• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.259.3-260
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• 2003

Alzheimer's disease(AD) is the most common cause of senile dementia in elderly people and the causes of AD are currently not fully understood. However, AD is generally understood to be associated with reduced levels of acetylcholine in the brain as cholinergic neurons are lost and cholinergic neurotransmission declines. There are growing evidences that two types of cholinesterase(ChE), i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) both play important roles in the regulation of acetylcholine level in brain and thus may have a crucial role in the development and progression of AD. (omitted)

• Journal of Korean Biological Nursing Science
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• 제16권3호
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• pp.219-225
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• 2014

Purpose: This study was aimed to evaluate the effect of blending oils on atopic dermatitis (AD) model of NC/Nga mice. Methods: Adult NC/Nga mice were assigned to 1 of 3 groups: control group (C, n=8), experimental group [AD-induced group, blending oil-treated group (E=8, 8)]. Mice in the E group were given a treatment of blending oils such as Lavender, Rosemary and Lemon Balm (LRL) for 2 sessions (every day) for 6 days. Results: The AD-induced mice with LRL blending oils treatment showed a significant decrease in epidermal thickness, number of mast cells and degranulation, expression of TNF-${\alpha}$ and scoring of sensual assessment. Conclusion: LRL blending oils may be a putative resource for the cure of or treatment of AD by the diminution of AD-pathological factors such as the epidermal thickness, the number of mast cells and degranulation as well as the expression of TNF-${\alpha}$.

• Asian Journal of Atmospheric Environment
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• 제8권3호
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• pp.154-161
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• 2014

The present study was undertaken to evaluate the chemical characteristics of Asian dust (hereafter called "AD") particles with the aid of the most advanced micro-PIXE (Particle-induced X-ray emission) analytical technique. To this end, size-selected particles were sampled on a rural peninsula of Korea (Byunsan, 35.37N; 126.27E) during AD and non-AD periods in 2004. The coarse particle (> $2{\mu}m$) number density during an AD event were 170 times higher than those of the non-AD counterpart. The average net-count of silica in individual particles collected on AD event was roughly 11 times higher than that of non-AD counterpart. The X-ray net-counts of trace elements (Zn, Co, Mn, and V) were also considerably high in AD relative to the non-AD day. Particle classification based on the inter ratio analysis of elemental net-count suggests that a large portion of the coarse particles collected during AD event underwent chemical transformation to a certain degree. The visual interpretation of micro-PIXE elemental maps and elemental localization data in and/or on individual AD particles clarified the internal mixture of AD particles with sea-salt and artificial metallic particles.

• Advances in pediatric surgery
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• 제11권1호
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• pp.27-33
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• 2005

Infantile hypertrophic pyloric stenosis (HPS) is a relatively common entity. A number of studies for the postoperative feeding schedule has been studied to allow for earlier hospital discharge and improve cost-effectiveness in the treatment of HPS. The purpose of this study was to compare 3 feeding-methods and to evaluate the usefulness of ad lib feeding for HPS. The authors retrospectively reviewed the records of 116 patients who underwent pyloromyotomy for HPS from 1995 to 2004. Three cases were excluded because of the duodenal perforation during pyloromyotomy. Three feeding-methods were defined as: Conventional feeding (>10 hours nothing by mouth and incremental feeding every 2 hours, C), Early feeding(for 4 to 8 hours nothing by mouth and incremental feeding every 2 hours, E), and Ad lib feeding (for 4 hours nothing by mouth and ad lib feeding, A). Time to normal feeing in C, E and A were $51{\pm}24$, $34{\pm}12$ and $24{\pm}6$ hours, respectively. Hospital-stay in C, E and A were $72{\pm}17$, $55{\pm}13$ and $43{\pm}12$ hours, respectively. There were statistically significant differences according to the method of feeding. Frequency of postoperative emesis in C, E and A were 38 %, 47 % and 53 %, but was not significant statistically. Ad lib feeding decreased time to normal feeding and hospital stay, and did not increase postoperative emesis. We conclude that ad lib feeding is recommended for patient with pyloromyotomy in HPS.

• Journal of Communications and Networks
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• 제4권3호
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• pp.161-169
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• 2002

Ad hoc wireless networks involving large populations of scattered communication nodes will play a key role in the development of low power, high capacity, interactive, multimedia communication networks. Such networks must support arbitrary network connections and provide coverage anywhere and anytime. This paper partitions such arbitrarily connected network architectures into three distinct groups, identifies the associated dual network architectures and counts the number of network architectures assuming there exist N network nodes. Connectivity between network nodes is characterized as a random event. Defining the link availability P as the probability that two arbitrary network nodes in an ad hoc network are directly connected, the network connection probability $ \integral_n$(p) that any two network nodes will be directly or indirectly connected is derived. The network connection probability $ \integral_n$(p) is evaluated and graphically demonstrated as a function of p and N. It is shown that ad hoc wireless networks containing a large number of network nodes possesses the same network connectivity performance as does a fixed network, i.e., for p>0, $lim_{N\to\infty} Integral_n(p)$ = 1. Furthermore, by cooperating with fixed networks, the ad hoc network connection probability is used to derive the global network connection probability for hybrid networks. These probabilities serve to characterize network connectivity performance for users of wireless ad hoc and hybrid networks, e.g., IEEE 802.11, IEEE 802.15, IEEE 1394-95, ETSI BRAN HIPERLAN, Bluetooth, wireless ATM and the world wide web (WWW).

• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.96-101
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• 2015

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

• 한국물환경학회지
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• 제32권3호
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• pp.297-302
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• 2016

Microbial electrochemical technology (MET) has recently been studied to improve the efficiency of a traditional anaerobic digestion (AD). The purpose of this study was to investigate the impact of MET in the system when MET was combined with traditional AD (i.e., AD-MET). Electrodes used in the MET were Cu coated graphite electrodes. They were supplied with a voltage of 0.3 V. AD started to generate methane in 80 days. But AD-MET started to generate methane from the initial operation after the system started. It was observed that AD-MET reached steady state faster and produced higher methane yield than AD. During the steady state, the average daily methane productions in AD and AD-MET were 2.3L/d and 4.9L/d, respectively. Methane yields were 0.07-CH₄/g‧CODre in AD and 0.25L-CH₄/g‧CODre in AD-MET. In AD-MET, the production rates of total volatile fatty acids (TVFAs) and soluble chemical oxygen demand (SCOD) were 0.12 mg TVFAs/mg VS‧d and 0.35 mg SCOD/mg VS‧d, respectively. They were significantly (p < 0.05) higher than those in AD. However, the concentrations of residual TVFAs in both systems were not significantly (p > 0.05) different from each other, confirming that methane conversion in AD-MET was greater than that in AD.

• 한국환경과학회지
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• 제16권4호
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• pp.399-407
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• 2007

The characteristics of meteorological conditions relevant to Asian dust (AD) outbreaks and their occurrence frequencies were analyzed in four source regions (R1 to R4) during spring months (March to May) of 1995-2002. Moreover, the concentration variations of AD (e.g., $PM_{10}$) observed in Korea were investigated during the study period. In the relationship between AD outbreaks and three meteorological parameters (i.e., air temperature, wind speed, and aridity), the largest AD outbreaks in April (${\sim}250$ observations) mostly occurred in R2 when air temperature ranging from 10.0 to $15^{\circ}C$ and surface wind speed from 7 to $9m\;s^{-1}$ were recorded. Moreover, the aridity ($\geq4$) in April was significantly high in R2 with the maximum frequency of AD outbreaks (i.e., 206 observations). On the other hand, the number (percentage) of days belonging to AD events observed in five Korean cities were found to be 116 (44%), 121 (46%), and 26 days (10%) in March, April, and May, respectively. The mean $PM_{10}$ concentrations were found to range from 150 to 220, 150 to 200, and 95 to $120{\mu}g\;m^{-3}$ in March, April, and May, respectively. Consequently, this implied that the AD events in Korea were found to be gradually frequent in early spring and to be affected from the large AD outbreaks observed in the source regions.

• 한국정보통신학회논문지
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• 제11권3호
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• pp.507-513
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• 2007

본 논문에서는 Certificateless 서명기법을 이용하여 Vehicular Ad-hoc 네트워크에서 공개키 인증서 관리 및 취소 문제를 다루지 않는 효율적인 인증 프로토콜을 제안한다. 또한, 빠르고 동적인 Vehicular Ad-hoc 네트워크의 노드(Vehicles)들의 특성을 고려하여 전통적인 공개키 구조에서의 인증서 취소 문제를 보다 효율적으로 해결하기위하여 구간 서명키 개념을 도입한다.

• 대한지역사회영양학회지
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• 제10권3호
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• pp.264-270
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• 2005

Breastfeeding has been known as the best feeding practice to prevent allergies including atopic dermatitis (AD) However, the benefit on the prevention of allergic disease is still controversial. The objectives of this study were to examine the rate of sensitization to the protein of eggs, cow's milk and soy in exclusively breastfed infants and to evaluate antigen-antibody reaction between breast milk and serum of AD infant. Data on feeding and food hypersensitivity were obtained for 62 AD infants (32 male, 30 female) aged < 6 month who had visited Samsung Medical Center from September 2001 to May 2003. Food hypersensitivity was determined by measuring specific IgE to egg, cow's milk and soy. Specific IgE levels > 0.7 kU/L by CAP assay (Pharmacia, Uppsala, Sweden) were considered positive. The rates of sensitization in breastfed infants were $41.9\%$ (26/62) to egg, $30.6\%$ (19/62) to milk and $18.0\%$ (11/62) to soy. Immunoblotting analyses were performed using breast milk with the matched serum of seven AD infants (4 male/3 female). Binding patterns of AD infant's IgE to breast milk extract showed visible specific band for immunoglobulin, especially in case of a lactating mother who did not completely restricted ingestion of egg, milk and soy. These results indicate that sensitization to food allergen develops via breast milk feeding. Breast milk feeding should be recommended in infants at risk of developing allergic disease, but maternal intake of highly allergenic food might be restricted for prevention and treatment of food allergy among the babies with AD.