pp.2203-2206
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    • 2011
  • A mild and efficient procedure has been developed for the one-pot, three-component reaction of aldehydes, benzyl carbamate and allyltrimethylsilane in the presence of 3 mol % of magnesium bistrifluoromethanesulfonimide at room temperature to afford the corresponding protected homoallylic amines in high yields.

One Pot Synthesis of Bioactive Novel Cyanopyridones

  • Khokhani, Kamlesh;Khatri, Taslimahemad;Patel, Praful
    • Journal of the Korean Chemical Society
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    • v.57 no.4
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    • pp.476-482
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    • 2013
  • Cyanopyridone was prepared by the condensation of cyanoacetamide, substituted arylaldehydes and malononitrile in presence of pipyridine. The structure of the synthesized compound CP 1-20 was assigned on the basis of elemental analysis, IR, $^1H$-NMR and mass spectroscopy. These compounds were also screened for antimicrobial activity. The Minimum Inhibitory Concentration (MIC) of all the synthesized compounds was compared with standard drugs.

One-pot Synthesis of Cinnamylamines with Various Protecting Groups from Cinnamyl Ethers

  • Jung, Young-Hoon;Kim, Ji-Duck
    • Archives of Pharmacal Research
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    • v.24 no.5
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    • pp.371-376
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    • 2001
  • The reaction of various alkyl cinnamyl ethers with CSI afforded the corresponding cinnamylamines with various protecting groups, such as -NHMoc, -NHiPoc, -NHCbz, -NHPnz, -NHTroc and -NHAloc. In the case of cinnamyl t-butyl ether and cinnamyl p-methoxybenzyl ether, the corresponding cinnamyl carbamates were formed via a different reaction pathway from the above.

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New Synthetic Method of Perfluoro-Silanes for the Stable Electrolyte of Lithium Ion Battery Application

  • Koh, Kyungkuk;Sohn, Honglae
    • Journal of Integrative Natural Science
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    • v.10 no.3
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    • pp.171-174
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    • 2017
  • Non-hydrolyzable fluorinated organosilicon compounds as an eletrolyte for the application of lithium-ion batteries (LIB) are synthesized. New synthetic method for the perfluorinated organosilicon compound containing spacer such as ethyl and propyl group with cyano moiety instead of ethylene glycol to prevent hydrolysis and to promote conductivity are developed in one pot reaction with moderately high yield. Air-sensitive boron trifluoride etherate is no longer required in this reaction. The products are characterized by spectroscopic analysis.