• Tunnel and Underground Space
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• v.32 no.2
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• pp.131-143
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• 2022

The lunar exploration autonomous vehicle operates based on the lunar topography information obtained from real-time image characterization. For highly accurate topography characterization, a large number of training images with various background conditions are required. Since the real lunar topography images are difficult to obtain, it should be helpful to be able to generate mimic lunar image data artificially on the basis of the planetary analogs site images and real lunar images available. In this study, we aim to artificially create lunar topography images by using the location information-based style transfer algorithm known as Wavelet Correct Transform (WCT2). We conducted comparative experiments using lunar analog site images and real lunar topography images taken during China's and America's lunar-exploring projects (i.e., Chang'e and Apollo) to assess the efficacy of our suggested approach. The results show that the proposed techniques can create realistic images, which preserve the topography information of the analog site image while still showing the same condition as an image taken on lunar surface. The proposed algorithm also outperforms a conventional algorithm, Deep Photo Style Transfer (DPST) in terms of temporal and visual aspects. For future work, we intend to use the generated styled image data in combination with real image data for training lunar topography objects to be applied for topographic detection and segmentation. It is expected that this approach can significantly improve the performance of detection and segmentation models on real lunar topography images.

• The Korea Journal of Herbology
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• v.27 no.6
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• pp.131-137
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• 2012

Objectives : Cyclooxygenase (COX) plays a central role in the inflammatory cascade by converting arachidonic acid into prostaglandin. COX-2 is typically induced by inflammatory stimuli in the majority of tissues, it is responsible for propagating the inflammatory response and thus, considered as the best target for anti-inflammatory drugs. The present study investigated the modulatory effect of ginsenoside Rg3, a principle active ingredient in Panax ginseng, on COX-2 expression in the brain tissue induced by systemic lipopolysaccharide (LPS) treatment in C57BL/6 mice. Methods : Because systemic LPS treatment induces COX-2 expression immediately in the brain, ginsenoside Rg3 was treated orally with doses of 10, 20, and 30 mg/kg at 1 hour before the LPS (3 mg/kg, i.p.) injection. At 4 hours after the LPS injection, COX-2 mRNA was measured by real-time polymerase chain reaction method, COX-2 protein levels were measured by Western blotting. In addition, COX-2 expressions in brain tissue were observed with immunohistochemistry and double immunofluoresence labeling. Results : Ginsenoside Rg3 (20 and 30 mg/kg) significantly attenuates up-regulation of COX-2 mRNA and protein expression in brain tissue at 4 hours after the LPS injection. Moreover, ginsenoside Rg3 (20 mg/kg) significantly reduced the number of COX-2 positive neurons in the cerebral cortex and amygdala. Conclusion : These results indicate that ginsenoside Rg3 plays a modulatory role in neuroinflammation through the inhibition of COX-2 expression in the brain and suggest that ginsenoside Rg3 and ginseng may be effective on neurodegenerative diseases caused by neuroinflammation.

• Journal of the Daesoon Academy of Sciences
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• v.31
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• pp.131-163
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• 2018

The concept of pilgrimage is a phenomenon that appears in almost every major religion. It is traditionally defined as religious travel to a sacred external place for spiritual purposes and introspection. However, there are many different relationships between pilgrimages and religious customs, including excursions through abstract dimensions and regular journeys such as annual holidays. Because modern pilgrimages are taken for a variety of reasons, they are not limited to faith-based historical locations. Thus, many scholars also perceive pilgrimages as an increasing part of the general industry of tourism. These journeys are now studied in a diverse range of fields (e.g., ethnography and tourism). In this way, pilgrimages have created a new market from an industrial perspective. This economic analysis has resulted in secular interest. Pilgrimages can now be taken by gil (walkways), which have gained tremendous popularity. Thus, religiosity and humanity as they are embraced through pilgrimages are now receiving outside influences. This study therefore is aimed at generating suggestions for developing the pilgrimage routes related to Kang Jeungsan (i.e., the Supreme God of Daesoon Jinrihoe). These proposed Jeungsan routes are not simply restricted to religious activities or nostalgia, nor are they exclusively concerned with encountering holiness. To realize this idea, it is necessary to reconsider the concept of a sacred space.

• Information Systems Review
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• v.21 no.3
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• pp.131-149
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• 2019

As smart phones, tablets, and other digital devices become more pervasive, theoretical arguments around digital divide, which has previously focused on "access," is now expanding to effectively "utilize," actively "produce" and "share" information. Such discussion is significant because the impact on inter-personal and social networks depends on how digital divides are used, which can then recreate or exacerbate social inequality structures. This study examines the effect of individual's social relations and two types of social capital (i.e., bonding and bridging) on economic and socio-participatory usage of digital devices. An empirical analysis of dataset from 740 surveys reveals that the more horizontal the social relations of the individual, the more both bonding and bridging social capital increase. However, rather than the social relationship of the individual directly influencing the two types of digital device usage, it has an indirect effect on both economic and socio-participatory usage of digital devices. In particular, mediating effects of both bonding and bridging social capital exist in the case of economic usage of digital devices, whereas bonding social capital only has mediating effects on economic usage of digital devices. We discuss the role of social capital on digital devices usage and present the theoretical and practical implications.

• Journal of fish pathology
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• v.6 no.2
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• pp.93-101
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• 1993

The RNAI mutation of Saccharomyces cerevisia is a recessive and temperature sensitive lethal mutation which interferes with the production of mRNA, rRNA, and tRNA. However, the precise role of RNAI gene have not been revealed until yet. We have cloned rna1-1 mutant gene from rna1-1 mutant yeast strain(R49 ; trpl, ura3-52, rna1-1). The 3.4kb BglII fragment of wild type RNAI clone(81-2-6) contains whole RNAI gene. The genomic southern blotting with BglII digested R49 genomic DNA as a probe shows the unique and identical band with wild type 3.4kb BglII fragment. Therefore, We prepared partial BglII genomic library(3~4kb BglII fragments) into BamH I site of pUC19. The rna 1-1 mutant clone was screened with Digoxigenin(DIG)-lableled probe by high density colony hybridization. The 5'-flanking region of rna1-1 gene was sequenced by dideoxy chain termination method. The 5'-flanking sequence of RNAI gene contains three TATA-like sequence ; TAATA, TATA and TTTTAA at position of -67, -45, and -36 from first ATG codon respectively. The 5'-flanking region of wild type RNA I gene from ATG codon to -103nt was deleted with Bal31 exonuclease digestion, generating $pUC{\Delta}$/RNA I. After constructing $pYEP{\Delta}RNA$ I (consists of -103nt deleting RNA I gene, URA3 gene, $2{\mu}m$ rep. origin), pYEPrna1-1(consists of Xba I fragment of pUCrna1-1. URA3 gene, $2{\mu}m$ rep. origin), and pYEPRNAI. each plasmid was transformed into host strain(trpl, ura3-52, rna1-1) by electroporation, respectively. Yeast transformant carrying $pYEP{\Delta}RNA$ I did not complement the thermal sensitivity of rna1-1 gene. It means that TATA-like sequences in 5'-flanking region is not TATA sequence for transcribing RNAI gene and there may be other essential sequence in upstream region for the transcription of RNAI gene.

• The Korean Journal of Nuclear Medicine
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• v.38 no.6
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• pp.516-521
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• 2004

Background: Radioactive iodine (RAI) therapy and whole-body scanning are the fundamentals of treatment and follow-up of patients with differentiated thyroid cancer. It is generally accepted that a Thyroid-Stimulating Hormone (TSH) level of at least 30 ${\mu}U/ml$ is a prerequisite for the effective use of RAI, and that it requires 4-6 weeks of off-thyroxine to attain these levels. Because thyroxine withdrawal and the consequent hypothyroidism are often poorly tolerated, and occasionally might be hazardous, it is important to be certain that these assumptions are correct. We have measured serial changes in serum TSH after total thyroidectomy or withdrawl of thyroxine in patients with thyroid cancer. Subjects and Methods: Serum TSH levels were measured weekly after thyroidectomy in 10 patients (group A) and after the discontinuation of thyroxine in 12 patients (group B). Symptoms and signs of hypothyroidism were also evaluated weekly by modified Billewicz diagnostic index. Results: By the second week, 78% of group A patients and 17% of group B patients had serum TSH levels ${\geq}30{\mu}U/ml$. By the third week, 89% of group A patients and 90% of group B patients had serum TSH levels ${\geq}30{\mu}U/ml$. By the fourth week, all patients in two groups achieved target TSH levels and there were no overt hypothyroidism. Conclusion: in all patients, serum TSH elevated to the target concentration (${\geq}30{\mu}U/ml$) within 4 weeks without significant manifestation of hypothyroidism. The schedule of RAI administration could be adjusted to fit the needs and circumstances of individual patients with a shorter preparation period than the conventional.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.63 no.2
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• pp.131-139
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• 2018

Unsaponifiables in the kernel and the cob of 7 maize varieties were analyzed by using thin-layer chromatography (TLC) and gas chromatography (GC) for the identification of phytosterols and their concentrations. The unsaponifiables of the kernel were clearly separated into band I (campesterol, stigmasterol, and ${\beta}$-sitosterol), band II (${\Delta}^5$-avenasterol), band III (${\Delta}^7$- stigmastenol), and band IV (${\Delta}^7$-avenasterol). In the cob, on the other hand, three or more bands were separated in addition to bands. The GC analysis of unsaponifiables showed good separation of campesterol, stigmasterol and ${\beta}$-sitosterol, but the mixture of ${\Delta}^7$-avenasterol (retention time[RT] 22.846), ${\Delta}^7$-stigmastenol (RT 22.852), and ${\Delta}^5$-avenasterol (RT 22.862) showed poor separation. Phytosterol content of the maize kernel was 635.9 mg/100 g, and that of the cob was 273.0 mg/100 g, respectively. The phytosterol content of the kernel was 2.4-fold higher than that of the cob. The phytosterol content of the kernel was higher in the order ${\beta}$sitosterol 80.05% > campesterol 10.5% > stigmasterol 9.46%, but that of the cob was higher in the order ${\beta}$-sitosterol 59.43% > stigmasterol 31.72% > campesterol 10.98%. Based on these results, it appears that the phytosterols of the maize kernel are synthesized in the maize cob and are transferred to the kernel, because the precursors (${\Delta}^7$-avenasterol, ${\Delta}^7$-stigmastenol, and ${\Delta}^5$-avenasterol) of major phytosterols were detected in maize cobs.

• Journal of the Society of Naval Architects of Korea
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• v.32 no.1
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• pp.118-131
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• 1995

The shock fracture analysis for the structures of navy vessels subject to underwater explosions or of high speed vessels frequently subject to impact loads has been carried out in two steps such as the global or macro analysis and the fine or micro analysis. In the macro analysis, Doubly Asymptotic Approximation(DAA) has been applied. The three main failure modes of structure members subject to strong shock loading are late time fracture mode such as plastic large deformation mainly due to dynamic plastic buckling, and the early time fracture mode such as tensile tearing failure or transverse shear failure. In this paper, the tensile tearing failure mode is numerically analyzed for the micro analysis by calculating the dynamic stress intensity factor $K_I(t)$, which shows the relation between stress wave and crack propagation on the longitudinal stiffener of the model. Especially, in calculating this factor, the numerical caustic method developed from shadow optical method of caustic well known as experimental method is used. The fully submerged vessel is adopted for the macro analysis at first, of which the longitudinal stiffener, subject to early shock pressure time history calculated in macro analysis, is adopted for the micro analysis.

• International Journal of Highway Engineering
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• v.13 no.2
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• pp.125-131
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• 2011

This research aims to investigate the cause of the occurrence of a weak road drainage section scientifically and specifically through a site survey for a poorly drained section occurring due to rainfalls during road operation. This paper deeply reviewed the existing research results and current situation data on the poorly drained sections accumulated in Korea Expressway Corporation in order to investigate the cause of the occurrence of a weak road drainage section, and deeply verified and analyzed the weak sections for the road surface drainage facilities and the other road drainage facilities by visiting the expressway controlled by the 6 local headquarters and 33 branches of Korea Expressway Corporation. As a result of site surveys for the weak road drainage sections, i) in a road surface section, occurrence of ponding in the road shoulder pavement due to slope changes, bad collection of water in the collecting well at a median strip, shortage of road shoulder dike height, and inferior construction, etc. was analyzed to be the main cause of the occurrence of poorly drained sections, and ii) in a road neighborhood section, the occurrence of pavement height difference in a main road and shoulder section due to inferior ditches on a slope and the bad drain age at the inlet and outlet of a culvert due to soil deposits, debris, etc. were analyzed to be the main cause of the occurrence of weak sections. Proposed as a plan to improve the poorly drainage section of road were i)calculation of capacity through material changes at the ditch, enhancement of vertical sections and hydraulic analysis in terms of construction and other aspects, ii)derivation of a combined slope considering a slope and a vertical linearity and maintenance of proper distance between drainage structures in a vertical concave section in terms of geometrical structure, and iii)calculation of the drainage facility installation interval using a minutely rainfall intensity formula and a non-uniform flow analysis technique in terms of hydraulics and hydrologics and prompt removal of rainfalls from the road surface according to a linear drainage method.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.123-131
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• 2001

To investigate the effects of electrical stimulation on vestibular compensation, which is the recovery of vestibular symptoms following unilateral labyrinthectomy (UL), intermittent electrical stimulation was applied to the injured vestibular portion in Sprague-Dawley rats. Vestibuloocular and vestibulospinal reflexes, electrical activity and expression of c-Fos protein in medial vestibular nuclei (MVN) were measured with time following UL. Spontaneous nystagmus occurred with frequency of $2.9{\pm}0.2$ beats/sec at 2 hours after UL and disappeared after 72 hours. Electrical stimulation decreased the frequency of nystagmus significantly till 24 hours after UL. Roll head deviation was $107{\pm}9.7^{\circ}$ at 2 hours after UL and the deviation was maintained till 72 hours, but electrical stimulation decreased the deviation significantly 6 hours after UL. Resting activity of type I neurons in ipsilateral MVN to the injured vestibular side decreased significantly compared with control at 6 and 24 hours after UL, but the activity of type I neurons was recovered to control level by electrical stimulation at 24 hours after UL. Gain of type I neurons induced by sinusoidal rotation of 0.1 Hz decreased significantly till 24 hours after UL, but electrical stimulation restored the activity at 24 hours. The gain of type II neurons decreased significantly at 6 hours after UL, but electrical stimulation restored the activity. Expression of c-Fos protein was asymmetric between bilateral MVN till 24 hours after UL, but the asymmetry disappeared by electrical stimulation 6 hours after UL. These results suggest that electrical stimulation to the injured vestibular portion facilitates vestibular compensation following UL by restoration of symmetry of neuronal activity between bilateral vestibular nuclei resulting from increased activity in ipsilateral vestibular nuclei to the injured side.