• 대한전자공학회논문지SD
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• 제37권1호
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• pp.75-82
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• 2000

본 논문에서는 새로운 16비트 저전력 ALU(Arithmetic Logic Unit) 구조 및 회로를 제안하여 트랜지스터 레벨로 설계, 제작 및 테스트하였다. 설계한 ALU는 16개의 명령어를 수행하며 2단계 파이프라인 구조를 가진다. 제안한 ALU는 switched capacitance를 줄이기 위해 논리연산시에는 덧셈기가 스위칭하지 않도록 하였으며, P(propagation)블록의 출력을 듀얼버스(dual bus)구조로 하였다. 또한 이와 같은 ALU구조를 위한 새로운 효율적인 P 및 G(generation)블록을 제안하였다. 그 외에 저전력 실현을 위하여 ELM덧셈기, 이중모서리 천이 플립플롭double-edge triggered flip-flop) 및 조합형 논리형태(combination of logic style)을 사용하여 ALU를 구현하였다. 모의실험결과, 제안한 구조는 기존의 구조$^{[1.2]}$에 비교하여 수행되는 산술연산의 사용횟수에 대하여 논리연산의 사용횟수가 증가할수록 전력감축의 효과가 증가하였다. 수행되는 산술연산 대 논리연산의 전형적인 비율을 7:3이라고 가정할 때, 제안한 구조는 기존 구조에 비해서 12.7%의 전력감축을 보였다. 설계한 ALU는 0.6${\mu}m$ 단일폴리, 삼중금속 CMOS 공정으로 제작하였다. 칩 테스트 결과 최대동작 주파수는 53MHz로 동작하였고 전력소모는 전원전압 3.3 V, 동작 주파수 50MHz에서 33mW를 소모하였다.

• 대한전자공학회논문지SD
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• 제41권3호
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• pp.101-108
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• 2004

단열회로를 이용하여 16-bit ALU와 단열회로에 4가지 위상을 가지는 전원클럭을 공급하기 위한 전원클럭 발생기를 설계하였다. 4개의 전원클럭 신호선의 전하는 AC 형태의 전원클럭을 통해서 복원되어 에너지 소모를 줄인다. 구현에 사용한 단열회로는 ECRL(efficient charge recovery logic) 형태를 기본으로 하였으며 0.35㎛ CMOS 공정을 사용하여 설계하였고 3.3V 전원을 사용하였다. 회로설계 후 layout을 진행하였으며, layout 후 LPE(layout parasitic extraction)를 수행하여 이를 모의실험에 사용하였다. 모의실험결과 전원클럭 발생기를 포함한 단열회로를 이용한 ALU는 동일한 구조를 갖는 기존의 CMOS ALU보다 1.15～1.77배 정도의 에너지소모를 감소 시켰다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 Ⅲ
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• pp.1383-1386
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• 2003

In this paper, an ALU for Simultaneous Multi-Threading (SMT) microprocessors is designed. The SMT architecture improves notably performance and utilization of processes compared with conventional superscalar architectures by executing instructions from multiple threads at the same time. This ALU adopts data bypassing method to process multi-threads. And it can flush instructions in the same thread that generate exceptions such as branch misprediction. interrupt etc, performance of SMT microprocessors with data bypassing and exception handler can be improved.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 합동 추계학술대회 논문집 정보 및 제어부문
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• pp.153-156
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• 2001

This paper analyzes the 74LS381 ALU and designs its equivalent circuit. The 74LS381 ALU is arithmetic logic units(ALUs)/function generators that perform eight binary arithmetic/logic operations on two 4-bit words. However there are only little information to understand and design this circuit. Thus, we not only analyzed it but also designed an equivalent circuit to the 74LS381.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5495-5501
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• 2013

Background: Alu elements are one of the most common repetitive sequences that now constitute more than 10% of the human genome and potential targets for epigenetic alterations. Correspondingly, methylation of these elements can result in a genome-wide event that may have an impact in cancer. However, studies investigating the genome-wide status of Alu methylation in cancer remain limited. Objectives: Oral squamous cell carcinoma (OSCC) presents with high incidence in South-East Asia and thus the aim of this study was to evaluate the Alu methylation status in OSCCs and explore with the possibility of using this information for diagnostic screening. We evaluated Alu methylation status in a) normal oral mucosa compared to OSCC; b) peripheral blood mononuclear cells (PBMCs) of normal controls comparing to oral cancer patients; c) among oral epithelium of normal controls, smokers and oral cancer patients. Materials and Methods: Alu methylation was detected by combined bisulfite restriction analysis (COBRA) at 2 CpG sites. The amplified products were classified into three patterns; hypermethylation ($^mC^mC$), partial methylation ($^uC^mC+^mC^uC$), and hypomethylation ($^uC^uC$). Results: The results demonstrate that the $%^mC^mC$ value is suitable for differentiating normal and cancer in oral tissues (p=0.0002), but is not significantly observe in PBMCs. In addition, a stepwise decrease in this value was observed in the oral epithelium from normal, light smoker, heavy smoker, low stage and high stage OSCC (p=0.0003). Furthermore, receiver operating characteristic (ROC) curve analyses demonstrated the potential of combined $%^mC$ or $%^mC^mC$ values as markers for oral cancer detection with sensitivity and specificity of 86.7% and 56.7%, respectively. Conclusions: Alu hypomethylation is likely to be associated with multistep oral carcinogenesis, and might be developed as a screening tool for oral cancer detection.

• 대한전자공학회논문지SD
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• 제38권1호
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• pp.55-68
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• 2001

본 논문에서는 기존의 P(캐리전파)/G(캐리발생) 블록을 가진 ALU구조에서 발생되는 글리칭 전력소모를 최소화시킨 새로운 구조에 대해서 기술한다. 일반적으로 회로에서 발생되는 많은 글리치가 다음 단 회로로 전파될 때, 필요 없이 많은 전력소모가 발생된다. 따라서 본 논문에서는 ALU의 P/G 블록에서 발생되는 글리치를 제거하는 구조를 제안하였다. P/G블록에서 글리치가 제거되면 다음 단인 Sum 발생 블록에서 글리치에 의한 신호천이가 줄어들고, 이에 따라 전력소모가 줄어든다. P/G 블록의 출력 단에 발생되는 글리치 제거를 위해, 기존의 P/G블록내에 래치를 삽입하였다. 래치의 인에이블 신호는 P/G블록의 출력 인에이블 시간을 제어함으로써, P/G블록의 출력 단의 글리치를 제거시키는 역할을 한다. 16비트 ALU를 구현하여 HSPICE로 모의 실험한 결과, 제안한 구조는 지연시간의 증가가 거의 없으면서 약 28%의 글리칭 전력소모가 감소되었다.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2003년도 추계학술대회 논문집
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• pp.117-119
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• 2003

We have designed fabricated, and tested an RSFQ(Rapid Single Flux Quantum) 1-bit ALU (Arithmetic Logic Unit). The 1-bit ALU was composed of a half adder and three SFQ DC switches. Three DC switches were attached to the two output ports of an ALU for the selection of each function from the available functions that were AND, OR, XOR and ADD. And we also attached two DC switches at the input ports of the half adder so that the input data were controlled using the function generators operating at low speed while we tested the circuit at high speed. The test bandwidth was from 1KHz to 5 ㎓. The chip was tested at the liquid helium temperature of 4.2 K.

• Progress in Superconductivity
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• 제6권1호
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• pp.7-12
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• 2004

Due to the very fast switching speed of Josephson junctions, superconductive digital circuit has been a very good candidate fur future electronic devices. High-speed and Low-power microprocessor can be developed with Josephson junctions. As a part of an effort to develop superconductive microprocessor, we have designed an RSFQ 4-bit ALU (Arithmetic Logic Unit) in a pipelined structure. To make the circuit work faster, we used a forward clocking scheme. This required a careful design of timing between clock and data pulses in ALU. The RSFQ 1-bit block of ALU used in this work consisted of three DC current driven SFQ switches and a half-adder. We successfully tested the half adder cell at clock frequency up to 20 GHz. The switches were commutating output ports of the half adder to produce AND, OR, XOR, or ADD functions. For a high-speed test, we attached switches at the input ports to control the high-speed input data by low-frequency pattern generators. The output in this measurement was an eye-diagram. Using this setup, 1-bit block of ALU was successfully tested up to 40 GHz. An RSFQ 4-bit ALU was fabricated and tested. The circuit worked at 5 GHz. The circuit size of the 4-bit ALU was 3 mm ${\times}$ 1.5 mm, fitting in a 5 mm ${\times}$ 5 mm chip.

• 한국컴퓨터산업학회논문지
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• 제3권2호
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• pp.149-158
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• 2002

본 논문에서는 광컴퓨터의 개발에 이용될 수 있는 산술논리연산회로(ALU)를 설계하고 검증한다. 전자회로 기술의 접목이 용이하고 가장 상용화가 잘된 $LiNbO_3$ 광스위칭 소자에 기반한 이 ALU는 산술논리 동작을 실행하는 연산회로, 오퍼런드와 연산결과를 저장하는 메모리 소자 그리고 명령어 선택을 위한 부가회로로 구성되며, 비트 단위 직렬 방식으로 동작하는 것이다. 본 논문에서는 또한 설계한 ALU 회로의 정확성을 검증할 수 있는 시뮬레이터를 구현하고, 일련의 기본 명령어들을 순차적으로 실행하면서 메모리와 누산기에 저장된 값의 단계적 변화를 확인하는 시뮬레이션을 통하여 설계한 ALU가 정확함을 보인다.

• Molecules and Cells
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• 제40권2호
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• pp.100-108
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• 2017

Cathepsin F, which is encoded by CTSF, is a cysteine proteinase ubiquitously expressed in several tissues. In a previous study, novel transcripts of the CTSF gene were identified in the crab-eating monkey deriving from the integration of an Alu element-AluYRa1. The occurrence of AluYRa1-derived alternative transcripts and the mechanism of exonization events in the CTSF gene of human, rhesus monkey, and crabeating monkey were investigated using PCR and reverse transcription PCR on the genomic DNA and cDNA isolated from several tissues. Results demonstrated that AluYRa1 was only integrated into the genome of Macaca species and this lineage-specific integration led to exonization events by producing a conserved 3' splice site. Six transcript variants (V1-V6) were generated by alternative splicing (AS) events, including intron retention and alternative 5' splice sites in the 5' and 3' flanking regions of CTSF_AluYRa1. Among them, V3-V5 transcripts were ubiquitously expressed in all tissues of rhesus monkey and crab-eating monkey, whereas AluYRa1-exonized V1 was dominantly expressed in the testis of the crab-eating monkey, and V2 was only expressed in the testis of the two monkeys. These five transcript variants also had different amino acid sequences in the C-terminal region of CTSF, as compared to reference sequences. Thus, species-specific Alu-derived exonization by lineage-specific integration of Alu elements and AS events seems to have played an important role during primate evolution by producing transcript variants and gene diversification.