• Molecules and Cells
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• v.24 no.1
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• pp.105-112
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• 2007

Most neuroblastoma cells have chromosomal aberrations such as gains, losses, amplifications and deletions of DNA. Conventional approaches like fluorescence in situ hybridization (FISH) or metaphase comparative genomic hybridization (CGH) can detect chromosomal aberrations, but their resolution is low. In this study we used array-based comparative genomic hybridization to identify the chromosomal aberrations in human neuroblastoma SH-SY5Y cells. The DNA microarray consisting of 4000 bacterial artificial chromosome (BAC) clones was able to detect chromosomal regions with aberrations. The SH-SY5Y cells showed chromosomal gains in 1q12~ q44 (Chr1:142188905-246084832), 7 (over the whole chro-mosome), 2p25.3~p16.3 (Chr2:18179-47899074), and 17q 21.32~q25.3 (Chr17:42153031-78607159), while chromosomal losses detected were the distal deletion of 1p36.33 (Chr1:552910-563807), 14q21.1~q21.3 (Chr14:37666271-47282550), and 22q13.1~q13.2 (Chr22:36885764-4190 7123). Except for the gain in 17q21 and the loss in 1p36, the other regions of gain or loss in SH-SY5Y cells were newly identified.

• Journal of the Korean Mathematical Society
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• v.59 no.2
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• pp.235-254
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• 2022

Let ℍⁿ be the Heisenberg group and Q = 2n + 2 be its homogeneous dimension. Let 𝓛 = -∆_ℍⁿ + V be the Schrödinger operator on ℍⁿ, where ∆_ℍⁿ is the sub-Laplacian and the nonnegative potential V belongs to the reverse Hölder class $B_{q_1}$ for q₁ ≥ Q/2. Let H^p_𝓛(ℍⁿ) be the Hardy space associated with the Schrödinger operator 𝓛 for Q/(Q+𝛿₀) < p ≤ 1, where 𝛿₀ = min{1, 2 - Q/q₁}. In this paper, we consider the Hardy type estimates for the operator T_𝛼 = V^𝛼(-∆_ℍⁿ + V )^-𝛼, and the commutator [b, T_𝛼], where 0 < 𝛼 < Q/2. We prove that T_𝛼 is bounded from H^p_𝓛(ℍⁿ) into L^p(ℍⁿ). Suppose that b ∈ BMO^𝜃_𝓛(ℍⁿ), which is larger than BMO(ℍⁿ). We show that the commutator [b, T_𝛼] is bounded from H¹_𝓛(ℍⁿ) into weak L¹(ℍⁿ).

• Journal of KSNVE
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• v.8 no.5
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• pp.964-973
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• 1998

In this paper we propose a levitation and imbalance compensation controller design methodology of magnetic bearing system. In order to achieve levitation and elimination of unbalance vibartion in some operation speed we use the discrete-time Q-parameterization control. When rotor speed p = 0 there are no rotor unbalance, with frequency equals to the rotational speed. So in order to make levitatiom we choose the Q-parameterization controller free parameter Q such that the controller has poles on the unit circle at z = 1. However, when rotor speed p $\neq$ 0 there exist sinusoidal disturbance forces, with frequency equals to the rotational speed. So in order to achieve asymptotic rejection of these disturbance forces, the Q-parameterization controller free parameter Q is chosen such that the controller has poles on the unit circle at z = $exp^{ipTs}$ for a certain speed of rotation p ( $T_s$ is the sampling period). First, we introduce the experimental setup employed in this research. Second, we give a mathematical model for the magnetic bearing in difference equation form. Third, we explain the proposed discrete-time Q-parameterization controller design methodology. The controller free parameter Q is assumed to be a proper stable transfer function. Fourth, we show that the controller free parameter which satisfies the design objectives can be obtained by simply solving a set of linear equations rather than solving a complicated optimization problem. Finally, several simulation and experimental results are obtained to evaluate the proposed controller. The results obtained show the effectiveness of the proposed controller in eliminating the unbalance vibrations at the design speed of rotation.

• Nonlinear Functional Analysis and Applications
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• v.26 no.2
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• pp.381-392
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• 2021

During the last several decades, a great variety of fractional kinetic equations involving diverse special functions have been broadly and usefully employed in describing and solving several important problems of physics and astrophysics. In this paper, we aim to find solutions of a type of fractional kinetic equations associated with the (p, q)-extended 𝜏 -hypergeometric function and the (p, q)-extended 𝜏 -confluent hypergeometric function, by mainly using the Laplace transform. It is noted that the main employed techniques for this chosen type of fractional kinetic equations are Laplace transform, Sumudu transform, Laplace and Sumudu transforms, Laplace and Fourier transforms, P_𝛘-transform, and an alternative method.

• Korean Journal of Poultry Science
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• v.43 no.1
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• pp.47-54
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• 2016

The aim of this study was to investigate the expression patterns of key genes involved in lipid metabolism in response to dietary Coenzyme Q10 (CoQ10) in hens. A total of 36 forty week-old Lohmann Brown were randomly allocated into 3 groups consisting of 4 replicates of 3 birds. Laying hens were subjected to one of following treatments: Control (BD, basal diet), T1 (BD+ CoQ10 100 mg/kg diet) and T2 (BD+ micellar of CoQ10 100 mg/kg diet). Birds were fed ad libitum a basal diet or the basal diet supplemented with CoQ10 for 5 weeks. Total RNA was extracted from the liver for quantitative RT-PCR. The mRNA levels of HMG-CoA reductase(HMGCR) and sterol regulatory element-binding proteins(SREBP)2 were decreased more than 30~50% in the liver of birds fed a basal diet supplemented with CoQ10 (p<0.05). These findings suggest that dietary CoQ10 can reduce cholesterol levels by the suppression of the hepatic HMGCR and SREBP2 genes. The gene expressions of liver X receptor (LXR) and SREBP1 were down regulated due to the addition of CoQ10 to the feed (p<0.05). The homeostasis of cholesterol can be regulated by LXR and SREBP1 in cholesterol-low-conditions. The supplement of CoQ10 caused a decreased expression of lipid metabolism-related genes including $PPAR{\gamma}$, XBP1, FASN, and GLUTs in the liver of birds (p<0.05). These data suggest that CoQ10 might be used as a dietary supplement to reduce cholesterol levels and to regulate lipid homeostasis in laying hens.

• Journal of Nutrition and Health
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• v.38 no.7
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• pp.570-577
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• 2005

The purpose of this study was to investigate the effect of bone mineral density on life styles, dietary habits and nutrient intakes among the male college students. The subjects were divided into four groups; $Q_1$ (calcaneus BMD < 25 percentile, n = 117), $Q_2$ (25 percentile $\le$ calcaneus BMD < 50 percentile, n = 118), $Q_3$ (50 percentile $\le$ calcaneus BMD < 75 percentile, n = 118) $Q_4$ (calcaneus BMD $\ge$ 75 percentile, n = 116). And they were asked about general characteristics, life style, dietary habit, and nutrient intake using questionnaire and 24-hr recall method. They were measured the bone mineral density of calcaneus using quantitative ultrasound. The average age of the subjects of the study was 23.0 yews and the average height, weight, and BMI were 174.7 cm, 69.0 kg, $22.5 kg/m^2$. The bone mineral density in calcaneus was $0.43 g/cm^2$ in $Q_1,\;0.50 g/cm^2$ in $Q_2,\;0.56 g/cm^2$ in $Q_3$, and $0.69 g/cm^2$ in $Q_4$ (p < 0.001). The results showed that $Q_1$ tended to have irregular exercise compared to the other three groups. Compared with $Q_1$ and $Q_2$, the frequency of skipping breakfast was lower in $Q_3$ and $Q_4$. Also the results showed that the $Q_4$ was significantly more often to drink coffee compared with the other three groups (p < 0.01). The mean daily energy intake was 2210.6 kcal ($88.4\%$ of RDA). The intake of energy, vitamin $B_2$, calcium, and zinc did not meet the Korean RDA. Also the $Q_2$consumed significantly lower intakes of protein (p < 0.05) and plant protein (p < 0.05) compared to the $Q_3$ and $Q_4$. The $Q_1$ and $Q_2$ consumed significantly lower intakes of vitamin $B_2$ (p < 0.01) compared to the $Q_3$ and $Q_4$. In conclusion, male student in lower bone mineral density appeared to have unhealthy life styles and dietary habits in terms of irregular exercise, high frequency of skipping breakfast and lower intakes of protein, vitamin $B_2$ showing a strong need proper education on meal practices and exercise habits for the bone health.

• Communications of the Korean Mathematical Society
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• v.13 no.4
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• pp.735-741
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• 1998

In this paper we will derive some new properties of q-extensions of p-adic gamma functions and p-adic Euler constants.

• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.277-283
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• 2010

CoQ with low melting temperature was exploited to improve its solubility by preparing its solid dispersions (SDs) with a meltable polymer, poloxamer 407 (P 407). P407 can be utilized for a relatively simple, quick, inexpensive, reproducible and potentially scalable manner in the low temperature melting method. CoQ 10 solubility and dissolution increased with increasing concentrations of P 407 in SDs. Comparison of the enhanced dissolution of CoQ 10 from different poloxamers suggested that the preparation of CoQ 10 SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its dissolution.

• Journal of the Korean Mathematical Society
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• v.8 no.1
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• pp.25-30
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• 1971

Put ($$^*$$) $$G[x,y]={\sum}\limits^{p+q=n}_{p,q=0}[-n]_{p+q}c_{p,q}x^py^q$$, where $[{\lambda}]_m$ is the Pocbhammer symbol and the $c_{p,q}$ are arbitrary constants. Making use of the specialized forms of some of his earlier results (see [8] and [9] the author derives here bilateral generating functions of the type ($$^{**}$$) $${\sum}\limits^{\infty}_{n=0}{\frac{[\lambda]_n}{n!}}_2F_1[\array{{\rho}-n,\;{\alpha};\\{\lambda}+{\rho};}x]\;G[y,z]t^n$$ where ${\alpha}$, ${\rho}$ and ${\lambda}$ are arbitrary complex numbers. In particular, it is shown that when G[y, z] is a double hypergeometric polynomial, the right-band member of ($^{**}$) belongs to a class of general triple hypergeometric functions introduced by the author [7]. An interesting special case of ($^{**}$) when ${\rho}=-m,\;m$ being a nonnegative integer, yields a class of bilateral generating functions for the Jacobi polynomials $\{P_n{^{{\alpha},{\beta}}}(x)\}$ in the form ($$^{***}$$) $${\sum\limits^{\infty}_{n=0}}\(\array{m+n\\n}\)P{^{({\alpha}-n,{\beta}-n)}_{m+n}(x)\;G[y,z]{\frac{t^n}{n!}}$$, which provides a unification of several known results. Further extensions of ($^{**}$) and ($^{***}$) with G[y, z] replaced by an analogous multiple sum $H\[y_1,{\cdots},y_m\]$ are also discussed.

• Bulletin of the Korean Mathematical Society
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• v.55 no.5
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• pp.1441-1462
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• 2018

In this paper, we investigate the fractional p&q-Kirchhoff type system $$\{M_1([u]^p_{s,p})(-{\Delta})^s_pu+V_1(x){\mid}u{\mid}^{p-2}u\\{\hfill{10}}={\ell}k^{-1}F_u(x,\;u,\;v)+{\lambda}{\alpha}(x){\mid}u{\mid}^{m-2}u,\;x{\in}{\Omega}\\M_2([u]^q_{s,q})(-{\Delta})^s_qv+V_2(x){\mid}v{\mid}^{q-2}v\\{\hfill{10}}={\ell}k^{-1}F_v(x,u,v)+{\mu}{\alpha}(x){\mid}v{\mid}^{m-2}v,\;x{\in}{\Omega},\\u=v=0,\;x{\in}{\partial}{\Omega},$$ where ${\Omega}{\subset}{\mathbb{R}}^N$ is an unbounded domain with smooth boundary ${\partial}{\Omega}$, and $0<s<1<p{\leq}q$ and sq < N, ${\lambda},{\mu}>0$, $1<m{\leq}k<p^*_s$, ${\ell}{\in}R$, while $[u]^t_{s,t}$ denotes the Gagliardo semi-norm given in (1.2) below. $V_1(x)$, $V_2(x)$, $a(x):{\mathbb{R}}^N{\rightarrow}(0,\;{\infty})$ are three positive weights, $M_1$, $M_2$ are continuous and positive functions in ${\mathbb{R}}^+$. Using variational methods, we prove existence of infinitely many high-energy solutions for the above system.