DOI QR코드

DOI QR Code

Metabolic Pharmacokinetics in Rats: Differences between Pure Amygdalin and Amygdalin in a Decoction of Peach Seeds

  • Received : 2011.09.26
  • Accepted : 2012.01.31
  • Published : 2012.05.20

Abstract

The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A $C_{18}$ column was used for separation at a column temperature of $25^{\circ}C$. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration ($C_{max}$) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The $C_{max}$ of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including $T_{max}$, $C_{max}$, AUC, $T_{1/2}$, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds.

Keywords

References

  1. The Pharmacopoeia of the People's Republic of China; Part 1. The Pharmacopoeia Commission of PRC: 2010; p 260.
  2. Liu, Q. Z. Chin. Pat. Med. Res. 1987, 8, 47.
  3. Xu, H. Y.; Yun, C. X.; Wang, Y. X. J. Qiqihar Med. 2004, 5, 487.
  4. Rui, H. K. Chin. Pat. Med. 1992, 14, 33.
  5. Sun, W. K. Hunan Med. J. 1993, 9, 47.
  6. Fang, M. F.; Fu, Z. L.; Wang, Q. L.; Wang, S. X.; Xiao, C. N.; Zhang, X. H. Chin. J. Chin. Mater. Med. 2010, 35, 2684.
  7. Wang, Y. L.; Li, H. B.; Hu, Y. Q. Chin. Pharm. 2002, 5, 550.
  8. Lian, Y. J.; Chen, D. D.; Xu, T. W.; Zheng, Y. B.; Huang, T.; Ke, M. L. Chin. J. Bas. Clin. Gen. Sur. 2005, 12, 138.
  9. Zhuo,Y. Z.; Zhao, L. G.; Liu, J. H. Tianjin J. Trad. Chin. Med. 2009, 26, 500.
  10. Strugala, G. J.; Stahl, R.; Elsenhans, B. Hum. Exp. Toxicol. 1995, 14, 895. https://doi.org/10.1177/096032719501401107
  11. Deng, Y.; Guo, Z. G.; Zeng, Z. L.; Wang, Z. Chin. J. Chin. Mater. Med. 2002, 27, 565.
  12. Rauws, A. G.; Gramberg, L. G.; Olling, M. Phar. Weekbl. Sci. Edi. 1982, 4, 172. https://doi.org/10.1007/BF01959135
  13. Ge, B. Y.; Chen, H. X.; Han, F. M.; Chen, Y. J. Chromatogr. B 2007, 857, 281. https://doi.org/10.1016/j.jchromb.2007.07.036
  14. Koo, J. Y.; Hwang, E. Y.; Cho, S. J. Chromatigr. B 2005, 814, 69. https://doi.org/10.1016/j.jchromb.2004.10.019
  15. Wu, H.; Zhu, Z. Y.; Zhang, G. Q.; Zhao, L.; Zhang, H.; Zhu, D. L. J. Ethnopharmacol. 2009, 125, 444. https://doi.org/10.1016/j.jep.2009.07.019
  16. Huang, X.; Wen, A. D.; Zang, Y. M. Chin. J. Int. Trad. Med. 1994, 14, 288.
  17. Hou, Y. C.; Hsiu, S. L.; Ching, H.; Lin, Y. T.; Tsai, S. Y.; Wen, K. C. Life Sci. 2005, 76, 1167. https://doi.org/10.1016/j.lfs.2004.10.020

Cited by

  1. Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers vol.6, pp.None, 2012, https://doi.org/10.1038/srep31364
  2. Acute health risks related to the presence of cyanogenic glycosides in raw apricot kernels and products derived from raw apricot kernels vol.14, pp.4, 2012, https://doi.org/10.2903/j.efsa.2016.4424
  3. Toxicity and Toxicokinetics of Amygdalin in Maesil (Prunus mume) Syrup: Protective Effect of Maesil against Amygdalin Toxicity vol.66, pp.43, 2012, https://doi.org/10.1021/acs.jafc.8b03686