• Biomolecules & Therapeutics
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• 제9권4호
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• pp.285-290
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• 2001

Bioequivalence of two acetyl-1-carnitine tablets, test product (Carnitile tablet: Hanmi Pharm. Co., Ltd.) and reference product (Nicetil $e^{R}$ tablet: Dong-A Pharm. Co., Ltd.), was evaluated according to the guide- lines of Korea Food and Drug Administration (KFDA). Twenty-six healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 500 mg as acetyl-1-carnitine in a 2$\times$2 crossover study. Blood samples were taken at predetermined time intervals for 12 hours and the plasma concentration of acetyl-1-carnitine was determined using HPLC by derivatization with p-bromophenacyl bromide. The pearmacokinetic parameters (AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$) were calculated and ANOVA was utilized for the statistical analysis of parameters. The apparent differences of these parameters between two drugs were less than 20% (i.e., 1.26,-5.08 and 8.59% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The powers (1-$\beta$) for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, and Tmax were over 0.9. Minimal detectable difference ($\Delta$) at $\alpha$=0.05, 1-$\beta$=0.8 were less than 20% (i.e.,7.31, 14.88 and 11.77% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The confidence intervals ($\delta$) for these parameters were also within $\pm$ 20% (i.e.,-3.03$\leq$$\delta$$\leq$5.54, -13.80$\leq$$\delta$$\leq$3.64 and 1.69$\leq$$\delta$$\leq$15.48 for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating Carnitile bioequivalent to Nicetil $e^{R}$ .TEX>$^{R}$ .> R/ . R/ .

• Applied Biological Chemistry
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• 제42권2호
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• pp.134-139
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• 1999

새로운 식용 적색색소자원을 개발하기 위하여 버찌의 anthocyanin색소를 ethanol 추출하여 광선, 온도, 유기산, 금속이온 및 pH에 의한 영향을 검토하였다. 본 색소는 광선에 안정하여 20일 까지도 69%의 색소잔존율을 나타내었고 광선 차단용 포장재를 사용 시 상당한 색소잔존효과를 나타내었다. 본 색소는 열에 대단히 안정하여 $115^{\circ}C$에서 30분까지 64%의 색소잔존율을 나타내었다. $25^{\circ}C$의 암소조건에서 첨가된 유기산에 의해서는 색소의 농색화효과가 높게 나타났으며, $25^{\circ}C$의 암소조건에서 첨가된 금속이온에 의해서는 $Na^+,\;K^+,\;Mg^{2+},\;Ca^{2+}$ 및 $Mn^{2+}$에 의해서는 20일까지 안정하였고, $Cu^{2+}$와 $Fe^{3+}$에 의해서는 심각한 안정성 저해를 나타냈으며, $Al^{3+}$에 의해서는 자색으로 전환되었다. pH가 낮을수록 색소의 농색화효과가 높았다. 이로 미루어 본 색소는 대단히 우수한 식용 적색색소자원임을 알 수 있었다.

• 한국정보통신학회논문지
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• 제21권4호
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• pp.679-687
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• 2017

본 논문에서는 DGS (Defected Ground Structure)를 적용한 WLAN/WiMAX 시스템에 적용 가능한 모노폴 안테나를 제안하였다. 제안된 안테나는 마이크로스트립 급전을 바탕으로 두 개의 선로와 DGS를 갖도록 구성하여 삼중대역 특성을 갖도록 설계하였다. 두 개의 선로 그리고 세 개의 슬릿의 위치 및 길이와 DGS 위치와 길이를 적절한 조정하여 본 논문에서 요구되는 특성을 얻기 위한 최적화 수치를 얻었다. 제안된 안테나는 $34mm(W_1){\times}34mm(L_1){\times}1.6mm(t)$의 비유전율 4.4인 FR-4 유전체 기판 위에 $17.0mm(W_6){\times}30.75mm(L_3+L_4+L_9)$의 크기로 제작되었다. 제작 및 측정결과로부터 -10 dB 임피던스 대역폭을 기준으로 360 MHz (2.335~2.695 GHz), 645 MHz (3.37~4.015 GHz) 그리고 1,770 MHz (5.14~6.91 GHz)의 대역폭을 얻었다. 또한 제안된 안테나는 요구되는 삼중대역에서 측정된 이득과 방사패턴의 얻었다.

• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1470-1474
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• 2012

The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A $C_{18}$ column was used for separation at a column temperature of $25^{\circ}C$. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration ($C_{max}$) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The $C_{max}$ of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including $T_{max}$, $C_{max}$, AUC, $T_{1/2}$, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds.

• Journal of Nutrition and Health
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• 제35권2호
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• pp.223-228
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• 2002

The purpose of this study was to investigate the relationship between iron deficiency without anemia and physical performance in healthy women aged 20-21 yrs. Ten subjects with normal iron stores (serum ferritin $\geq$ 12$\mu\textrm{g}$/L: iron-sufficient group) and 11 subjects with iron depletion without anemia (serum ferritin < 12 $\mu\textrm{g}$/L and serum hemoglobin > 120 g/L: iron-depleted group) were chosen from a group of 50 women and were given physical-performance tests, including determinations of maximum oxygen consumption (VO$_2$ max) and ventilatory threshold. Iron status assessment included determination of hemoglobin, hematocrit, seam ferritin, total iron-binding rapacity, serum iron and transferrin saturation values. Dietary iron intake was assessed based on seven-day food intake records written by the subjects. Physical activity level was estimated by frequency questionnaires and two-week physical activity records were compiled daily by the subjects. Blood ferritin concentration was significantly lower in the iron-depleted group than in the iron-sufficient group (p < 0.05). However, other variables showing iron status was not different between the groups. There were no significant differences in body size, body composition and physical activity levels between the groups. Daily dietary iron, total protein and animal protein intakes of the iron-sufficient group were significantly higher than those of the iron depleted group. However, no differences were found in the amount of dietary vitamin C and fiber between the groups. The values for VO$_2$max and VO$_2$max corrected with weight or fat-free mass were not different between the groups. However, the ventilatory threshold was significantly higher in the iron sufficient group than in the iron-depleted group. The lower ventilatory threshold in the iron-depleted group suggests that iron depletion without anemia could diminish aerobic physical performance in young women. In addition, a significant correlation of physical performance to serum fferritin level was shown only in the iron depleted group.

• 한국물환경학회지
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• 제24권5호
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• pp.550-555
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• 2008

This study was conducted to assess the growth characteristics of phytoplankton and to understand seasonal dynamics of phytoplankton in response to limiting nutrients in an agricultural reservoir from November 2002 to December 2003. Marked increase of chl.a concentration observed in July ($99.0{\mu}g/L$) and November ($109.7{\mu}g/L$) after heavy rainfall. TP concentration ranged $48.0{\sim}126.6{\mu}g/L$, and its the temporal variation was similar to that of chl.a concentration. Microcystis spp., dominant phytoplankton species were used for the growth kinetics experiment, except for the season when Aulacoseira spp. (March, April) and Aphanocapsa sp. (May) dominated. In the temperature range between $10{\sim}25^{\circ}C$, the rate of growth increase per $10^{\circ}C$ was almost two folds. The highest maximum growth rate (${\mu}_{max}=1.09day^{-1}$) of phytoplankton observed September, and ${\mu}_{max}$ was lowest ($0.34day^{-1}$) in March when Aulacoseira spp. dominated. The ${\mu}_{max}$ ($0.78{\pm}0.20day^{-1}$) was relatively high in the summer season when water temperature is above $20^{\circ}C$ and cyanobacteria dominated compared to the spring when diatoms dominated ($0.43{\pm}0.08day^{-1}$). The maximum growth rate ($0.55{\pm}0.12day^{-1}$) and the half saturation concentration ($K_s=0.73{\pm}0.15{\mu}M$) of cyanobacteria during winter season (November, December) was higher than those of diatoms. However, the ${\mu}_{max}$ and $K_s$ of cyanobacteria in December was similar to those of diatom, reflecting that diatom cell quota (Mean 48.4 pgP/cell) was greater than cyanobacteria (34.0 pgP/cell) during this time.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제12권3호
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• pp.161-169
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• 2008

We investigate the existence of solutions u(x, t) for perturbations of the elliptic system with Dirichlet boundary condition $$\array {L{\xi}+{\mu}g({\xi}+2{\eta})=f\;in\;{\Omega}}\\{L{\eta}+{\nu}g({\xi}+2{\eta})=f\;in\;{\Omega}}$$ (0.1) where $g(u)=Bu^+-Au^-$, $u^+=max\{u,\;0\}$, $u^-=max\{-u,\;0\}$, ${\mu}$, ${\nu}$ are nonzero constants and the nonlinearity $({\mu}+2{\nu})g(u)$ crosses the eigenvalues of the elliptic operator L.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.127-127
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• 2018

Probiotics are microorganisms that have beneficial effects on the health of the host. The health promoting effect by probiotics influences suppressing harmful bacteria, prevention of constipation, blood cholesterol reduction and regulation of blood pressure. Prebiotics are used to promote the growth or activity of microorganisms. Synbiotics, which are a mixture of probiotics and prebiotics, synergize in the intestines by complementing each other. Synbiotics not only improves the viability of the probiotics while passing through the gastrointestinal tract, maintain intestinal homeostasis, but also regulate balance of harmful and useful bacterial growth. Glycine max Merr (GMM) has been widely used in Asian countries to treat cancer, obesity, oxidative stress and imbalanced immune diseases. In addition, it has been reported that dietary fiber-rich grains promote bowel movements and prevent constipation. In this study, we investigated the viability of LactobacillIus buchneri (L.buchneri) strains, known as lactic acid bacteria under conditions of gastric fluid and intestinal fluid to determine the suitability of L.buchneri as probiotics. The adhesion ability of L.buchneri to caco-2 cells was also confirmed. The present studies showed that GMM extract promoted the growth and activity of L.buchneri strains as prebiotics. Also, this results suggested that the mixture of L.buchneri and GMM extract can helps maintain intestinal health and healthy body as synbiotics and health functional food material.

• 한국식품영양과학회지
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• 제38권6호
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• pp.750-756
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• 2009

기능성 소재로서의 버찌분말의 이용가능성을 알아보기 위해 버찌분말을 0, 3, 5, 7 및 10% 첨가한 머핀을 제조하여 품질특성을 조사하였다. 머핀의 물성은 버찌분말의 첨가에 따라 경도(hardness)는 증가하였고 검성(gumminess) 및 씹힘성(chewiness)은 감소하였다. 색도는 첨가량이 증가할수록 빵껍질(crust)과 빵속(crumb)에서 명도와 황색도가 감소하고 적색도는 증가하였다. 또한 버찌 분말의 농도가 증가함에 따라 항산화 활성이 증가하였다. 관능검사 결과 버찌분말첨가 머핀에서 색, 향, 맛, 부드러움, 촉촉함, 전체적인 기호도면에서 무첨가구에 비해 전반적으로 높게 평가되었으며, 전체적인 기호도는 5% 첨가구에서 가장 높은 점수를 나타내었다. 이러한 결과로 볼 때 머핀의 품질 및 관능 특성, 기능성을 고려한 버찌분말 첨가량은 5% 첨가구가 최적 조건일것으로 판단되었다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2001년도 춘계 학술대회지
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• pp.266-267
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• 2001