• Current Research on Agriculture and Life Sciences
• /
• 제4권
• /
• pp.119-123
• /
• 1986

본(本) 연구(硏究)는 마우스의 이유시체중(離乳時體重) 및 60일령(日齡) 체중(體重)에 대한 유전자(遺傳子) 효과(效果)를 구명하기 위하여, BALB/c, CBA, C3H 및 C57BL의 4 계통(系統)을 양면교잡(兩面交雜)시켜 생산(生産)된 후대(後代) 343마리를 대상으로 조사(調査) 분석(分析)한 것이다. 공시(供試)된 마우스는 1984년(年) 11월(月)부터 1985년(年) 2월(月)까지 경북대학교(慶北大學校) 농과대학(農科大學) 부속동물사육장(附屬動物飼育場)에서 사육(飼育)되었으며, Harvey의 방법(方法)에 의하여 일반결합능력(一般結合能力), 모체효과(母體效果), 특수결합능력(特殊結合能力) 및 상반교잡(相反交雜) 효과(效果) 등(等)이 분석(分析)되었다. 일반결합능력(一般結合能力) 효과(效果)는 이유시체중(離乳時體重)에서 -0.6033~0.5298 그리고 60일령(日齡) 체중(體重)에서 -0.5086~1.0012로 추정(推定)되었으며, 두 형질(形質)에 대한 일반결합능력(一般結合能力) 효과(效果)는 BALB/c와 C57BL이 CBA와 C3H보다 우수하였다(P<0.05). 모체효과(母體效果)는 C3H가 BALB/c보다 크게 나타났다(P<0.05). 모체효과(母體效果)는 이유시체중(離乳時體重)에서 -0.9678~0.4609 그리고 60일령(日齡) 체중(體重)에서 -1.1886~0.7029로 추정(推定)되었다. 특수결합능력(特殊結合能力) 효과(效果)도 유의성(有意性)이 인정(認定)되었는데(P<0.05), 그 효과(效果) 추정치(推定値)는 이유시체중(離乳時體重)에서 -0.1999~0.3380 그리고 60일령(日齡) 체중(體重)에서 -0.4056~0.3317 이었다. 상반교잡(相反交雜) 효과(效果)는 BALB/c${\times}$C57BL 및 BALB/c${\times}$C3H에서 크게 나타났는데 이유시체중(離乳時體重)에 있어서 효과(效果) 추정치(推定値)는 각각(各各) -0.5049 및 0.4972 그리고 60일령(日齡) 체중(體重)에 있어서 효과(效果) 추정치(推定値)는 각각(各各) -1.0336 및 1.2793이었다.

• Archives of Pharmacal Research
• /
• 제12권2호
• /
• pp.88-93
• /
• 1989

In order to obtain some informations about the effect of molecular weight on the release rate of drug from drug carrier, two types of poly-L-glutamic acid (PLGA)-cytarabine (ara-C) conjugates, PLGA-ara-C:I and PLGA-ara-C:II, were synthesized using two types of PLGA having different average molecular weight, 43,000 and 77,800, respectively. The PLGA-ara-C conjugates were synthesized by mixed anhydride method and found to be covalently linked. Both types of conjugates charged negatively at biological pH. The pH-dependent release rate of ara-C was observed in both cases, and the release rate was accelerated in basic, acidic conditions (the k values were 0.015 $day^{-1}$ at pH 7.0, 0.024 $day^{-1}$ at pH 5.0, and 0.059 $day^{-1}$ at pH 9.0 in the case of PLGA-ara-C:I) and in the presence of pretense. The time required for the release of 16.5% of ara-C from PLGA-ara-C:I were 8 hr and 144 hr in the presence and absence of protease, respectively. Although both types of conjugates showed similar drug substitution ratio, they showed different release rates. Between the two types of conjugates, PLGA-ara-C:II showed the faster release rate (0.030 vs 0.042 $day^{-1}$ in pH 7.4 phosphate buffer solution at $37^{\circ}C$) and the smaller activation energy for the release of drug (12.5 vs 7.7 Kcal/mol) than PLGA-ara-C:I. The characteristic effect of molecular weight on the release rates of PLGA-ara-C conjugates suggests that the drug release rate might be effectively controlled over a prolonged period of time by the combined use of the different types of PLGA-ara-C conjugates having different molecular weights.

• 대한수학회논문집
• /
• 제27권3호
• /
• pp.557-564
• /
• 2012

This study concerns the existence of positive solution for the following nonlinear system $$\{-div(|x|^{-ap}|{\nabla}u|^{p-2}{\nabla}u)=|x|^{-(a+1)p+c_1}({\alpha}_1f(v)+{\beta}_1h(u)),x{\in}{\Omega},\\-div(|x|^{-bq}|{\nabla}v|q^{-2}{\nabla}v)=|x|^{-(b+1)q+c_2}({\alpha}_2g(u)+{\beta}_2k(v)),x{\in}{\Omega},\\u=v=0,x{\in}{\partial}{\Omega}$$, where ${\Omega}$ is a bounded smooth domain of $\mathbb{R}^N$ with $0{\in}{\Omega}$, 1 < $p,q$ < N, $0{{\leq}}a<\frac{N-p}{p}$, $0{{\leq}}b<\frac{N-q}{q}$ and $c_1$, $c_2$, ${\alpha}_1$, ${\alpha}_2$, ${\beta}_1$, ${\beta}_2$ are positive parameters. Here $f,g,h,k$ : $[0,{\infty}){\rightarrow}[0,{\infty})$ are nondecresing continuous functions and $$\lim_{s{\rightarrow}{\infty}}\frac{f(Ag(s)^{\frac{1}{q-1}})}{s^{p-1}}=0$$ for every A > 0. We discuss the existence of positive solution when $f,g,h$ and $k$ satisfy certain additional conditions. We use the method of sub-super solutions to establish our results.

• Asian-Australasian Journal of Animal Sciences
• /
• 제19권8호
• /
• pp.1206-1211
• /
• 2006

The effects of taurine supplementation on growth performance, serum and liver concentrations of lipid, fatty acid composition and lipid peroxidation in the livers of broilers under chronic heat exposure conditions were investigated. The chicks with a similar body weight were equally assigned to one of three controlled-environment chambers. The brolier chicks, which were kept at $34^{\circ}C$ were fed either with a control diet or the control diet supplemented with 0.8% taurine, whereas broiler chicks kept at $22^{\circ}C$ were fed a control diet. Both of the BW and BW gains of broilers maintained at a temperature of $34^{\circ}C$ were significantly lower than those of the control group, which was maintained at a temperature of $22^{\circ}C$ (p<0.05). However, taurine addition in the diet of birds submitted to heat stress siginficantly improved BW gain (p<0.05). The feed intake of chicks declined with increases in temperature. The relative liver and gall bladder weights of chicks fed the control diet and maintained at $34^{\circ}C$ were significantly lower than those measured in the control birds (p<0.05). However, dietary taurine was found to compensate for these reductions in liver and gall bladder weights. Relative weights of abdominal fat did not differ significantly among the three groups. Serum triglyceride concentrations were significantly lower in the chicks fed the control diet and maintained at $34^{\circ}C$ compare to those measured in the chicks fed the control diet at $22^{\circ}C$ (p<0.05). Heat stress resulted in a significant reduction in total lipid and triglyceride levels, but also increased the levels of total cholesterol in the liver (p<0.05). However, dietary taurine supplementation under the heat stress condition resulted in the recovery, to control levels, of serum triglyceride concentrations, as well as the amounts of total lipids, triglycerides, and cholesterol in the liver. The livers of chicks fed on taurine diets at $34^{\circ}C$ showed significantly higher proportions of C14:0, C16:1, C18:1, C18:2, and 20:3, and lower C18:0 and C20:4 proportions than those of chicks fed on control diets at the same temperature (p<0.05). The total levels of saturated fatty acids decreased, but monounsaturated fatty acids and unsaturated fatty acid levels increased in chicks fed the taurine diet, as compared to chicks fed the control diet at $34^{\circ}C$ (p<0.05). Peroxidizability indices were significantly lower in the heat-exposed chicks fed the taurine diet than in the non-taurine heat-exposed groups (p<0.05). In conclusion, dietary taurine results in an increase in the growth performances of chicks under heat stress conditions via improvements in lipid absorption and metabolism, as well as an induced reduction in lipid peroxidation.

• Biomolecules & Therapeutics
• /
• 제2권1호
• /
• pp.54-58
• /
• 1994

BALB/C mice were intraperitoneally injected with methamphetamine (5 mg/kg) to observe the effect of methamphetamine on the immune system. Body weights were decreased in both acutely treated group (twice for 2 weeks with 7 days interval) and subchronically treated group (daily injection for 14 days). The relative spleen weights and the numbers of splenocytes were unexpectedly increased (p<0.05) in acutely treated group, but subchronically treated group showed the trend of decrease without significance. But there was no significant effect on antibody formation to hen egg Iysozyme which was immunized during the treatment of methamphetamine and on plaque forming cell number. The relative thymus weights of both groups were significantly decreased by the treatment of methamphetamine (acutely treated group, p<0.05; subchronically treated group, p<0.01). These results suggest that the effect of methamphetamine on the immune system may be caused by thymic dysfunction.

• Journal of applied mathematics & informatics
• /
• 제35권1_2호
• /
• pp.121-130
• /
• 2017

This study is concerned with the existence of positive solution for the following nonlinear elliptic system $$\{-M_1(\int_{\Omega}{\mid}x{\mid}^{-ap}{\mid}{\nabla}u{\mid}^pdx)div({\mid}x{\mid}^{-ap}{\mid}{\nabla}u{\mid}^{p-2}{\nabla}u)\\{\hfill{120}}={\mid}x{\mid}^{-(a+1)p+c_1}\({\alpha}_1A_1(x)f(v)+{\beta}_1B_1(x)h(u)\),\;x{\in}{\Omega},\\-M_2(\int_{\Omega}{\mid}x{\mid}^{-bq}{\mid}{\nabla}v{\mid}^qdx)div({\mid}x{\mid}^{-bq}{\mid}{\nabla}v{\mid}^{q-2}{\nabla}v)\\{\hfill{120}}={\mid}x{\mid}^{-(b+1)q+c_2}\({\alpha}_2A_2(x)g(u)+{\beta}_2B_2(x)k(v)\),\;x{\in}{\Omega},\\{u=v=0,\;x{\in}{\partial}{\Omega},$$ where ${\Omega}$ is a bounded smooth domain of ${\mathbb{R}}^N$ with $0{\in}{\Omega}$, 1 < p, q < N, $0{\leq}a$ < $\frac{N-p}{p}$, $0{\leq}b$ < $\frac{N-q}{q}$ and ${\alpha}_i,{\beta}_i,c_i$ are positive parameters. Here $M_i,A_i,B_i,f,g,h,k$ are continuous functions and we discuss the existence of positive solution when they satisfy certain additional conditions. Our approach is based on the sub and super solutions method.

• 한국가금학회지
• /
• 제22권1호
• /
• pp.1-6
• /
• 1995

A total of 514 birds were used to investigate the influence of body weight and shank length at hatch on the body weights at various ages in growing pheasant. Statistical model included the terms of hatch and sex as fixed effects and the two covariates of body weight and shank length at hatch. In this model, the effects of hatch and sex on the body weights at the age of 4, 8, 12, 16 and 20 wk, and the average daily gains from hatch to 8 wk and from 8 to 16 wk of age were highly significant(P<0.01). All the regression coefficients of body weights and average daily gains on the body weight at hatch were also significant(P<0.01). Their estimates were 3.05.7.21. 13.89, 15.18 and 15.33 for the body weights at 4. 8, 12, 16 and 20 wk of age ; 0.111 and 0.142 for the average daily gains from hatch to 8 wk, and from 8 to 16 wk of age, respectively. On the shank length, only the regression coefficients of the body weights at 4 and 8 wk of age and the average daily gains from hatch to 8 wk of age were significant(P<0.01). Results of this study suggest that body weight at hatch do significantly affect the body weights in the growing periods up to' the 20 wk of age, but the shank length at hatch influences the body weights only at early age.1)

• 한국컴퓨터정보학회논문지
• /
• 제10권2호
• /
• pp.113-121
• /
• 2005

본 논문에서는 근전도 패턴인식을 수행하기 위한 혼합 LVQ 학습 알고리즘을 설계하였다. 제안된 혼합 LVQ 학습 알고리즘은 초기 참조벡터의 학습을 위해 SOM을 이용하고, LVQ 출력뉴런의 부류지정을 위하여 out-star학습법을 사용하는 변형된 C.p Net.이다. 제안된 C.p. Net.의 입력 층과 종속 클래스 층 사이의 연결강도는 SOM과 LVQ 알고리즘을 이용하여 초기 참조벡터의 설정 및 학습이 가능하게 하였고, 패턴벡터를 종속 클래스 층의 뉴런에 의해 종속 클래스로 분류하고, C.p. Net.의 종속 클래스 층과 클래스 층 사이의 연결강도는 분류된 종속 글래스를 클래스로 지정하는 학습을 하게 된다 근전도 패턴 분류를 위하여 제안된 학습알고리즘을 이용하여 시뮬레이션 되었고 기존의 LVQ 학습방식 보다 우수한 분류성공률을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제28권1호
• /
• pp.95-101
• /
• 2015

Fermented Chlorella vulgaris was examined for its effects on growth performance, cecal microflora, tibia bone strength, and meat qualities in commercial Pekin ducks. A total of three hundred, day-old male Pekin ducks were divided into three groups with five replicates (n = 20 ducklings per replicate) and offered diets supplemented with commercial fermented C. vulgaris (CBT$^{(R)}$) at the level of 0, 1,000 or 2,000 mg/kg, respectively for 6 wks. The final body weight was linearly (p = 0.001) increased as the addition of fermented C. vulgaris into diets increased. Similarly, dietary C. vulgaris linearly increased body weight gain (p = 0.001) and feed intake (p = 0.001) especially at the later days of the feeding trial. However, there was no C. vulgaris effect on feed efficiency. Relative weights of liver were significantly lowered by dietary fermented C. vulgaris (linear effect at p = 0.044). Dietary fermented C. vulgaris did not affect total microbes, lactic acid bacteria, and coliforms in cecal contents. Finally, meat quality parameters such as meat color (i.e., yellowness), shear force, pH, or water holding capacity were altered by adding fermented C. vulgaris into the diet. In our knowledge, this is the first report to show that dietary fermented C. vulgaris enhanced meat qualities of duck meats. In conclusion, our study indicates that dietary fermented C. vulgaris exerted benefits on productivity and can be employed as a novel, nutrition-based strategy to produce value-added duck meats.

• Asian-Australasian Journal of Animal Sciences
• /
• 제16권10호
• /
• pp.1510-1517
• /
• 2003

Two experiments were carried out to evaluate the effects of brewery waste (BW) replacement of concentrate (C) in growing duck diets. In Exp. 1, which was carried out on-station, 300 ducklings were allocated in a $2{\times}5$ factorial experiment: Two breeds (local Muscovy and crosses of French and local Muscovy)${\times}5$ levels of C and with BW offered ad libitum. Concentrate only ad libitum as the control diet (C100), and levels of 75% (C75), 50% (C50), 25% (C25) and 0% (C0) of the amount of the control diet consumed, and with BW ad libitum. In Exp. 2, 200 ducklings were allocated in a $2{\times}2$ factorial experiment on five smallholdings: two breeds (local and crossbred Muscovy ducks)${\times}2$ diets (the C100 and C50 diets from Exp.1). In Exp.1 total dry matter (DM), BW, crude fiber (CF) and crude protein (CP) intakes were highest on the C0 diet and ME and lysine intakes lowest (p<0.001). Daily live weight gains were higher for the crossbred ducks than for the local Muscovies (p<0.05) and were highest for treatments C100 and C50, and lowest for treatment C0 (p<0.05). Weights of breast muscle, liver and abdominal fat were significantly higher for the crossbred ducks. Breast and thigh muscle and abdominal fat weights were significantly higher for the C100, C75 and C50 diets, while gizzard weights were highest for the C25 and C0 treatments. Net profits were higher for the crosses, and for treatments C50 and C25. In Exp. 2 total DM, CF and CP intakes were significantly higher for the C50 diet, and ME intakes lower (p<0.001). Daily gains of the crosses were significantly higher than those of the local Muscovy ducks, and were similar for the C100 and C50 diets. The highest net profits were from the crosses and ducks fed the C50 diet. It was concluded that BW can replace 50% of the concentrate in growing Muscovy duck diets without reducing daily live weight gains and with improved economic benefits.