Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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The Effect of Essential Oil on Atopic Dermatitis Model of NC/Nga Mice

라벤더, 로즈마리, 레몬밤을 이용한 생쥐의 아토피피부염모델에 대한 효과

  • Han, Sun Hee (Department of Nursing, Wonkwang Health Science University) ;
  • Seo, Young Mi (Department of Nursing, Wonkwang Health Science University)
  • 한선희 (원광보건대학교 간호학과) ;
  • 서영미 (원광보건대학교 간호학과)
  • Received : 2014.05.25
  • Accepted : 2014.08.11
  • Published : 2014.08.31
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Abstract

Purpose: This study was aimed to evaluate the effect of blending oils on atopic dermatitis (AD) model of NC/Nga mice. Methods: Adult NC/Nga mice were assigned to 1 of 3 groups: control group (C, n=8), experimental group [AD-induced group, blending oil-treated group (E=8, 8)]. Mice in the E group were given a treatment of blending oils such as Lavender, Rosemary and Lemon Balm (LRL) for 2 sessions (every day) for 6 days. Results: The AD-induced mice with LRL blending oils treatment showed a significant decrease in epidermal thickness, number of mast cells and degranulation, expression of TNF-${\alpha}$ and scoring of sensual assessment. Conclusion: LRL blending oils may be a putative resource for the cure of or treatment of AD by the diminution of AD-pathological factors such as the epidermal thickness, the number of mast cells and degranulation as well as the expression of TNF-${\alpha}$.

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References

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