• Journal of the Korean Chemical Society
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• v.34 no.6
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• pp.676-679
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• 1990

• Bulletin of the Korean Chemical Society
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• v.12 no.6
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• pp.716-717
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• 1991

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.575-582
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• 2012

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against $CCl_4$-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.

• Journal of the Korean Chemical Society
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• v.4 no.1
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• pp.58-61
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• 1957

The organic titanium compounds, $Ti(OR)_4\;and\;Cl_2Ti(OR)_2$ were prepared by adding theoretical amounts of $TiCl_4$ to ROH in the medium of $CCl_4$. Among the compounds of the above two types, the former $Ti(OR)_4$was polymerized by refluxing them with R·OH and water at ordinary temperature and the latter, $Cl_2Ti(OR)_2$, by adding water to them.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.17 no.1
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• pp.23-29
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• 2007

Pitch-coated anatase $TiO_2$ typed was prepared by $CCl_4$ solvent mixing method with different mixing ratios. Since the carbon layers derived from pitch on the $TiO_2$ particles were porous, the pitch-coated $TiO_2$ sample series showed a good adsorptivity and photo decomposition activity. The BET surface area for the carbon layer in the sample increases to increasing with pitch contents. The SEM results present to the characterization of porous texture on the pitch-coated $TiO_2$ sample and pitch distributions on the surfaces for all the materials used. From XRD data a weak and broad carbon peak of graphene with pristine anatase peaks were observed in the X-ray diffraction patterns for the pitch-coated $TiO_2$. The EDX spectra show the presence of C, O and S with strong Ti peaks. Most of these samples are richer in carbon and major Ti metal than any other elements. Finally, the excellent photocatalytic activity of pitch-coated $TiO_2$ with slope relationship between relative concentration of MB ($c/c_o$) and t could be attributed to the homogeneous coated pitch on the external surface by $CCl_4$ solvent method.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.626-629
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• 2003

The water extracts of Hovenia dulcis Thunb. showed significant reducing alcohol concentration in blood and hepatoprotective acitivity against D-galactoseamine/LPS and CCl4-toxicity. The concentration of blood alcohol was decreased from 2hr after injected in rats with Hovenia dulcis extracts. The water extracts of Hovenia dulcis significantly inhibited the elevation of serum ALT, AST and LDH levels. In this study, we investigated the effect of Hovenia dulcis extract on reducing alcohol concentration in blood. Also the efficacy and toxicity of Hovenia dulcis extract were evaluated by in vivo and in vitro tests.

• Biomolecules & Therapeutics
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• v.5 no.2
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• pp.194-201
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• 1997

The hepatoprotective activity of six extracts (BE, EE, HH, PS-1, PS-2, KP) from Artimisia iwayomogi was investigated against experimentally produced hepatic damages. Silymarin, DDB and UDCA were used as reference compounds. Treatment with PS-1 extract reduced hepatic demages induced by $CCl_4$, acetaminophen and ANIT but it did not alter ethionine-induced hepatotoxicity In addition, PS-1 extract showed a protective effect against chronic $CCl_4$-induced hepatotoxicity as well as liver regeneration. PS-2 and KP extracts exhibited significant antihepatotoxic effects on D-galactosamine-induced hepatitis. Treatment with EE extract inhibited ethionine-induced fatty liver. These data indicate that the PS-1 extract is the roost hepato-protective constituent and rationalize the traditional use of this plant in hepatobiliary disorders.

• The Journal of Internal Korean Medicine
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• v.22 no.1
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• pp.5-11
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• 2001

Object : This study was carried out to examine the effect of Hwangryunhaedoktang on the liver and kidney of rats induced by carbon tetrachloride and ethanol. Methods : The histopathological changes were examined after preadministration of 100 and 200mg/100g Hwangryunhaedoktang. Results : The perivenular ballooning degeneration and infiltration of basophilic inflammatory cells were decreased in the experimental group when compared with the control group. No abnormalities were observed in the kidneys of both groups. But, interstitial nephritis was observed only in the experimental group. Conclusion : This study suggests that Hwangryunhaedoktang may be of benefit to the prevention of hepatotoxicity induced by carbon tetrachloride and ethanol, and it is more effective in high dosages.

• Aerospace Engineering and Technology
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• v.11 no.2
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• pp.216-224
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• 2012

This study described about the procedure and method to type certification of KAS 23 civil aircraft that is developed in domestic. It is important to obtain type certification within defined period based on the proposed process and method to prove compliance through certification basis according to certification plan. This process referred to FAA Order 8110.4 C, "Type Certification" and domestic regulation and showed example of compliance check list(CCL) defining means of compliance(MOC). Also, proposed method to prove compliance according to means of compliance and classified item of test & evaluation.

• The Journal of Internal Korean Medicine
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• v.1 no.1
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• pp.70-77
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• 1976

The Sam Mool Injin extract is occasionally used as a kind of remedies for the treatment of hepatic discomfort in herb medicine. The study for the effect on the hepatic parenchymal cells, especially regenerating activity and even its toxicity have. little been done and only a very few pharmacological properties have been reported. So, an experimental study for the morphologic changes in the acute carbon tetrachloride poisoning of wister rat by administration of its extract has been performed. Male Wister rat weighing around 200gm were used in this experiment. Results were as follows; 1) In the $Ccl_4$ 0.3c.c 7day group, there is noted considerable increase of regenerating activity in the experimental group compared with non-extract treated group, in half of them. 2) Remaining all of the experimental group do not show significant difference of regenerating activity compared with control group. 3) In the group treated with Sam Mool Injin extract alone, there was noted some considerable increase of nonspecific leukocytic infiltrations compared with saline control group. This can be considered as a possibility of hepatic tissue reaction on the Sam Mool Injin extract.