Hopatoprotective Effects of Extracts form Artemisia iwayomogi

한인진 추출물의 간질환모델에 대한 활성

  • 이순복 (성균관대학교 약학대학) ;
  • 정철 (성균관대학교 약학대학) ;
  • 정성학 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 심성보 (코오롱그룹 중앙연구소) ;
  • 조태순 (성균관대학교 약학대학)
  • Published : 1997.06.01

Abstract

The hepatoprotective activity of six extracts (BE, EE, HH, PS-1, PS-2, KP) from Artimisia iwayomogi was investigated against experimentally produced hepatic damages. Silymarin, DDB and UDCA were used as reference compounds. Treatment with PS-1 extract reduced hepatic demages induced by $CCl_4$, acetaminophen and ANIT but it did not alter ethionine-induced hepatotoxicity In addition, PS-1 extract showed a protective effect against chronic $CCl_4$-induced hepatotoxicity as well as liver regeneration. PS-2 and KP extracts exhibited significant antihepatotoxic effects on D-galactosamine-induced hepatitis. Treatment with EE extract inhibited ethionine-induced fatty liver. These data indicate that the PS-1 extract is the roost hepato-protective constituent and rationalize the traditional use of this plant in hepatobiliary disorders.

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