• Journal of Environmental Health Sciences
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• v.32 no.3
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• pp.235-239
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• 2006

Cichorium intybus (Compositae) has been used for fevers, dyspepsia, headache and jaundice, as a demulcent. Also, it has relaxation effects and relief effects against coffee and teas, and is widely used as food. We investigated anti-lipid peroxidative effects and liver protective activity on $CCl_4$ induced lipid peroxidation and hepatotoxicity in rats. MeOH Ex. enhanced the inhibition of anti-lipid peroxidative effects in liver lipid. In chemical parameters obtained from serum analysis, MeOH Ex. revealed significant decrease on hepatotoxicity. The results were as follows; 1. The inhibitory effects of lipid peroxidation were shown in accordance with the increase of samples' concentration level. 2. In chemical parameters obtained from serum analysis, the activities of GOT, GPT, AlP were restored to near the normal level. The contents of cholesterol and BUN showed inhibitory effects with valence. 3. The weights of liver and spleen were not able to restore to the normal level. But on a general level, they were reduced more than the control group.

• Textile Coloration and Finishing
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• v.4 no.1
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• pp.16-20
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• 1992

This study was to examine the dry cleaning resistance of chrome bonding in the chrome-tanned garment leathers, and to analyze their chrome content. The results are as follows: 1. The average percentage of the chrome content (as $Cr_2O_3$) in the chrome-tanned garment leathers was 2.7%. 2. By the dry cleaning treatment and its numbers, the values of chrome content were little affected. 3. The resistance against dry cleaning with perchloroethylene $(Cl_2C = CCl_2)$ of samples was confirmed.

• Korean Journal of Pharmacognosy
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• v.30 no.2
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• pp.111-114
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• 1999

Inhibitory effect of water and ethyl acetate extract of 60 kinds of herbal medicines was investigated on ${\beta}-glucuronidase$. Among water extract of them, Galla Rhois had the most potent ${\beta}-glucuronidase-inhibitory\;activity$. Termaliae Fructus, Amomi Tsa-ko Fructus and Arecae Semen were also potent inhibitors. Among ethyl acetate extract of them, Galla Rhois had the most potent ${\beta}-glucuronidase-inhibitory\;activity$. Nelumbinis Semen. Ephedrae Radix and Termaliae Fructus were also potent inhibitors. The extract of Galla Rhois had potent hepatoprotective effect on $CCl_4-induced$ hepatotoxicity of rats. These results suggest that the ${\beta}-glucuronidase$ seems to be closely related to the liver injury, which could be prevented by the inhibitor of ${\beta}-glucuronidase$.

• Korean Journal of Pharmacognosy
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• v.25 no.3
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• pp.264-271
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• 1994

Pharmacological effects of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis from Lycium chinensis were investigated. Lycii Folium significantly protected the hepatic function from damages orally caused by $CCl_4 $administration in mice and had a strong hypoglycemic effect in hyperglycemic mice induced by streptozotocin. Lycii Fructus decreased the blood pressure rise associated with the growth of normal rats. Lycii Cortex Radicis had a strong hypoglycemic effect in hyrerglycemic mice induced by streptozotocin. Also, hypolipidemic effects in hyperlipidemic rats induced by 1% cholesterol fed-diet and 75% fructose were significantly observed by oral administration of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis.

• Journal of environmental and Sanitary engineering
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• v.11 no.1
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• pp.57-61
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• 1996

This study was to decompose carbon tetrachloride and CFC with pyrolytic incineration unit because of prohibition of their usage sooner or later. We have investigated heating value and temperature versus decomposing rate, removal of $Cl_2$ and dust in the flue gas, The results obtained were as follows; 1. In combustion condition to decompose $CCl_4$ heating value was 3,300Kcal/Kg, retention time was 2,0 sec. incinerator exit temperature was $950^{\circ}C$. 2.The removal of HCI and $Cl_2$ in flue gas used NaOH as reagent, then molar ratio o of $Na^+/Cl^-$ was 1.07. 3. NaCI of dust component was more than 90 %, 2 stage venturi scrubber was used to remove dust, then removal rate of dust was 99% over at L/G of $1.7Vm^3$

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.341-341
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• 1994

생체막의 주요 구성성분인 인지질의 2번 위치에 결합한 불포화지방산은 각종 전이금속이나 각종 활성산소들의 공격을 쉽게 받아 지질과산화반응이 일어나서 생체에 유독한 화합물을 생성하게 된다. 생체는 이러한 기구의 해독을 위하여 크게 2가지 방어기전을 갖고 있다. 즉 Vitamin- C, $\alpha$-tocopherol, flavonoid, SOD, catalase 등과 같이 생성된 활성산소를 제거시키는 기구와. 활성산소에 의해 생성된 과산화물을 제거시키는 기구로 glutathione peroxidase (GPX)가 알려졌으며 GPX에 의해 독성이 낮은 수산화물까지 환원시키는 기구가 보고되었다. 그러나 인지질의 과산화물 그대로는 GPX의 기질이 쥘수 없으므로, 산화된 지방산을 절단하는 효소에 대한 기구의 해석이 요구되고 있다. 최근 여러질병에 관련되어 있는 인지질 2번위치의 지방산을 분해하는 phospholipase $A_2$ (PLA$_2$)가 과산화지질의 분해에 관여한다는 주장이 제기되었다. 따라서 본 연구에서는 rat liver microsome에 $CCl_4$투여로 일어나는 과산화반응에 있어서 PLA$_2$의 역할을 규명하기 위하여 본 실험을 행하였다.

• Korean Journal of Pharmacognosy
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• v.12 no.1
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• pp.23-25
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• 1981

Methanol extracts of the roots of Atractylodes japonica (alba) (Compositae) and Gentiana scabra (Gentianaceae) were further fractionated with n-butanol, chloroform, n-hexane and water. Then each fraction was p.o. administered to an animal model of hepatitis caused by $CCl_4$ intoxication. Measurements of sleeping time of mice induced by hexobarbital administration indicated that n-butanol and chloroform fractions of Atractylodes japonica (alba), and chloroform and n-hexane fractions of Gentiana scabra showed significant liver protective activities. Measurements of the activities of serum transaminase, S-GOT and S-GPT appeared to support these results.

• Proceedings of the Korean Institute of Resources Recycling Conference
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• 2005.10a
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• pp.266-270
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• 2005

본 연구는 Ta, Nb, Zr, 및 희토류 등을 복합적으로 함유한 복합광을 대상으로 사염화탄소에 의한 염화반응을 알아보기 위한 기초연구로서 각 산화물의 염화반응 특성을 알아보고 이를 토대로 복합광의 염화반응을 비교하여 보았다. 실험결과 산화물 상태의 Nb, Ta 및 Zr은 비교적 낮은 온도에서 염화반응이 일어나고 염화물이 휘발됨을 알 수 있었다. 복합광을 반응 온도 $400^{\circ}C,\;CCl_4$ 분압 0.28 일때 반응시간이 10분에서 60분으로 변함에 따라 니오븀 및 탄탈륨은 $91%{\sim}99%$의 높은 회수율을 나타내었으나 지르코늄은 각각 16.5%에서 27.5%로 약간 증가하는 경향을 나타내었다. 희토류의 경우 세륨은 반응율이 71.7에서 73% 정도였고 란타늄은 51%에서 54% 정도의 반응율을 나타내었다.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.155.2-156
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• 2003

The adducts of lipid peroxidation and related aldehydic end are mediators of chronic poisoning and affect the development of chronic liver damage leading to fibrosis and cirrhosis. Substances delayed or suppresed lipid peroxidation could have an antioxidant and protective effect in liver disease. In this study, it was attempted to find out above mentioned effect of Solanum lycopersicum investigated in CCl4 induce liver fibrosis model. (omitted)

• Natural Product Sciences
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• v.12 no.3
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• pp.157-161
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• 2006

The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxyten derived free radicals (ODFR) in vitro with $4000\;{\mu}g/ml$ ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen(200 mg/kg, p.o.).