• 한국공작기계학회논문집
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• 제13권5호
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• pp.110-117
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• 2004

In automatic welding process using a robot, seam tracking is one of the important parts. Sensor for seam tracking is divided broadly into two categories as non contact sensor and contact sensor. The arc sensor is one of the non contact sensors, and it can be applied in weaving arc and rotating arc welding process. In such the arc sensors, rotating arc sensor can be applied to high speed welding over tens of Hz. The decrease of self regulation by high rotating speed causes to improve accuracy and response of sensor. In this study, fuzzy controller was used to track the seam for the $CO_2$ arc welding which had unstable arc. It could be shown that the rotating arc sensor was better than the weaving arc sensor.

• 열처리공학회지
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• 제21권2호
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• pp.101-110
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• 2008

• Asian-Australasian Journal of Animal Sciences
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• 제33권3호
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• pp.398-407
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• 2020

Objective: The Yip1 domain family (YIPF) proteins were proposed to function in endoplasmic reticulum (ER) to Golgi transport and maintenance of the morphology of the Golgi, which were homologues of yeast Yip1p and Yif1p. YIPF3, the member 3 of YIPF family was a homolog of Yif1p. The aim of present study was to investigate the expression and regulation mechanism of porcine YIPF3. Methods: Quantitative realtime polymerase chain reaction (qPCR) was used to analyze porcine YIPF3 mRNA expression pattern in different tissues and pig kidney epithelial (PK15) cells stimulated by polyinosine-polycytidylic acid (poly [I:C]). Site-directed mutations combined with dual luciferase reporter assays and electrophoretic mobility shift assay (EMSA) were employed to reveal transcription regulation mechanism of porcine YIPF3. Results: Results showed that the mRNA of porcine YIPF3 (pYIPF3) was widely expressed with the highest levels in lymph and lung followed by spleen and liver, while weak in heart and skeletal muscle. Subcellular localization results indicated that it expressed in Golgi apparatus and plasma membranes. Upon stimulation with poly (I:C), the level of this gene was dramatically up-regulated in a time- and concentration-dependent manner. pYIPF3 core promoter region harbored three cis-acting elements which were bound by ETS proto-oncogene 2 (ETS2), zinc finger and BTB domain containing 4 (ZBTB4), and zinc finger and BTB domain containing 14 (ZBTB14), respectively. In which, ETS2 and ZBTB4 both promoted pYIPF3 transcription activity while ZBTB14 inhibited it, and these three transcription factors all played important regulation roles in tumorigenesis and apoptosis. Conclusion: The pYIPF3 mRNA expression was regulated by ETS2, ZBTB4, and ZBTB14, and its higher expression in immune organs might contribute to enhancing ER to Golgi transport of proteins, thus adapting to the immune response.

• 대한의생명과학회지
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• 제28권3호
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• pp.192-194
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• 2022

The trophic factor Neuregulin-1 (NRG-1) plays a critical role in the development of the peripheral nervous system and the repair of nerve injuries. The regulation of neutrophil apoptosis by cytokine secretion from structural cells is an important process in inflammatory diseases, including asthma. This study aimed to investigate the relationship between NRG-1 and the alteration of neutrophil apoptosis by the regulation of cytokine release in the human lung epithelial BEAS-2B cells. Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) induce the increase in the release of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1 (MCP-1). NRG-1 alone had no effect on the secretion of IL-6, IL-8, and MCP-1. However, co-treatment of TNF-α and IFN-γ with NRG-1 inhibited the secretion of IL-6, IL-8, and MCP-1 that had been increased by TNF-α and IFN-γ. Treatment with NRG-1 did not have a direct effect on neutrophil apoptosis. Co-treatment of TNF-α and IFN-γ with NRG-1 was not effective on suppression of neutrophil apoptosis due to TNF-α and IFN-γ. The supernatant of BEAS-2B cells after co-treatment of TNF-α and IFN-γ with NRG-1 suppressed the inhibition of neutrophil apoptosis that had been caused due to the supernatant treated with TNF-α and IFN-γ. Taken together, NRG-1 has an anti-inflammatory effect in an inflammatory milieu by the regulation of cytokine secretion and neutrophil apoptosis.

• 자원ㆍ환경경제연구
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• 제18권3호
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• pp.523-544
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• 2009

본 연구는 목적은 내생적 환경정책모형(endogenous environmental policy)에 기초하여 외국인직접투자(foreign direct investment), 경제성장, 환경규제의 상호관계를 실증적으로 분석하는 것이다. 외국인자본비율의 1% 증가는 0.044%(고정효과), 0.047%(확률효과)의 경제성장효과를 유발하였으며, 노동자 1인당 생산량의 1% 증가는 2.038%(고정효과), 1.890%(확률효과)의 환경규제강화를 유도하는 것으로 계측되었다. 그러나 생산 과정에 있어 강력한 환경규제가 기술혁신의 유인으로 작용한다는 포터의 가설(Porter's theory)을 지지할 만한 실증결과는 보여주지 못하였다. 또한 2개의 대기오염물질 (NOx, $CO_2$)을 기준으로 규모효과(0.0119, 0.0172)가 기술효과(-0.0048, -0.0007)보다 크게 추정되었다. 이는 국제사회의 꾸준한 노력에도 불구하고 더욱 적극적인 환경보호를 위해 각국의 공공지출액을 증액시킬 필요성이 있음을 의미한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4607-4611
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• 2012

Objective: Endometrial cancer (EC) is the most common gynecologic malignancy. Identification of potential biomarkers of EC would be helpful for the detection and monitoring of malignancy, improving clinical outcomes. Methods: The Weighted Gene Co-expression Network Analysis method was used to identify prognostic markers for EC in this study. Moreover, underlying molecular mechanisms were characterized by KEGG pathway enrichment and transcriptional regulation analyses. Results: Seven gene co-expression modules were obtained, but only the turquoise module was positively related with EC stage. Among the genes in the turquoise module, COL5A2 (collagen, type V, alpha 2) could be regulated by PBX (pre-B-cell leukemia homeobox 1)1/2 and HOXB1(homeobox B1) transcription factors to be involved in the focal adhesion pathway; CENP-E (centromere protein E, 312kDa) by E2F4 (E2F transcription factor 4, p107/p130-binding); MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived [avian]) by PAX5 (paired box 5); and BCL-2 (B-cell CLL/lymphoma 2) and IGFBP-6 (insulin-like growth factor binding protein 6) by GLI1. They were predicted to be associated with EC progression via Hedgehog signaling and other cancer related-pathways. Conclusions: These data on transcriptional regulation may provide a better understanding of molecular mechanisms and clues to potential therapeutic targets in the treatment of EC.

• 생명과학회지
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• 제20권7호
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• pp.991-998
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• 2010

저산소상태(hypoxia)는 세포유형 및 성장조건에 따라 apoptosis를 유발하거나 또는 apoptosis의 진행을 억제한다. 저산소상태 유발물질인 cobalt chloride ($CoCl_2$) 역시 여러 세포 유형에서 apoptosis를 유발한다고 알려져 있으나 그 기작은 불명확하다. 본 연구에서는 PC-3 세포에서 $CoCl_2$에 의해 down-regulation되는 puromycin-sensitive aminopeptidase (PSA)의 세포 내 기능을 조사하였다. 본 연구 결과, PC-3 세포에 puromycin을 처리한 결과 전체 세포 집단의 약 42%에서 apoptosis가 유도되었다. PSA가 apoptosis에 관여하는지를 확인하고자 PSA siRNA로 내재성 PSA의 발현을 억제시킨 다음 apoptosis 연관 특성을 조사한 결과 PSA의 발현 억제에 의해 효과적으로 apoptosis가 유도되었다. 이러한 결과는 PC-3 세포에서 PSA가 세포생존에 중요한 역할을 할 것임을 보여주는 것이라 사료된다.

• 자원ㆍ환경경제연구
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• 제22권2호
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• pp.329-365
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• 2013

본 연구의 목적은 2000-2009년 국가별로 환경과 화석에너지의 제약 하에서 경제와 환경의 효율을 측정하고자 함이다. 본 연구는 국가별 소득수준에 따른 OECD국가, 중고소득국가, 저소득국가 등 세 그룹으로 구분하여, 생산가능집합에서 바람직한 산출물인 GDP와 오염물을 동시에 포함한 '환경지향형, 경제지향형, 환경-경제지향형, Two-stage DEA모형' 등의 네 가지 방법을 제시하여 비교한다. OECD국가는 상대적으로 경제효율성이 높으나 환경효율성은 낮았고 비OECD국가는 환경효율성이 높고 경제효율성이 낮았다. 화석에너지와 온실가스의 저감의 여지는 OECD국가가 더 높았다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.154.2-154.2
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• 2003

Mammalian cell cycles are tightly regulated by cyclins, cyclin dependent kinase (CDK), Retinoblatoma (Rb) protein, and cellular CDK inhibitors (CDKI). Cyelin dependent kinases (CDK) are key enzymes regulating eukaryotic cell cycle. And also it is recognized that the abnormal increase of CDK activities is one of the common events in human cancer and CDK inhibitors have therapeutic values in cancer treatment. Until now it is known that over 10 different CKDs participate in cell cycle regulation. (omitted)

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 추계학술대회 논문집
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• pp.242-245
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• 2008

In the power generation industry, various efforts are needed to cope with tightening regulation on carbon dioxide emission. Integrated gasification combined cycle (IGCC) is a relatively environment friendly power generation method using coal. Moreover, pre-combustion $CO_2$ removal is possible in the IGCC system. Therefore, much effort is being made to develop advanced IGCC systems. However, removal of $CO_2$ may affect the system performance and operation through reduction of fuel gas supplied to the gas turbine. This study predicts system performance change due to $CO_2$ capture by pre-combustion process from the normal IGCC performance without $CO_2$ capture and presents results of design parametric analysis.