• Title/Summary/Keyword: $pK_a$

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A Note on the Bias in the Multi-nomial Classification (다항분류상 편의에 관한 연구)

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    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.1 no.1
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    • pp.45-48
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    • 1978
  • If two inspectors classify items in a lot into m classes, it is possible that each of them makes wrong classification in some cases, thus causing bias. Expressions have been obtained for the limits of this bias in estimating the proportion of the different classes. From the results of the classification they obtained limit for the estimates of Proportions have been worked out, based on assumption regarding the magnitudes of probabilities of misclassification. Now we suppose that $P_{ti}{\;}(t=1.2)$ is the probability that t the inspector classifies correctly an item in class $A_i$ and $q_{tji}$ is the probability that he misclassifies in $A_j$ an item actually belonging to $A_i$, therefor, $P_{ti}+ \sum\limits_{j{\neq}i}q_{tji}=1$ An estimate for the proportion $P_k$ of the class $A_k$ in the lot would be $\hat{P}_k=r_{kk}+(\frac{1}{2})\sum\limits_{j{\neq}k}r_{kj}+r_{jk}$ The % Bias in proportion $\hat{P}_k$ is $\frac{E(\hat{P}_k)-P_k}{P_k}{\times}100$

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Synchronization and desynchronization in a biological neural network

  • Cancedda, Stefano;Corsini, Filippo;Marini, Massimiliano;Morabito, Federico;Stillo, Giuliano;Davide, Fabrizio
    • Proceedings of the IEEK Conference
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    • 2002.07c
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    • pp.1867-1870
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    • 2002
  • In the present paper, we will focus on the characterization of the biological network behaviour, in terms of synchronization and desynchronization of the measured signals by Micro Electrode array. We evaluate a easy calculable estimator that implies de/synchronization property of the biological neural network.

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Membership Management based on a Hierarchical Ring for Large Grid Environments

  • Gu, Tae-Wan;Hong, Seong-Jun;Uhmn, Saang-Yong;Lee, Kwang-Mo
    • Journal of Information Processing Systems
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    • v.3 no.1
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    • pp.8-15
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    • 2007
  • Grid environments provide the mechanism to share heterogeneous resources among nodes. Because of the similarity between grid environments and P2P networks, the structures of P2P networks can be adapted to enhance scalability and efficiency in deployment and to search for services. In this paper, we present a membership management based on a hierarchical ring which constructs P2P-like Grid environments. The proposed approach uses only a limited number of connections, reducing communication cost. Also, it only keeps local information for membership, which leads to a further reduction in management cost. This paper analyzes the performance of the approach by simulation and compares it with other approaches.

VARIOUS CENTROIDS OF POLYGONS AND SOME CHARACTERIZATIONS OF RHOMBI

  • Kim, Dong-Soo;Kim, Wonyong;Lee, Kwang Seuk;Yoon, Dae Won
    • Communications of the Korean Mathematical Society
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    • v.32 no.1
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    • pp.135-145
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    • 2017
  • For a polygon P, we consider the centroid $G_0$ of the vertices of P, the centroid $G_1$ of the edges of P and the centroid $G_2$ of the interior of P. When P is a triangle, (1) we always have $G_0=G_2$ and (2) P satisfies $G_1=G_2$ if and only if it is equilateral. For a quadrangle P, one of $G_0=G_2$ and $G_0=G_1$ implies that P is a parallelogram. In this paper, we investigate the relationships between centroids of quadrangles. As a result, we establish some characterizations for rhombi and show that among convex quadrangles whose two diagonals are perpendicular to each other, rhombi and kites are the only ones satisfying $G_1=G_2$. Furthermore, we completely classify such quadrangles.

Analysis of TP53 Polymorphisms in North Indian Sporadic Esophageal Cancer Patients

  • Kaur, Sukhpreet;Sambyal, Vasudha;Guleria, Kamlesh;Manjari, Mridu;Sudan, Meena;Uppal, Manjit Singh;Singh, Neeti Rajan;Singh, Gursimran;Singh, Harpreet
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8413-8422
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    • 2014
  • Background: To investigate the relationship of five TP53 polymorphisms (p.P47S, p.R72P, PIN3 ins16bp, p.R213R and r.13494g>a) with the esophageal cancer (EC) risk in North Indians. Materials and Methods: Genotyping of p.P47S, p.R72P, PIN3 ins16bp, p.R213R and r.13494g>a polymorphisms of TP53 in 136 sporadic EC patients and 136 controls using polymerase chain reaction and PCR-RFLP. Results: The frequencies of genotype RR, RP and PP of p.R72P polymorphism were 16.91 vs 26.47%, 58.82 vs 49.27% and 24.27 vs 24.27% among patients and controls respectively. We observed significantly increased frequency of RP genotype in cases as compared to controls (OR=1.87, 95% CI, 1.01-3.46, p=0.05). The frequencies of genotype A1A1, A1A2 and A2A2 of PIN3 ins16bp polymorphism were 69.12 vs 70.59%, 27.20 vs 25% and 3.68 vs 4.41% among patients and controls. There was no significant difference among genotype and allele distribution between patients and controls. The frequencies of genotype GG, GA and AA of r.13494g>a polymorphism were 62.50 vs 64.70%, 34.56 vs 30.15% and 2.94 vs 5.15% among patients and controls respectively. No significant difference between genotype and allele frequency was observed in the patients and controls. For p.P47S and p.R213R polymorphisms, all the cases and controls had homozygous wild type genotype. The RP-A1A1-GG genotype combination shows significant risk for EC (OR=2.01, 95%CI: 1.01-3.99, p=0.05). Conclusions: Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility.

Identification of Responsible Region for the Polymerization of Plasmid pEC-3 (Plamid pEC-3의 중합에 필요한 부위의 동정)

  • Jang, Sung-Key;Lee, Ha-Kyu;Rho, Hyune-Mo
    • Korean Journal of Microbiology
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    • v.22 no.3
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    • pp.183-189
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    • 1984
  • In order to find specific acting site of Rec A protein in plasmic polymerization in E. coli, we randomly deleted various part of pEC-3 (a derivative of pBR322) with SI nuclease treatment. Self-ligated plasmids were introduced into E. coli WA802(Rec $A^+$). A number of colonies were analyzed if they contained monomeric or polymeric plasmids by gel electrophoresis. The plasmid (pEC-43), which was deleted the region of tetracycline gene, revealed only monomeric form in Rec $A^+$ E. coli. When two plasmids, pEC-3 and pEC-43, were co-transformed in the same E. coli, the original pEC-3 showed polymerization but pEC-43 revealed monomeric form only. These results suggest that Rec A protein requires the specific site for polymerization.

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A WEAK SOLUTION OF A NONLINEAR BEAM EQUATION

  • Choi, Q.H.;Choi, K.P.;Jung, T.;Han, C.H.
    • Korean Journal of Mathematics
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    • v.4 no.1
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    • pp.51-64
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    • 1996
  • In this paper we investigate the existence of weak solutions of a nonlinear beam equation under Dirichlet boundary condition on the interval $-\frac{\pi}{2}<x<\frac{\pi}{2}$ and periodic condition on the variable $t$, $u_{tt}+u_{xxxx}=p(x,t,u)$. We show that if $p$ satisfies condition $(p_1)-(p_3)$, then the nonlinear beam equation possesses at least one weak solution.

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Characterization of Xanthomonas axonopodis pv. glycines plasmids

  • Park, Sejung;Kim, Jung-Gun;Ingyu Hwang
    • Proceedings of the Korean Society of Plant Pathology Conference
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    • 2003.10a
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    • pp.135.2-136
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    • 2003
  • To characterize plasmids in Xanthomonu axonopodis pv. glycines, we isolated plasmids pAG1 from the strain AG1 and pXAG81 and PXAG82 from the strain Bra, respectively, and sequenced three plasmids. The size of plasmids, pAG1, pXAG81, and pXAG82 was 15,149-base pairs (bp), 26,727-bp, and 1,496-bp, respectively Fifteen and twenty six possible open reading frames (ORFs) were present in pAG1 and pXAG81, respectively. Only one ORF homologous to a rep gene of Xylella fastidiosa was present in pXAG82. pAG1 contained genes homologous to avrBs3, tnpA, tnpR, repA, htrA, three parA genes, M.XmaI, R.XmaI, and six hypothetical proteins. pXAG81 contained genes homologous to avrBs3, tnpA, tnpR, repA, htrA, two parA genes, pemI, pemK, mobA, mobB, mobC, mobD, mobE, trwB, traF, traH, ISxac2, and eleven hypothetical proteins. Based on DNA sequence analysis, we presume that pXAG81 is a conjugal plasmid. Interestingly, we found 0.5-kb truncated avirulence gene similar to aurXacE3 on the right border of avrBs3 homolgs of pAG1 and pXAG81. Two hundred twenty five isolates were analyzed to find aurBS3 or tra gene homologs by Southern hybridization. The numbers of avrBs3 homolog varied from 3 in AG1 to 8 in AG166. Two hundred seventeen isolates appeared to can conjugative plasmids (pXAG81 type), and thirty eight isolates appeared to carry non-conjugative plamids (pAGl type). This indicated that aurBs3 gene homologs might be spread by conjugation in X. axonopodis pv. glycines.

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Molecular Analysis of Salmonella Enterotoxin Gene Expression

  • Lim, Sang-Yong;Seo, Ho-Seong;Yoon, Hyun-Jin;Choi, Sang-Ho;Heu, Sung-Gi;Ryu, Sang-Ryeol
    • Journal of Microbiology and Biotechnology
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    • v.13 no.4
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    • pp.598-606
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    • 2003
  • Salmonella encodes an enterotoxin (Stn) which possesses biological activity similar to the cholera toxin. Stn contributes significantly to the overall virulence of S. typhimurium in a murine model. The production of Stn is enhanced in a high-osmolarity medium and by contact with epithelial cells. In the present study, the in vitro and in vivo transcriptional regulations of the sin promoter revealed two promoters, P1 and P2. The P1 promoter identified by a primer extension analysis of stn mRNA exhibited a switching mechanism in vivo. Depending on the growth stage, transcription was initiated from different start sites termed $P1_S\;and\;P1_E$. $P1_S$, recognized by RNA polymerase containing ${\sigma}^S(E{\sigma}^S),\;and\;P1_E$, recognized by $E{\sigma}^70$, were activated during the stationary and exponential phases, respectively, while $P1_S\;and\;P1_E$ were both negatively regulated by CRPㆍcAMP and H-NS. Results revealed that $P1_S$ was the responsible promoter activated under a high osmolarity and low pH. The P2 promoter was identified 45 nucleotides downstream from $P1_E$ and negatively controlled by CRPㆍcAMP in vitro. No P2 activity was detected in vivo. The regulation of stn expression monitored using a Pstn::egfp fusion indicated that $E{\sigma}^S$ was required for the induction of stn and various factors were involved in stn regulation inside animal cells.

Carbon and Nitrogen Responses of Litterfall Components by NPK and PK Fertilizers in a Red Pine (Pinus densiflora S. et Z.) Stand

  • Park, Seong-Wan;Baek, Gyeongwon;Kim, Seongjun;Yang, A-Ram;Kim, Choonsig
    • Journal of Korean Society of Forest Science
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    • v.108 no.1
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    • pp.21-28
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    • 2019
  • This study was conducted to determine the carbon (C) and nitrogen (N) response of litterfall components as affected by N addition in compound fertilizer in a Korean red pine (Pinus densiflora S. et Z.) stand in southern Korea. Litterfall in a mature red pine stand was collected for two years following compound fertilizer application ($N_3P_4K_1$; $P_4K_1$) and no fertilization (control). The C concentration of litterfall components was not significantly (P > 0.05) different between the $N_3P_4K_1$ and the control plots, whereas the N concentration of the litterfall components was significantly higher in the $N_3P_4K_1$ plot than in the control plot. The $N_3P_4K_1$ and $P_4K_1$ additions induced a lower C/N ratio of litterfall components compared with the control plot. Annual C and N fluxes via litterfall components were not affected by the $N_3P_4K_1$ addition over the study period, except for reproduction litter. Annual N fluxes via reproduction litter were significantly higher in the $N_3P_4K_1$ plot than in the control plot. Thus, the $N_3P_4K_1$ and $P_4K_1$ additions could modify differently nutrient distribution of the forest floor and mineral soils in a red pine stand. These results indicate that N concentration and C/N ratio in litterfall components are more susceptible to fertilizer application than the C response in litterfall components.