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Study of Single-dose Toxicity of Guseonwangdo-go Glucose Intramuscular Injection in Sprague-Dawley Rats

  • Jo, Su-Jeong;Kim, Sung-Chul;Kim, Yu-Jong;Kim, Eun-Jung;Kim, Kap-Sung;Lee, Seung-Deok
    • Journal of Pharmacopuncture
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    • v.17 no.1
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    • pp.51-58
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    • 2014
  • Objectives: This study was performed to analyze single-dose intramuscular toxicity of Guseonwangdo-go glucose pharmacopuncture. Methods: Eighty six-week-old Sprague-Dawley rats were divided into two large groups of forty rats; Guseonwangdo-go glucose 5% and Guseonwangdo-go glucose 20% groups. Each group was sub-divided into four smaller groups of five males and five females, with the following dosages of pharmacopuncture being administered by intramuscular (IM) injection in each group: group 1 (G1, control group): 1.0 mL of normal saline solution, group 2 (G2, low-dose group): 0.1 mL, group 3 (G3, mid-dose group): 0.5 mL, and group 4 (G4, high-dose group): 1.0 mL. Results: No mortalities or clinical signs were observed in any group. Also, no significant changes in body weights or in hematological/biochemical analyses were observed between the control and the experimental groups during necropsy or histopathology. Conclusion: The above findings suggest that the lethal dose of Guseonwangdo-go glucose 5% and 20% pharmacopuncture administered via IM injection is more than 1.0 mL per animal in both male and female rats. Further studies on the repeated-dose toxicity of Guseonwangdo-go glucose should be conducted to yield more concrete data.

Effect of Aconiti Radix on the Toxicity Induced by Glucose Oxidase in Cultured Myocardial Cells (배양심근세포에 있어서 Glucose Oxidase의 독성에 대한 천오두의 영향)

  • Lee Jung Hun;Lee Kang Chang;Kim Sang Su;Hong Gi Youn;Oh Yeon Kyun;Suk Seung Whan;Lee Gap Sang;Jin Bok Hee;Shin Hong Chul;Ryu Do Gon;Park Seung Taeck
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.3
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    • pp.495-498
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    • 2002
  • Cytotoxicity of glucose oxidase(GO) and neuroprotective effect of Aconiti Radix(AKR) against GO-induced neurotoxicity were measured for elucidating the mechanism of cardiotoxicity on cultured mouse myocardial cells by MTT assay after myocardial cells were cultured for 24 hours at various concentrations of GO. GO was toxic in a time-and dose-dependent manner on cultured myocardial cells after myocardial cells were grown for 24 hours in media containing 5~40mU/ml GO. While, cultures were pretreated with 50 μg/ml AKR for 2 hours increased remarkably cell viability. From the above results, it is suggested that GO is toxic on cultured mouse myocardial cells by the decrease of cell viability, and herb medicine such as AKR is very effective in the prevention of myocardial toxicity induced by GO.

Electromagnetic Interference Shielding Efficiency Characteristics of Ammonia-treated Graphene Oxide (암모니아수 처리된 그래핀 옥사이드의 전자파 차폐효율 특성)

  • Park, Mi-Seon;Yun, Kug Jin;Lee, Young-Seak
    • Applied Chemistry for Engineering
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    • v.25 no.6
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    • pp.613-618
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    • 2014
  • In this study, nitrogen doped graphene oxide (GO) was prepared using liquid phase ammonia treatment to improve its electrical properties. Also, the aminated GO was manufactured into a film format and the electromagnetic interference (EMI) shielding efficiency was measured to evaluate its electrical properties. The XPS result showed that the increase of liquid phase ammonia treatment concentration led to the increased nitrogen functional group on the GO surface. The measurement of EMI shielding efficiency reveals that EMI shielding efficiency of the liquid phase ammonia treated GO was better than that of non-treated GO. When GO was treated using the ammonia solution of 21% concentration, the EMI shielding efficiency increased by -5 dB at higher than 2950 MHz. These results were maybe due to the fact that nitrogen functional groups on GO help to improve the absorbance of electromagnetic waves via facile electron transfer.

Partial Go back N Scheme for Occupancy Control of Reordering Buffer in 3GPP ARQ (3GPP ARQ에서 재정렬 버퍼의 점유량 조절을 위한 부분 Go back N 방식)

  • Shin, Woo-Cheol;Park, Jin-Kyung;Ha, Jun;Choi, Cheon-Won
    • Proceedings of the IEEK Conference
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    • 2003.11c
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    • pp.302-305
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    • 2003
  • 3GPP RLC protocol specification adopted an error control scheme based on selective repeat ARQ. In the 3GPP ARQ, distinctive windows are provided at transmitting and receiving stations so that those stations are prohibited to send or receive data PDU's out of window. An increase in window size enhances delay performance. Such an increase, however, raises the occupancy at re-ordering buffer, which results in a long re-ordering time. Aiming at suppressing the occupancy at re-ordering buffer, we propose partial go back N scheme in this paper In the partial go back N scheme, the receiving station regards all data PDU's between the first (lowest sequence numbered) error-detected PDU and last (highest sequence numbered) error-detected PDU. By the employment of the partial go back N scheme, the occupancy at the re-ordering buffer is apparently reduced, while the delay and throughput performance may be degraded due to the remaining properties of go back N. We thus consider peak occupancy of re-ordering buffer, mean sojourn time at re-ordering buffer, mean delay time, and maximum throughput as measures to evaluate tile proposed scheme and investigate such performance by using a simulation method. From numerical examples, we observe a trade-off among performance measures and conclude that the partial go back N scheme is able to effectively reduce the occupancy of re-ordering buffer.

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A Situation Evaluation System based on the Strength and the Influence Distribution of Stones in Computer Go (컴퓨터 바둑에서 돌의 세기와 영향력 분포에 기반한 형세 평가 시스템)

  • 김영상
    • Journal of the Korea Computer Industry Society
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    • v.3 no.3
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    • pp.259-270
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    • 2002
  • In computer Go, the method evaluating the situation of a face is not generalized. To evaluate the situations all the faces accurately, computer Go must judge owners of 361 positions according the changes of the faces. In this paper, we apply the structure of graph as a method analyzing the rules and characters of Go. The Situation Evaluation System(SES) which can evaluate the situation of a face without DB information oかy using strength of stone(SS), influence power(IP), safety(S), position value(PV), and position-value matrix(PM) is proposed. This system is very effective to evaluate the whole situations of Go because it can show the owner of 361 positions between Black and White. As a result, SES can well compute the situations in the opening game of Go. It makes 70.9% hit-ratio as compared with the practical Go games of professional players. According to the results compared with Nemesis, the commercial program which has the joseki(established stones: hewn sequences of moves near the corner which result in near-equal positions for White and Black), SES is superior to Nemesis by 10% higher in the hit-ratio of situation evaluations of professional players.

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Effect of γ-Oryzanol on Blood Glucose in Diabetic KK Mice (γ-Oryzano1의 급여가 KK 당뇨 마우스의 혈당에 미치는 영향)

  • 이성현;전혜경;장순옥;이연숙
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.5
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    • pp.827-831
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    • 2004
  • This study was carried out to investigate the supplementary effects of ${\gamma}$-oryzanol on the blood glucose level in diabetic mice. We supplied 2 experimental diets (CO without and GO with 0.2% ${\gamma}$-oryzanol) to diabetic mice for 8 weeks. Diet intake, body weight and levels of blood glucose, hemoglobin $A_{lc}$ and insulin were measured. Though there was no significant difference in diet intake between experimental groups, the concentration of fasting blood glucose and blood glucose area from glucose tolerance test in diabetic mice was lower in GO group than CO group during the supplementary period of experimental diets. Hemoglobin Ai, was lower and serum insulin level was higher in GO group than CO group without significance. These results suggest that r-oryzanol decrease the blood glucose level, and ${\gamma}$ -oryzanol produced from residual product of rice may be developed with high value.

Effect of Time-to-go Estimate to Impact Time Control Guidance Laws (충돌시간 제어 유도법칙에 대한 잔여비행시간 추정의 영향)

  • Kim, Mingu
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.47 no.8
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    • pp.558-565
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    • 2019
  • A lot of studies on the survivability of missiles have been widely studied, since the technology of modern warships equipped with state-of-the-art defense systems has been improved. The survivability of missiles can be improved by attacking a target simultaneously using multiple missiles. For this reason, impact time control guidance (ITCG) laws have been widely studied. This paper deals with the effect of time-to-go estimate to ITCG laws. In this paper, two kinds of time-to-go estimate are first introduced in two-dimensional and three-dimensional environment and then ITCG laws are derived using the time-to-go estimate. Numerical simulations are performed to analyze the performance of the designed ITCG laws and the effect of time-to-go estimate is discussed.

Application and Functionalization of Graphene Oxide on Cotton Fabric Via Aerosol Spray Pyrolysis (그래핀 옥사이드의 에어로졸 분무열분해 공정을 통한 면직물의 전기전도성 및 물성 평가)

  • Ohm, Hyunji;Cho, Gilsoo
    • Fashion & Textile Research Journal
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    • v.24 no.1
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    • pp.138-145
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    • 2022
  • Today, graphene loaded textiles are being considered promising smart clothing due to their high conductivity. In this study, we reported reduced graphene oxide(r-GO) deposited pure cotton fabrics fabricated with a colloidal solution of graphene(GO), using a one-step aerosol spray pyrolysis(ASP) process and their potential application on smart textiles. The ASP process is advantageous in that it is easily implementable and can be applied for continuous processing. Moreover, this process has never been applied to deposit r-GO on pure cotton fabric. The field emission-scanning microscopy (FE-SEM) observation, Fourier transform-infrared(FT-IR) analysis, Raman spectroscopy, X-ray diffraction(XRD) analysis, and ultraviolet transmittance(UVT) were used to evaluate material properties of the r-GO colloids. The resistance was also measured to evaluate the electrical conductivity of the specimens. The results revealed that the r-GO was successfully deposed on specimens, and the specimen with the highest electrical conductivity demonstrated an electrical resistance value of 2.27 kΩ/sq. Taken together, the results revealed that the ASP method demonstrated a high potential for effective deposition of r-GO on cotton fabric specimens and is a prospect for the development of conductive cotton-based smart clothing. Therefore, this study is also meaningful in that the ASP process can be newly applied by depositing r-GO on the pure cotton fabric.

Mathematical modeling of concrete beams containing GO nanoparticles for vibration analysis and measuring their compressive strength using an experimental method

  • Kasiri, Reza;Massah, Saeed Reza
    • Advances in nano research
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    • v.12 no.1
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    • pp.73-79
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    • 2022
  • Due to the extensive use of concrete structures in various applications, the improvement of their strength and quality has become of great importance. A new way of achieving this purpose is to add different types of nanoparticles to concrete admixtures. In this work, a mathematical model has been employed to analyze the vibration of concrete beams reinforced by graphene oxide (GO) nanoparticles. To verify the accuracy of the presented model, an experimental study has been conducted to compare the compressive strengths of these beams. Since GO nanoparticles are not readily dissolved in water, before producing the concrete samples, the GO nanoparticles are dispersed in the mixture by using a shaker, magnetic striker, ultrasonic devices, and finally, by means of a mechanical mixer. The sinusoidal shear deformation beam theory (SSDBT) is employed to model the concrete beams. The Mori-Tanaka model is used to determine the effective properties of the structure, including the agglomeration influences. The motion equations are calculated by applying the energy method and Hamilton's principle. The vibration frequencies of the concrete beam samples are obtained by an analytical method. Three samples containing 0.02% GO nanoparticles are made and their compressive strengths are measured and compared. There is a good agreement between our results and those of the mathematical model and other papers, with a maximum difference of 1.29% between them. The aim of this work is to investigate the effects of nanoparticle volume fraction and agglomeration and the influences of beam length and thickness on the vibration frequency of concrete structures. The results show that by adding the GO nanoparticles, the vibration frequency of the beams is increased.

Henry James's The Turn of the Screw: The Subject and the Ontological Status of the Real Gaze

  • Kim, Kyung-Soon
    • Journal of English Language & Literature
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    • v.57 no.6
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    • pp.999-1016
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    • 2011
  • In The Turn of the Screw, the go'erness encounters with the apparitions that harrow her throughout the story: she sees a frightening male ghost that Mrs. Grose identifies as Peter Quint, deceased former 'alet of the children's uncle, who had pre'iously shared the charge of the children with the pre'ious go'erness, Miss Jessel. The appearance of the ghosts hails the go'erness and thereby forces her to be jarred out of the comfortable habits of indi'iduality and plunged into a negati'ity de'oid of the socio-normati'e directi'es and guarantees. Such an encounter shows the idea that consciousness is a plenum of existence e'ocati'e of human mind as a decentered pandemonium. For the go'erness in The Turn of the Screw, the foundation to force her to experience the uncanny, as an inconsistency in the symbolic order, is particular. Its particularity is absolute in the same way e'ery one of us dreams his or her world. It resists mediation and cannot be made part of a symbolic medium. Just as Lacan's conceptions of desire, feminine sexuality, 'Object a,' not-whole, sla'ery, mastery, self-deception, authenticity, and act of psychoanalysis help us understand our contradictory social reality, so does The Turn of the Screw help us make sense of the way the go'erness, as the being who is capable of raising the question of being, questions the idea of being. In conclusion, the particular way the go'erness dreams her world is e'ocati'e of an excessi'e being, an anatomical complement, and a particular experience, such as the go'erness's encounter with the ghosts testifies to a knowledge that escapes the knowledge of the speaking being.