• The Korean Journal of Physiology and Pharmacology
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• v.17 no.1
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• pp.51-56
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• 2013

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons. The purpose of this study was to examine which PKC isoforms are responsible for the PMA-induced augmentation of long-term potentiation (LTP) in the CA1 stratum radiatum of the hippocampus in vitro and verify that this facilitation requires NMDAR activation. We found that PMA enhanced the induction of LTP by a single episode of theta-burst stimulation in a concentration-dependent manner without affecting to magnitude of baseline field excitatory postsynaptic potentials. Facilitation of LTP by PMA (200 nM) was blocked by the nonspecific PKC inhibitor, Ro 31-8220 ($10{\mu}M$); the selective $PKC{\delta}$ inhibitor, rottlerin ($1{\mu}M$); and the $PKC{\varepsilon}$ inhibitor, TAT-${\varepsilon}V1$-2 peptide (500 nM). Moreover, the NMDAR blocker DL-APV ($50{\mu}M$) prevented enhancement of LTP by PMA. Our results suggest that PMA contributes to synaptic plasticity in the nervous system via activation of $PKC{\delta}$ and/or $PKC{\varepsilon}$, and confirm that NMDAR activity is required for this effect.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.6
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• pp.295-300
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• 2004

Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 $(50 {\mu}M)$, an NMDA receptor antagonist. Whereas bath application of 5-HT $(10 {\mu}M)$ inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine $(PCA,\;10{\mu}M)$, for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and $10 {\mu}M)$ suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.4 s.148
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• pp.422-430
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• 2006

The horn and movable parts around the gap of the conventional semi-spade rudder are visualized by high speed CCD camera with the frame rate of 4000 fps (frame per second) to study the unsteady cavity pattern on the rudder surface and gap. In addition, the pressure measurements are conducted on the rudder surface and inside the gap to find out the characteristics of the flow behavior. The rudder without propeller wake is tested at the range of $1.0{\leq}{\sigma}_v\;1.6$ and at the rudder deflection angle of $-8{\leq}{\theta}{\leq}10^{\circ}$. The time resolved cavity images are captured and show strong cavitation around the rudder gap in all deflection angles. As the deflection angle gets larger, the flow separated from the horn surface increases the strength of cavitation. The accelerated flow along the horn decreases its pressure and the separated flow from the horn increases the pressure abruptly. The pressure distribution inside the gap reveals the flow moving from the pressure to suction side. In the negative deflection angle, the turning area on the movable part initiates the flow separation and cavitation on it.

• Journal of Korean Society on Water Environment
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• v.23 no.5
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• pp.683-688
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• 2007

Water flow into unsaturated soils is most often modeled by Richards equation consisting of the mass conservation law and Darcy's law. Three standard forms of Richards equation are presented as the head (${\Psi}$)-based form, the moisture content (${\theta}$) based form, and the mixed form. Numerical solutions of these partial differential equations with highly nonlinear terms can cause poor results along with significant mass balance errors. The numerical solution based on the mixed form of Richards equation is known that the mass is perfectly conserved without any additional computational efforts. The aim of this study is to develop fully implicit numerical scheme of Richards equation for one-dimensional vertical unsaturated flow in homogeneous soils using the finite difference approximation, and then to perform sensitivity analysis of infiltration to the variations in the unsaturated soil properties and to different soil types.

• Journal of the Korean Magnetics Society
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• v.26 no.4
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• pp.129-132
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• 2016

The effect of thermal-nitrification on L1o transfomation in nano-sized FePt particles was studied. As-synthesized FePt nanoparticles by thermal decomposition method have fcc structured phase and their Hc and Ms were 247.34 Oe and 27.308 emu/g, respectively. According to the XRD analysis, phase transformation from fcc (face centered cubic) to fct (face centered tetragonal) structure was revealed by heating under $NH_3+H_2$ mixed-gas atmosphere. Also a slight shift of each (111) peak indicated phase transformation from fcc to fct structure. Hc and Ms of fct FePtN were 1058.2 Oe and 32.718 emu/g, respectively. The nano-sized FePtN magnetic particles synthesized by thermal decomposition method and mixed-gas nitrification are expected for advanced applications such as high density magnetic recording media and biomedical materials.

• Corrosion Science and Technology
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• v.14 no.6
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• pp.261-266
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• 2015

The capacity of passive metal to repassivate after film damage determines the development of local corrosion and the resistance to corrosion failures. In this work, the repassivation kinetics of 316L stainless steel (316L SS) was investigated in borate buffer solution (pH 9.1) using a novel abrading electrode technique. The repassivation kinetics was analyzed in terms of the current density flowing from freshly bare 316L SS surface as measured by a potentiostatic method. During the early phase of decay (t < 2 s), according to the Avrami kinetics-based film growth model, the transient current was separated into anodic dissolution ($i_{diss}$) and film formation ($i_{film}$) components and analyzed individually. The film reformation rate and thickness were compared according to applied potential. Anodic dissolution initially dominated the repassivation for a short time, and the amount of dissolution increased with increasing applied potential in the passive region. Film growth at higher potentials occurred more rapidly compared to at lower potentials. Increasing the applied potential from 0 $V_{SCE}$ to 0.8 $V_{SCE}$ resulted in a thicker passive film (0.12 to 0.52 nm). If the oxide monolayer covered the entire bare surface (${\theta}=1$), the electric field strength through the thin passive film reached $1.6{\times}10^7V/cm$.

• Journal of Korean Society of Steel Construction
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• v.21 no.4
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• pp.351-360
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• 2009

This study is a series of experimental investigations of the buckling strengths of eccentrically compressed, cold-formed, stainless-steel, circular, hollow-section beam columns. The principal parameters that were used in this study were the slenderness ratios (Lk/r = 30, 50, 70) and the magnitude of eccentricity e(one way: 0, 25, 50, 75, and 100mm: the other way: 0, 12.5, 25, 37.5, and 50mm) on the asymmetrical end-moment of a double curvature. The objectives of the study were to obtain the maximum loads through an experiment and to compare the experimental behaviors with the analysis results. The ultimate buckling strength of the square section members were evaluated using a numerical method, in accordance with the bending moment-axial force(M-P) interaction curves. The behavior of each specimen was displayed in the form of the strength-displacement and moment-angle(M-$\theta$) relationship.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.3
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• pp.527-532
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• 2020

In this paper, we presented the results of analysis through EEG measurement for the purpose of checking the frequency band of EEG signals that can be used for personal authentication. The measurement status was divided into the open-eye state and the closed-eye state depending on the presence or absence of an optical task. The data measured in the EEG experiments was divided into seven frequency bands : delta waves, theta waves, alpha waves, SMR waves, mid-beta waves, beta waves and gamma waves to identify the frequency band with the smallest power fluctuation over time. In our results, there was no significant difference between the open-eye state and the closed-eye state, and the SMR waves and mid-beta waves related to human concentration had the smallest fluctuation in power over time, and were a highly reproducible frequency band.

• Journal of Environmental Science International
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• v.15 no.4
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• pp.333-340
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• 2006

A (5 wt.%)Mn-(1 wt.%)$V_{2}O_{5}/TiO_{2}$ catalyst were prepared by co-precipitation method and used for low-temperature selective catalytic reduction (SCR) of $NO_x$ with ammonia in the presence of oxygen. The properties of the catalysts were studied by X-ray diffraction (XRD), temperature programmed reduction (TPR) and scanning electron microscope-energy dispersive X-ray spectroscopy (SEM-EDS). The experimental results showed that (5 wt.%)Mn-(1 wt.%)$V_{2}O_{5}/TiO_{2}$ catalyst yielded 81% NO conversion at temperature as low as $150^{\circ}C$ and a space velocity of $2,400\;h^{-1}$. Crystalline phase of $Mn_{2}O_3$ was present at ${\ge}\;15%$ Mn on $V_{2}O_{5}/TiO_{2}$. XRD confirmed the presence of manganese oxide ($Mn_{2}O_{3}$) at $2{\theta}=32.978^{\circ}(222)$. The XRD patterns presented of (5 wt.%)Mn-(1 wt.%)$V_{2}O_{5}/TiO_{2}$ did not show intense or sharp peaks for manganese oxides and vanadia oxides. The TPR profiles of (5 wt.%)Mn-(1 wt.%)$V_{2}O_{5}/TiO_{2}$ catalyst showed main reduction peat of a maximum at $595^{\circ}C$.

• Journal of Aquaculture
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• v.18 no.3
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• pp.180-188
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• 2005

The separation performances for thirty different dimensions of a low-pressure hydrocyclone (LPH) were tested in order to obtain an optimum dimension scale for fecal solid removal from an aquaculture system. The geometric variables were considered on two inlet diameters (Di: 30 and 50 mm), five overflow diameters (Do: 30, 50, 60, 70 and 100 mm), and three cylinder lengths (Lc: 250, 345 and 442 mm), while the cylinder diameter (Dc) of 335 mm, underflow diameter (Du) of 50 mm and cone angle (${\theta}$) of $68^{\circ}$ were kept constant. A small size for carp feces was regarded as the target for the removal of solids. Spherical polystyrene particles (1.1-1.3 mm dia., ${\rho}_s=1.05g/cm^3$), which demonstrate a similar settling velocity and specific gravity to the carp feces, were used as feed. The separation performance was tested in the range of 330 to 1200 ml/s of the inflow rate. Experimental results using ANCOVA and the Tukey test (${\alpha}=0.05$) demonstrated that the separation performances of LPH were significantly affected (P<0.05) by fi, Di and Do. In contrast, there was no significant Lc effect (P>0.05) on the separation performances. The maximum separation performance was detected at dimension combinations of 30 mm of inflow diameter (Di), 50, 60 and 70 mm of overflow diameter (Do), 345 mm of cylinder length (Lc). The dimension proportions were 0.09, 1.03, 0.15-0.21 and 0.15 (or Di/Dc, Lc/Dc, Do/Dc and Du/Dc, respectively.