• Journal of The Geomorphological Association of Korea
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• v.19 no.3
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• pp.143-151
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• 2012

The tsunami disasters and tectonic movements derived from mega-earthquake(M 9.0) which occured in the sea floor of the Pacific side of northeast Japan in March, 2011 were investigated. Landward invasion limit of the tsunami was 4.0km from the present coastline in Sendai coastal plain. It was observed that sandy deposit was dristributed largely in coastward part and muddy deposit was distributed largely in landward part. The ratios of distribution distances of the above two deposits were, respectively, 60~75% and 25~40% of the whole invasion distance of the 2011 tsunami. The ratios of the above distribution distances of tsunami deposits could be used to estimate landward invasion distances of the past maga-tsunamies(e.g. '2,000year B.P. Mega-Tsunami' and 'Jogan Tsunami' etc.) in Sendai coastal plain. The mega-scale tsunami disasters were caused by the low and flat geomorphic condition in the Sendai coastal plain and the increasing effect of tsunami height affected by narrow inlet condition of the so-called Ria's coast in the Sanriku coastal area respectively. Tectonic subsidences caused by the mega-earthquake in march, 2011 were observed in many areas of Ishinomaki, Ogawa, Ogachi and Onagawa coasts in northeast Japan. The displacements of tectonic subsidence were between 0.5 meters and 1.0 meters.

• Journal of Korean Society of Health-System Pharmacists
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• v.35 no.4
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• pp.453-462
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• 2018

Background : The prevalence of chronic hepatitis C virus (HCV) tends to be higher in the elderly. Pegylated interferon and ribavirin therapy (Peg-IFN/RBV) was recommended as the first-line treatment in the past decades, but this regimen showed unsatisfactory results in terms of safety and efficacy especially in elderly patients. Recently, it was demonstrated that dual therapy with daclatasvir and asunaprevir was well tolerated and led to high sustained virological response (SVR) rates, irrespective of age. We conducted a study to evaluate the efficacy and safety of daclatasvir plus asunaprevir by involving elderly patients aged above 65 years. Methods : We retrospectively analyzed clinical data from chronic hepatitis C virus (HCV) genotype 1b patients treated with daclatasvir plus asunaprevir from September 2015 to December 2016 at Seoul St. Mary's hospital. The patients were divided into two groups as elderly patients (older than 65 years) and non-elderly patients (younger than 65 years) and compared the efficacy and safety. Results : A total of 112 patients were treated with daclatasvir plus asunaprevir for chronic hepatitis C. Among them, 101 patients completed the whole treatment, and in 88 patients the amount of HCV RNA was measured after 12 weeks of treatment. There was no significant difference in SVR at 12 weeks between both the groups (p=0.68). Typically, 91.4%(32/35) of elderly patients and 94.3%(50/53) of non-elderly patients achieved SVR12. Common adverse events included elevation in transaminase level, headache, and gastrointestinal disorders. There was no statistical difference in the symptoms between the two groups. Conclusions : The combination therapy with daclatasvir plus asunaprevir exhibited similar rates of SVR12 in HCV elderly patients without leading to further adverse events compared to non-elderly patients. Therefore, it is proposed that daclatasvir plus asunaprevir therapy could be considered as an effective and safe treatment, even in patients aged over 65 years.

• Korean Journal of Environmental Biology
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• v.38 no.4
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• pp.667-677
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• 2020

This study was conducted to investigate the fish fauna and characteristics of the Carassius auratus population in the Boryeong Reservoir in Chungcheongnam-do from October 2017 to June 2018. The collected fish were identified as 3,506 individuals of 15 species from a total of nine families. The dominant and subdominant species were H. nipponensis with 1,706 (48.6%) individuals and C. auratus with 1,021 (29.1%) individuals, respectively. The biomass of C. auratus (246,130g), P. fulvidraco(50,610g), C. cuvieri (14,730 g), S. asotus (11,560 g), and C. carpio (10,930 g) was analyzed. The results of the community analysis showed a dominant index value of 0.87 (±0.2), a diversity index value of 0.78 (±0.5), an evenness index value of 0.47 (±0.2), and a richness index value of 0.99 (±0.5). The length-weight analysis of C. auratus showed a regression coefficient b of 3.06, and a condition factor (K) of 0.0004 with a positive slope. The frequency distribution of the total length analysis of the C. auratus population inhabiting the Boryeong Reservoir showed a high distribution of lengths between 140-160 mm and a low distribution between 230-280 mm. The normalized difference water index (NDWI) was analyzed over the Boryeong Reservoir water surface from 2013 to 2014 using Landsat 8 channel data. The areas where the NDWI was decreased were located at the inflow site of Ungcheon Stream.

• Korean Journal of Plant Resources
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• v.35 no.2
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• pp.248-288
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• 2022

The study on vascular plants of Gayasan National Park was conducted in 2016 over a period of 34 days from March to October 2016. As the study, a total of 768 taxa were recorded, including 118 families, 396 genera, 691 species, 15 subspecies, 51 varieties, and 11 forms. In the vascular plants, four endangered wild plants were recorded, Ponerorchis cucullata (L.) X.H.Jin, Trientalis europaea var. arctica (Fisch.) Ledeb., Cypripedium macranthos Sw., and Pedicularis hallaisanensis Hurus. Taxa of Least Concern (LC) or higher level on National Red List published by the Ministry of Environment of Korea were 21 taxa for example Tricyrtis macropoda Miq., and Lilium cernuum Kom. A total of 37 Korean endemic plants were investigated for example Abies koreana E.H.Wilson and Impatiens atrosanguinea (Nakai) B.U.Oh & Y.P.Hong. A total of 162 taxa of floristic regional indicators (3^rd to 5^th degree) were investigated including 9 taxa of V, 15 taxa of IV, 38 taxa of III, 45 taxa of II, and 53 taxa of I. Naturalized plants were recorded a total of 46 taxa with a Naturalization Index of 6.0%, the Urbanization Index was calculated to be 14.3% and 5 taxa of ecosystem disturbance plants were investigated such as Sicyos angulatus L., Rumex acetosella L., and Humulus scandens (Lour.) Merr. As the result of comparison with previous studies, in this study a total of 206 taxa were newly identified including 62 families, 144 genera, 184 species, 2 subspecies, 15 varieties, and 5 forms.

• Journal of the Korean Wood Science and Technology
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• v.31 no.4
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• pp.8-15
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• 2003

This study was carried out to investigate the dimensional stability of wood treated with PEG for better utilization of domestic small-diameter logs. Four species of ring- porous wood(Quercus mongolica F_ISCH, Quercus variabilis B_LUME, Fraxinus rhynchophylla H_ANCE, Paulownia coreana U_YEKI,) and four species of diffuse-porous wood(Prunus sargentii R_EHDER, Betula davurica P_ALL, Populus tomentiglandulosa T. L_EE, Cornus controversa H_EMSLEY) were used for this experiment. The shrinkage of wood decreased with increasing the concentration of PEG. The shrinkage of diffuse- porous woods was lower than that of ring-porous woods. The weight gain increased in proportional to the PEG concentration. Diffuse-porous woods showed a little higher weight gain than ring-porous woods. Bulking effect also increased with increasing the PEG concentration, but was in inverse proportional to the molecular weight of PEG. Diffuse-porous woods showed higher bulking effect than ring-porous woods. Consequently, diffuse-porous woods showed better dimensional stability than ring- porous woods. It was considered that dimensional stability was affected by characteristics of wood such as vessel and tylosis, and density.

• The Korea Journal of Herbology
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• v.34 no.2
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• pp.15-23
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• 2019

Objective : Reflux esophagitis (RE) is a disease that caused gastric acid reflux and inflammation due to unstable gastroesophageal sphincter, as increasing worldwide respectively. This study was conducted to evaluate the effect of Evodiae Fructus (EF) extract on chronic reflux esophagitis in rats. Methods : The EF was measured antioxidant activity, such as total polyphenol and total flavonoid contents, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2'-azinobis-3-ethyl-enzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity. Rats were divided into 3 groups; Nor (normal group), Con (chronic acid reflux esophagitis rats treatment with water), EF (chronic acid reflux esophagitis rat treatment with EF 200 mg/kg body weight group). A surgically-induced chronic acid reflux esophagitis (CARE) model was established in SD rats, and treated with water or EF 200 mg/kg body weight for 14 consecutive days. Results : Administration of EF to rats of induction of chronic acid reflux esophagitis was found to reduce esophagus tissues injury. Reactive oxygen species (ROS) and produces peroxynitrite ($ONOO^-$) levels of esophagus tissues were significantly decreased in EF compared to Con group. As results of esophagus protein analyses, EF effectively reduce inflammatory-related factors ($NF-{\kappa}Bp65$, $p-I{\kappa}B{\alpha}$, iNOS, $TNF-{\alpha}$, IL-6), and increase anti-oxidant enzyme (Nrf2, HO-1, SOD, catalase, GPx-1/2). Conclusions : These results suggest that EF administration comfirmed that decreased esophagus tissues injury, oxidantive stress, anti-inflammation effect, and increased anti-oxidant effect. Therefore, EF was the potential to be used as a natural therapeutic drug.

• The Korea Journal of Herbology
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• v.34 no.6
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• pp.79-89
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• 2019

Objective : This study investigated the anti-diabetic effects of DM1, a herbal mixture with Atractylodis Rhizoma, Anemarrhenae Rhizoma, and Cinnamomi Cortex in high fat diet (HFD)-induced diabetic mice and the mechanism in C2C12 mouse skeletal muscle cells. Methods : The C57B/6 mice were fed high fat for 12 weeks, and then administrated DM1 extract (500 mg/kg, p.o.) for 4 weeks. The changes of body weight, calorie and water intakes, fasting blood glucose levels and the serum levels of glucose, insulin, triglyceride, HDL-cholesterol, AST and ALT were measured in mice. The histological changes of liver and pancreas tissues were also observed by H&E stain. C2C12 myoblasts were differentiated into myotubes and then treated with DM1 extract (0.5, 1, and 2 mg/㎖) for 24 hr. The expression of myosin heavy chain (MHC), PGC1α, Sirt1 and NRF1, and the AMPK phosphorylation were determined in the myotubes by western blot, respectively. Results : The DM1 extract administration significantly decreased the calorie and water intakes, glucose, triglyceride, AST and ALT levels and increased insulin and HDL-cholesterol in HFD-induced diabetic mice. DM1 extract inhibited lipid accumulation in liver tissue and improved glucose tolerance. In C2C12 myotubes, DM1 treatment increased the expression of MHC, PGC1α, Sirt-1, NRF-1 and the AMPK phosphorylation. Conclusion : In our results indicate that DM1 can improve diabetic symptoms by decreasing the obesity, glucose tolerance and fatty liver in HFD-induced diabetic mice, and responsible mechanism is might be related with energy enhancement.

• The Korea Journal of Herbology
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• v.34 no.1
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• pp.117-124
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• 2019

Objective : Chronic acid reflux esophagitis (CARE), one of gastroesophageal reflux disease (GERD) is increasing worldwide. Coptidis rhizoma extract (CRE) is a traditional herb that cures a variety of diseases. This study was conducted to evaluate the protective effect of CR on rats with chronic acid reflux esophagitis. Methods : The antioxidant activities were evaluated through radical scavenging assays using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) radical scavenging assays. CARE was surgically induced in 5-week-old male SD rats by ligating the border between forestomach and glandular portion with a 2-0 silk tie and covering the duodenum using 18-Fr $N{\acute{e}}laton$ catheter. To evaluate the esophageal protective effect of CRE, rats were divided into 3 groups: Nor (normal rats), Veh (chronic acid reflux esophagitis induced rats), CR (chronic acid reflux esophagitis induced rats treated with CRE 200 mg/kg body weight). Results : The administration of CRE significantly prevented the mucosal injury of the esophagus tissue and histological findings improved the esophageal lesion. It has been shown that inflammation is prevented by the increase of antioxidant-related factors (Nrf-2, HO-1, SOD, catalase, and GPx-1/2) through the antioxidant pathway of esophageal tissue. The administration of CRE reduced the increase of serum peroxynitrite ($ONOO^-$) and markedly reduced the protein expression of inflammatory mediator such as $NF-{\kappa}Bp65$, $p-I{\kappa}B{\alpha}$, iNOS, and IL-6. Conclusions : Overall, these results suggest that CRE administration confirmed the protective effect of esophageal mucosa, suggesting that it is a potential treatment for chronic acid reflux esophagitis.

• The Korea Journal of Herbology
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• v.35 no.1
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• pp.35-44
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• 2020

Objectives : The objective of this study was to investigate the therapeutic effect of Corni Fructus 30% ethanol extract (CFE) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods : The subjects were divided into 4 groups ; Normal group (N, n=10), MIA-induced osteoarthritis control group (Con, n=10), indomethacin 5 mg/kg treated group (INDO, n=10), CFE 200 mg/kg treated group (CFE, n=10). Blood and articulation tissues were collected after two weeks of drug administration. Oxidative stress was analyzed with reactive oxygen species (ROS), peroxynitrite (ONOO-). And the Nuclear factor erythroid-2 (Nrf2), heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase, glutathione peroxidase-1/2 (GPx-1/2), Nuclear Factor Kappa B p65 (NF-κBp65), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNFα), interleukin-6 (IL-6), Interleukin 1β (IL-1β), matrix metalloproteinase-1 (MMP-1), and tissue inhibitor of metalloproteinases-1 (TIMP-1) were investigated by western blot. Results : The administration of CFE showed a significant reduction of changes in relative hind paw weight distribution. Reactive oxygen species (ROS) and peroxy nitrite (ONOO-) levels of articulation tissues were significantly decreased in CFE compared to the control group. Western blot measurements of Nrf2, HO-1, SOD, catalase, GPx-1/2 showed that the CFE group was increased compared to the Con group. And western blot measurements of NF-κBp65, COX-2, iNOS, TNFα, IL-6, IL-1β showed that the CFE group was reduced compared to the Con group. Also CFE group decreased MMP-1 and increased TIMP-1. Conclusion : Based on the above results, it can be seen that osteoarthritis is improved when Corni Fructus 30% ethanol extract treated.

• ALGAE
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• v.37 no.3
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• pp.227-237
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• 2022

Knowledge on the seaweeds of eastern Sorsogon in the Philippines is uneven. Not only is eastern Sorsogon among the areas of high seaweed diversity but locals there have interacted with seaweeds for ages. Despite seaweeds' assumed importance to Sorsoganon, ethnobotanical records are missing. In this study, we documented the traditional knowledge on seaweed use and determined the rate of knowledge transmission among the locals of eastern Sorsogon. Vernacular names and modes of preparation were given of the 12 identified species bearing culinary and medicinal importance. Ten species were eaten while three were used therapeutically. Based on ethnobotanical indices, Caulerpa chemnitzia ecad turbinata and Gelidiella acerosa were the most important seaweeds. The least cited was Caulerpa racemosa. Our study demonstrated that most of the seaweed resources in eastern Sorsogon remain largely untapped, as the identified ethnotaxa were only about 5% of the total seaweed species diversity reported for the area. The seaweed knowledge in eastern Sorsogon appeared to be homogenous across age groups with primary sources of knowledge biased towards female relatives (mothers and grandmothers) and to children as inheritors. Cessation of seaweed knowledge may come at a potential cost, as a significant fraction of the population did not transmit their knowledge to others. Our study furthered the interest in providing sophisticated resource management recommendations that consider the relationships of traditional and scientific knowledge of seaweed selection and use in eastern Sorsogon and beyond.