• Applied Chemistry for Engineering
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• v.32 no.3
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• pp.299-304
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• 2021

This study focuses on the preparation of acetaminophen (AP) imprinted functional biomaterials for a transdermal drug delivery using mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (S) as a crosslinking agent, glycerol (GL) as a plasticizer, and melanin (MEL) as a photothermal agent. The prepared AP imprinted biomaterials were characterized using FE-SEM and their physical properties were evaluated. The photothermal effect and AP release property for functional biomaterials were examined with the irradiation of near infrared (NIR) laser (1.5 W/cm²). When the NIR laser was irradiated on functional biomaterials with/without the addition of MEL, the temperature of MEL added biomaterial increased from 25 ℃ to 41 ℃, whereas the biomaterial without MEL increased from 25 ℃ to 28 ℃. Results indicate that there is the photothermal effect of prepared biomaterial with the addition of MEL. Based on the results, AP release properties were evaluated using standard buffer solutions and artificial skin. It was found that AP release rates of MEL added AP loaded biomaterials were 1.2 times faster than those of MEL non-added AP loaded biomaterials when irradiating with NIR laser. We envision that the developed functional biomaterials can be utilized for an acute pain-killing treatment.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.165-174
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• 2018

Background: Extended endoplasmic reticulum (ER) stress may initiate apoptotic pathways in cancer cells, and ER stress has been reported to possibly increase tumor death in cancer therapy. We previously reported that caspase-8 played an important role in compound K-induced apoptosis via activation of caspase-3 directly or indirectly through Bid cleavage, cytochrome c release, and caspase-9 activation in HL-60 human leukemia cells. The mechanisms leading to apoptosis in A549 and SK-MES-1 human lung cancer cells and the role of ER stress have not yet been understood. Methods: The apoptotic effects of compound K were analyzed using flow cytometry, and the changes in protein levels were determined using Western blot analysis. The intracellular calcium levels were monitored by staining with Fura-2/AM and Fluo-3/AM. Results: Compound K-induced ER stress was confirmed through increased phosphorylation of $eIF2{\alpha}$ and protein levels of GRP78/BiP, XBP-1S, and $IRE1{\alpha}$ in human lung cancer cells. Moreover, compound-K led to the accumulation of intracellular calcium and an increase in m-calpain activities that were both significantly inhibited by pretreatment either with BAPTA-AM (an intracellular $Ca^{2+}$ chelator) or dantrolene (an RyR channel antagonist). These results were correlated with the outcome that compound K induced ER stress-related apoptosis through caspase-12, as z-ATAD-fmk (a specific inhibitor of caspase-12) partially ameliorated this effect. Interestingly, 4-PBA (ER stress inhibitor) dramatically improved the compound K-induced apoptosis. Conclusion: Cell survival and intracellular $Ca^{2+}$ homeostasis during ER stress in human lung cancer cells are important factors in the induction of the compound K-induced apoptotic pathway.

• The Journal of Korean Medical History
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• v.23 no.2
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• pp.37-41
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• 2010

There are two transcriptions of "ChiJongBang" in Korea at the moment. The first is the Jangseo-gak ibrary transcription(K3-380). The title is "ChiJongBang(治腫方)" and it starts with the contents of "ChiJongBang(治腫方)", followed by "HoeChunYoGyeol(回春要訣)", "NoInSeopYangBang(老人攝養方)", "SoABang(小兒方)". "ChiJongBang(治腫方)" does not even take up a large portion of the book. The other transcription is "ChiJongBang(治腫方)" in Geojil's "Uihui(宜彙)", which was presented into the worldin 1871(the 8th year of King Go-jong)by GeumRiSanIn(錦里山人). The contents of the two transcriptions are the same, and both are left by ImEonGuk. The latter part is identical to the contents of "ChimGuGyeongHeomBang". It was common fora medical book to have additional useful information attatched in the end, so it was thought that somebody added a part of "ChimGuGyeongHeomBang" at the end of "ChiJongBiBang". But the discovery of a woodcut "ChiJongBang" in Korean annotation confirmed that the making of this book was led by the government, and the fact that abscess was a big part of healthcare around the ImJinWaeRan(Japanese Invasion of Korea in 1592) period.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.9
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• pp.3517-3523
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• 2010

Single exposure dual X-ray imaging can be used to separate soft and dense-material images for medical and industrial applications. This study keep focusing baggage inspection system(BIS) specifically. New detector modules for single exposure dual X-ray imaging are consisted of low energy detector (LED) and high energy detector (HED). First, the optimized thickness of copper filter coupled HED to separate low energy and high energy was simulated by the given X-ray energy (140 kVp, 1 mA) using Monte Carlo simulation codes, MCNPX. So as a result of simulation, the copper filter thickness is 0.7 mm. For the design of PIN photodiode, ATLAS device simulation tool was used. 16 channels PIN photodiode of 1.5 mm ${\times}$ 3.2 mm for Dual X-ray imaging detector was fabricated in the process of ETRI. And its dark current and quantum efficiency, terminal capacitance were measured. It was proven that the Lanex Fast B coupled HED were a sufficient candidate to replace the CsI(Tl) commerced in dual X-ray system, since these give a strong signal, overcoming system noise. Finally dual X-ray image was acquired through correction of the LED X-ray Image and the HED X-ray Image.

• Journal of Astronomy and Space Sciences
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• v.28 no.1
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• pp.93-102
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• 2011

Korea Astronomy and Space Science Institute (KASI) launched the development project of two satellite laser ranging (SLR) systems in early 2008 after the government fund approval of the SLR systems in 2007. One mobile SLR system and one permanent SLR station will be developed with the completion of the project. The main objectives of these systems will be focused on the Space Geodetic researches. A system requirement review was held in the second half of the same year. Through the following system design review meeting and other design reviews, many unsolved technical and engineering issues would be discussed and resolved. However, the design of the mobile SLR system is a corner stone of whole project. The noticeable characteristics of Korea's first SLR system are 1) use of light weight main mirror, 2) design of compact optical assembly, 3) use of KHz laser pulse, 4) use of commercial laser generator, 5) remote operation capability, 6) automatic tracking, 7) state of art operation system, etc. In this paper, the major user requirement and pre-defined specification are presented and discussed.

• Journal of Environmental Impact Assessment
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• v.7 no.2
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• pp.103-112
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• 1998

Nature-friendly river project has became common practice in Japan. In order to make it available for the conservation and rehabilitation of desirable water environment, water criteria for water environmental assessment must be established. Especially, the criteria estimating the effects on ecosystem in and around river should be constructed. In this paper, classification method for water quality has been developed using biological indices and applied to observed data in Honmyo River, Nagasaki, Japan. Modified PI method (BI') has been suggested and those of three most abundant species resulted effective estimate for an overall water quality with comparatively simple procedure. Extensive database management code was prepared for the comprehensive ecological monitoring of river basin, which includes various biota. That system enables easy access of all the ecological data for a dissemination of a sound and sustainable water environment. The result of this study could improve knowledge base, serve making consensus for citizens, and help river management plans. In Japan, citizen's realization and action are the most critical factor for nature-friendly river restoration project.

• Journal of the Korean Society of Clothing and Textiles
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• v.20 no.5
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• pp.915-929
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• 1996

The purpose of this study is to investigate the visual illusions and image of the combinated collars and sleeves which are combinated by the computer simulation. The detail object of this study as follows; 1) to know the visual illusions of the clothing as the collar and sleeves are combinated 2) to constract the clothing image using sementic differential scales 3) to know the differet image of the clothing as the collars and sleeves are combinted 4) to know the interaction effect of the collars and sleeves of the clothing The detail method of this study is as follows; In the first experiment, there are two groups; the first 8 groups are the combination of the same collar and the different sleeves. The second 8 groups are the combination of the same sleeve and the different collars. The second experiment has done for the 32 clothings which are the combination of the 8 collars and 4 sleeves. For the 14 clothing the image has tested by 13 semantic differential bi- polar scale. The subjects were 50 female students majoring in clothing and textile. The data analyzed by Kendall cofficient of concodance, Factor analysis, Anova and scheffe's test. Briefly the image of the clothing is much influenced by the varing of the collar than that of the sleeve. Thus, we also can conclude that the recognition of the clothing are much more dependent on the collar than sleeve.

• Economic and Environmental Geology
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• v.50 no.5
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• pp.325-340
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• 2017

The Seongdo Pb-Zn deposit, located in the northwestern part of the Ogcheon Metamorphic Belt, consists of skarn ore replacing limestone within the Hwajeonri Formation of Ogcheon Group and hydrothermal vein ore filling the fracture of host rock. Skarn minerals comprise mostly hedenbergitic pyroxene, garnet displaying oscillatory zonal texture composed of grossular and andradite, and a small amount of wollastonite, tremolite, and epidote, indicating reducing condition of formation. Ore minerals of skarn ore include sphalerite and galena with a small amount of pyrite, pyrrhotite, and chalcopyrite. In hydrothermal vein ore, arsenopyrite, sphalerite, chalcopyrite, and pyrite occur with a small amount of galena, native Bi, and stannite. Chemical compositions of sphalerite vary from 17.4 mole% FeS in average for dark grey sphalerite, 3.6 mole% for reddish brown sphalerite in skarn ore, and to 10.3 mole% FeS in hydrothermal vein ore. In comparison with representative metallic deposits in South Korea on the FeS-MnS-CdS diagram, skarn and hydrothermal vein ore plot close to the field of Pb-Zn deposits and Au-Ag deposits, respectively. Arsenic contents of arsenopyrite in hydrothermal vein ore decrease from 31.93~33.00 at.% in early stage to 29.58~30.21 at.% in middle stage, and their corresponding mineralizing temperature and sulfur fugacity are $441{\sim}490^{\circ}C$, $10^{-6}{\sim}10^{-4.5}atm$. and $330{\sim}364^{\circ}C$, <$10^{-8}atm$. respectively. Phase equilibrium temperatures calculated from Fe and Zn contents for coexisting sphalerite and stannite in hydrothermal vein are $236{\sim}254^{\circ}C$. Sulfur isotope compositions are 5.4~7.2‰ for skarn ore and 5.4~8.4‰ for hydrothermal vein ore, being similar or slightly higher to magmatic sulfur, suggesting that ore sulfur was mostly of magmatic origin with partial derivation from host rocks. However, much higher sulfur isotope equilibrium temperatures of $549^{\circ}C$와 $487^{\circ}C$, respectively for skarn ore and hydrothermal ore, than those estimated from phase equilibria imply that isotopic equilibrium has not been fully established.

• Journal of Conservation Science
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• v.32 no.2
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• pp.141-154
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• 2016

The gilt-bronze decorated bamboo mudguards with heavenly horse design excavated in 1973 at Cheonma Tomb of Shilla are the unprecedented relics in Korean history as it has its original structure. Although the bamboo mudguards were excavated in not only Cheonma Tomb, but also in Geumgwanchong and Geumryeongchong, all of them remains into pieces. In addition, there are no exact data related with its structure and manufacturing technique. The report deals with the manufacturing technique of the bamboo mudguards with heavenly horse design excavated in Cheonma Tomb through the naked eye's observation, X-Ray Fluorescence, and Transmission X-rays analysis etc. Bamboo mudguards basically have the three divided structure with central-focus structure of a radiation style. And the mudguards consists of Bratticing gilt-bronze, fabric, and bamboo plates together, as ornamental fringe of 4 plates. The surface of the gilt bronze plates was decorated with a variety of workmanship and pendant. Bamboo plates have a waved pattern by using about three hundred bamboo bark. Two types of textiles were mainly found in the textile plates, and the leather were partially found. In order to combine all plates together, gilt-bronze bottonhead, pendant decoration, and ornamental fringe were used. It would be helpful to study bamboo mudguards during 5th-6th centuries in Shilla period and basis investigations of Geumgwanchong and Geumryeongchong excavations.

• Journal of Life Science
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• v.33 no.3
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• pp.268-276
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• 2023

This study was conducted to optimize the formulation conditions of the immediate-release layer of carvedilol in the development of a two-layer tablet formulation for carvedilol and ivabradine. Using a 2⁴+3 full-factorial design of experiments, excipients (microcrystalline cellulose, citric acid, and crospovidone) of the carvedilol immediate-release layer (wet granulation part) and process parameters for the tablet compression process (main compression) were optimized, and seven types of each dependent variable (assay, content uniformity, hardness, friability, disintegration, and dissolution [pH 1.2 and 6.8]) were evaluated using design expert software. The analysis of variance results confirmed that the main compression has a significant effect on hardness, friability, and disintegration time and that microcrystalline cellulose has a major effect on friability and dissolution. In addition, it was confirmed that citric acid has a significant effect on friability. Crospovidone affects friability and dissolution. According to the design space from the design of the experiment results, the optimized range is microcrystalline cellulose (~18.0-32.0 mg), citric acid (~0.5-12 mg), and main compression (~615-837 kgf). Consequently, this study confirmed the availability of manufacturing the carvedilol immediate-release layer in which all risk factors evaluated in the initial risk assessment are removed.