• Preventive Nutrition and Food Science
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• 제21권1호
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• pp.38-43
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• 2016

Matrix metalloproteinases (MMPs) are crucial extracellular matrices degrading enzymes that take important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. Natural products are on the rise for their potential to provide remarkable health benefits. In this context, halophytes have been of interest in the nutraceutical field with reported instances of isolation of bioactive compounds. In this study, Limonium tetragonum, an edible halophyte, was studied for its ability to inhibit MMP-2 and -9 using HT1080 fibrosarcoma cells. Results showed that L. tetragonum extract was able to inhibit the enzymatic activity and mRNA expression of MMP-2 and -9 according to gelatin zymography and RT-PCR assays, respectively, but it was not able to significantly change the MMP pathway related factors such as tissue inhibitors of metalloproteinases. Also, Mitogen-activated protein kinases pathway-related protein levels and their phosphorylation were assayed. While the phosphorylated p38 levels were decreased, extracellular signal-regulated kinase and c-Jun N-terminal kinase were not affected by L. tetragonum treatment. In conclusion, it was suggested that L. tetragonum contains substances acting as MMP inhibitors on enzymatic activity rather than intracellular pathway intervention, which could be useful for further utilization of L. tetragonum as a source for anti-MMP agents.

• 웰빙융합연구
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• 제5권4호
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• pp.51-56
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• 2022

Purpose: By applying an ultrasonic mechanical device to the liquid fertilizer storage in the pig dropping treatment plant, the initial odor of the odor source is reduced, and the air dilution drainage of the complex odor is fundamentally recognized to facilitate odor treatment on the mechanical and chemical biological treatment devices at the rear. Research design, data and methodology: The odor concentration on the site boundary was measured to confirm the state of reduction. In order to prevent the spread of odor from the collection of the pig dropping treatment plant, it was measured by installing an ultrasonic generator inside the installation wall after installing the sealing wall. Results: The average value of the March and April measurement data remained close to neutral at 8.2 after 8.6 treatment before pH treatment, decreased 97.3% from 462 mg/L before SS treatment to 10.5 mg/L after treatment, and the composite odor was reduced by 85% from 20 to 3 before treatment. It was confirmed that ammonia (NH3) was reduced by 99% from 5.8 ppm to 0.09 ppm, and general bacteria were also reduced by 99% from 3,200 CFU/mL to 57 CFU/mL Conclusion: Applying the ultrasonic air ejector hybrid system and zigzag air complex module development product to resource circulation centers or sewage treatment facilities is thought to reduce inconvenience to residents due to odors caused.

• International journal of advanced smart convergence
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• 제4권1호
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• pp.93-98
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• 2015

Recently, Radon has been gotten attention for problems of Nuclear Generating Station and a variety of nuclear. It is naturally arises that is accumulated in the interior through the soil with radioactive materials. People exposed to indoor a Radon increase the high risks of lung cancer. The data are consisted of regional Country, The Location, Average Radon pCi/L, Geo Mean and Geo S.D etc. The research is experimented using E-M algorithm. The research result appears to make a division of soil distance, regional and cluster. It requires in effort to minimize exposure to people who live in areas with high radon levels. A country must apprise to people about Radon risk and needs to work out measures plan.

• Journal of information and communication convergence engineering
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• 제9권5호
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• pp.583-586
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• 2011

In this paper, subthreshold swing characteristics have been presented for double-gate MOSFETs, using the analytical model based on series form of potential distribution. Subthreshold swing is very important factor for digital devices because of determination of ON and OFF. In general, subthreshold swings have to be under 100mV/dec. The channel length $L_g$ is varied from 30nm to 100nm, and channel thickness $t_{si}$ from 15 to 20nm according to channel length, and oxide thickness 5nm to investigate subthreshold swing. The doping of channel is fixed with $10^{16}cm^{-3}$ p-type. The results show good agreement with numerical simulations, confirming this model.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제11권1호
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• pp.13-30
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• 2007

In this paper we study the numerical solutions of the stochastic functional differential equations of the following form $$du(x,\;t)\;=\;f(x,\;t,\;u_t)dt\;+\;g(x,\;t,\;u_t)dB(t),\;t\;>\;0$$ with initial data $u(x,\;0)\;=\;u_0(x)\;=\;{\xi}\;{\in}\;L^p_{F_0}\;([-{\tau},0];\;R^n)$. Here $x\;{\in}\;R^n$, ($R^n$ is the ${\nu}\;-\;dimenional$ Euclidean space), $f\;:\;C([-{\tau},\;0];\;R^n)\;{\times}\;R^{{\nu}+1}\;{\rightarrow}\;R^n,\;g\;:\;C([-{\tau},\;0];\;R^n)\;{\times}\;R^{{\nu}+1}\;{\rightarrow}\;R^{n{\times}m},\;u(x,\;t)\;{\in}\;R^n$ for each $t,\;u_t\;=\;u(x,\;t\;+\;{\theta})\;:\;-{\tau}\;{\leq}\;{\theta}\;{\leq}\;0\;{\in}\;C([-{\tau},\;0];\;R^n)$, and B(t) is an m-dimensional Brownian motion.

• Journal of information and communication convergence engineering
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• 제8권6호
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• pp.635-639
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• 2010

A multi-resonance antenna for wireless communications is reported. By using double inverted-L strips, the antenna demonstrated compact size (15 mm ${\times}$ 14 mm) including the ground, multi-band operation for IEEE 802.11 a/b/g/p applications, and wide bandwidth of 1.7 GHz at 5 GHz band. Good radiation features of omni-directional patterns and 1.98 and 2.29 dBi peak antenna gains for the lower and upper bands, respectively, have been achieved.

• Interaction and multiscale mechanics
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• 제1권2호
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• pp.211-230
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• 2008

Owing to the growing size of the eigenvalue problem and the growing number of eigenvalues desired, solution methods of iterative nature are becoming more popular than ever, which however suffer from low efficiency and lack of proper convergence criteria. In this paper, three efficient iterative eigenvalue algorithms are considered, i.e., subspace iteration method, iterative Ritz vector method and iterative Lanczos method based on the cell sparse fast solver and loop-unrolling. They are examined under the mode error criterion, i.e., the ratio of the out-of-balance nodal forces and the maximum elastic nodal point forces. Averagely speaking, the iterative Ritz vector method is the most efficient one among the three. Based on the mode error convergence criteria, the eigenvalue solvers are shown to be more stable than those based on eigenvalues only. Compared with ANSYS's subspace iteration and block Lanczos approaches, the subspace iteration presented here appears to be more efficient, while the Lanczos approach has roughly equal efficiency. The methods proposed are robust and efficient. Large size tests show that the improvement in terms of CPU time and storage is tremendous. Also reported is an aggressive shifting technique for the subspace iteration method, based on the mode error convergence criteria. A backward technique is introduced when the shift is not located in the right region. The efficiency of such a technique was demonstrated in the numerical tests.

• 한국버섯학회지
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• 제13권1호
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• pp.16-20
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• 2015

큰느타리 (Pleurotus eryngii), 표고 (Lentinula edodes ), 노루궁뎅이 (Hericium erinaceus ) 버섯 수확 후 배지 (spent mushroom substrate, SMS) 물 추출액(SMSE)의 고추생장촉진과 고추역병균 억제효과를 조사하였다. 큰느타리버섯, 표고버섯 및 노루궁뎅이버섯 SMSE는 유묘생장시에 잎폭, 잎장, 초장, 절간, 절수 등에서 대조구에 비하여 모두 11~41%로 평균 20% 이상의 높은 생육효과가 있었으며 잎수에서는 거의 1.5배 높게 나타났다. 노루궁뎅이 SMSE혼합 PDA배지는 고추역병균사 성장을 거의 99-100% 억제하였다. 큰느타리, 표고버섯 및 노루궁뎅이 SMSE는 고추역병에 대하여 각각 25%, 65% 75%이상의 방제효과를 보였다.

• 한국해양생명과학회지
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• 제8권2호
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• pp.104-114
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• 2023

플라스틱은 전세계적으로 사용량이 증가함에 따라 해양 환경으로 유입되는 플라스틱 쓰레기의 양도 꾸준히 증가하고 있으며, 미세플라스틱은 해양 생물에 의해 섭취되어 소화관에 축적됨에 따라 성장과 생식에 유해한 영향을 미친다. Cytochrome P450 (CYP)는 환경 오염물질을 대사하는 해독효소로 알려져 있으나 지각류에서는 그 기능에 대해서는 잘 알려져 있지 않다. 본 연구에서는 기수산 물벼룩 Diaphanosoma celebensis에서 clan 2, 3, 4에 각각 속하는 CYP 유전자 9종(clan 2: CYP370A4, CYP370C5; clan 3: CYP350A1, CYP350C5, CYP361A1; clan 4: CYP4AN-like, CYP4AP2, CYP4AP3, CYP4C33-like1)의 서열에 대해 진화적으로 보존된 서열의 유사도를 분석하고 계통분석을 실시하였다. 또한 3종류의 서로 다른 크기의 polystyrene beads (0.05-, 0.5-, 6-㎛ PS beads; 0.1, 1, and 10 mg/L)에 48시간 노출된 기수산 물벼룩에서 이들 9종의 CYP 유전자의 발현을 real time reverse transcription polymerase chain reaction (RT-PCR)로 분석하였다. 결과적으로 기수산 물벼룩 CYP 유전자는 모두 진화적으로 보존된 motif를 가지고 있으며 계통분석 결과 각각 clan 2, 3, 4에 속하는 것으로 확인되었다. 이는 기능적으로 보존되어 있음을 의미한다. CYP 유전자 중 clan 2에 속하는 CYP370C5와 clan 3에 속하는 CYP360A1, 그리고 clan 4에서는 CYP4C122 유전자의 발현이 0.05-㎛ PS beads에 노출되었을 때 유의하게 증가하는 양상을 보였으며, 이는 이들 유전자가 PS 대사에 관여한다는 것을 의미한다. 본 연구는 미세플라스틱이 해양 무척추 동물에 미치는 생물 영향을 분자적 수준에서 이해하는데 도움이 될 것이다.

• International journal of advanced smart convergence
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• 제11권4호
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• pp.227-239
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• 2022

Purpose: In our study, in order to find lactic acid bacteria (LAB) with multi-drug resistance to antibiotics, we isolated 140 strains from 15 types of kimchi commercially available in Korea and 20 types of Kimchi made at home from January to December in 2016, and investigated their H₂O₂ generating ability and multi-drug resistance to antibiotics. Methods: In order to observe the H₂O₂ generation ability of LAB, we performed the experiment with methods such as Rabe, Hillier, and Kang. To test the antibacterial susceptibility of LAB, we used the disc agar diffusion method using MRS agar (Difco, USA) according to the CLSI and WHO test methods. There are 18 types of antibiotic discs used. Results: Out of the total numbers of 140 strains, 6 strains of Ent. Faecium, 25 strains of L. plantarum, 1 strain of L. rhamnosus, 3 strains of L. sakei, 1 strain of L. acidophilus, 1 strains St. thermophilus, and 7 of unidentified strains generated H₂O₂. The antibiotic susceptibility of Ent. Faecium indicated SXT, OX, NA, and E; and the antibiotic susceptibility of L. plantarum indicated NA; and the antibiotic susceptibility of St. thermophilus indicated NA, CC, RA, CTT, CM, and P ; and the antibiotic susceptibility of L. rhamnosus indicated SXT, VA, NA and CTT; and the antibiotic susceptibility of 6 strains of L. sakei indicated SXT, OX, NOR, NA, CTT and CIP, all indicating antibiotic resistance. In the case of multi-drug resistance to antibiotics for 53 strains of L. antarum, 8-drug resistance was the most common with 25 strains, followed by 7-drug-resistant strains with 18 strains, 9-drug-resistant strains with 4 strains, 6-drug-resistant strains with 3 strains, 5-drug-resistant strains with 2 strains, and 17-drug-resistant strains with 1 strain. In the case of multi-drug resistance to antibiotics for Ent. Faecium 27 strains, 9-drug resistance was most commonly identified as 9 strains, 8-drug resistance was identified as 6 strains, 7- and 11 drug resistances were identified as 4 strains each, and 4- and 6-drug resistances were identified as 1 strain each. Conclusion: Ent. Faecium, L. plantarum, L. rhamnosus, L. sakei, and St. thermophilus, shown to have anantibacterial activity in previous studies on LAB and shown to have and H₂O₂ generating ability, antibiotic resistance and multi-drug resistance in this study, are expected to be able to play an excellent role for long-term inpatients to use as an alternative to antibiotics and to cope with emerging antibiotic resistance.