• Clinical and Experimental Pediatrics
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• 제60권6호
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• pp.189-195
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• 2017

Purpose: The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. Methods: Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, $9.1{\pm}3.4years$) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before treatment with lamotrigine and after doses had been administered. The mean interval of ADHD testing was approximately 12.3 months. The initial dosage of lamotrigine was 1 mg/kg/day (maximum 25 mg/day for the first 2 weeks), and increased by 1 mg/kg every 2 weeks until titrated up to 7 mg/kg/day (or maximum 200 mg/day). Results: The mean ADHD test score of the 90 subjects was $17.0{\pm}1.8$ at baseline. It was slightly reduced to $15.6{\pm}1.7$ after lamotrigine monotherapy (P>0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy ($28.0{\pm}1.6$ reduced to $18.1{\pm}2.6$, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy. Conclusion: The results from our study show that lamotrigine had a positive effect in pediatric epilepsy patients by reducing ADHD symptoms, preventing seizures, and normalizing EEG. However, further research is required to determine whether lamotrigine is efficacious against ADHD symptoms independent of its effects on epileptic seizures.

• 한국콘텐츠학회논문지
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• 제21권4호
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• pp.565-575
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• 2021

본 연구는 노인의 건강상태가 삶의 만족도에 미치는 영향에서 가족 지지의 매개 효과와 성별 차이를 규명하는 것을 목적으로 한다. 연구방법은 한국복지패널 12차(2017년)에서 만 65세 이상 노인 4,698명의 자료를 SPSS V22.0으로 분석한 결과는 다음과 같다. 첫째, 건강상태에서 주관적 건강상태는 삶의 만족도에 정의 영향을 미치며, 만성질환은 부적인 영향을 미치는 것으로 나타났다. 둘째, 노인의 건강상태와 삶의 만족도 관계에서 가족 지지는 정적인 매개 효과, 만성질환과 삶의 만족도 관계에서 가족 지지는 부적인 매개 효과가 있는 것으로 나타났다. 셋째, 건강상태가 삶의 만족도에 미치는 영향은 여성보다 남성이 더 정적인 영향을 미치며, 만성질환이 삶의 만족도에 미치는 영향에서 여성보다 남성이 더 부적인 영향을 미치며, 가족 지지가 삶의 만족도에 미치는 영향에서 여성보다 남성이 더 정적인 영향을 미치는 것으로 나타났다.

• 대한한의학원전학회지
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• 제22권2호
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• pp.71-83
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• 2009

The documentary characteristics of acupuncture and moxibustion recorded in Dusagyeong(杜思敬)'s".Jesaengbalsu(濟生拔粹)" can be summarized into 3 major parts: 1. "Gyeolgo-ungichimbeop(潔古雲岐鍼法)" and "Dutaesachimbeop(竇太師鍼法)" 1) "Gyeolgo-ungichimbeop" was edited by Dusagyeong of the Won dynasty, and was recorded in "Jesaengbalsu". Du was influenced by his teacher Heohyeong(許衡) and followed Janggyeolgo(張潔古) and his son Jangbyeok(張璧), and collected his work "Chimgu-pyeon(鍼灸篇)" for Jang and named it "Gyeolgo-ungichimbeop", and took the content from the medical book of Jang and his student Wang-haejang(王海藏). (2) "Jesaengbalsu"'s original edition exists today. The "Gyeolgo-ungichimbeop" listed in "Jesaengbalsu"'s index contain two collections, the first collection being "Gyeolgo-ungichimbeop" and the second collection being "Dutaesachimbeop(竇太師鍼法)" (3) Gyeolgo(潔古)、Un-gija(雲岐子)'s acupuncture methods can be seen in Un-gija "Bomyeongjipryuyo(保命集類要)" and Wanghaejang "Chasananji(此事難知)". (4) The related acupuncture methods are 'Non-gyeong-rak-yeongsubosabeop(論經絡迎隨補瀉法)', 'Gyeong-rakchwiwonbeop(經絡取原法)', 'Jeopgyeongbeop(接經法)', and 'Sang-hanyeolbyeongjabeop(傷寒熱病刺法)' (5) Du's edition of the entire text of 'Gyeolgojajetongbeop(潔古刺諸痛法)' 'Jasimtongjehyeol(刺心痛諸穴)' and the first half of 'Jeopgyeongbeop(接經法)' is all recorded in "Somunbyeonggigi-uibomyeongjip(素問病機氣宜保命集)". The existing "Somunbyeonggigi-uibomyeongjip" is a combination of the unfinished posthumous work of Yuwanso(劉完素), "Gi-ui(氣宜)" and "Byeonggi(病機)" with works such as Jangwonso(張元素)'s '"Bomyeongseo(保命書)"'. (6) Of the titles "Gyeolgo-ungichimbeop" and "Dutaesachimbeop", the 14$\sim$19th chapters "Dutaesachimbeop" should be concentrated at the end of the chapter, and the 16th chapter that Du added was put after chapter 14 "Yujujiyobu(流注指要賦)", and chapters 20, 21 should be put in "Gyeolgoungichimbeop" after chapter 13. 2. "Chimgyeongjeok-yeongjip(鍼經摘英集)" (1) "Chimgyeongjeok-yeongjip" is a collection of the acupuncture and moxibustion contents of medical books from the Geum and Won dynasties that Dusagyeong collected and organized during the Won dynasty, which is consisted of 5 chapters : "Guchimshik(九鍼式)", "Jeolyangchwisuhyeolbeop(折量取腧穴法)", "Bosabeop(補瀉法)", "Yongchimhoheupbeop(用鍼呼吸法)", "Chibyeongjik-ralgyeol(治病直剌訣)". (2) First, the contents. The nine acupuncture needles[九鍼] listed in "Guchimshik(九鍼式)" is the first existing document recording to systematically illustrate the 'nine classical needles' in drawing and text form which reflects the forms of the needles of the era. Second, "Jeolyangchwisuhyeolbeop(折量取腧穴法)" has the same basic way of measuring points [量穴法] as Wang-yuil's "Dong-insuhyeolchimgudo-gyeong(銅人腧穴鍼灸圖經)" and the same point selection rules as "Jeonyeongbang(全嬰方)". Third, in "Bosabeop(補瀉法)", "Somun(素問)" and Janggyeolgo's "Yeongsubosabeop(迎隨補瀉法)" is put together. Fourth, in "Yongchimhoheupbeop(用鍼呼吸法)", the cold and heat supplementation and draining [寒熱補瀉] method that combines breathing with inner and outer rotation[外 內撚] is recorded. Fifth, "Chi-byeongjik-ralgyeol(治病直剌訣)" is the main part of "Chimgyeongjeok-yeongjip(鍼經摘英集)" listing 69 acupuncture treatments reflecting Du's scholastic ideas on aspects such as syndrome differentiation[辨證], needling method and type of needle[鍼具]. (3) The content of this book was quoted by "Bojebang Chimgumun(普濟方 鍼灸門)" and when Gomu compiled "Chimguchwiyeong", he put the acupuncture treatments for the main indications of the disease patterns[鍼方主治病證] of this book in the related main indications of acupuncture points[腧穴主治證], which influenced books on acupuncture points there after. 3. "Chimgyeongjeolyo(鍼經節要)" (1) Consists of 1 volume. The original title of this book is "Dong-insuhyeolchimgudo-gyeong (銅人腧穴鍼灸圖經)" and the author is Wang-yuil of the Northern Song dynasty, written in the 4th year of the Cheonseong(天聖) era of the Song dynasty(1026). (2) Dusagyeong selected the contents on pathology of the 12 meridians in volume one and two, the introduction and five transport points[五輸穴] in volume 5 of "Dong-indo-gyeong(銅人圖經)" and named it "Chimgyeongjeolyo." During the Won dynasty it was recorded in "Jesaengbalsu".

• 생약학회지
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• 제50권4호
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• pp.312-317
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• 2019

In order to obtain basic data on the shelf life of Epimedii Herba (EH), a physicochemical characteristics including weight loss rate, loss on drying, ash, acid-insoluble ash, and quantitative determination were evaluated to compare the data by packaging methods including general (G), general + silica gel (GS), alumium (AL), and alumium + silica gel (ALS) packaging and storage periods (0-66 months). All physicochemical analyzes were conducted using the method of "The Korean Pharmacopoeia (KP) 9^th edition". As a result, weight loss rate (%), loss on drying (%), ash (%), acid-insoluble ash (%) of EH according to the packaging methods and storage periods were -0.27-4.73%, 3.06-9.35%, 5.48-7.37%, and 0.45-0.99, respectively. In the quantitative analysis of icariin, the marker compound of EH using high-performance liquid chromatography, the initial content was 0.44% at 0 month in all packaging methods. After that, the result of analyzing the content of icariin every 6 months was detected 0.44-1.18%. All of the above results satisfied the acceptance criteria for loss on drying, ash, acid-insoluble ash, and quantification contained in the KP. This study can be used as a basic data for establishing the packaging method and shelf life of EH.

• 생물정신의학
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• 제21권1호
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• pp.28-35
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• 2014

Objectives This study aimed to identify the relationship between quality of life (QoL) and psychosocial factors of schizophrenia patients registered in a community mental health center. Methods The ninety patients with schizophrenia, diagnosed by Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition-Text Revision, registered in a community mental health center were studied cross-sectionally. Four trained personnels interviewed each subject individually for the assessment of QoL, psychopathology, severity of depressed mood, insight of illness, attitude toward drugs, social function, degree of social supports and conflicts. Results QoL was significantly related to the psychopathology, depressed mood, social conflict, social support; and other aspects of QoL were slightly differently related to depressed mood, social conflict, social support and attitude toward drug by scales. In multiple regression analysis, depressed mood (20.0%) and social conflict (10.3%) were contributed to QoL assessed by Korean version of 4th revision of Schizophrenia Quality of Life. Social support (21.4%), social conflict (20.9%) and depressed mood (3.1%) were contributed to QoL assessed by Korean modification of the Scale to measure Subjective Well-being under Neuroleptic treatment. Conclusions These findings demonstrated that QoL of schizophrenia patients in a community is affected by depressed mood, social support and conflict rather than psychotic symptoms, insight and attitude toward drugs. And this result suggests the necessity of approaching not only to the psychotic symptoms but also to the psychosocial characteristics in caring schizophrenia patients in the community.

• 정보관리학회지
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• 제4권2호
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• pp.47-61
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• 1987

하나의 주제가 분류표 상에서 둘 이상의 기본주제로 구성된 경우를 콜론분류법에서는 복합주제라고 하고, 이 복합주제를 구성하고 있는 각 주제 간의 관계를 불완전한 결합이라고 한다. 상이한 두 주제가 이와 같은 결합을 구성할 때 개개의 구성요소를 상이라고 하고 주제의 패싯 관계와 구분하고 있으며 3가지 수준에서 각각 6가지 종류로 규정하고 있다. DDC 나 UDC 등에서도 부분적으로는 이러한 상 관계가 도입되고 있으나, 그 관계나 수준에 대한 규정이 마련되어 있지 않으며 더우기 이들 관계의 표현방법이 제시되어 있지 않고 있다. 전통적인 체계분류법에서도 복합주제의 처리에 있어, 상 관계의 설정 및 주제구성을 위한 구체적인 방법이 더욱 확대, 도입되어야 할 것이다.

• 한국도서관정보학회지
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• 제15권
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• pp.113-151
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• 1988

The enumerative classification schemes do not represent the tiny mass of knowledge embodied in a article in a periodical or in a chapter or a paragraph of a book. But today's information centers regard a tiny spot of knowledge embodied in a article as a class. we call this micro-thought. But the enumerative classification are manual systems, it cannot be a n.0, pplied to the automation of classification. The purpose of this study is to build a general principle for the automatic book-classification which can be put to use in library operation, and to present a methodology of the automatic classification for the library. The methodology used is essentially theoretical, Published works by and about Ranganathan, especially 6th edition of the CC were studied, analyzed. The principle of automatic book classification derived from the analysis of colon classification and facet combinations. The results of this study can be summarized as follows ; (1) This study confined the fields of library science and agriculture. (2) This study represent a general principles for the automatic book classification of library science and agriculture. (3) Program flowcharts are designed as a basis of system analysis and program procedure in library science and agriculture. (4) The principles of the automatic classification in library, science is different from that of agriculture. (5) Automatic book classification can be performed by the principle of faceted classification, by inputting the title and subject code into a computer. In addition, the expected value from the automatic book-classification is as follows (1) The prompt and accurate of classification is possible. (2) Though a book is classified in any library, it can have same classification number. (3) The user can retrieve the classification code of a book for which he or she wants to search through dialogue with the computer. (4) Since the concept coordination method is employed, a tiny mass of knowledge embodied in a article in a periodical or in a chapter or a paragraph of a book can be represented as a class. (5) By performing automatic book-classification, the automation of library operation can be completed.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3183-3186
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• 2013

Purpose: The 7th edition of the American Joint Committee on Cancer Staging Manual for esophageal cancer (EC) categorizes N stage according to the number of metastatic lymph nodes (LNs), irrespective of the site. The aim of this study was to determine the prognostic value of subcarinal LN metastasis in patients undergoing esophagectomy for esophageal squamous cell carcinoma (ESCC). Methods: A retrospective analysis of 507 consecutive patients with ESCC was conducted. Potential clinicopathological factors that could influence subcarinal LN metastasis were statistically analyzed. Univariate and multivariate analyses were also performed to evaluate the prognostic parameters for survival. Results: The frequency of subcarinal LN metastasis was 22.9% (116/507). Logistic regression analysis showed that tumor length (>3cm vs ${\leq}3cm$; P=0.027), tumor location (lower vs upper/middle; P=0.009), vessel involvement (Yes vs No; P=0.001) and depth of invasion (T3-4a vs T1-2; P=0.012) were associated with 2.085-, 1.810-, 2.535- and 2.201- fold increases, respectively, for risk of subcarinal LN metastasis. Multivariate analyses showed that differentiation (poor vs well/moderate; P=0.001), subcarinal LN metastasis (yes vs no; P=0.033), depth of invasion (T3-4a vs T1-2; P=0.014) and N staging (N1-3 vs N0; P=0.001) were independent prognostic factors. In addition, patients with subcarinal LN metastasis had a significantly lower 5-year cumulative survival rate than those without (26.7% vs 60.9%; P<0.001). Conclusions: Subcarinal LN metastasis is a predictive factor for long-term survival in patients with ESCC.

• 한국문헌정보학회지
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• 제43권1호
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• pp.5-26
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• 2009

본 연구는 KDC 4판을 중심으로 국내 어린이도서관의 어린이 자료 분류의 개선 방안을 제안하였다. 이를 위해 문헌 연구, 국내 51개 어린이도서관의 KDC 적용 현황 조사와 부모 및 어린이 이용자의 요구 분석을 실시하였다. 국내 현황과 이용자 요구 분석 결과를 토대로 KDC 개선 방안을 분류체계 부문과 배가 부문으로 나누어 제시하였다. 우선, 분류체계 부문에서는 특정 기호에 집중되는 주제를 분산시키고, 어린이 자료의 다양한 유형과 특성, 다양한 어린이 문학 장르를 KDC 상에 반영해야 한다. 또한 학제적 주제에 대하여 상세한 주기 및 분류지침을 제공해야 한다. 배가 부문에서는 첫째, 이용자 친화적인 청구기호 구성과 배열 방법을 도입하고, 둘째, 이용자의 다양한 관심 분야를 반영한 컬렉션 구성과 어린이와 부모를 대상으로 이용교육을 실시하도록 제언하였다.

• 대한본초학회지
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• 제37권4호
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• pp.9-16
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• 2022

Objectives : In the Korean Pharmacopoeia 12th edition (KP 12) and the Korean Herbal Pharmacopoeia (KHP), two authentic herbal medicines are described, namely Bang-gi (Cheong-pung-deung) and Mok-bang-gi, respectively. In China, Bun-bang-gi is also used as herbal medicine. This study was conducted to develop a molecular authentication tool for distinguishing the three herbal medicine used as Bang-gi, which are Sinomeni Caulis et Rhizoma (Rhizome of Sinomenium acutum), Stephaniae Tetrandrae Radix (Root of Stephania terandra), and Cocculi Radix (Root of Cocculus trilobus). Methods : Twelve samples of three species (four samples of S. acutum, five samples of S. tetrandra, and three samples of C. trilobus) were collected from different habitats. The sequences of internal transcribed spacer (ITS) regions were obtained and comparatively analyzed to design the species-specific sequence characterized amplified region (SCAR) primers. The specificity of each pair of SCAR primers that amplified species-specific amplicon was evaluated for establishing the singleplex and multiplex PCR assay tools. Results : The singleplex SCAR markers show discriminability in C. acutum, S. tetrandra, and C. trilobus. These SCAR markers were also efficiently authenticated three species in the multiplex SCAR amplification using single PCR reaction. Furthermore, these PCR assay methods were applicable to authenticate dried herbal medicines distributed in the markets. Conclusions : The SCAR markers and PCR assay tools help discriminate the three herbal medicines used as Bang-gi at the species levels and provide a reliable genetic method to prevent the inauthentic distribution of these herbal medicines.